The investigation of contribution of incretin to the pathogenesis of NASH

• Project/Area Number: 25460999
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Kochi University
• Principal Investigator: Okamoto Nobuto 高知大学, 教育研究部医療学系臨床医学部門, 講師 (10346710)
• Co-Investigator(Kenkyū-buntansha): SAIBARA Toshiji 高知大学, 教育研究部医療学系臨床医学部門, 教授 (60145125) ; ONO Masafumi 高知大学, 教育研究部医療学系臨床医学部門, 准教授 (70304681)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 肝臓学 / 非アルコール性脂肪肝炎 / インクレチン / GLP-1 receptor / NASH / DM / ＤＭ / ＮＡＳＨ

Outline of Final Research Achievements

The direct mechanisms of contribution of incretin to hepatocytes on the pathogenesis of nonalcoholic steatohepatitis (NASH) was investigated. We found GLP-1 receptor (GLP-1R) expressed on the hepatocytes. It was clarified that incretin contributed glucose metabolisms and pathogenesis of NASH by overexpression of GLP-1R on hepatocytes. In addition, it was clarified that this system had close talk with insulin signal, IRS-1, -2, and had important roles for the glucose metabolisms in liver.

Research Products

• [Journal Article] PNPLA3 is involved in hepatic fatty acid and triglyceride metabolism through XBP1 and modulation of endoplasmic reticulum stress in mice. (2016)
  • Author(s): Ochi T, Munekage K, Ono M, Higuchi T, Tsuda M, Hayashi Y, Okamoto N, Toda K, Sakamoto S, Oben JA, Saibara T
  • Journal Title: Hepatol Res Volume: 印刷中 Issue: 6 Pages: 584-592
  • DOI: 10.1111/hepr.12587
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hepatocellular carcinoma in Japanese patients with nonalcoholic fatty liver disease and alcoholic liver disease: multicenter survey. (2016)
  • Author(s): Tokushige K, Hyogo H, Nakajima T, Ono M, Kawaguchi T, Honda K, Eguchi Y, Nozaki Y, Kawanaka M, Tanaka S, Imajo K, Sumida Y, Kamada Y, Fujii H, Suzuki Y, Kogiso T, Karino Y, Munekage K, Kuromatsu R, Oeda S, Yanase M, Mori K, Ogawa Y, Seko Y, Takehara T, Itoh Y, Nakajima A, Kanemasa K, Saibara T
  • Journal Title: J Gastroenterol Volume: 印刷中 Issue: 6 Pages: 586-96
  • DOI: 10.1007/s00535-015-1129-1
  • Peer Reviewed / Open Access
• [Journal Article] Magnetic Resonance Imaging More Accurately Classifies Steatosis and Fibrosis in Nonalcoholic Fatty Liver Disease Than Transient Elastography. (2016)
  • Author(s): Imajo K, Kessoku T, Honda Y, Tomeno W, Ogawa Y, Mawatari H, Fujita K, Yoneda M, Taguri M, Hyogo H, Sumida Y, Ono M, Eguchi Y, Inoue T,Yamanaka T, Wada K, Saito S, Nakajima A
  • Journal Title: Gastroenterology Volume: 150 Issue: 3 Pages: 626-37
  • DOI: 10.1053/j.gastro.2015.11.048
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Are genetic variations the most important risk factors for development of hepatocellular carcinoma? (2016)
  • Author(s): Ono M，Saibara T
  • Journal Title: J Gastroenterol. Volume: 51 Issue: 4 Pages: 404-5
  • DOI: 10.1007/s00535-015-1130-8
  • Peer Reviewed / Open Access
• [Journal Article] 脂肪肝を防ぐ食生活と治療を考える (2016)
  • Author(s): 西原利治
  • Journal Title: 日本内科学会雑誌 Volume: 105 Pages: 406-10
• [Journal Article] 非アルコール性脂肪肝炎を来す薬剤 (2016)
  • Author(s): 宮村充彦，横田淳子，西原利治
  • Journal Title: 薬学雑誌 Volume: 136 Pages: 579-82
  • NAID: 130005140771
• [Journal Article] A novel noninvasive diagnostic method for nonalcoholic steatohepatitis using two glycobiomarkers. (2015)
  • Author(s): Kamada Y, Ono M, Hyogo H, Fujii H, Sumida Y, Mori K, Tanaka S, Yamada M, Akita M, Mizutani K, Fujii H, Yamamoto A, Takamatsu S, Yoshida Y, Itoh Y, Kawada N, Chayama K, Saibara T, Takehara T, Miyoshi E
  • Journal Title: Hepatology. Volume: 62 Issue: 5 Pages: 1433-1443
  • DOI: 10.1002/hep.28002
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Biphasic effect of alcohol intake on the development of fatty liver disease. (2015)
  • Author(s): Takahashi H, Ono M, Ono N, Eguchi T, Fujimoto K, Chayama K, Saibara T, Anzai K, Eguchi Y
  • Journal Title: J Gastroenterol Volume: 50 Issue: 11 Pages: 1114-23
  • DOI: 10.1007/s00535-015-1058-z
  • Peer Reviewed / Open Access
• [Journal Article] Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. (2015)
  • Author(s): Watanabe S, Hashimoto E, Ikejima K, Uto H, Ono M, Sumida Y, Seike M, Takei Y, Takehara T, Tokushige K, Nakajima A, Yoneda M, Saibara T, Shiota G, Sakaida I, Nakamuta M, Mizuta T, Tsubouchi H, Sugano K, Shimosegawa T.
  • Journal Title: Hepatol Res. Volume: 45 Issue: 4 Pages: 363-377
  • DOI: 10.1111/hepr.12511
  • Peer Reviewed / Open Access
• [Journal Article] NASHはどれくらい存在するのか (2015)
  • Author(s): 越智経浩，小野正文，西原利治
  • Journal Title: Mebio Volume: 33 Pages: 4-9
• [Journal Article] NASH/NAFLDおよび肥満研究の最前線 (2015)
  • Author(s): 小野正文，西原利治
  • Journal Title: 分子消化器病 Volume: 12 Pages: 165-70
• [Journal Article] NAFLD、NASHの発症頻度はどれくらい？男女別および国内外の頻度について (2015)
  • Author(s): 小野正文，西原利治
  • Journal Title: Nutrition Care Volume: 8 Pages: 672-5
• [Journal Article] 肝臓における糖代謝の最新知見 (2015)
  • Author(s): 小野正文，越智経浩，西原利治
  • Journal Title: Diabetes Frontier Volume: 26 Pages: 287-96
• [Journal Article] 尿酸血症と非アルコール性脂肪性肝疾患（NAFLD・NASH） (2015)
  • Author(s): 西原利治
  • Journal Title: 尿酸と血糖 Volume: 1 Pages: 55-8
• [Journal Article] Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. (2015)
  • Author(s): Watanabe S, Hashimoto E, Ikejima K, Uto H, Ono M, Sumida Y, Seike M,
  • Journal Title: J Gastroenterol Volume: 50(4) Issue: 4 Pages: 364-377
  • DOI: 10.1007/s00535-015-1050-7
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Prdx1 promotes pancreatic cancer cell invasion by modulating p38 MAPK activity. (2015)
  • Author(s): Taniuchi K, Furihata M, Hanazaki K, Iwasaki S, Tanaka K, Shimizu T, Saito M, Saibara T
  • Journal Title: Pancreas Volume: 44 Issue: 2 Pages: 331-340
  • DOI: 10.1097/mpa.0000000000000270
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Is nonalcoholic fatty liver disease a systemic disease that promotes extrahepatic cancer development？． (2014)
  • Author(s): Ono M
  • Journal Title: Hepatology Reseach Volume: 45 Issue: 7 Pages: 711-713
  • DOI: 10.1111/hepr.12435
  • Peer Reviewed / Open Access
• [Journal Article] Clinical effects of fenofibrate on serum uric acids，triglyceride，and creatinine in patients with hypertriglyceridemia． (2014)
  • Author(s): Oe K，Ono M，Ochi T，Munekage K，Mizuta H，Masuda K，Okamoto N，Saibara T
  • Journal Title: Int Med J Volume: 21 Pages: 363-366
  • Peer Reviewed
• [Journal Article] Functional role of estrogen for regulation of serum uric acid levels in pre-monopause patients with breast cancer (2014)
  • Author(s): Yoshioka R，Ono M，Oe K，Ochi T，Munekage K，Masuda K，Mizuta H，Okamoto N，Saibara T
  • Journal Title: Int Med J Volume: 21 Pages: 1-4
  • Peer Reviewed
• [Journal Article] Pilot study of liraglutide effects in nonalcoholic steatohepatitis and nonalcoholic fatty liver disease with glucose intolerance in Japanese patients (LEAN-J). (2014)
  • Author(s): Eguchi Y, Kitajima Y, Hyogo H, Takahashi H, Kojima M, Ono M, Araki N, Tanaka K, Yamaguchi M, Matsuda Y, Ide Y, Otsuka T, Ozaki I, Ono N,3 Eguchi T, Anzai K, and Japan Study Group for NAFLD (JSG-NAFLD)
  • Journal Title: Hepatol Res Volume: 45 Issue: 3 Pages: 269-78
  • DOI: 10.1111/hepr.12351
  • Peer Reviewed
• [Journal Article] Simple scoring system for predicting cirrhosis in nonalcoholic fatty liver disease. (2014)
  • Author(s): Kessoku T, Ogawa Y, Yoneda M, Imajo K, Sumida Y, Eguchi Y, Fujii H, Hyogo H, Ono M, Suzuki Y, Kawaguchi T, Chayama K, Tanaka S, Fujimoto K, Anzai K, Saibara T, Sata M, Itoh Y, Nakajima A, Okanoue T
  • Journal Title: World J Gastroenterol Volume: 20（29） Issue: 29 Pages: 10108-10114
  • DOI: 10.3748/wjg.v20.i29.10108
  • Peer Reviewed / Open Access
• [Journal Article] nsulin Resistance Correlated With the Severity of Liver Histology in Japanese NAFLD Patients: A Multicenter Retrospective Study. (2014)
  • Author(s): Kessoku T, Yoneda M, Sumida Y, Eguchi Y, Fujii H, Hyogo H, Ono M, Kawaguchi T, Nakajima A; Japan Study Group of NAFLD (JSG-NAFLD)
  • Journal Title: J Clin Gastroenterol Volume: 49 Issue: 2 Pages: 169-70
  • DOI: 10.1097/mcg.0000000000000186
  • Peer Reviewed
• [Journal Article] Clinical Usage of Serum Ferritin to Assess Liver Fibrosis in Patients with Nonalcoholic Fatty Liver Disease: Proceed with Caution. (2014)
  • Author(s): Yoneda M, Thomas E, Sumida Y, Imajo K, Eguchi Y, Hyogo H, Fujii H, Ono M, Kawaguchi T, Schiff ER
  • Journal Title: Hepatol Res Volume: 44 Issue: 14
  • DOI: 10.1111/hepr.12327
  • Peer Reviewed
• [Journal Article] Uric acid levels decrease with fibrosis progression in patients with nonalcoholic fatty liver disease. (2014)
  • Author(s): Yoneda M, Thomas E, Sumida Y, Imajo K, Hyogo H, Fujii H, Ono M, Kawaguchi T, Eguchi Y, Nakajima A
  • Journal Title: Clin Biochem Volume: 47 Issue: 12 Pages: 1138-9
  • DOI: 10.1016/j.clinbiochem.2014.04.026
  • Peer Reviewed
• [Journal Article] Type 2 diabetes mellitus is associated with the fibrosis severity in patients with nonalcoholic fatty liver disease in a large retrospective cohort of Japanese patients. (2014)
  • Author(s): Nakahara T, Hyogo H, Yoneda M, Sumida Y, Eguchi Y, Fujii H, Ono M, Kawaguchi T, Imajo K, Aikata H, Tanaka S, Kanemasa K, Fujimoto K, Anzai K, Saibara T, Sata M, Nakajima A, Itoh Y, Chayama K, Okanoue T
  • Journal Title: J Gastroenterol Volume: 49(11) Issue: 11 Pages: 1477-1484
  • DOI: 10.1007/s00535-013-0911-1
  • Peer Reviewed / Open Access
• [Journal Article] The association of insomnia with gastroesophageal reflux symptoms in biopsy-proven nonalcoholic fatty liver disease. (2014)
  • Author(s): Taketani H, Sumida Y, Tanaka S, Imajo K, Yoneda M, Hyogo H, Ono M, Fujii H, Eguchi Y, Kanemasa K, Chayama K, Itoh Y, Yoshikawa T, Saibara T, Fujimoto K, Nakajima A
  • Journal Title: J Gastroenterol Volume: 49(7) Issue: 7 Pages: 1163-1174
  • DOI: 10.1007/s00535-013-0871-5
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of Ki-67 index in EUS-FNA specimens for the assessment of malignancy risk in pancreatic neuroendocrine tumors. (2014)
  • Author(s): Hasegawa T, Yamao K, Hijioka S, Bhatia V, Mizuno N, Hara K, Imaoka H, Niwa Y, Tajika M, Kondo S, Tanaka T, Shimizu Y, Kinoshita T, Kohsaki T, Nishimori I, Iwasaki S, Saibara T, Hosoda W, Yatabe Y
  • Journal Title: Endoscopy Volume: 46(1) Issue: 01 Pages: 32-38
  • DOI: 10.1055/s-0033-1344958
  • Peer Reviewed / Open Access
• [Journal Article] Multicenter validation study of anti-programmed cell death-1 antibody as a serological marker for type 1 autoimmune hepatitis (2014)
  • Author(s): Miyake Y, Yamamoto K, Matsushita H, Abe M, Takahashi A, Umemura T, Tanaka A, Nakamuta M, Nakamoto Y, Ueno Y, Saibara T, Takikawa H, Yoshizawa K, Ohira H, Zeniya M, Onji M, Tsubouchi H; Intractable Liver and Biliary Diseases Study Group of Japan
  • Journal Title: Hepatol Res. Volume: 44 Issue: 13 Pages: 1299
  • DOI: 10.1111/hepr.12305
  • Peer Reviewed / Open Access
• [Journal Article] Autoantibody status and histological variables influence biochemical response to treatment and long-term outcomes in Japanese patients with primary biliary cirrhosis (2014)
  • Author(s): Nakamura M, Kondo H, Tanaka A, Komori A, Ito M, Yamamoto K, Ohira H, Zeniya M, Hashimoto E, Honda M, Kaneko S, Ueno Y, Kikuchi K, Shimoda S, Harada K, Arai K, Miyake Y, Abe M, Taniai M, Saibara T, Sakisaka S, Takikawa H, Onji M, Tsubouchi H, Nakanuma Y, Ishibashi H.
  • Journal Title: Hepatol Res. Volume: 45 Issue: 8 Pages: 846
  • DOI: 10.1111/hepr.12423
  • Peer Reviewed / Open Access
• [Journal Article] Simultaneous occurrence of gastric lipoma and early gastric cancer. (2014)
  • Author(s): Namikawa T, Munekage E, Mizuta H, Kobayashi M, Saibara T, Hanazaki K.
  • Journal Title: Endoscopy Volume: 46 Issue: S 01 Pages: E338-E339
  • DOI: 10.1055/s-0034-1377279
  • Peer Reviewed / Open Access
• [Journal Article] Safety and efficacy of image-guided enzyme-targeting radiosensitization and intraoperative radiotherapy for locally advanced unresectable pancreatic cancer. (2014)
  • Author(s): Nishioka A, Ogawa Y, Miyatake K, Tadokoro M, Nogami M, Hamada N, Kubota K, Kariya S, Kohsaki T, Saibara T, Okabayashi T, Hanazaki K
  • Journal Title: Oncol Lett Volume: 8 Pages: 404-8
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] KIF20A-mediated RNA granule transport system promotes the invasiveness of pancreatic cancer cells. (2014)
  • Author(s): Taniuchi K, Furihata M, Saibara T
  • Journal Title: Neoplasia Volume: 16 Issue: 12 Pages: 1082-1093
  • DOI: 10.1016/j.neo.2014.10.007
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] IGF2BP3-mediated translation in cell protrusions promotes cell invasiveness and metastasis of pancreatic cancer． (2014)
  • Author(s): Taniuchi K，Furihata M，Hanazaki K，Saito M，Saibara T
  • Journal Title: Oncotarget Volume: 30 Pages: 6832-45
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] RUVBL1 directly binds actin filaments and induces formation of cell protrusions to promote pancreatic cancer cell invasion. (2014)
  • Author(s): Taniuchi K, Furihata M, Iwasaki S, Tanaka K, Shimizu T, Saito M, Saibara T
  • Journal Title: International Journal of Oncology Volume: 44 Issue: 6 Pages: 1945-1954
  • DOI: 10.3892/ijo.2014.2380
  • Peer Reviewed
• [Journal Article] NAFLDの診療・研究の進歩． (2014)
  • Author(s): 汐田剛史，宇都浩文，小野正文，徳重克年，角田圭雄，兵庫秀幸
  • Journal Title: 日本消化器病学会雑誌 Volume: 111 Pages: 6-11
  • NAID: 130003383343
• [Journal Article] 特集 肝臓に焦点を当てた糖尿病治療 肝臓の糖代謝． (2014)
  • Author(s): 小野正文，西原利治
  • Journal Title: 月刊 糖尿病DIABETES Volume: 6 Pages: 6-11
• [Journal Article] NASHの疾患概念 (2014)
  • Author(s): 西原利治，廣瀬享，小笠原光成
  • Journal Title: 最新医學 Volume: 69 Pages: 1791-4
• [Journal Article] NASH肝癌の臨床的特徴 (2014)
  • Author(s): 羽柴基，小野正文，西原利治
  • Journal Title: 消化器の臨床 Volume: 17 Pages: 62-5
• [Journal Article] 診断の進歩（biomarker） (2014)
  • Author(s): 石川洋一，水田洋，西原利治
  • Journal Title: 肝胆膵 Volume: 69 Pages: 903-8
• [Journal Article] タモキシフェン (2014)
  • Author(s): 藤村靖子，西原桜子，西原利治
  • Journal Title: 肝胆膵 Volume: 68 Pages: 193-7
• [Journal Article] Bofutsushosan, a Japanese herbal (Kampo) medicine, attenuates progression of nonalcoholic steatohepatitis in mice (2013)
  • Author(s): Masafumi Ono, Mitsunari Ogasawara, Akira Hirose, Sachiko Mogami, Nobuhiro Ootake, Kosuke Aritake, Takuma Higuchi, Nobuto Okamoto, Shuji Sakamoto, Masahiro Yamamoto, Yoshihiro Urade, Toshiji Saibara, Jude A. Oben.
  • Journal Title: Journal of Gastroenterology Volume: 49(6) Issue: 6 Pages: 1065-1173
  • DOI: 10.1007/s00535-013-0852-8
  • Peer Reviewed / Open Access
• [Journal Article] The upper limit of normal serum alanine aminotransferase levels in Japanese subjects. (2013)
  • Author(s): Tanaka K,Ono M,Saibara T et.al
  • Journal Title: Hepatology Research Volume: 23 Issue: 12 Pages: 1196-1207
  • DOI: 10.1111/hepr.12293
  • Peer Reviewed / Open Access
• [Journal Article] A romatese-null mice expressing enhanc ed green fluorescent protein in germ cells provide a model system to ass ess estrogen-dependent ovulatory res ponses (2013)
  • Author(s): Toda K,Ono M,Saibara T(他3名)
  • Journal Title: Transgenic Res Volume: (E-pub) Issue: 2 Pages: 293-302
  • DOI: 10.1007/s11248-013-9771-y
  • Peer Reviewed / Open Access
• [Journal Article] Clinical efficacy of combination therapy with ME3738 and pegylated interferon-alpha-2a in patients with hepatitis C virus genotype 1. (2013)
  • Author(s): Saibara T, Enomoto N, Kaneko S, Chayama K, Sata M, Imawari M, Onishi S, Okita K.
  • Journal Title: Hepatol Res. Volume: Apr 19 Issue: 4 Pages: 410-419
  • DOI: 10.1111/hepr.12139
  • Peer Reviewed
• [Journal Article] Glycemic variability is an independent predictive factor for development of hepatic fibrosis in nonalcoholic Fatty liver disease. (2013)
  • Author(s): Hashiba M,Ono M,Okamoto N,Saibara T et.al
  • Journal Title: PLoS One Volume: 8(11) Issue: 11 Pages: e76161-e76161
  • DOI: 10.1371/journal.pone.0076161
  • Peer Reviewed
• [Journal Article] Type 2 diadetes mellitus is associated with the fibrosis severity in patients with nonalcoholic fatty liver disease in a large retrospective cohort of Japanese patients． (2013)
  • Author(s): Nakahara T,Ono M,Saibara T et.al
  • Journal Title: J Gastroenterol Volume: E-pub
  • Peer Reviewed
• [Journal Article] Bofutsushosan，a Japanese herbal（Kampo）medicine，attenuates progression of nonalcoholic steatohepatitis in mice． (2013)
  • Author(s): Ono M,Okamoto N,Saibara T et.al
  • Journal Title: J Gastroenterol Volume: E-pub
  • Peer Reviewed
• [Journal Article] The association of insomnia with gastroesophageal reflux symptoms in biopsy-proven nonalcoholic fatty liver disease. (2013)
  • Author(s): Taketani H,Ono M,Saibara T et.al
  • Journal Title: J Gastroenterol Volume: E-pub
  • Peer Reviewed
• [Journal Article] Hepatocyte destruction with enhanced collagen synthesis: Characteristic feature of chronic hepatitis C patients on haemodialysis (2013)
  • Author(s): Ue, M., Ikebe, N., Munekage, K., Ochi, T., Hirose, A., Kataoka, H., Fujimoto, S., Kikuchi, K., Okuhara, Y., Ono, M.a , Saibara, T.
  • Journal Title: Journal of Viral Hepatitis Volume: 20(6) Issue: 5 Pages: 350-357
  • DOI: 10.1111/jvh.12031
  • Peer Reviewed
• [Journal Article] 非アルコール性脂肪肝炎(NASH)の診療 (2013)
  • Author(s): 越智経浩,小野正文，西原利治 他
  • Journal Title: 臨床と研究 Volume: 90(2) Pages: 53-57
• [Journal Article] 飲酒よりも肥満や内臓脂肪蓄積の方が脂肪肝発症に重要である (2013)
  • Author(s): 小野正文,西原利治 他
  • Journal Title: 消化器内科 Volume: 56（1） Pages: 120-125
• [Journal Article] 脂肪肝発症には肥満や耐糖異常、脂質異常が飲酒よりもよ重要な危険因子である (2013)
  • Author(s): 小野正文,西原利治 他
  • Journal Title: 消化器内科 Volume: 57(6) Pages: 685-689
• [Journal Article] 特集 糖尿病と脂質代謝異常の病態リンク 糖尿病と脂肪肝 (2013)
  • Author(s): 西原利治,小野正文 他
  • Journal Title: Diabetes Frontier Volume: 24（4） Pages: 408-411
• [Journal Article] NASH鑑別のためのスコアリングシステム (2013)
  • Author(s): 角田圭雄,小野正文 他
  • Journal Title: 臨牀消化器内科 Volume: 28(4) Pages: 417-422
• [Journal Article] NAFLD/NASHの疫学 (2013)
  • Author(s): 徳光敬太,小野正文，西原利治
  • Journal Title: 臨牀消化器内科 Volume: 28(4) Pages: 403-407
• [Journal Article] 非アルコール性脂肪性肝疾患の疾患関連遺伝子 (2013)
  • Author(s): 宮本敬子，小野正文，西原利治
  • Journal Title: 日本消化器病学会雑誌 Volume: 110（9） Pages: 21-25
  • NAID: 10031195129
  • Peer Reviewed
• [Journal Article] Third-generation inhibitor for the renin–angiotensin system: Can it strongly protect against progression of hepatic fibrosis in non-alcoholic steatohepatitis? Editorial. (2013)
  • Author(s): Ono M
  • Journal Title: Hepatol Res Volume: 43 Issue: 11 Pages: 1127-1129
  • DOI: 10.1111/hepr.12113
  • Peer Reviewed
• [Journal Article] Tumor necrosis factor-α promotes cholestasis-induced liver fibrosis in the mouse through tissue inhibitor of metalloproteinase-1 production in hepatic stellate cells． (2013)
  • Author(s): Osawa Y,Saibara T et.al
  • Journal Title: PloS One Volume: 8（6） Issue: 6 Pages: e65251-e65251
  • DOI: 10.1371/journal.pone.0065251
  • Peer Reviewed
• [Journal Article] Liver acid sphingomyelinase inhibits growth of metastatic colon cancer． (2013)
  • Author(s): Osawa Y,Saibara T et.al
  • Journal Title: Journal Clin Invest Volume: 123(2) Pages: 834-843
  • DOI: 10.1172/jci65188
  • Peer Reviewed
• [Journal Article] 非アルコール性脂肪性肝疾患（NASH/NAFLD） (2013)
  • Author(s): 西原利治
  • Journal Title: 日本臨床内科医会会誌 Volume: 28 Pages: 11-18
  • Peer Reviewed
• [Journal Article] アルコール性肝障害と非アルコール性脂肪性肝疾患のストローク (2013)
  • Author(s): 坪井麻記子,西原利治 他
  • Journal Title: 消化器内科 Volume: 57(6) Pages: 675-680
• [Journal Article] Noninvasive scoring systems in patients with nonalcoholic fatty liver disease with normal alanine aminotransferase levels. (2012)
  • Author(s): Yoneda M
  • Journal Title: J Gastroenterology Volume: Nov 27 Issue: 9 Pages: 1051-1060
  • DOI: 10.1007/s00535-012-0704-y
  • Peer Reviewed
• [Presentation] 高インスリン血症は糖尿病未発症NAFLD患者の肝線維化進展に重要な因子である (2015)
  • Author(s): 宗景玄祐，小野正文，西原利治
  • Organizer: 第41回日本肝臓学会西部会
  • Place of Presentation: 名古屋国際会議場（愛知県・名古屋市）
  • Year and Date: 2015-12-03
• [Presentation] A novel noninvasive diagnostic method for nonalcoholic steatohepatitis（NASH） using two glycobiomarkers． (2015)
  • Author(s): Kamada Y，Ono M，Hyogo H，Fujii H，Sumida Y，Mori K，Tanaka S，Yamada M，Akita M，Mizutani K，Fujii H，Yamamoto A，Takamatsu S，Yoshida Y，Itoh Y，Kawada N，Chayama K，Saibara T，Takehara T，Miyoshi E
  • Organizer: AASLD The Liver Meeting．
  • Place of Presentation: Sanfrancisco(USA)
  • Year and Date: 2015-11-13
  • Int'l Joint Research
• [Presentation] Risk factors for hepatocellular carcinoma recurrence in patients with nonalcoholic and alcoholic fatty liver disease： Japanese multicenter survey． (2015)
  • Author(s): Kogiso T，Hashimoto E，Hyogo H，Nakajima T，Ono M，Kawaguchi T，Honda K，Eguchi Y，Nozaki Y，Kawanaka M，Imajo K，Sumida Y，Kamada Y，Fujii H，Suzuki Y，Tokushige K
  • Organizer: AASLD The Liver Meeting．
  • Place of Presentation: Sanfrancisco （USA）
  • Year and Date: 2015-11-13
  • Int'l Joint Research
• [Presentation] 糖尿病発症前NAFLD患者の肝線維化進展に寄与する因子の解析-男女別の比較検討より- (2015)
  • Author(s): 久家直子，小野正文，増田弘誠，宗景玄祐，越智経浩，西原利治
  • Organizer: 第11回消化器病における性差医学・医療研究会
  • Place of Presentation: 旭川グランドホテル（北海道・旭川市）
  • Year and Date: 2015-07-25
• [Presentation] 脂肪肝発症に対する性差の影響について-多施設検診受診者の解析より- (2015)
  • Author(s): 黒川早紀，宗景玄祐，越智経浩，高橋宏和，兵庫秀幸，小野正文，江口有一郎，西原利治
  • Organizer: 第11回消化器病における性差医学・医療研究会
  • Place of Presentation: 旭川グランドホテル（北海道・旭川市）
  • Year and Date: 2015-07-25
• [Presentation] C型慢性肝炎患者とNAFLD患者の血糖日中変動に影響を及ぼす要因についての比較検討 (2015)
  • Author(s): 越智経浩，小野正文，西原利治
  • Organizer: 第101回日本消化器病学会総会
  • Place of Presentation: 仙台国際センター（宮城県・仙台市）
  • Year and Date: 2015-04-23
• [Presentation] PNPLA3遺伝子はER stressを介したapoptosisに関与する (2015)
  • Author(s): 越智経浩，宗景玄祐，小野正文
  • Organizer: 第101回日本消化器病学会総会
  • Place of Presentation: 仙台国際センター（宮城県・仙台市）
  • Year and Date: 2015-04-23
• [Presentation] 脂肪肝に対する肥満と飲酒の影響について (2015)
  • Author(s): 小野正文，江口有一郎，兵庫秀幸，西原利治
  • Organizer: 第34回アルコール医学生物研究会
  • Place of Presentation: ホテルグリーンパーク津（三重）
  • Year and Date: 2015-01-23 – 2015-01-24
• [Presentation] Ruvbl1 directly binds actin filaments and induces formation of cell protrusions to promote pancreatic cancer cell invasion (2014)
  • Author(s): Taniuchi K，Furihata M，Iwasaki S，Shimizu S，Shimizu T，Saito M，Saibara T
  • Organizer: Asian Pacific Digestive week 2014
  • Place of Presentation: Bali Nusa Dua Convention Center（Indonesia）
  • Year and Date: 2014-11-22 – 2014-11-25
• [Presentation] IgG4関連疾病に合併した門脈血栓症の一例． (2014)
  • Author(s): 江渕みのり，羽柴基，小笠原光成，廣瀬享，藤村靖子，麻植啓輔，小野正文，耕﨑拓大，岩﨑信二，西原利治，伊達慶一，岡林雄大，尾崎和秀
  • Organizer: 第102回日本消化器病学会四国支部例会．
  • Place of Presentation: かがわ国際会議場（高松）
  • Year and Date: 2014-11-02 – 2014-11-03
• [Presentation] ESWL併用EPLBDが有用であった巨大総胆管結石症の1例． (2014)
  • Author(s): 麻植啓輔，耕﨑拓大，木岐淳，石川洋一，高橋友香里，西原利治
  • Organizer: 第113回日本消化器内視鏡学会四国支部例会．
  • Place of Presentation: かがわ国際会議場他（香川）
  • Year and Date: 2014-11-02 – 2014-11-03
• [Presentation] Sister Mary Joseph’s noduleを認めた膵癌1例 (2014)
  • Author(s): 木岐淳，耕﨑拓大，麻植啓輔，石川洋一，西原利治，濱田典彦，西岡明人，宗景匡哉，北川博之，花崎和弘，戸井慎，弘井誠
  • Organizer: 第102回日本消化器病学会四国支部例会
  • Place of Presentation: かがわ国際会議場他（香川）
  • Year and Date: 2014-11-02 – 2014-11-03
• [Presentation] 膵悪性腫瘍に対するFOLFIRINOX療法の経験 (2014)
  • Author(s): 木岐淳，耕﨑拓大，麻植啓輔，石川洋一，西原利治，濱田典彦，西岡明人，宗景匡哉，北川博之，花崎和弘，弘井誠
  • Organizer: 第102回日本消化器病学会四国支部例会、第113回日本消化器内視鏡学会四国支部例会
  • Place of Presentation: かがわ国際会議場他（香川）
  • Year and Date: 2014-11-02 – 2014-11-03
• [Presentation] PNPLA3遺伝子は小胞体ストレスによる肝脂肪酸代謝による． (2014)
  • Author(s): 越智経浩，小野正文，西原利治
  • Organizer: 第56回日本消化器病学会大会
  • Place of Presentation: 神戸国際展示場（神戸）
  • Year and Date: 2014-10-23 – 2014-10-26
• [Presentation] Prdx1 promotes pancreatic cancer cell motility and invasion by modu-lating p38 mapk activity． (2014)
  • Author(s): Taniuchi K，Furihata M，Iwasaki S，Shimizu S，Shimizu T，Saito M，Saibara T
  • Organizer: uegweek2014
  • Place of Presentation: Austria center vienna（Austria）
  • Year and Date: 2014-10-18 – 2014-10-22
• [Presentation] 膵Solid Pseudopapillary Tumorの2例． (2014)
  • Author(s): 耕﨑拓大，木岐淳，麻植啓輔，石川洋一，西原利治，宗景匡哉，花﨑和弘，濱田典彦，西岡明人，弘井誠，耕﨑志乃
  • Organizer: JSAWI2014
  • Place of Presentation: 淡路夢舞台国際会場（淡路）
  • Year and Date: 2014-09-05 – 2014-09-06
• [Presentation] NAFLD患者における肝脂肪化に対する肝脂肪酸β酸化能の影響-男女の比較解析結果より-． (2014)
  • Author(s): 小野正文，増田弘誠，宗景玄祐，越智経浩，廣瀬享，西原利治，福本光孝，西岡明人，小川恭弘
  • Organizer: 第10回消化器病における性差医学・医療研究会
  • Place of Presentation: TKPガーデンシティ品川（東京）
  • Year and Date: 2014-07-26
• [Presentation] 飲酒は脂肪肝の「リスク」か？肥満，性差からみた脂肪肝との関連性の検討． (2014)
  • Author(s): 辻千賀，高橋宏和，小野正文，兵庫秀幸，北島陽一郎，小野尚文，江口尚久，江口有一郎，藤本一眞，茶山一彰，西原利治，安西慶三，江口有一郎
  • Organizer: 第10回消化器病における性差医学・医療研究会．
  • Place of Presentation: TKPガーデンシティ品川（東京）
  • Year and Date: 2014-07-26
• [Presentation] 24時間血糖測定から見たNAFLDとC型慢性肝炎患者の耐糖能異常の特徴 (2014)
  • Author(s): 越智経浩，小野正文，川口巧，羽柴基，宗景玄祐，岡本宣人，西原利治
  • Organizer: 第1回肝臓と糖尿病・代謝研究会
  • Place of Presentation: 伊藤国際学術研究センター 伊藤謝恩ホール（東京）
  • Year and Date: 2014-07-03 – 2014-07-05
• [Presentation] 糖原病Ⅰ型に合併した肝細胞癌の1例． (2014)
  • Author(s): 北川達也，石川洋一，宗景匡哉，小笠原光成，廣瀬享，小野正文，岩﨑信二，小林道也，花﨑和弘，西原利治
  • Organizer: 第101回日本消化器病学会四国支部例会．
  • Place of Presentation: 松山市総合コミュニティセンター（愛媛）
  • Year and Date: 2014-06-14 – 2014-06-15
• [Presentation] 腎癌術後20年目に遅発性膵転移を来した1例 (2014)
  • Author(s): 麻植啓輔，耕﨑拓大，木岐淳，石川洋一，西原利治，宗景匡哉，北川博之，花崎和弘，井上啓史，執印太郎，弘井誠
  • Organizer: 第101回日本消化器病学会四国支部例会
  • Place of Presentation: 松山市総合コミュニティセンター（愛媛）
  • Year and Date: 2014-06-14 – 2014-06-15
• [Presentation] 当院における超音波内視鏡ガイド下胆道ドレナージ術の検討． (2014)
  • Author(s): 麻植啓輔，耕﨑拓大，木岐淳，石川洋一，羽柴基，西原利治，宗景匡哉，北川博之，並川努，花崎和弘
  • Organizer: 第101回日本消化器病学会四国支部例会、第112回日本消化器内視鏡学会四国支部例会合同
  • Place of Presentation: 松山市総合コミュニティセンター（愛媛）
  • Year and Date: 2014-06-14 – 2014-06-15
• [Presentation] 十二指腸乳頭部腺腫に対して内視鏡的乳頭切除術を施行した1例． (2014)
  • Author(s): 木岐淳，耕﨑拓大，麻植啓輔，石川洋一，西原利治，弘井誠，坂本芳也
  • Organizer: 第112回日本消化器内視鏡学会四国支部例会
  • Place of Presentation: 松山市総合コミュニティセンター（愛媛）
  • Year and Date: 2014-06-14 – 2014-06-15
• [Presentation] Correlation between glucose intolerance and histological severity in non-alcoholic fatty liver disease. (2014)
  • Author(s): Ohmi S, Ono M, Nishi Y, Hirano S, Tsugita S, Takata H, Yoshimura K, Mori S, Terada Y, Saibara T, Fujimoto S.
  • Organizer: American Diabetes Association 74th Scientific Sessions 2014
  • Place of Presentation: San Francisco, US
  • Year and Date: 2014-06-13 – 2014-06-17
• [Presentation] 治療による合併症等に難渋した重症自己免疫性肝炎の1例 (2014)
  • Author(s): 石川洋一，羽柴基，坪井麻記子，藤村靖子，小笠原光成，廣瀬享，高橋昌也，小野正文，岩﨑信二，西原利治
  • Organizer: 第110回日本内科学会四国地方会．
  • Place of Presentation: あわぎんホール（徳島）
  • Year and Date: 2014-06-08
• [Presentation] 退形成性膵管癌の1例 (2014)
  • Author(s): 坪井麻記子，耕﨑拓大，麻植啓輔，木岐淳，石川洋一，吉岡玲子，西原利治，岡林雄大，志摩泰生，岩田純
  • Organizer: 第110回日本内科学会四国地方会
  • Place of Presentation: あわぎんホール（徳島）
  • Year and Date: 2014-06-08
• [Presentation] 基調講演 (2014)
  • Author(s): 西原利治
  • Organizer: 第50回日本肝癌研究会
  • Place of Presentation: 国立京都国際会館（京都）
  • Year and Date: 2014-06-05 – 2014-06-06
• [Presentation] 75gOGTTおよびCGMSから見たNAFLDの耐糖能異常の特徴について． (2014)
  • Author(s): 小野正文，越智経浩，西原利治
  • Organizer: 第50回日本肝臓学会総会
  • Place of Presentation: ホテルニューオータニ（東京）
  • Year and Date: 2014-05-29 – 2014-05-30
• [Presentation] 胆膵癌による悪性十二指腸狭窄に対するthrough the scopeタイプの十二指腸ステント治療の検討 (2014)
  • Author(s): 耕﨑拓大，石川洋一，木岐淳，麻植啓輔，西原利治
  • Organizer: 第87回日本消化器内視鏡学会
  • Place of Presentation: 福岡国際会議場（福岡）
  • Year and Date: 2014-05-15 – 2014-05-17
• [Presentation] CGMSからみたNAFLDとC型慢性肝炎の耐糖能異常の特徴と比較検討． (2014)
  • Author(s): 小野正文，川口巧，西原利治
  • Organizer: 第100回日本消化器病学会総会
  • Place of Presentation: 東京国際フォーラム（東京）
  • Year and Date: 2014-04-23 – 2014-04-26
• [Presentation] KIF20AはRNA結合蛋白質とメッセンジャーRNAの複合体を郵送することにより膵癌浸潤・転移を亢進させる． (2014)
  • Author(s): 谷内恵介，岩﨑信二，西原利治
  • Organizer: 第100回日本消化器病学会総会
  • Place of Presentation: 東京国際フォーラム（東京）
  • Year and Date: 2014-04-23 – 2014-04-24
• [Presentation] Insulin secretory function and HbA1c are related to liver fibrosis in nonalcoholic fatty liver disease． (2014)
  • Author(s): Eguchi Y，Kitajima Y，Takahashi H，Ono M，Okada M，Hyogo H，Sumida Y，Araki N，Ono N，Eguchi T，Iwakiri R，Anzai K
  • Organizer: EASL（49th Annual Meeting of The European Association For The Study of The Liver）
  • Place of Presentation: London UK
  • Year and Date: 2014-04-09 – 2014-04-13
• [Presentation] The association of insomnia with gastroesophageal reflux symptoms in biopsy-proven nonalcoholic fatty liver disease． (2013)
  • Author(s): Taketani H,Ono M,Saibara T et.al
  • Organizer: The 64th Annual Meeting of the American Association for the Study of Liver Diseases 2013
  • Place of Presentation: Walter E. Washington convention center (Washington USA)
• [Presentation] Small dense low-density lipoprptein as a useful biomarker for predicting arteriosclerotic diseases in nonalcoholic steatohepatitis． (2013)
  • Author(s): Imajyo K,Ono M et.al
  • Organizer: The 64th Annual Meeting of the American Association for the Study of Liver Diseases 2013
  • Place of Presentation: Walter E. Washington convention center (Washington USA)
• [Presentation] The association of insomnia with gastroesophageal reflux symptoms in biopsy-proven nonalcoholic fatty liver disease． (2013)
  • Author(s): Taketani H,Ono M, Saibara T et.al
  • Organizer: AASLD 2013
  • Place of Presentation: Walter E. Washington convention center (Washington USA)
• [Presentation] Glycemic variability is an independent predictive factor for development of hepatic fibrosis in nonalcoholic fatty liver disease． (2013)
  • Author(s): Ochi T,Ono M,Okamoto N,Saibara T et.al
  • Organizer: The 64th Annual Meeting of the American Association for the Study of Liver Diseases 2013
  • Place of Presentation: Walter E. Washington convention center (Washington USA)
• [Presentation] 人工透析C型慢性肝炎患者の臨床的特徴とインターフェロン治療開始に対する判断因子の検討 (2013)
  • Author(s): 小野正文,西原利治 他
  • Organizer: 第39回高知県透析研究会
  • Place of Presentation: サザンシティホテルアンジェブラン (高知)
• [Presentation] NAFLDにおける肝脂肪化，線維化に及ぼす耐糖能異常についての男女別検討 (2013)
  • Author(s): 小野正文 他
  • Organizer: 第9回消化器病における性差医学・医療研究会
  • Place of Presentation: 大阪大学中之島センター (大阪)
• [Presentation] 24時間血糖測定から見たC型慢性肝炎患者とNAFLD患者の耐糖能異常の相違についての検討 (2013)
  • Author(s): 小野正文,西原利治 他
  • Organizer: 第55回日本消化器病学会大会
  • Place of Presentation: グランドプリンス高輪他 (東京)
• [Presentation] 人工透析C型慢性肝炎患者における病状進展評価とインターフェロン治療開始指標の検討 (2013)
  • Author(s): 植瑞希,小野正文,西原利治 他
  • Organizer: 第49回日本肝臓学会総会
  • Place of Presentation: 京王プラザホテル (東京)
• [Presentation] シャント脳症に対する部分的B-RTOの検討 (2013)
  • Author(s): 小笠原光成,小野正文,西原利治 他
  • Organizer: 第99回日本消化器病学会四国支部例会
  • Place of Presentation: 高知市文化プラザかるぽーと (高知)
• [Presentation] 耐糖能異常からみたNAFLDの組織学的，生化学的特徴についての検討 (2013)
  • Author(s): 越智経浩,小野正文 他
  • Organizer: 第40回日本肝臓学会西部会
  • Place of Presentation: 長良川国際会議場・岐阜都ホテル (岐阜)
• [Presentation] NASHに対するメトホルミンの有効性とその有効性に関連するマイクロRNAの同定 (2013)
  • Author(s): 桂明子,小野正文 他
  • Organizer: 第49回日本肝臓学会総会
  • Place of Presentation: 京王プラザホテル (東京)
• [Presentation] 門脈血栓症に対するダナパロイドナトリウムの有用性についての検討 (2013)
  • Author(s): 廣瀬享,小野正文,西原利治 他
  • Organizer: 第99回日本消化器病学会四国支部例会．第110回日本消化器内視鏡学会四国支部例会．合同シンポジウム「肝胆膵疾患領域における診療の現状と展望」
  • Place of Presentation: 高知市文化プラザかるぽーと (高知)
• [Presentation] 当院におけるNASH肝癌とASH肝癌の臨床背景の比較検討 (2013)
  • Author(s): 宗景玄祐,小野正文,西原利治 他
  • Organizer: 第17回日本肝臓学会大会
  • Place of Presentation: グランドプリンス高輪他 (東京)
• [Presentation] B0031 enhances pancreatic cancer cell motility and invasion through binding to ANXA2． (2013)
  • Author(s): Taniuchi K,Saibara T et.al
  • Organizer: IAP&KPBA 2013 Joint Meeting of the International Association of Pancreatology & the Korean Pancreatobiliary Association 2013
  • Place of Presentation: Sheraton Grande WalkerHill hotel (Seoul Korea)
• [Presentation] 胆管癌に膵管内乳頭粘液性腺癌および乳癌を合併した同時性3重複癌の１例 (2013)
  • Author(s): 石川洋一,西原利治 他
  • Organizer: 第108回日本内科学会四国地方会
  • Place of Presentation: 高知高知市文化プラザかるぽーと (高知)
• [Presentation] 進行膵癌に対するgemcitabine、S1併用科学療法の検討 (2013)
  • Author(s): 木岐淳,西原利治 他
  • Organizer: 第99回日本消化器病学会四国支部例会．第110回日本消化器内視鏡学会四国支部例会．合同シンポジウム「肝胆膵疾患領域における診療の現状と展望」
  • Place of Presentation: 高知市文化プラザかるぽーと (高知)
• [Presentation] 術後早期に発症した膵管内乳頭粘液性癌による播種性骨髄癌腫症の1例 (2013)
  • Author(s): 木岐淳,西原利治 他
  • Organizer: 第100回日本消化器病学会四国支部例会
  • Place of Presentation: アルファあなぶきホール (高松)
• [Presentation] 化膿性膵管炎の1例 (2013)
  • Author(s): 木岐淳,西原利治 他
  • Organizer: 第109回日本内科学会四国地方会
  • Place of Presentation: かがわ国際会議場他 (高松)
• [Presentation] EUS-FNAにより膵管内出血を来した膵神経内分泌腫瘍の1例 (2013)
  • Author(s): 耕﨑拓大,西原利治 他
  • Organizer: 日本超音波医学会第23回四国地方会学術集会
  • Place of Presentation: 高知市文化プラザかるぽーと (高知)
• [Presentation] 当院におけるEUS-FNAの検討～特に合併症について～ (2013)
  • Author(s): 耕﨑拓大,西原利治 他
  • Organizer: 第85回日本消化器内視鏡学会総会
  • Place of Presentation: 国立京都国際会館 (京都)
• [Presentation] 十二指腸副乳頭より出血を認めたhemosuccus pancreaticusの1例 (2013)
  • Author(s): 耕﨑拓大,西原利治 他
  • Organizer: 第44回日本膵臓学会大会
  • Place of Presentation: 仙台国際センター (仙台)
• [Presentation] 超音波内視鏡下膵仮性嚢胞ドレナージの検討 (2013)
  • Author(s): 耕﨑拓大,西原利治 他
  • Organizer: 第44回日本膵臓学会大会
  • Place of Presentation: 仙台国際センター (仙台)
• [Presentation] 十二指腸穿孔による後腹膜膿瘍を来した十二指腸ガストリノーマ再発の1例 (2013)
  • Author(s): 耕﨑拓大,西原利治 他
  • Organizer: 第86回日本消化器内視鏡学会総会
  • Place of Presentation: グランドプリンス高輪他 (東京)
• [Presentation] EUS-FNAが診断に有用であった卵巣癌胃転移の1例 (2013)
  • Author(s): 耕﨑拓大,西原利治 他
  • Organizer: 第14回JSAWI
  • Place of Presentation: 淡路夢舞台国際会議場 (兵庫)
• [Presentation] 後腹膜Schwannomaの1例 (2013)
  • Author(s): 永田友梨,西原利治 他
  • Organizer: 第99回日本消化器病学会四国支部例会
  • Place of Presentation: 高知市文化プラザかるぽーと (高知)
• [Book] 見て読んでわかるNASH/NAFLD診療 かかりつけ医と内科医のために (2014)
  • Author(s): 小野正文
  • Total Pages: 184
  • Publisher: 診断と治療社
• [Book] 最新肥満症学-基礎・臨床研究の最前線 (2014)
  • Author(s): 長谷川俊之，小野正文，西原利治
  • Total Pages: 724
  • Publisher: 日本臨床社
• [Book] 今日の治療指針 私はこう治療している TODAY’S THERAPY 2013 (2013)
  • Author(s): 小野正文
  • Publisher: 医学書院
• [Book] Debate 薬物起因による“NASH”はNASHではない？ (2013)
  • Author(s): 小野正文,西原利治
  • Publisher: 文光堂
• [Book] 消化器疾患 最新の治療2012-2013 (2013)
  • Author(s): 西原利治,小野正文
  • Publisher: 南江堂
• [Book] 専門医のための消化器病学 第2版 (2013)
  • Author(s): 西原利治,小野正文
  • Publisher: 医学書院
• [Book] カラー版 消化器病学 基礎と臨床 (2013)
  • Author(s): 宗景玄祐,小野正文,西原利治
  • Publisher: 西村書店
• [Book] メタボ肝癌の高危険群① (2013)
  • Author(s): 腰山裕一,西原利治 他
  • Publisher: アークメディア
• [Book] 脂肪肝・非アルコール性脂肪性肝炎 (2013)
  • Author(s): 西原利治
  • Publisher: ヌーヴェルヒロカワ
• [Book] 治療過程で一目でわかる消化器薬物療法STEP1・2・3 (2013)
  • Author(s): 西原利治
  • Publisher: メジカルビュー社
• [Book] 肥満症と脂肪肝，NASH (2013)
  • Author(s): 西原利治
  • Publisher: 診断と治療社
• [Book] III 治療編 1 治療学総論 (2013)
  • Author(s): 西原利治
  • Publisher: 文光堂