Roles of small G-proteins in regulating pancreatic cancer cell invasion and metastasis
| Project/Area Number |
25461023
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kochi University |
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Principal Investigator |
Iwasaki Shinji 高知大学, 教育研究部医療学系臨床医学部門, 准教授 (10232654)
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| Co-Investigator(Kenkyū-buntansha) |
TANIUCHI Keisuke 高知大学, 医学部附属病院, 特任准教授 (50626869)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 膵臓学 / 低分子量Ｇタンパク質 / 膵臓がん / 浸潤・転移 / 低分子量G タンパク質 / 低分子量 G タンパク質 |
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| Outline of Final Research Achievements |
We previously reported that BART inhibited pancreatic cancer cell invasion and metastasis. This project seeks to identify the mechanisms by which BART inhibits the invasiveness and metastasis through regulating specific small G-proteins. The data provided here could provide important information to aid to improve the clinical outcome of pancreatic cancer patients. We determined the binding sites of two small G-proteins ARL2 and Rac1 with endogenous BART in pancreatic cancer cells. Furthermore, a specific ARL2-peptide and a specific Rac-1 peptide that could inhibit their binding with BART were found. Each peptide functioned in altering the activities of ARL2 and Rac1, and thereby inhibited pancreatic cancer cell motility and invasion. These discovery based studies will provide insight into the manner in which BART acts on the specific small G-proteins that are important to the motility and invasiveness of pancreatic cancer cells.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Evaluation of Ki-67 index in EUS-FNA specimens for the assessment of malignancy risk in pancreatic neuroendocrine tumors.2014
Author(s)
Hasegawa T, Yamao K, Hijioka S, Bhatia V, Mizuno N, Hara K, Imaoka H, Niwa Y, Tajika M, Kondo S, Tanaka T, Shimizu Y, Kinoshita T, Kohsaki T, Nishimori I, Iwasaki S, Saibara T, Hosoda W, Yatabe Y
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Journal Title
Endoscopy
Volume: 46(1)
Issue: 01
Pages: 32-38
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Brain RVD-haemopressin, a haemoglobin-derived peptide, inhibits bombesin-induced central activation of adrenomedullary outflow in the rat2014
Author(s)
Tanaka K, Shimizu T, Yanagita T, Nemoto T, Nakamura K, Taniuchi K, Dimitriadis F, Yokotani K, Saito M
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Journal Title
Br. J. Pharmacol.
Volume: 171
Issue: 1
Pages: 202-213
DOI
Related Report
Peer Reviewed
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[Journal Article] Possible involvement of brain prostaglandin E2 and prostanoid EP3 receptors in prostaglandin E2 glycerol ester-induced activation of central sympathetic outflow in the rat2014
Author(s)
Shimizu T, Tanaka K, Nakamura K, Taniuchi K, Yawata T, Higashi Y, Ueba T, Dimitriadis F, Shimizu S, Yokotani K, Saito M.
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Journal Title
Neuropharmacology
Volume: 82
Pages: 19-27
DOI
Related Report
Peer Reviewed / Open Access
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