Study on the proliferation mechanism of mature and progenitor hepatocytes for the treatment of impaired regeneration of the liver
| Project/Area Number |
25461008
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
Wang Ting 岩手医科大学, 医学部, 助教 (70416171)
Kakisaka Keisuke 岩手医科大学, 医学部, 助教 (40583563)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 肝再生 / 肝前駆細胞 / 急性肝不全 / AFP / アルファフェトプロテイン / 偽胆管 / 増殖環境 |
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| Outline of Final Research Achievements |
Progenitor hepatocyte, but not mature hepatocyte is considered to repair the injured liver in the patients with severe liver injury. We investigated the suitable condition for the proliferation of progenitor hepatocyte (PHC) to reveal the best microenvironment for recovery from acute liver failure (ALF). We found that PHC proliferate under the condition with the existence of the serum from ALF patients. The signal of the proliferation was transduced through P2Y receptor, JNK and ATF2 activation.
We also found that PHC introduced in the liver tissue of the patients with severe liver injury, which was reflected to the elevation of serum AFP levels.
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Report
(4 results)
Research Products
(16 results)
