| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
We examined the role of coagulopathy in chronic liver disease (CLD).Blood samples and liver tissues were taken from 15 chronic hepatitis (CH)-B, 27 CHC, 10 autoimmune hepatitis (AIH), and 8 non-alcoholic steatohepatitis (NASH).Von Willebrand factor (vWF) was high 8/15 in CHB, 14/27 in CHC, 6/8 in AIH, was low 4/8 in NASH. Thrombin and Antithrombin 3 complex (TAT) was high 3/15 in CHB, 4/27 in CHC, 3/11 in AIH, 2/8 in NASH. Protein C (PC) and S (PS) were low in 6/15 and 3/15 in CHB,10/27 and 9/27 in CHC, 2/10 and 1/10 in AIH,0/8 and 0/8 in NASH respectively. But these clotting factors rarely working simultaneously. Liver samples were analyzed by immunohistochemical staining. Both vWF-Ag and PAI-1 were stained uniformly in the liver tissue, especially around sinusoids.
Hypercoagulopathy (high vWF and low PC and PS) was found in CLD, lead to thrombin overproduction in some cases.
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