Objective Evaluation for Functional Bowel Disorder Using Video Capsule Endoscopy

• Project/Area Number: 25461032
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Nagoya University
• Principal Investigator: Nakamura Masanao 名古屋大学, 医学部附属病院, 助教 (60467321)
• Co-Investigator(Kenkyū-buntansha): 大宮 直木 藤田保健衛生大学, 医学部, 教授 (00335035) ; 後藤 秀実 名古屋大学, 医学系研究科, 教授 (10215501) ; 山村 健史 名古屋大学, 医学部附属病院, 病院助教 (10709091)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: カプセル内視鏡 / 過敏性腸症候群 / 客観的評価 / 消化管運動機能 / 消化管機能 / 小腸

Outline of Final Research Achievements

We previously found the irregularity of the images of intestinal lumen on small bowel capsule endoscopy (CE) with irritable bowel syndrome (IBS) patients, comparing with those with healthy subjects. The aim of this study was to evaluate the detailed characteristics of the findings of intestinal lumens shown by CE images and to try to diagnose IBS objectively. The factor, abdominal pain, affected the passage of CE in the gastrointestinal tract. We considered that CE was useful for evaluating IBS with active phase. On the other hand, colon capsule endoscopy was not affected by abdominal symptoms. Therefore, our results suggested that the image analysis of small bowel CE images in active IBS may be important for diagnosing IBS.

Research Products

• [Journal Article] Prospective study of factors important to achieve observation of the entire colon on colon capsule endoscopy. (2017)
  • Author(s): Sato J, Nakamura M, Watanabe O, Yamamura T, Funasaka K, Ohno E, Miyahara R, Kawashima H, Goto H, Hirooka Y.
  • Journal Title: Therap Adv Gastroenterol. Volume: 10 Issue: 1 Pages: 20-31
  • DOI: 10.1177/1756283x16673556
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of mRNA and protein expression of nutritional biomarkers in the gastrointestinal mucosa of patients with small intestinal disorders (2016)
  • Author(s): Masanao Nakamura, Yoshiki Hirooka, Osamu Watanabe, Takeshi Yamamura, Kohei Funasaka, Eizaburo Ohno, Ryoji Miyahara, Hiroki Kawashima, Yoshie Shimoyama, Hidemi Goto
  • Journal Title: Ｉｎｔｅｒｎａｌ Ｍｅｄｉｃｉｎｅ Volume: in press
  • NAID: 130005169386
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A Retrospective Evaluation of the Utility of Capsule Endoscopy and Double-Balloon Endoscopy in Crohn's Disease (2016)
  • Author(s): Masanao Nakamura, Yoshiki Hirooka, Osamu Watanabe, Takeshi Yamamura, Kohei Funasaka, Eizaburo Ohno, Hiroki Kawashima, Ryoji Miyahara, Hidemi Goto
  • Journal Title: Gastroenterology Research and Practice Volume: in press Pages: 1-7
  • DOI: 10.1155/2016/1085027
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The Clinical Usefulness of the Novel Tag-Less Agile Patency Capsule Prior to Capsule Endoscopy for the Patients with Suspected Small Bowel Stenosis. (2015)
  • Author(s): Nakamura M, Hirooka Y, Watanabe O, Yamamura T, Furukawa K, Funasaka K, Ohno E, Miyahara R, Kawashima , Ando T, Ohmiya N, Goto H.
  • Journal Title: Digestive Endoscopy Volume: 27 Issue: 1 Pages: 61-66
  • DOI: 10.1111/den.12306
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] 大腸カプセル内視鏡における全大腸観察を達成するために重要な臨床因子の検討 (2016)
  • Author(s): 佐藤淳一、廣岡芳樹、渡辺修、中村正直、山村健史、後藤秀実
  • Organizer: 第12回日本消化管学会総会学術集会
  • Place of Presentation: 東京都新宿区 京王プラザホテル
  • Year and Date: 2016-02-26
• [Presentation] The Clinical Experiences of Novel Tag-Less Agile Patency Capsule for 100 Cases With Suspected Small Bowel Stenosis (2014)
  • Author(s): Nakamura M, Hirooka Y, Yamamura T, Yamada K, Nagura A, Yoshimura T, Nakano A, Oshima H, Furukawa K, Funasaka K, Ohno E, Miyahara R, Kawashima H, Itoh A, Watanabe O, Ando T, Ohmiya N, Goto H
  • Organizer: Digestive Disease Week in America
  • Place of Presentation: Chicago,U.S.A
  • Year and Date: 2014-05-05