| Project/Area Number |
25461017
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kurume University |
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Principal Investigator |
Sata Michio 久留米大学, 先端癌治療研究センター, 教授 (10162398)
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| Co-Investigator(Kenkyū-buntansha) |
Kawaguchi Takumi 久留米大学, 医学部, 講師 (00320177)
Kawaguchi Atsushi 佐賀大学, 医学部, 教授 (60389319)
Yamada Shingo 久留米大学, 医学部, 助教 (50425188)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 肝臓がん / 遺伝子異常 / 代謝異常 / 網羅的解析 / 非B非C肝がん / アルブミン / PNPLA3 / Brinkman index / γGTP / 一塩基多型 / 宿主因子 / 環境因子 / 肝がん / 遺伝子解析 / データマイニング |
|---|
| Outline of Final Research Achievements |
Recently, the number of patients with hepatocellular carcinoma without infection of hepatitis B and C virus (NBNC-HCC) is increasing. We aimed to identify risk factor for NBNC-HCC by GWAS and data-mining analysis. Subjects are 223 NBNC-HCC patients and 669 healthy subjects. We demonstrated that serum level of gamma-GTP, Brinkman index, and serum level of albumin were independent risk factor for NBNC-HCC. We also found that variant（I148M）of patatin-like phospholipase domain containing 3 gene（PNPLA3） is frequently seen in patients with NBNC-HCC.
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