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Roles of small G-proteins in regulating pancreatic cancer cell invasion and metastasis

Research Project

Project/Area Number 25461023
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionKochi University

Principal Investigator

Iwasaki Shinji  高知大学, 教育研究部医療学系臨床医学部門, 准教授 (10232654)

Co-Investigator(Kenkyū-buntansha) TANIUCHI Keisuke  高知大学, 医学部附属病院, 特任准教授 (50626869)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords膵臓学 / 低分子量Gタンパク質 / 膵臓がん / 浸潤・転移 / 低分子量G タンパク質 / 低分子量 G タンパク質
Outline of Final Research Achievements

We previously reported that BART inhibited pancreatic cancer cell invasion and metastasis. This project seeks to identify the mechanisms by which BART inhibits the invasiveness and metastasis through regulating specific small G-proteins. The data provided here could provide important information to aid to improve the clinical outcome of pancreatic cancer patients. We determined the binding sites of two small G-proteins ARL2 and Rac1 with endogenous BART in pancreatic cancer cells. Furthermore, a specific ARL2-peptide and a specific Rac-1 peptide that could inhibit their binding with BART were found. Each peptide functioned in altering the activities of ARL2 and Rac1, and thereby inhibited pancreatic cancer cell motility and invasion. These discovery based studies will provide insight into the manner in which BART acts on the specific small G-proteins that are important to the motility and invasiveness of pancreatic cancer cells.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (26 results)

All 2015 2014 2013

All Journal Article (10 results) (of which Peer Reviewed: 8 results,  Open Access: 5 results,  Acknowledgement Compliant: 3 results) Presentation (15 results) (of which Int'l Joint Research: 1 results) Book (1 results)

  • [Journal Article] 低分子量Gタンパク質が膵癌細胞の浸潤・転移に関わる機序2015

    • Author(s)
      谷内恵介,岩﨑信二
    • Journal Title

      別冊Bio Clinica

      Volume: 4 Pages: 148-53

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Prdx1 promotes pancreatic cancer cell invasion by modulating p38 MAPK activity.2015

    • Author(s)
      Taniuchi K, Furihata M, Hanazaki K, Iwasaki S, Tanaka K, Shimizu T, Saito M, Saibara T
    • Journal Title

      Pancreas

      Volume: 44 Issue: 2 Pages: 331-340

    • DOI

      10.1097/mpa.0000000000000270

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] KIF20Aと結合するRNA結合蛋白質由来ペプチドワクチンの新規膵癌治療への応用2015

    • Author(s)
      谷内恵介
    • Journal Title

      がん治療のあゆみ

      Volume: 34 Pages: 34-39

    • Related Report
      2014 Research-status Report
  • [Journal Article] IGF2BP3-mediated translation in cell protrusions promotes cell invasiveness and metastasis of pancreatic cancer.2014

    • Author(s)
      Taniuchi K, Furihata M, Hanazaki K, Saito M, Saibara T
    • Journal Title

      Oncotarget

      Volume: 5 Pages: 6832-6845

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] KIF20A-mediated RNA granule transport system promotes the invasiveness of pancreatic cancer cells.2014

    • Author(s)
      Taniuchi K, Furihata M, Saibara T
    • Journal Title

      Neoplasia

      Volume: 16 Issue: 12 Pages: 1082-1093

    • DOI

      10.1016/j.neo.2014.10.007

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Evaluation of Ki-67 index in EUS-FNA specimens for the assessment of malignancy risk in pancreatic neuroendocrine tumors.2014

    • Author(s)
      Hasegawa T, Yamao K, Hijioka S, Bhatia V, Mizuno N, Hara K, Imaoka H, Niwa Y, Tajika M, Kondo S, Tanaka T, Shimizu Y, Kinoshita T, Kohsaki T, Nishimori I, Iwasaki S, Saibara T, Hosoda W, Yatabe Y
    • Journal Title

      Endoscopy

      Volume: 46(1) Issue: 01 Pages: 32-38

    • DOI

      10.1055/s-0033-1344958

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Brain RVD-haemopressin, a haemoglobin-derived peptide, inhibits bombesin-induced central activation of adrenomedullary outflow in the rat2014

    • Author(s)
      Tanaka K, Shimizu T, Yanagita T, Nemoto T, Nakamura K, Taniuchi K, Dimitriadis F, Yokotani K, Saito M
    • Journal Title

      Br. J. Pharmacol.

      Volume: 171 Issue: 1 Pages: 202-213

    • DOI

      10.1111/bph.12471

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Central bombesin possibly induces S-nitrosylation of cyclooxygenase-1 in pre-sympathetic neurons of rat hypothalamic paraventricular nucleus2014

    • Author(s)
      Tanaka K, Shimizu T, Higashi Y, Nakamura K, Taniuchi K, Dimitriadis F, Shimizu S, Yokotani K, Saito M.
    • Journal Title

      Life Sci.

      Volume: 100 Issue: 2 Pages: 85-96

    • DOI

      10.1016/j.lfs.2014.01.079

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Possible involvement of brain prostaglandin E2 and prostanoid EP3 receptors in prostaglandin E2 glycerol ester-induced activation of central sympathetic outflow in the rat2014

    • Author(s)
      Shimizu T, Tanaka K, Nakamura K, Taniuchi K, Yawata T, Higashi Y, Ueba T, Dimitriadis F, Shimizu S, Yokotani K, Saito M.
    • Journal Title

      Neuropharmacology

      Volume: 82 Pages: 19-27

    • DOI

      10.1016/j.neuropharm.2014.03.005

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] RUVBL1 directly binds actin filaments and induces formation of cell protrusions to promote pancreatic cancer cell invasion.2014

    • Author(s)
      Taniuchi K, Furihata M, Iwasaki S, Tanaka K, Shimizu T, Saito M, Saibara T
    • Journal Title

      International Journal of Oncology

      Volume: 44 Issue: 6 Pages: 1945-1954

    • DOI

      10.3892/ijo.2014.2380

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] BCL enhances cell motility and invasion of pancreatic cancer cells.2015

    • Author(s)
      Taniuchi K,Furihata M,Iwasaki S,Saibara T
    • Organizer
      Asia-Pacific Digestive Week 2015
    • Place of Presentation
      Taipei Taiwan
    • Year and Date
      2015-12-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] IgG4関連疾病に合併した門脈血栓症の一例.2014

    • Author(s)
      江渕みのり,羽柴基,小笠原光成,廣瀬享,藤村靖子,麻植啓輔,小野正文,耕﨑拓大,岩﨑信二,西原利治,伊達慶一,岡林雄大,尾崎和秀
    • Organizer
      第102回日本消化器病学会四国支部例会
    • Place of Presentation
      かがわ国際会議場(高松)
    • Year and Date
      2014-11-02 – 2014-11-03
    • Related Report
      2014 Research-status Report
  • [Presentation] 細胞内ストレス顆粒に局在するCD24の膵癌転移抑制機序の解析2014

    • Author(s)
      谷内恵介, 降幡睦夫
    • Organizer
      第73回日本癌学会総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2014-09-24 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] RUVBL1はアクチンとの結合を介して膵癌細胞の運動・浸潤を亢進させる2014

    • Author(s)
      坪井麻記子, 谷内恵介, 降幡睦夫
    • Organizer
      第73回日本癌学会総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2014-09-24 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Prdx1はp38 MAPKの活性制御を介して膵癌細胞の運動・浸潤を亢進させる2014

    • Author(s)
      田内亜紀, 谷内恵介, 降幡睦夫
    • Organizer
      第73回日本癌学会総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2014-09-24 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 門脈圧亢進症に対するダナパロイドナトリウムの有用性についての検討.2014

    • Author(s)
      廣瀬享,越智経浩,岩﨑信二
    • Organizer
      第21回日本門脈圧亢進症学会総会.
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2014-09-12 – 2014-09-13
    • Related Report
      2014 Research-status Report
  • [Presentation] 糖原病Ⅰ型に合併した肝細胞癌の1例.2014

    • Author(s)
      北川達也,石川洋一,宗景匡哉,小笠原光成,廣瀬享,小野正文,岩﨑信二,小林道也,花﨑和弘,西原利治
    • Organizer
      第101回日本消化器病学会四国支部例会.
    • Place of Presentation
      松山市総合コミュニティセンター(愛媛)
    • Year and Date
      2014-06-14 – 2014-06-15
    • Related Report
      2014 Research-status Report
  • [Presentation] 治療による合併症等に難渋した重症自己免疫性肝炎の1例.2014

    • Author(s)
      石川洋一,羽柴基,坪井麻記子,藤村靖子,小笠原光成,廣瀬享,高橋昌也,小野正文,岩﨑信二,西原利治
    • Organizer
      第110回日本内科学会四国地方会.
    • Place of Presentation
      あわぎんホール(徳島)
    • Year and Date
      2014-06-08
    • Related Report
      2014 Research-status Report
  • [Presentation] Prdx1 promotes pancreatic cancer cell motility and invasion by modulating p38 MAPK activity2014

    • Author(s)
      Taniuchi K, Furihata M, Iwasaki S, Shimizu S, Shimizu T, Saito M, Saibara T
    • Organizer
      United European Gastroenterology Week
    • Place of Presentation
      Austria Center Vienna (Vienna, Austria)
    • Related Report
      2013 Research-status Report
  • [Presentation] RUVBL1 directly binds actin filaments and induces formation of cell protrusions to promote pancreatic cancer cell invasion2014

    • Author(s)
      Taniuchi K, Furihata M, Iwasaki S, Shimizu S, Shimizu T, Saito M, Saibara T
    • Organizer
      Asian Pacific Digestive Week
    • Place of Presentation
      Bali Nusa Dua Convention Center (Bali, Indonesia)
    • Related Report
      2013 Research-status Report
  • [Presentation] KIF20AはRNA結合蛋白質とメッセンジャーRNAの複合体を輸送することにより膵癌浸潤・転移を亢進させる2014

    • Author(s)
      谷内恵介, 岩﨑信二, 西原利治
    • Organizer
      第100回日本消化器病学会総会
    • Place of Presentation
      東京国際フォーラム (東京)
    • Related Report
      2013 Research-status Report
  • [Presentation] KIF20A結合型RNA結合蛋白質を標的とした膵癌新規治療法の確立に向けて2014

    • Author(s)
      谷内恵介
    • Organizer
      第45回日本膵臓学会大会
    • Place of Presentation
      北九州国際会議場 西日本総合展示場 新館 AIMビル3F (北九州)
    • Related Report
      2013 Research-status Report
  • [Presentation] B0031 enhances pancreatic cancer cell motility and invasion through binding to ANXA2.2013

    • Author(s)
      Taniuchi K, Furihata M, Saito M, Saibara T
    • Organizer
      Joint Meeting of the International Association of Pancreatology & the Korean Pancreatobiliary Association
    • Place of Presentation
      Sheraton Grande WalkerHill hotel (Seoul, Korea)
    • Related Report
      2013 Research-status Report
  • [Presentation] ヘモグロビンRVD-ヘモプレッシンは脳内カンナビノイドCB1受容体を介してボンベシンによる中枢性副腎髄質系賦活を抑制する2013

    • Author(s)
      清水孝洋, 田中健二朗, 柳田俊彦, 根本隆行, 中村久美子, 谷内恵介, 横谷邦彦, 齊藤源顕
    • Organizer
      第66回日本自律神経学会総会
    • Place of Presentation
      愛知県産業労働センター ウィンクあいち (名古屋)
    • Related Report
      2013 Research-status Report
  • [Presentation] KIF20AがRNA結合蛋白質を介して膵癌浸潤・転移を亢進させる機序2013

    • Author(s)
      谷内恵介
    • Organizer
      第44回日本膵臓学会大会
    • Place of Presentation
      仙台国際センター (仙台)
    • Related Report
      2013 Research-status Report
  • [Book] Autoimmune Liver Diseases2014

    • Author(s)
      Iwasaki S
    • Total Pages
      305
    • Publisher
      Springer
    • Related Report
      2014 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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