Technological development of endoscopic ultrasonography for improvement of diagnosis and prognosis of pancreatic diseases

• Project/Area Number: 25461035
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Kinki University
• Principal Investigator: KITANO Masayuki 近畿大学, 医学部, 准教授 (50314571)
• Co-Investigator(Kenkyū-buntansha): KUDO Masatoshi 近畿大学, 医学部, 教授 (10298953) ; NISHIO Kazuto 近畿大学, 医学部, 教授 (10208134)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 超音波内視鏡学 / 膵臓病学 / 消化器病学 / 消化器内視鏡学 / 検査診断システム / 超音波内視鏡 / 膵疾患 / 画像診断 / 内視鏡治療 / ドレナージ術 / 超音波造影剤

Outline of Final Research Achievements

Contrast-enhanced harmonic endoscopic ultrasonography improved the ability of conventional endoscopic ultrasonography for differentiating malignant from benign cystic lesion in the pancreas as well as diagnosing lymph node metastases of pancreatobiliary tumors. Surveillance of pancreatic cancer using endoscopic ultrasonography in patients with intraductal papillary mucinous neoplasms detected small pancreatic cancer in 7%, which may lead to early diagnosis of pancreatic cancer. Endoscopic ultrasonography-guided bile duct and gallbladder drainage allowed treatment of difficult obstructive jaundice. Preclinical study revealed that radial force and structure of the flare strongly affect the anti-migration property of the biliary metal stent. Neurolysis of both broad plexus and ganglia was a predictor of a good pain response in endoscopic ultrasonography-guided neurolyisis for pancreatic cancer-related pain. The larger number of neurolytic spread areas lead to better outcomes.

Research Products

• [Journal Article] Acute spinal cord infarction after EUS-guided celiac plexus neurolysis (2016)
  • Author(s): Minaga K, Kitano M, Imai H, Miyata T, Kudo M
  • Journal Title: Gastrointest Endosc Volume: 印刷中 Issue: 5 Pages: 1039-1040
  • DOI: 10.1016/j.gie.2015.10.044
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Contrast-enhanced harmonic endoscopic ultrasonography for differential diagnosis of pancreatic cysts (2016)
  • Author(s): Kamata K, Kitano M, Omoto S, Kadosaka K, Miyata T, Yamao K, Imai H, Sakamoto H, Harwani Y, Chikugo T, Chiba Y, Matsumoto I, Takeyama Y, Kudo M
  • Journal Title: Endoscopy Volume: 48 Issue: 01 Pages: 35-41
  • DOI: 10.1055/s-0034-1393564
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] EUS-guided gallbladder drainage for rescue treatment of malignant distal biliary obstruction after unsuccessful ERCP (2016)
  • Author(s): Imai H, Kitano M, Omoto S, Kadosaka K, Kamata K, Miyata T, Yamao K, Sakamoto H, Harwani Y, Kudo M
  • Journal Title: Gastrointest Endosc Volume: 印刷中 Issue: 1 Pages: 147-151
  • DOI: 10.1016/j.gie.2015.12.024
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Stent migration into the abdominal cavity after EUS-guided hepaticogastrostomy (2016)
  • Author(s): Minaga K, Kitano M, Yamashita Y, Nakatani Y, Kudo M
  • Journal Title: Gastrointest Endosc Volume: 印刷中 Issue: 1 Pages: 263-264
  • DOI: 10.1016/j.gie.2016.03.016
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Contrast-enhanced harmonic endoscopic ultrasonography for assessment of lymph node metastases in pancreatobiliary carcinoma (2016)
  • Author(s): Miyata T, Kitano M, Omoto S, Kadosaka K, Kamata K, Imai H, Sakamoto H, Nisida N, Harwani Y, Murakami T, Takeyama Y, Chiba Y, Kudo M
  • Journal Title: World J Gastroenterol Volume: 22 Issue: 12 Pages: 3381-3391
  • DOI: 10.3748/wjg.v22.i12.3381
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Predicting Through-the-Scope Gastroduodenal Stenting Outcomes in Patients with Gastric Outlet Obstruction: A Large Multicenter Retrospective Study in West Japan (2016)
  • Author(s): Yamao K, Kitano M, Kayahara T, Ishida E, Yamamoto H, Minaga K, Yamashita Y, Nakajima J, Asada M, Okabe Y, Osaki Y, Chiba Y, Imai H, Kudo M
  • Journal Title: Gastrointest Endosc Volume: 印刷中 Issue: 5 Pages: 757-763.e6
  • DOI: 10.1016/j.gie.2016.03.1498
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Urgent endoscopic ultrasound-guided choledochoduodenostomy for acute obstructive suppurative cholangitis-induced sepsis (2016)
  • Author(s): Minaga K, Kitano M, Imai H, Yamao K, Kamata K, Miyata T, Omoto S, Kadosaka K, Yoshikawa T, Kudo M
  • Journal Title: World J Gastroenterol Volume: 印刷中
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Surgically resected needle tract seeding following endoscopic ultrasound-guided fine-needle aspiration in pancreatic cancer (2015)
  • Author(s): Minaga K, Kitano M, Yamashita Y
  • Journal Title: J Hepatobiliary Pancreat Sci Volume: 22 Issue: 9 Pages: 708-709
  • DOI: 10.1002/jhbp.269
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Synchronous pancreatic and gastric metastasis from an ovarian adenocarcinoma diagnosed by endoscopic ultrasound-guided fine-needle aspiration (2015)
  • Author(s): Yamao K, Kitano M, Kudo M, Maenishi O
  • Journal Title: Endoscopy Volume: 47 Suppl 1 Issue: S 01 Pages: E596-E597
  • DOI: 10.1055/s-0034-1393649
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Activin signal promotes cancer progression and is involved in cachexia in a subset of pancreatic cancer. (2015)
  • Author(s): Togashi Y, Kogita A, Sakamoto H, Hayashi H, Terashima M, De Velasco MA, Sakai K, Fujita Y, Tomida S, Kitano M, Okuno K, Kudo M, Nishio K
  • Journal Title: Cancer Letters Volume: 356 Issue: 2 Pages: 819-827
  • DOI: 10.1016/j.canlet.2014.10.037
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Contrast-enhanced harmonic endoscopic ultrasonography for pancreatobiliary diseases. (2015)
  • Author(s): Kitano M, Kamata K, Imai H, Miyata T, Yasukawa S, Yanagisawa A, Kudo M
  • Journal Title: Dig Endosc Volume: 27 Suppl 1 Issue: S1 Pages: 60-67
  • DOI: 10.1111/den.12454
  • Peer Reviewed / Open Access
• [Journal Article] Homozygous deletion of the activin A receptor, type IB gene is associated with an aggressive cancer phenotype in pancreatic cancer. (2014)
  • Author(s): Togashi Y, Sakamoto H, Hayashi H, Terashima M, de Velasco MA, Fujita Y, Kodera Y, Sakai K, Tomida S, Kitano M, Ito A, Kudo M, Nishio K
  • Journal Title: Molecular Cancer Volume: 13 Issue: 1 Pages: 126-126
  • DOI: 10.1186/1476-4598-13-126
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Endoscopic ultrasonography-guided gallbladder drainage procedures: is the glass half-full or half-empty? (2014)
  • Author(s): Kitano M, Kamata K, Kudo M
  • Journal Title: Dig Endosc Volume: 26 Issue: 5 Pages: 636-637
  • DOI: 10.1111/den.12327
  • Peer Reviewed / Open Access
• [Journal Article] Transrectal endoscopic ultrasound-guided fine-needle aspiration for diagnosis of ovarian tumors. (2014)
  • Author(s): Minaga K, Yamashita Y, Kitano M
  • Journal Title: Dig Endosc Volume: 26 Issue: 6 Pages: 756-757
  • DOI: 10.1111/den.12376
  • Peer Reviewed
• [Journal Article] Contrast-enhanced endoscopic ultrasound. (2014)
  • Author(s): Kitano M, Sakamoto H, Kudo M
  • Journal Title: Digest Endosc Volume: 26 Issue: S1 Pages: 79-85
  • DOI: 10.1111/den.12179
  • Peer Reviewed
• [Journal Article] Value of EUS in early detection of pancreatic ductal adenocarcinomas in patients with intraductal papillary mucinous neoplasms. (2014)
  • Author(s): Kamata K, Kitano M, Kudo M, Sakamoto H, Kadosaka K, Miyata T, Imai H, Maekawa K, Chikugo T, Kumano M, Hyodo T, Murakami T, Chiba Y, Takeyama Y
  • Journal Title: Endoscopy Volume: 46 Issue: 01 Pages: 22-29
  • DOI: 10.1055/s-0033-1353603
  • Peer Reviewed
• [Journal Article] Covered self-expandable metal stents with an anti-migration system improve patency duration without increased complications compared with uncovered stents for distal biliary obstruction caused by pancreatic carcinoma: a randomized multicenter trial. (2013)
  • Author(s): Kitano M, Yamashita Y, Tanaka K, Konishi H, Yazumi S, Nakai Y, Nishiyama O, Uehara H, Mitoro A, Sanuki T, Takaoka M, Koshitani T, Arisaka Y, Shiba M, Hoki N, Sato H, Sasaki Y, Sato M, Hasegawa K, Kawabata H, Okabe Y, Mukai H.
  • Journal Title: Am J Gastroenterol Volume: 108 Issue: 11 Pages: 1713-1722
  • DOI: 10.1038/ajg.2013.305
  • Peer Reviewed
• [Journal Article] Recent advances in EUS-guided biliary drainage (2013)
  • Author(s): 北野雅之, 工藤正俊
  • Journal Title: Nippon Shokakibyo Gakkai Zasshi Volume: 110 Issue: 4 Pages: 557-567
  • DOI: 10.11405/nisshoshi.110.557
  • NAID: 10031163784
  • ISSN: 0446-6586, 1349-7693
  • Peer Reviewed
• [Presentation] Advanced EUS imaging-elastography and contrast techniques (2015)
  • Author(s): Kitano M
  • Organizer: EUS Australia 2015
  • Place of Presentation: Sydney, Australia
  • Year and Date: 2015-06-21
  • Invited
• [Presentation] Interventional EUS (2015)
  • Author(s): Kitano M
  • Organizer: 12th Beijing International Digestive Disease Forum
  • Place of Presentation: Beijing, China
  • Year and Date: 2015-06-12
  • Int'l Joint Research / Invited
• [Presentation] Contrast-enhanced harmonic endoscopic ultrasonography for diagnosing cystic tumors in the pancreas (2015)
  • Author(s): Kamata K, Kitano M, Omoto S, Kadosaka K, Miyata T, Yamao K, Imai H, Kudo M
  • Organizer: Digestive disease Week 2015
  • Place of Presentation: Washington DC
  • Year and Date: 2015-05-16
  • Int'l Joint Research
• [Presentation] Quantitative perfusion analysis with contrast-enhanced harmonic EUS in pancreatic tumors (2015)
  • Author(s): Omoto S, Kitano M, Kadosaka K, Minaga K, Kamata K, Miyata T, Yamao K, Imai H, Sakamoto H, Kudo M
  • Organizer: Digestive Disease Week 2015
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2015-05-16
  • Int'l Joint Research
• [Presentation] Role of EUS for biliary pancreatic diseases: From a diagnostic perspective (2015)
  • Author(s): Kitano M
  • Organizer: the 46th Annual Congress of Korean Society of Ultrasound in Medicine
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2015-05-15
  • Invited
• [Presentation] Best evidence-based techniques for performing EUS-guided FNA (2014)
  • Author(s): Kitano M
  • Organizer: 19th International Symposium on Endoscopic Ultrasonography (EUS2014)
  • Place of Presentation: Chennai, India
  • Year and Date: 2014-09-18 – 2014-09-20
  • Invited
• [Presentation] CH-EUS: the invention of a new technique and how to get the best results out of it (setting the equipment, different presets, qualitative and quantitative techniques) (2014)
  • Author(s): Kitano M
  • Organizer: The 2nd European Workshop on CH-EUS and EUS Image Enhancement Techniques
  • Place of Presentation: Imola, Italy
  • Year and Date: 2014-06-29 – 2014-07-01
  • Invited
• [Presentation] Innovative applications: prediction and evaluation of response to chemotherapy, vascular lesions, guidance for EUS interventions, and other (2014)
  • Author(s): Kitano M
  • Organizer: The 2nd European Workshop on CH-EUS and EUS Image Enhancement Techniques
  • Place of Presentation: Imola, Italy
  • Year and Date: 2014-06-29 – 2014-07-01
  • Invited
• [Presentation] Prospective multicenter randomized controlled trial of histological diagnostic yield comparing 25G EUS-FNA needles with and without a core trap n patients with solid pancreatic masses (2014)
  • Author(s): Reiko Ashida, Satoru Yasukawa, Akio Yanagisawa, Ken kamata, Masatoshi Kudo, Takeshi Ogura, Kazuhide Higuchi, Nobuyasu Fukutake, Hiroko Nebiki, Satoru Hirose, Noriyuki Hoki6), Masanori Asada, Shujiro Yazumi, Makoto Takaoka, Kazuichi Okazaki, Fumihiro Matsuda, Yoshihiro Okabe, Masayuki Kitano
  • Organizer: Digestive Disease Week 2014
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-05-03 – 2014-05-06
• [Presentation] Contrast agents and elastography: enhancing EUS (2013)
  • Author(s): Kitano M
  • Organizer: 18th Annual Endoscopic Ultrasonography Live 2013
  • Place of Presentation: Chicago
  • Invited
• [Presentation] EUS-guided celiac neurolysis and block: ending the pain (2013)
  • Author(s): Kitano M
  • Organizer: 18th Annual Endoscopic Ultrasonography Live 2013
  • Place of Presentation: Chicago
  • Invited
• [Presentation] The future of CH-EUS? (2013)
  • Author(s): Kitano M
  • Organizer: 1st European CH-EUS Workshop
  • Place of Presentation: Lyon
  • Invited
• [Presentation] Contrasst harmonic echo in EUS: the principles (2013)
  • Author(s): Kitano M
  • Organizer: 1st European CH-EUS Workshop
  • Place of Presentation: Lyon
  • Invited
• [Presentation] Contrast-enhanced EUS: Can this replace EUS-FNA or just fancy? (2013)
  • Author(s): Kitano M
  • Organizer: International Digestive Endoscopy Network 2013
  • Place of Presentation: Seoul
  • Invited