Roles of adipose tissue in survival, proliferation, differentiation and lipotoxicity of hepatocytes

• Project/Area Number: 25461001
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Akita University (2014-2015); Saga University (2013)
• Principal Investigator: Nishijima Aki 秋田大学, 医学(系)研究科(研究院), 助教 (40566105)
• Co-Investigator(Kenkyū-buntansha): Toda Shuji 佐賀大学, 医学部, 教授 (80188755)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 脂肪毒性 / 脂肪組織 / 肝細胞 / アポトーシス / NAFLD

Outline of Final Research Achievements

This research has shown that visceral, but not subctaneous adipose tissue promotes apoptosis and lipid droplet deposition of hepatocytes together with the inhibition of the growth and differentiation. That is, visceral adipose tissue promotes lipotoxicity of hepatocytes. Our results support the clinical findinf that metabolic syndrome based on visceral fat accumulation is closely associated with non-alcoholic fatty liver disease. Our study has demonstrated that the free fatty acid palmitate may be involved in the lipotoxicity of hepatocytes partially.

Research Products

• [Journal Article] Interaction between Esophageal Squamous Cell Carcinoma and Adipose Tissue in Vitro. (2016)
  • Author(s): Nakayama A, Aoki S, Uchihashi K, Nishijima-Matsunobu A, Yamamoto M, Kakihara N, Iwakiri R, Fujimoto K, Toda S
  • Journal Title: Am J Pathol. Volume: 印刷中 Issue: 5 Pages: 1180-94
  • DOI: 10.1016/j.ajpath.2016.01.003
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Differential effects of adipose tissue stromal cells on the apoptosis, growth and invasion of bladder urothelial carcinoma between the superficial and invasive types. (2016)
  • Author(s): Kawasaki-Nanri M, Aoki S, Uchihashi K, Yamamoto M, Udo K, Nishijima-Matsunobu A, Kakihara N, Noguchi M, Uozumi J, Toda S.
  • Journal Title: Int J Urol. Volume: 印刷中 Issue: 6 Pages: 510-19
  • DOI: 10.1111/iju.13086
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The Apoptotic Effect of HIF-1α Inhibition Conbined with Glucose plus Insulin Treatment on Gastric Cancer under Hypoxic Conditions (2015)
  • Author(s): Tanaka T, Kitajima Y, Miyake S, Yanagihara K, Hara H, Nishijima-Matsunobu A, Baba K, Shida M, Wakiyama K, Nakamura J, Noshiro H.
  • Journal Title: PLoS One Volume: 10 Issue: 9 Pages: e0137257-e0137257
  • DOI: 10.1371/journal.pone.0137257
  • Peer Reviewed / Open Access
• [Journal Article] Three-dimensional culture model for analyzing crosstalk between adipose tissue and hepatocytes (2013)
  • Author(s): Nishijima-Matsunobu A, Aoki S, Uchihashi K, Fujimoto K, Toda S
  • Journal Title: Cell Tissue Res Volume: 352 Issue: 3 Pages: 611-621
  • DOI: 10.1007/s00441-013-1588-8
  • Peer Reviewed
• [Presentation] 慢性肝疾患患者による脂肪組織と肝組織の病理学的検討 (2015)
  • Author(s): 西島亜紀、高橋宏和、戸田修二、江口雄一郎
  • Organizer: 第2回肝臓と糖尿病・代謝研究会
  • Place of Presentation: 山口県下関市
  • Year and Date: 2015-05-23
• [Presentation] 肥大した成熟脂肪細胞径は肝の脂肪沈着と相関する (2015)
  • Author(s): 西島亜紀、山本美保子、内橋和芳、青木茂久、大森泰文、杉原甫、戸田修二
  • Organizer: 第104回日本病理学会総会
  • Place of Presentation: 愛知県名古屋市
  • Year and Date: 2015-05-02
• [Presentation] 肝細胞―脂肪組織相互作用解析モデルの確立 (2014)
  • Author(s): 西島 亜紀、青木 茂久、内橋 和芳、山本 美保子、戸田 修二
  • Organizer: 第21回肝細胞研究会
  • Place of Presentation: 東京医科歯科大学
  • Year and Date: 2014-06-27 – 2014-06-28
• [Presentation] 脂肪組織―肝細胞相互作用解析モデルの確立
  • Author(s): 西島亜紀、青木茂久、内橋和芳、藤本一眞、戸田修二
  • Organizer: 第18回アディポサイエンス・シンポジウム
  • Place of Presentation: 大阪千里ライフサイエンスセンター