Roles of adipose tissue in survival, proliferation, differentiation and lipotoxicity of hepatocytes
| Project/Area Number |
25461001
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Akita University (2014-2015)
Saga University (2013) |
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Principal Investigator |
Nishijima Aki 秋田大学, 医学(系)研究科(研究院), 助教 (40566105)
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| Co-Investigator(Kenkyū-buntansha) |
Toda Shuji 佐賀大学, 医学部, 教授 (80188755)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 脂肪毒性 / 脂肪組織 / 肝細胞 / アポトーシス / NAFLD |
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| Outline of Final Research Achievements |
This research has shown that visceral, but not subctaneous adipose tissue promotes apoptosis and lipid droplet deposition of hepatocytes together with the inhibition of the growth and differentiation. That is, visceral adipose tissue promotes lipotoxicity of hepatocytes. Our results support the clinical findinf that metabolic syndrome based on visceral fat accumulation is closely associated with non-alcoholic fatty liver disease. Our study has demonstrated that the free fatty acid palmitate may be involved in the lipotoxicity of hepatocytes partially.
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Report
(4 results)
Research Products
(8 results)
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[Journal Article] Differential effects of adipose tissue stromal cells on the apoptosis, growth and invasion of bladder urothelial carcinoma between the superficial and invasive types.2016
Author(s)
Kawasaki-Nanri M, Aoki S, Uchihashi K, Yamamoto M, Udo K, Nishijima-Matsunobu A, Kakihara N, Noguchi M, Uozumi J, Toda S.
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Journal Title
Int J Urol.
Volume: 印刷中
Issue: 6
Pages: 510-19
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] The Apoptotic Effect of HIF-1α Inhibition Conbined with Glucose plus Insulin Treatment on Gastric Cancer under Hypoxic Conditions2015
Author(s)
Tanaka T, Kitajima Y, Miyake S, Yanagihara K, Hara H, Nishijima-Matsunobu A, Baba K, Shida M, Wakiyama K, Nakamura J, Noshiro H.
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Journal Title
PLoS One
Volume: 10
Issue: 9
Pages: e0137257-e0137257
DOI
Related Report
Peer Reviewed / Open Access
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