Development of new antiangiogenic therapy specific for tumor tissue of hepatocellular carcinoma with microRNA
| Project/Area Number |
25461018
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | Kurume University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
中村 徹 久留米大学, 医学部, 助教 (30341332)
古賀 浩徳 久留米大学, 医学部, 教授 (90268855)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 肝細胞癌 / 内皮細胞 / 血管新生抑制療法 / マイクロRNA / 血管新生 / 血管新生抑制 / マイクロＲＮＡ / 血管内皮細胞 |
|---|
| Outline of Final Research Achievements |
We extracted mRNA and microRNA from endothelial cells in HCC tissues. The expression of twelve mRNAs related angiogenesis was upregulated. The expression of miR-127-3p, miR-379-5p and miR-711 was upregulated and 70 microRNAs were downregulated in HCC tissues. miR30a-5p which was the most downregulated was added to cultured endothelial cells from HCC tissues. The growth activity of endothelial cells from HCC tissues was suppressed by miR30a-5p addition. In vivo experiments, tumor growth of HCC was suppressed by miR30a-5p addition from mouse tail vein. Tumor angiogenesis was suppressed in HCC tissues by miR30a-5p addition. However, sinusoidal density was not reduced by miR30a-5p.
|
Report
(4 results)
Research Products
(15 results)
-
-
-
[Journal Article] Sorafenib for the treatment of advanced hepatocellular carcinoma with extrahepatic metastasis: a prospective multicenter cohort study.2015
Author(s)
Nakano M, Tanaka M, Kuromatsu R, Nagamatsu H, Tajiri N, Satani M, Niizeki T, Aino H, Okamura S, Iwamoto H, Shimose S, Shirono T, Koga H, Torimura T; Kurume Liver Cancer Study Group of Japan.
-
Journal Title
Cancer Medicine
Volume: 12
Issue: 12
Pages: 1836-1843
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
[Journal Article] Inhibition of hypoxia-inducible factor via upregulation of von Hippel-Lindau protein induces "angiogenic switch off" in a hepatoma mouse model.2015
Author(s)
Iwamoto H, Nakamura T, Koga H, Izaguirre-Carbonell J, Kamisuki S, Sugawara F, Abe M, Iwabata K, Ikezono Y, Sakaue T, Masuda A, Yano H, Ohta K, Nakano M, Shimose S, Shirono T, Torimura T.
-
Journal Title
Molecular Therapy Oncolytics
Volume: 2
Pages: 15020-15020
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
-
-
-
-
-
