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Evaluation of pulmonary circulation and right ventricular function by radiographic and invasive hemodynamic methods in patients with pulmonary hypertension

Research Project

Project/Area Number 25461037
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionTohoku University

Principal Investigator

Tatebe Shunsuke  東北大学, 大学病院, 助教 (90456062)

Co-Investigator(Kenkyū-buntansha) FUKUMOTO Yoshihiro  久留米大学, 医学部, 教授 (70363372)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords肺高血圧症 / 慢性血栓塞栓性肺高血圧症 / 右心機能 / 肺循環 / 心臓MRI / FDG-PET / 肺動脈バルーン形成術 / 心筋代謝 / BMIPP / 4D-Flow / 糖代謝 / 脂肪酸代謝 / 心臓PET / 心臓核医学 / インプットインピーダンス / 心臓PET / 心臓MRI
Outline of Final Research Achievements

The purpose of the present study was to evaluate both pulmonary circulation and right ventricular function by radiographic and invasive hemodynamic methods in patients with pulmonary hypertension. We have reported that (1)enhanced [18F] fluorodeoxyglucose accumulation in the right ventricular free wall predicts long-term prognosis of patients with pulmonary hypertension. We have also reported that in patients with chronic thromboembolic pulmonary hypertension, balloon pulmonary angioplasty improves (2) the severity of vortex flow in the main pulmonary artery assessed by four-dimensional magnetic resonance, (3) biventricular function and (4) systemic organ dysfunctions caused by right heart failure, associated with marked pulmonary hemodynamic improvements.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (14 results)

All 2016 2015 2014 2013

All Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 6 results,  Open Access: 5 results,  Acknowledgement Compliant: 6 results) Presentation (8 results) (of which Invited: 1 results)

  • [Journal Article] Multiple Beneficial Effects of Balloon Pulmonary Angioplasty in Patients With Chronic Thromboembolic Pulmonary Hypertension2016

    • Author(s)
      Tatebe S, Sugimura K, Aoki T, Miura M, Nochioka K, Miyamichi-Yamamoto S, Yaoita N, Suzuki H, Sato H, Satoh K, Fukumoto Y, Shimokawa H.
    • Journal Title

      Circulation Journal

      Volume: 80 Issue: 4 Pages: 980-988

    • DOI

      10.1253/circj.CJ-15-1212

    • NAID

      130005139581

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Enhanced [18F]fluorodeoxyglucose accumulation in the right ventricular free wall predicts long-term prognosis of patients with pulmonary hypertension: a preliminary observational study.2014

    • Author(s)
      Tatebe S, Fukumoto Y, Oikawa-Wakayama M, Sugimura K, Satoh K, Miura Y, Aoki T, Nochioka K, Miura M, Yamamoto S, Tashiro M, Kagaya Y, Shimokawa H.
    • Journal Title

      Eur Heart J Cardiovasc Imaging.

      Volume: 15 Issue: 6 Pages: 666-672

    • DOI

      10.1093/ehjci/jet276

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Platelets are highly activated in patients of chronic thromboembolic pulmonary hypertension2014

    • Author(s)
      Yaoita N, Shirakawa R, Fukumoto Y, Sugimura K, Miyata S, Miura Y, Nochioka K, Miura M, Tatebe S, Aoki T, Miyamichi-Yamamoto S, Satoh K, Kimura T, Shimokawa H, Horiuchi H.
    • Journal Title

      Arterioscler Thromb Vasc Biol.

      Volume: 34 Issue: 11 Pages: 2486

    • DOI

      10.1161/atvbaha.114.304404

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Basigin mediates pulmonary hypertension by promoting inflammation and vascular smooth muscle cell proliferation2014

    • Author(s)
      Satoh K, Satoh T, Kikuchi N, Omura J, Kurosawa R, Suzuki K, Sugimura K, Aoki T, Nochioka K, Tatebe S, Yamamoto S, Miura M, Shimizu T, Ikeda S, Yaoita N, Fukumoto Y, Minami T, Miyata S, Nakamura K, Ito H, Kadomatsu K, Shimokawa H.
    • Journal Title

      Circ Res.

      Volume: 115 Issue: 8 Pages: 738

    • DOI

      10.1161/circresaha.115.304563

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] OCT imaging for the management of pulmonary hypertension.2014

    • Author(s)
      Dai Z, Fukumoto Y, Tatebe S, Sugimura K, Miura Y, Nochioka K, Aoki T, Miyamichi-Yamamoto S, Yaoita N, Satoh K, Shimokawa H.
    • Journal Title

      JACC-Cardiovasc Imaging.

      Volume: 7 Issue: 8 Pages: 843-845

    • DOI

      10.1016/j.jcmg.2014.01.020

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Visualization of Complete Regression of Pulmonary Arterial Remodeling on Optical Coherence Tomography in a Patient With Pulmonary Arterial Hypertension2014

    • Author(s)
      Dai Z, Sugimura K, Fukumoto Y, Tatebe S, Miura Y, Nochioka K, Aoki T, Miyamichi-Yamamoto S, Yaoita N, Satoh K, Shimokawa H
    • Journal Title

      Circulation Journal

      Volume: 78 Issue: 11 Pages: 2771-2773

    • DOI

      10.1253/circj.CJ-14-0224

    • NAID

      130004700253

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 肺高血圧症を合併した成人先天性心疾患のマネジメント2015

    • Author(s)
      建部俊介
    • Organizer
      第51回日本小児循環器学会学術総会
    • Place of Presentation
      東京 ホテル日航東京
    • Year and Date
      2015-07-06
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Percutaneous Transluminal Balloon Angioplasty Ameliorates Metabolic and Renal Dysfunctions Associated with Hemodynamic Improvement in Patients with Chronic Thromboembolic Pulmonary Hypertension2014

    • Author(s)
      Shunsuke Tatebe, Koichiro Sugimura, Kotaro Nochioka, Masanobu Miura, Saori Yamamoto, Nobuhiro Yaoita, Haruka Sato, Kimio Satoh, Hiroaki Shimokawa
    • Organizer
      米国心臓病学会学術集会
    • Place of Presentation
      アメリカ、シカゴ
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] 肺動脈バルーン形成術がCTEPH 患者の代謝腎機能へ及ぼす効果2014

    • Author(s)
      建部俊介、杉村宏一郎、後岡広太郎、青木竜男、三浦正暢、山本沙織、矢尾板信裕、佐藤遥、佐藤公雄、 下川宏明
    • Organizer
      日本肺循環・肺高血圧学会合同学術集会
    • Place of Presentation
      大手町サンケイプラザ(東京)
    • Year and Date
      2014-10-03 – 2014-10-05
    • Related Report
      2014 Research-status Report
  • [Presentation] Percutaneous transluminal pulmonary angioplasty ameliorates metabolic and renal dysfunctions associated with hemodynamic improvement in patients with chronic thromboembolic pulmonary hypertension2014

    • Author(s)
      Shunsuke Tatebe, Koichiro Sugimura, Kotaro Nochioka, Masanobu Miura, Saori Yamamoto, Kimio Satoh, Hiroaki Shimokawa
    • Organizer
      欧州心臓病学会学術集会
    • Place of Presentation
      スペイン、バルセロナ
    • Year and Date
      2014-08-30 – 2014-09-03
    • Related Report
      2014 Research-status Report
  • [Presentation] 右室へのFDG取り込み亢進は肺高血圧患者の長期予後を予測する2014

    • Author(s)
      佐藤遥、杉村宏一郎、建部俊介、矢尾板信裕、山本沙織三浦正暢、青木竜男、後岡広太郎、佐藤公雄、下川宏明
    • Organizer
      宮城心臓核医学研究会
    • Place of Presentation
      江陽グランドホテル(仙台)
    • Year and Date
      2014-07-11
    • Related Report
      2014 Research-status Report
  • [Presentation] Percutaneous Transluminal Balloon Angioplasty Ameliorates Metabolic and Renal Dysfunctions Associated with Hemodynamic Improvement in Patients with Chronic Thromboembolic Pulmonary Hypertension2014

    • Author(s)
      Shunsuke Tatebe, Yoshihiro Fukumoto, Koichiro Sugimura, Kotaro Nochioka, Masanobu Miura, Saori Yamamoto, Kimio Satoh, Hiroaki Shimokawa
    • Organizer
      米国胸部学会学術集会
    • Place of Presentation
      アメリカ、サンディエゴ
    • Year and Date
      2014-05-16 – 2014-05-21
    • Related Report
      2014 Research-status Report
  • [Presentation] 4D Flow MRI for Pulmonary Hypertension: An Imaging Tool to Estimate Pulmonary Arterial Pressure2014

    • Author(s)
      Hideki Ota, Koichiro Sugimura, Kotaro Nochioka, Shunsuke Tatebe, Saori Yamamoto, Masanobu Miura, Kimio Satoh, Hiroaki Shimokawa
    • Organizer
      日本循環器学会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 右室FDG取込みの亢進は肺高血圧患者の長期予後を予測する2013

    • Author(s)
      建部俊介、福本義弘、杉村宏一郎、若山美奈子、後岡広太郎、三浦正暢、山本沙織、加賀谷豊、下川宏明
    • Organizer
      日本心臓病学会
    • Place of Presentation
      熊本
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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