• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Comprehensive gene analysis of small intestinal cancer tumor

Research Project

Project/Area Number 25461031
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Ohtsuka Kazuo  東京医科歯科大学, 医学部附属病院, 特別診療教授 (00338443)

Co-Investigator(Kenkyū-buntansha) TSUCHIYA Kiichiro  東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (40376786)
WATANABE Mamoru  東京医科歯科大学, 大学院医歯学総合研究科, 教授 (10175127)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords小腸がん / 網羅的遺伝子解析 / バルーン内視鏡
Outline of Final Research Achievements

In late years, a small intestinal endoscope technology has been developed, resulting in a lot of diseases being reported in the small intestine than it was assumed. The early checkup example of the small intestine adenocarcinoma came to be reported, but, as for the cause, it is unknown.
In this study, we grasp the natural history of the small intestine adenocarcinoma and am intended that we clarify the whole aspect of the cell biochemical character during carcinogenesis in small intestine at a stem cell level. With the approval of the ethic screening committee, we identified the patient with a small intestine cancer in the database of our hospital. We performed the cause of the informed consent, the exhaustive gene analysis by the resected samples of small intestinal cancer.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (18 results)

All 2016 2015 2014 2013

All Journal Article (11 results) (of which Peer Reviewed: 11 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (7 results) (of which Invited: 2 results)

  • [Journal Article] Reduced human α-defensin 6 in non-inflamed jejunal tissue of Crohn’s disease patients2016

    • Author(s)
      Hayashi R , Tsuchiya K, Okamoto R,Watanabe M,et al
    • Journal Title

      Inflammatory Bowel Diseases

      Volume: 22 Issue: 5 Pages: 1119-28

    • DOI

      10.1097/mib.0000000000000707

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epithelial Nuclear Factor-kB Activation in Inflammatory Bowel Diseases and Colitis-Associated Carcinogenesis. "2016

    • Author(s)
      Nagaishi T,Watabe T,Jose N, Tokai A, Fujii T, Matsuoka K, Nagahori M, Ohtsuka K
    • Journal Title

      Digestion

      Volume: 93 Issue: 1 Pages: 40-46

    • DOI

      10.1159/000441670

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Correlation of the Endoscopic and Magnetic Resonance Scoring Systems in the Deep Small Intestine in Crohn's Disease.2015

    • Author(s)
      Takenaka K, Ohtsuka K, Kitazume Y, Nagahori M, Fujii T, Saito E, Fujioka T, Matsuoka K, Naganuma M, Watanabe M
    • Journal Title

      Inflamm Bowel Dis.

      Volume: 21 Issue: 8 Pages: 1832-1838

    • DOI

      10.1097/mib.0000000000000449

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Tacrolimus for the Treatment of Ulcerative Colitis.2015

    • Author(s)
      Matsuoka K, Saito E, Fujii T, Takenaka K, Kimura M, Nagahori M, Ohtsuka K, Watanabe M.
    • Journal Title

      Intest Res.

      Volume: 13 Issue: 3 Pages: 219-226

    • DOI

      10.5217/ir.2015.13.3.219

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of Magnetic Resonance and Balloon Enteroscopic Examination of Deep Small Intestine in Patients with Crohn's Disease.2014

    • Author(s)
      Takenaka K, Ohtsuka K,Watanabe M et al
    • Journal Title

      Gastroenterology

      Volume: [Epub ahead of print] Issue: 2 Pages: 334-342

    • DOI

      10.1053/j.gastro.2014.04.008

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Carbon dioxide insufflation improves the intubation depth and total enteroscopy rate in single-balloon enteroscopy: a randomised, controlled, double-blind trial2014

    • Author(s)
      Li X, Zhao YJ, Dai J, Li XB, Xue HB, Zhang Y, Xiong GS, Ohtsuka K, Gao YJ, Liu Q, Song Y, Fang JY, Ge ZZ
    • Journal Title

      Gut

      Volume: in press Issue: 10 Pages: 1560-1565

    • DOI

      10.1136/gutjnl-2013-306069

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Magnetically Guided Capsule Versus Conventional Gastroscopy for Upper Abdominal Complaints: A Prospective Blinded Study2014

    • Author(s)
      Denzer UW, Rosch T, Hoytat B, Abdel-Hamid M, Hebuterne X, Vanbiervielt G, Filippi J, Ogata H, Hosoe N, Ohtsuka K, Ogata N, Ikeda K, Aihara H, Kudo SE, Tajiri H, Treszl A, Wegscheider K, Greff M, Rey JF
    • Journal Title

      J Clin Gastroenterol.

      Volume: in press

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Efficacy of salvage therapy and its effect on operative outcomes in patients with ulcerative colitis.2014

    • Author(s)
      Saito E, Nagahori M, Fujii T, Otsuka K, Watanabe M
    • Journal Title

      Digestion

      Volume: 89 Issue: 1 Pages: 55-60

    • DOI

      10.1159/000356221

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Advancing magnetic resonance imaging in Crohn's disease.2014

    • Author(s)
      Fujii T, Naganuma M, Kitazume Y, Saito E, Nagahori M, Ohtsuka K, Watanabe M.
    • Journal Title

      Digestion

      Volume: 89 Issue: 1 Pages: 24-30

    • DOI

      10.1159/000356210

    • NAID

      130005084744

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Lineage-specific expression of Bestrophin-2 and Bestrophin-4 in human intestinal epithelial cells.2013

    • Author(s)
      Ito G, Okamoto R, Nakamura T, Watanabe M et al
    • Journal Title

      PloS One.

      Volume: 8 Issue: 11 Pages: e79693-e79693

    • DOI

      10.1371/journal.pone.0079693

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Endocytoscopy provides an in vivo virtual histopathological diagnosis of Whipple's disease.2013

    • Author(s)
      Watanabe D, Kudo SE, Hayashi S, Mori Y, Kodama K, Wakamura K, Miyachi H, Yamamura F, Ohtsuka K, Mikogami T, Kimura S, Fukuchi K, Ikehara N.
    • Journal Title

      Endoscopy

      Volume: 45 Issue: S 02 Pages: 143-144

    • DOI

      10.1055/s-0032-1326276

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 小腸内視鏡の適応と手技2016

    • Author(s)
      大塚和朗
    • Organizer
      第12回日本消化管学会総会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2016-02-26
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] クローン病小腸狭窄に対するMREC所見と内視鏡下バルーン拡張術の手術回避に対する検討2016

    • Author(s)
      竹中健人、大塚和朗、北詰良雄、福田将義、野崎賢吾、渡辺 守、岩本史光、木村麻衣子、藤井俊光、松岡克善、長堀正和
    • Organizer
      第12回日本消化管学会総会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2016-02-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] クローン病小腸病変に対するバルーン内視鏡およびMRI所見.2015

    • Author(s)
      竹中健人、大塚和朗、北詰良雄、福田将義、野崎賢吾、岩本史光、木村麻衣子、藤井俊光、松岡克善、長堀正和、渡辺 守
    • Organizer
      第53回小腸研究会
    • Place of Presentation
      いわて県民情報交流センター(アイーナ)(岩手県盛岡市)
    • Year and Date
      2015-11-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] クローン病治療における生物学的製剤と内視鏡治療・外科手術2015

    • Author(s)
      大塚和朗、長堀正和、渡辺 守
    • Organizer
      JDDW2015
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都港区)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] 潰瘍性大腸炎関連腫瘍の内視鏡診断と治療2015

    • Author(s)
      大塚和朗、和田祥城、渡辺 守
    • Organizer
      第89回日本消化器内視鏡学会総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-05-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] 当院における生物学的製剤の長期予後とクローン画像評価の重要性.2015

    • Author(s)
      竹中健人、大塚和朗、渡辺 守
    • Organizer
      第101回日本消化器病学会総会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2015-04-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] カプセル内視鏡の未来ー小腸、大腸、そして上部へー2013

    • Author(s)
      大塚和朗 荒木昭博 渡辺 守
    • Organizer
      第6回日本カプセル内視鏡学会
    • Place of Presentation
      東京、都市センターホテル
    • Related Report
      2013 Research-status Report
    • Invited

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi