Identification of new risk factor for nonB, nonC hepatocellular carcinoma: Global analysis using GWAS and data-mining analysis

• Project/Area Number: 25461017
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Kurume University
• Principal Investigator: Sata Michio 久留米大学, 先端癌治療研究センター, 教授 (10162398)
• Co-Investigator(Kenkyū-buntansha): Kawaguchi Takumi 久留米大学, 医学部, 講師 (00320177) ; Kawaguchi Atsushi 佐賀大学, 医学部, 教授 (60389319) ; Yamada Shingo 久留米大学, 医学部, 助教 (50425188)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 肝臓がん / 遺伝子異常 / 代謝異常 / 網羅的解析 / 非B非C肝がん / アルブミン / PNPLA3 / Brinkman index / γGTP / 一塩基多型 / 宿主因子 / 環境因子 / 肝がん / 遺伝子解析 / データマイニング

Outline of Final Research Achievements

Recently, the number of patients with hepatocellular carcinoma without infection of hepatitis B and C virus (NBNC-HCC) is increasing. We aimed to identify risk factor for NBNC-HCC by GWAS and data-mining analysis. Subjects are 223 NBNC-HCC patients and 669 healthy subjects. We demonstrated that serum level of gamma-GTP, Brinkman index, and serum level of albumin were independent risk factor for NBNC-HCC. We also found that variant（I148M）of patatin-like phospholipase domain containing 3 gene（PNPLA3） is frequently seen in patients with NBNC-HCC.

Research Products

• [Journal Article] An association between dietary habits and traffic accidents in patients with chronic liver disease: A data-mining analysis. (2016)
  • Author(s): Kawaguchi T, Suetsugu T, Ogata S, Imanaga M, Ishii K, Esaki N, Sugimoto M, Otsuyama J, Nagamatsu A, Taniguchi E, Itou M, Oriishi T, Iwasaki S, Miura H, Torimura T.
  • Journal Title: Biomed Rep. Volume: 4 Pages: 615-622
  • Peer Reviewed
• [Journal Article] Effect of pioglitazone on outcome following curative treatment for hepatocellular carcinoma in patients with hepatitis C virus infection: A prospective study. (2015)
  • Author(s): Sumie S, Kawaguchi T, Kawaguchi A, Kuromatsu R, Nakano M, Satani M, Yamada S, Okamura S, Yonezawa Y, Kakuma T, Torimura T, Sata M.
  • Journal Title: Mol Clin Oncol Volume: 3 Issue: 1 Pages: 115-120
  • DOI: 10.3892/mco.2014.435
  • Peer Reviewed / Open Access
• [Journal Article] Effects of branched-chain amino acids and zinc-enriched nutrients on prognosticators in HCV-infected patients: a multicenter randomized controlled trial. (2015)
  • Author(s): Kawaguchi T, Nagao Y, Abe K, Imazeki F, Honda K, Yamasaki K, Miyanishi K, Taniguchi E, Kakuma T, Kato J, Seike M, Yokosuka O, Ohira H, Sata M.
  • Journal Title: Mol Med Rep Volume: 11 Issue: 3 Pages: 2159-2166
  • DOI: 10.3892/mmr.2014.2943
  • Peer Reviewed / Open Access
• [Journal Article] The morbidity and associated risk factors of cancer in chronic liver disease patients with diabetes mellitus: a multicenter field survey. (2015)
  • Author(s): Kawaguchi T, Kohjima M, Ichikawa T, Seike M, Ide Y, Mizuta T, Honda K, Nakao K, Nakamuta M, Sata M.
  • Journal Title: J Gastroenterol Volume: 50 Issue: 3 Pages: 333-341
  • DOI: 10.1007/s00535-014-0968-5
  • Peer Reviewed / Open Access
• [Journal Article] Serum albumin level is a notable profiling factor for non-B, non-C hepatitis virus-related hepatocellular carcinoma: A data-mining analysis (2014)
  • Author(s): Yamada S, Kawaguchi A, Kawaguchi T, Fukushima N, Kuromatsu R, Sumie S, Takata A, Nakano M, Satani M, Tonan T, Fujimoto K, Shima H, Kakuma T, Torimura T, Charlton MR, Sata M.
  • Journal Title: Hepatol Res. Volume: in press Issue: 8 Pages: 837-845
  • DOI: 10.1111/hepr.12192
  • Peer Reviewed / Open Access
• [Journal Article] Exendin-4, a glucagon-like peptide-1 receptor agonist, modulates hepatic fatty acid composition and Δ-5-desaturase index in a murine model of non-alcoholic steatohepatitis. (2014)
  • Author(s): Kawaguchi T, Itou M, Taniguchi E, Sata M.
  • Journal Title: Int J Mol Med Volume: 34 Issue: 3 Pages: 782-787
  • DOI: 10.3892/ijmm.2014.1826
  • Peer Reviewed / Open Access
• [Journal Article] Clinical characteristics and prognostic factors for advanced hepatocellular carcinoma with extrahepatic metastasis. (2014)
  • Author(s): Aino H, Sumie S, Niizeki T, Kuromatsu R, Tajiri N, Nakano M, Satani M, Yamada S, Okamura S, Shimose S, Sumie H, Torimura T, Sata M.
  • Journal Title: Mol Clin Oncol Volume: 2 Issue: 3 Pages: 393-398
  • DOI: 10.3892/mco.2014.259
  • Peer Reviewed / Open Access
• [Journal Article] 肝癌と素因 糖尿病と肝癌 (2013)
  • Author(s): 川口 巧、佐田 通夫
  • Journal Title: The LIVER CANCER JOURNAL Volume: 5 Pages: 258-266
• [Presentation] 糖尿病を合併する肝疾患患者のがん有病率とがん関連因子
  • Author(s): 川口 巧、國府島 庸之、市川 辰樹、清家 正隆、井手 康史、水田 敏彦、本田 浩一、中尾 一彦、中牟田 誠、佐田 通夫
  • Organizer: 第17回 日本肝臓学会大会
  • Place of Presentation: グランドプリンスホテル新高輪（東京都港区）