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The establishment of treatment for pancreatic cancer using miRNA associated with stem cells related pancreatic cancer.

Research Project

Project/Area Number 25461020
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionTohoku University

Principal Investigator

Kanno Atsushi  東北大学, 大学病院, 助教 (70509190)

Co-Investigator(Kenkyū-buntansha) HAMADA Shin  東北大学, 医学系研究科, 助教 (20451560)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords膵癌 / EUS-FNA / miRNA
Outline of Final Research Achievements

We have obtained the histological sample of pancreatic cancer using Endoscopic ultrasonography-fine needle aspiration (EUS-FNA) and continued to make the genetic profile. The evaluation of expression of the marker associated with stem cells related pancreatic cancer was performed. However, we could not detect these markers. Since one of the causes not to detect these markers is that the amount of histological sample by EUS-FNA is very small, we continue to evaluate these markers using the histological samples acquired by operation. Furthermore, sensitivity test of anti cancer drug for pancreatic caner using histological sample acquired by EUS-FNA has been continued. We have compared the clinical information and surgical stage. The cell lines of resistance for anti-cancer drug were used for checking the genetic profile.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (16 results)

All 2016 2015 2014 2013

All Journal Article (13 results) (of which Peer Reviewed: 12 results,  Acknowledgement Compliant: 5 results) Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Risk factors for recurrent biliary obstruction following placement of self-expandable metallic stents in patients with malignant perihilar biliary stricture.2016

    • Author(s)
      Miura S, Kanno A, Masamune A, Hamada S, Hongou S, Yoshida N, Nakano E, Takikawa T, Kume K, Kikuta K, Hirota M, Yoshida H, Katayose Y, Unno M, Shimosegawa T.
    • Journal Title

      Endoscopy

      Volume: 印刷中

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Diagnosis of autoimmune pancreatitis by endoscopic ultrasonography -guided fine-needle aspiration using a 22-gauge needle: a prospective multicenter study2016

    • Author(s)
      Atsushi Kanno, Atsushi Masamune, Fumiyoshi Fujishima, Takuji Iwashita, Yuzo Kodama, Akio Katanuma, Hirotaka Ohara, Masayuki Kitano, Hiroyuki Inoue, Takao Itoi, Nobumasa Mizuno, Hiroyuki Miyakawa, Rintaro Mikata, Atsushi Irisawa, Satoko Sato, Kenji Notohara, Tooru Shimosegawa
    • Journal Title

      Gastrointestical Ensosc

      Volume: 印刷中

    • Related Report
      2015 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] Clinicopathological Features of Type 2 Autoimmune Pancreatitis in Japan: Results of a Multicenter Survey.2015

    • Author(s)
      Notohara K, Nishimori I, Mizuno N, Okazaki K, Ito T, Kawa S, Egawa S, Kihara Y, Kanno A, Masamune A, Shimosegawa T.
    • Journal Title

      Pancreas

      Volume: 44 Issue: 7 Pages: 1072-7

    • DOI

      10.1097/mpa.0000000000000438

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IgG4-unrelated type 1 autoimmune pancreatitis.2015

    • Author(s)
      Nakano E, Kanno A, Masamune A, Yoshida N, Hongo S, Miura S, Takikawa T, Hamada S, Kume K, Kikuta K, Hirota M, Nakayama K, Fujishima F, Shimosegawa T.
    • Journal Title

      World J Gastroenterol.

      Volume: 21 Issue: 33 Pages: 9808-16

    • DOI

      10.3748/wjg.v21.i33.9808

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Nationwide Epidemiological Survey of Autoimmune Pancreatitis in Japan in 2011.2015

    • Author(s)
      Kanno A, Masamune A, Okazaki K, Kamisawa T, Kawa S, Nishimori I, Tsuji I, Shimosegawa T; Research Committee of Intractable Diseases of the Pancreas.
    • Journal Title

      Pancreas

      Volume: 印刷中

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Bismuth classification is associated with the requirement for multiple biliary drainage in preoperative patients with malignant perihilar biliary stricture.2015

    • Author(s)
      Miura S, Kanno A, Masamune A, Hamada S, Takikawa T, Nakano E, Yoshida N, Hongo S, Kikuta K, Kume K, Hirota M, Yoshida H, Katayose Y, Uuno M, Shimosegawa T.
    • Journal Title

      Surg Endosc.

      Volume: 印刷中

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 12. Endoscopic approaches for the diagnosis of autoimmune pancreatitis.2015

    • Author(s)
      Kanno A, Masamune A, Shimosegawa T.
    • Journal Title

      Dig Endosc.

      Volume: 27 Pages: 250-8

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sudden disappearance of the blood flow in a case of pancreatic acinar cell carcinoma.2014

    • Author(s)
      Kanno A, Masamune A, Hamada S, Kikuta K, Kume K, Hirota M, Shima K, Okada T, Motoi F, Fujishima F, Ishida K, Unno M, Shimosegawa T.
    • Journal Title

      Intern Med.

      Volume: 53 Pages: 2589-93

    • NAID

      130004713252

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The usefulness of endoscopic ultrasound-guided fine-needle aspiration for the diagnosis of pancreatic neuroendocrine tumors based on the World Health Organization classification.2014

    • Author(s)
      Unno J, Kanno A, Masamune A, Kasajima A, Fujishima F, Ishida K, Hamada S, Kume K, Kikuta K, Hirota M, Motoi F, Unno M, Shimosegawa T.
    • Journal Title

      Scand J Gastroenterol.

      Volume: 49 Pages: 1367-74

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] miR-197 induces epithelialmesenchymal transition in pancreatic cancer cells by targeting p120 catenin. J Cell Physiol2013

    • Author(s)
      Hamada S, et al
    • Journal Title

      J Cell Physiol

      Volume: 228(6) Issue: 6 Pages: 1255-63

    • DOI

      10.1002/jcp.24280

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Establishment of a Serum IgG4 Cut-off Value for the Differential Diagnosis of IgG4-related Sclerosing Cholangitis- A Japanese Cohort.2013

    • Author(s)
      Ohara H, Nakazawa T, Kawa S, Kamisawa T, Shimosegawa T, Uchida K, Hirano K, Nishino T, Hamano H, Kanno A, Notohara K, Hasebe O, Muraki T, Ishida E, Naitoh I, Okazaki K.
    • Journal Title

      J Gastroenterol Hepatol

      Volume: 28 Issue: 7 Pages: 1247-51

    • DOI

      10.1111/jgh.12248

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Japanese multicenter experience of endoscopic necrosectomy for infected walled-off pancreatic necrosis: The JENIPaN study.2013

    • Author(s)
      Yasuda I, Nakashima M, Iwai T, Isayama H, Itoi T, Hisai H, Inoue H, Kato H, Kanno A, Kubota K, Irisawa A, Igarashi H, Okabe Y, Kitano M, Kawakami H, Hayashi T, Mukai T, Sata N, Kida M, Shimosegawa T
    • Journal Title

      Endoscopy.

      Volume: 45 Issue: 08 Pages: 627-634

    • DOI

      10.1055/s-0033-1344027

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pancreati duct drainage using EUS-guided rendezvous technique for stenotic pancreaticojejunostomy2013

    • Author(s)
      Takikawa T, Kanno A, Masamune A, Hamada S, Nakano E, Miura S, Ariga H, Unno J, Kume K, Kikuta K, Hirota M, Yoshida H, Katayose Y, Unno M, Shimosegawa T
    • Journal Title

      World J Gastroenterol

      Volume: 19 Issue: 31 Pages: 5182-5186

    • DOI

      10.3748/wjg.v19.i31.5182

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Diagnosis of autoimmune pancreatitis by endoscopic ultrasonography -guided fine-needle aspiration using a 22-gauge needle: a prospective multicenter study2015

    • Author(s)
      Atsushi Kanno, Atsushi Masamune, Fumiyoshi Fujishima, Takuji Iwashita, Yuzo Kodama, Akio Katanuma, Hirotaka Ohara, Masayuki Kitano, Hiroyuki Inoue, Takao Itoi, Nobumasa Mizuno, Hiroyuki Miyakawa, Rintaro Mikata, Atsushi Irisawa, Satoko Sato, Kenji Notohara, Tooru Shimosegawa
    • Organizer
      DDW 2015
    • Place of Presentation
      Washington DC,USA
    • Year and Date
      2015-05-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A nationwide epidemiological survey of autoimmune pancreatitis in Japan2014

    • Author(s)
      Atsushi Kanno, Atsushi Masamune, Tooru Shimosegawa.
    • Organizer
      第45回日本膵臓学会大会
    • Place of Presentation
      小倉
    • Year and Date
      2014-07-11 – 2014-07-12
    • Related Report
      2014 Research-status Report
  • [Presentation] EUS-FNA is useful to diagnose pancreatic neuroendocrine tumors based on the World Health Organization classification2014

    • Author(s)
      Atsushi Kanno, MD, PhD,1 Jun Unno, MD, PhD,1 Atsushi Masamune, MD, PhD,1Atsuko Kasajima, MD, PhD,2 Fumiyoshi Fujishima, MD, PhD,2 Kazuyuki Ishida, MD, PhD,3 Tooru Shimosegawa, MD, PhD1
    • Organizer
      2014 DDW ASGE
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2014-05-03 – 2014-05-06
    • Related Report
      2014 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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