Evaluation of pulmonary circulation and right ventricular function by radiographic and invasive hemodynamic methods in patients with pulmonary hypertension

• Project/Area Number: 25461037
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Tohoku University
• Principal Investigator: Tatebe Shunsuke 東北大学, 大学病院, 助教 (90456062)
• Co-Investigator(Kenkyū-buntansha): FUKUMOTO Yoshihiro 久留米大学, 医学部, 教授 (70363372)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 肺高血圧症 / 慢性血栓塞栓性肺高血圧症 / 右心機能 / 肺循環 / 心臓MRI / FDG-PET / 肺動脈バルーン形成術 / 心筋代謝 / BMIPP / ４D-Flow / 糖代謝 / 脂肪酸代謝 / 心臓PET / 心臓核医学 / インプットインピーダンス / 心臓ＰＥＴ / 心臓ＭＲＩ

Outline of Final Research Achievements

The purpose of the present study was to evaluate both pulmonary circulation and right ventricular function by radiographic and invasive hemodynamic methods in patients with pulmonary hypertension. We have reported that （1）enhanced [18F] fluorodeoxyglucose accumulation in the right ventricular free wall predicts long-term prognosis of patients with pulmonary hypertension. We have also reported that in patients with chronic thromboembolic pulmonary hypertension, balloon pulmonary angioplasty improves (2) the severity of vortex flow in the main pulmonary artery assessed by four-dimensional magnetic resonance, (3) biventricular function and (4) systemic organ dysfunctions caused by right heart failure, associated with marked pulmonary hemodynamic improvements.

Research Products

• [Journal Article] Multiple Beneficial Effects of Balloon Pulmonary Angioplasty in Patients With Chronic Thromboembolic Pulmonary Hypertension (2016)
  • Author(s): Tatebe S, Sugimura K, Aoki T, Miura M, Nochioka K, Miyamichi-Yamamoto S, Yaoita N, Suzuki H, Sato H, Satoh K, Fukumoto Y, Shimokawa H.
  • Journal Title: Circulation Journal Volume: 80 Issue: 4 Pages: 980-988
  • DOI: 10.1253/circj.CJ-15-1212
  • NAID: 130005139581
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Enhanced [18F]fluorodeoxyglucose accumulation in the right ventricular free wall predicts long-term prognosis of patients with pulmonary hypertension: a preliminary observational study. (2014)
  • Author(s): Tatebe S, Fukumoto Y, Oikawa-Wakayama M, Sugimura K, Satoh K, Miura Y, Aoki T, Nochioka K, Miura M, Yamamoto S, Tashiro M, Kagaya Y, Shimokawa H.
  • Journal Title: Eur Heart J Cardiovasc Imaging. Volume: 15 Issue: 6 Pages: 666-672
  • DOI: 10.1093/ehjci/jet276
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Platelets are highly activated in patients of chronic thromboembolic pulmonary hypertension (CTEPH). (2014)
  • Author(s): Yaoita N, Shirakawa R, Fukumoto Y, Sugimura K, Miyata S, Miura Y, Nochioka K, Miura M, Tatebe S, Aoki T, Miyamichi-Yamamoto S, Satoh K, Kimura T, Shimokawa H, Horiuchi H.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 34 Issue: 11 Pages: 2486-2494
  • DOI: 10.1161/atvbaha.114.304404
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Basigin mediates pulmonary hypertension by promoting inflammation and vascular smooth muscle cell proliferation. (2014)
  • Author(s): Satoh K, Satoh T, Kikuchi N, Omura J, Kurosawa R, Suzuki K, Sugimura K, Aoki T, Nochioka K, Tatebe S, Yamamoto S, Miura M, Shimizu T, Ikeda S, Yaoita N, Fukumoto Y, Minami T, Miyata S, Nakamura K, Ito H, Kadomatsu K, Shimokawa H.
  • Journal Title: Circ Res. Volume: 115 Issue: 8 Pages: 738-750
  • DOI: 10.1161/circresaha.115.304563
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] OCT imaging for the management of pulmonary hypertension. (2014)
  • Author(s): Dai Z, Fukumoto Y, Tatebe S, Sugimura K, Miura Y, Nochioka K, Aoki T, Miyamichi-Yamamoto S, Yaoita N, Satoh K, Shimokawa H.
  • Journal Title: JACC-Cardiovasc Imaging. Volume: 7 Issue: 8 Pages: 843-845
  • DOI: 10.1016/j.jcmg.2014.01.020
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Visualization of Complete Regression of Pulmonary Arterial Remodeling on Optical Coherence Tomography in a Patient With Pulmonary Arterial Hypertension (2014)
  • Author(s): Dai Z, Sugimura K, Fukumoto Y, Tatebe S, Miura Y, Nochioka K, Aoki T, Miyamichi-Yamamoto S, Yaoita N, Satoh K, Shimokawa H
  • Journal Title: Circulation Journal Volume: 78 Issue: 11 Pages: 2771-2773
  • DOI: 10.1253/circj.CJ-14-0224
  • NAID: 130004700253
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] 肺高血圧症を合併した成人先天性心疾患のマネジメント (2015)
  • Author(s): 建部俊介
  • Organizer: 第51回日本小児循環器学会学術総会
  • Place of Presentation: 東京 ホテル日航東京
  • Year and Date: 2015-07-06
  • Invited
• [Presentation] Percutaneous Transluminal Balloon Angioplasty Ameliorates Metabolic and Renal Dysfunctions Associated with Hemodynamic Improvement in Patients with Chronic Thromboembolic Pulmonary Hypertension (2014)
  • Author(s): Shunsuke Tatebe, Koichiro Sugimura, Kotaro Nochioka, Masanobu Miura, Saori Yamamoto, Nobuhiro Yaoita, Haruka Sato, Kimio Satoh, Hiroaki Shimokawa
  • Organizer: 米国心臓病学会学術集会
  • Place of Presentation: アメリカ、シカゴ
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] 肺動脈バルーン形成術がCTEPH 患者の代謝腎機能へ及ぼす効果 (2014)
  • Author(s): 建部俊介、杉村宏一郎、後岡広太郎、青木竜男、三浦正暢、山本沙織、矢尾板信裕、佐藤遥、佐藤公雄、 下川宏明
  • Organizer: 日本肺循環・肺高血圧学会合同学術集会
  • Place of Presentation: 大手町サンケイプラザ（東京）
  • Year and Date: 2014-10-03 – 2014-10-05
• [Presentation] Percutaneous transluminal pulmonary angioplasty ameliorates metabolic and renal dysfunctions associated with hemodynamic improvement in patients with chronic thromboembolic pulmonary hypertension (2014)
  • Author(s): Shunsuke Tatebe, Koichiro Sugimura, Kotaro Nochioka, Masanobu Miura, Saori Yamamoto, Kimio Satoh, Hiroaki Shimokawa
  • Organizer: 欧州心臓病学会学術集会
  • Place of Presentation: スペイン、バルセロナ
  • Year and Date: 2014-08-30 – 2014-09-03
• [Presentation] 右室へのFDG取り込み亢進は肺高血圧患者の長期予後を予測する (2014)
  • Author(s): 佐藤遥、杉村宏一郎、建部俊介、矢尾板信裕、山本沙織三浦正暢、青木竜男、後岡広太郎、佐藤公雄、下川宏明
  • Organizer: 宮城心臓核医学研究会
  • Place of Presentation: 江陽グランドホテル（仙台）
  • Year and Date: 2014-07-11
• [Presentation] Percutaneous Transluminal Balloon Angioplasty Ameliorates Metabolic and Renal Dysfunctions Associated with Hemodynamic Improvement in Patients with Chronic Thromboembolic Pulmonary Hypertension (2014)
  • Author(s): Shunsuke Tatebe, Yoshihiro Fukumoto, Koichiro Sugimura, Kotaro Nochioka, Masanobu Miura, Saori Yamamoto, Kimio Satoh, Hiroaki Shimokawa
  • Organizer: 米国胸部学会学術集会
  • Place of Presentation: アメリカ、サンディエゴ
  • Year and Date: 2014-05-16 – 2014-05-21
• [Presentation] 4D Flow MRI for Pulmonary Hypertension: An Imaging Tool to Estimate Pulmonary Arterial Pressure (2014)
  • Author(s): Hideki Ota, Koichiro Sugimura, Kotaro Nochioka, Shunsuke Tatebe, Saori Yamamoto, Masanobu Miura, Kimio Satoh, Hiroaki Shimokawa
  • Organizer: 日本循環器学会
  • Place of Presentation: 東京
• [Presentation] 右室FDG取込みの亢進は肺高血圧患者の長期予後を予測する (2013)
  • Author(s): 建部俊介、福本義弘、杉村宏一郎、若山美奈子、後岡広太郎、三浦正暢、山本沙織、加賀谷豊、下川宏明
  • Organizer: 日本心臓病学会
  • Place of Presentation: 熊本