| Project/Area Number |
25461013
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HONDA Akira 東京医科大学, 医学部, 教授 (10468639)
MIYAZAKI Teruo 東京医科大学, 医学部, 講師 (60532687)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUZAKI Yasushi 東京医科大学, 医学部, 教授 (50209532)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 酸化ステロール / 非アルコール性脂肪性肝炎 / 非B非C肝細胞癌 / 胆汁酸 / 腸内細菌 / コレステロール代謝 / 胆汁酸代謝 / 肝細胞がん / 肝細胞癌 |
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| Outline of Final Research Achievements |
Through the determination of profiles of serum bile acids (BA) in patients with NASH with or without HCC, a presence of specific serum BA pattern in NASH and NASH-HCC was demonstrated. This supports possible alteration of intestinal microbiota in these diseases as previously reported. However, as only modest change between NASH and NASH -HCC was observed, altered BA profile may not be a screening marker for high-risk group in HCC development among NASH patients.
Next, we employed an animal NASH model developing HCC, and determined BA profile as well as various oxysterol (OS) levels. Decrease of OS synthesized by enzymatic response and increase of OS induced by autoxidation have been seen in early phase of disease development. It is hypothesized that these qualitative differences in OS could influence the disease progression through the regulation of cholesterol accumulation in various hepatic cells..
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