| Project/Area Number |
25461006
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Osaka City University |
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Principal Investigator |
Enomoto Masaru 大阪市立大学, 大学院医学研究科, 准教授 (20423874)
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| Co-Investigator(Kenkyū-buntansha) |
MURAKAMI YOSHIKI 大阪市立大学, 大学院医学研究科, 准教授 (00397556)
KAWADA NORIFUMI 大阪市立大学, 大学院医学研究科, 教授 (30271191)
TAMORI AKIHIRO 大阪市立大学, 大学院医学研究科, 准教授 (30291595)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | B型慢性肝炎 / マイクロRNA / B型肝炎 |
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| Outline of Final Research Achievements |
In liver biopsy samples obtained from 35 patients with chronic hepatitis B, differences in some microRNA (miRNA) expressions were found between F1 and F2-4, between F1/F2 and F3/F4, and between F1-3 and F4, but not significantly. Regarding the IL28b and ITPA genotypes, about 60 miRNA expressions were significantly up- or down-regulated depending on the latter genotypes, some of which showed significant differences also in real-time PCR analysis. Some of circulating miRNA expressions, which were correlated with miRNA in liver, significantly changed during PEG IFN treatment.
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