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Non-invasive modality for diagnosis of pancreatic neoplasm

Research Project

Project/Area Number 25461029
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionCenter for Clinical and Biomedical Research, Sapporo Higashi Tokushukai Hospital

Principal Investigator

Mizukami Yusuke  医療法人徳洲会札幌東徳洲会病院付属臨床研究センター, その他部局等, その他 (30400089)

Co-Investigator(Kenkyū-buntansha) ASHIDA Toshifumi  医療法人徳洲会 札幌東徳洲会病院, 付属臨床研究センター IBD研究部, 研究員 (50261409)
MORIICHI Kentaro  旭川医科大学, 医学部 内科学講座, 講師 (70455715)
井内 康之  医療法人徳洲会札幌東徳洲会病院付属臨床研究センター, その他部局等, 研究員 (90640615)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords膵癌 / 低侵襲診断 / がん低侵襲診断 / 液体生検 / 血管新生 / 血漿遊離DNA
Outline of Final Research Achievements

Recent technologies are emerging to allow genotyping of plasma cell-free DNA (cfDNA) shed from tumors into the general circulation. There are two main types of pathologically distinct precursors for PDA, pancreatic intraepithelial neoplasias and intraductal papillary mucinous cystic neoplasias (IPMNs), and the mutations in KRAS and/or GNAS mediate key signaling during early development of the tumors. The clinical viability of cfDNA genotyping using digital PCR targeting mutations in KRAS and GNAS were examined. Ten PDA and 21 IPMN patients were recruited. The primary endpoint of this study was to evaluate whether such an approach can appropriately monitor the risk IPMN progression and detect localized early-stage PDA non-invasively. The major technical challenge of widespread implementation of this clinical test is the coverage for uncommon forms of KRAS mutation, as well as sensitivity for early stages cancer where the amount of cfDNA may be limited.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (15 results)

All 2016 2015 2014 2013 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (6 results) (of which Int'l Joint Research: 1 results) Remarks (1 results)

  • [Journal Article] Tracking the clonal evolution of adenosquamous carcinoma, a rare variant of intraductal papillary mucinous neoplasm of the pancreas.2016

    • Author(s)
      Matsuzaka S, Karasaki H, Ono Y, Ogata M, Oikawa K, Tamakawa S, Chiba S, Muraki M, Yokochi T, Funakoshi H, Kono T, Nagashima K, Mizukami Y.
    • Journal Title

      Pancreas

      Volume: xx

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The protein expression level of Gli2 is a feasible marker of ligand-dependent hedgehog activation in pancreatic neoplasms.2016

    • Author(s)
      Sugiyama Y, Sasajima J, Mizukami Y, Koizumi K, Kawamoto T, Karasaki H, Yusuke Ono, Tanabe H, Fujiya M, Kohgo Y.
    • Journal Title

      Pol J Pathol

      Volume: xx

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Rare Case of Epidermoid Cyst in the Pancreatic Tail Invaginated from the Splenic Hilum: Long-term Alteration in Imaging Findings.2016

    • Author(s)
      Sugiyama Y, Kawamoto T, Sasajima J, Koizumi K, Karasaki H, Mizukami Y.
    • Journal Title

      Internal Medicine

      Volume: xx

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metachronous pancreatic cancer originating from disseminated founder pancreatic intraductal neoplasias (PanINs)2015

    • Author(s)
      Imai K, Karasaki K, Ono Y, Sasajima J, Chiba S, Funakoshi H, Muraki M, Hanaoka H, Furukawa T, Furukawa H, Kono T, Nagashima K, Mizukami Y
    • Journal Title

      The Journal of Pathology: Clinical Research

      Volume: 1 Issue: 2 Pages: 76-82

    • DOI

      10.1002/cjp2.8

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Germline mutations in oncogene-induced senescence pathways are associated with multiple sessile serrated adenomas.2014

    • Author(s)
      Gala MK, Mizukami Y, Le LP, Moriichi K, Austin T, Yamamoto M, Lauwers GY, Bardeesy N, Chung DC
    • Journal Title

      Gastroenterology

      Volume: 146 Issue: 2 Pages: 520-9

    • DOI

      10.1053/j.gastro.2013.10.045

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Cyst infection of intraductal papillary mucinous neoplasms of the pancreas: management of a rare complication: report of 2 cases.2014

    • Author(s)
      Watanabe K, Karasaki H, Mizukami Y, Kawamoto T, Kono T, Imai K, Einama T, Taniguchi M, Kohgo Y, Furukawa H
    • Journal Title

      Pancreas

      Volume: 43 Issue: 3 Pages: 478-81

    • DOI

      10.1097/mpa.0000000000000036

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Macrophages in pancreatic cancer: starting things off on the wrong track.2013

    • Author(s)
      Deschenes-Simard X, Mizukami Y, Bardeesy N
    • Journal Title

      J Cell Biol

      Volume: 202 Issue: 3 Pages: 403-5

    • DOI

      10.1083/jcb.201307066

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Ex vivo activation of angiogenic property in human peripheral blood-derived monocytes by thrombopoietin.2013

    • Author(s)
      Kawamoto T, Sasajima J, Sugiyama Y, Nakamura K, Tanabe H, Fujiya M, Nata T, Iuchi Y, Ashida T, Torimoto Y, Mizukami Y, Kohgo Y.
    • Journal Title

      Int J Hematol

      Volume: 98 Issue: 4 Pages: 417-429

    • DOI

      10.1007/s12185-013-1423-8

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Plasma DNA genotyping using digital PCR for early detection of pancreatic neoplasm2015

    • Author(s)
      Mizukami Y, Ono Y, Karasaki H, Ogata M, Koizumi K, Ando K, Yokochi T, Yamada M, Kono T, Nagashima K
    • Organizer
      46th Annual Meeting of the American Pancreatic Association
    • Place of Presentation
      San Diego
    • Year and Date
      2015-11-04
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Plasma DNA genotyping using digital PCR for early detection of pancreatic cancer2015

    • Author(s)
      Mizukami Y, Ono Y, Karasaki H, Asahara S, Ando K, Shinohara T, Nagashima K
    • Organizer
      第74回日本癌学会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] 液体生検による膵癌リスク評価2015

    • Author(s)
      水上裕輔、真口宏介、小泉一也
    • Organizer
      第23回日本消化器関連学会週間
    • Place of Presentation
      東京
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] Metachronous pancreatic cancer originating from disseminated founder pancreatic intraductal neoplasias.2015

    • Author(s)
      Ono Y, Karasaki H, Imai K, Sasajima J, Chiba S, Funakoshi H, Muraki M, Hanaoka H, Furukawa T, Furukawa H, Kono T, Nagashima K, Mizukami Y.
    • Organizer
      2015 Gastrointestinal Cancers Symposium
    • Place of Presentation
      San Francisco
    • Year and Date
      2015-01-15 – 2015-01-17
    • Related Report
      2014 Research-status Report
  • [Presentation] Adenosquamous cell carcinoma derived from intraductal papillary mucinous neoplasm of the pancreas confirmed by genetic analysis.2015

    • Author(s)
      Karasaki H, Kono T, Ono Y, Maejima T, Mizukami Y.
    • Organizer
      2015 Gastrointestinal Cancers Symposium
    • Place of Presentation
      San Francisco
    • Year and Date
      2015-01-15 – 2015-01-17
    • Related Report
      2014 Research-status Report
  • [Presentation] A case of metachronous ductal adenocarcinomas (PDAs) with unique KRAS mutation.2014

    • Author(s)
      Mizukami Y, Imai K,Chiba S, Ono Y, Sasajima J, Karasaki H, Kono T, Nagashima K.
    • Organizer
      日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-26
    • Related Report
      2014 Research-status Report
  • [Remarks] 札幌東徳洲会病院付属臨床研究センター

    • URL

      http://www.higashi-tokushukai.or.jp/clinical_study/research/detail.php?pid=434583114140

    • Related Report
      2015 Annual Research Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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