Development of three dimensional speckle tracking echocardiography system specialized for the right ventricle

• Project/Area Number: 25461041
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: University of Tsukuba
• Principal Investigator: Seo Yoshihiro 筑波大学, 医学医療系, 准教授 (40375499)
• Co-Investigator(Kenkyū-buntansha): Ishizu Tomoko 筑波大学, 医学医療系, 講師 (10507859)
• Co-Investigator(Renkei-kenkyūsha): Aonuma Kazutaka 筑波大学, 医学医療系, 教授 (10375488)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 超音波 / スペックルトラッキング法 / 右心室 / 心機能 / 右室 / 心エコー図 / 三次元画像 / 右室機能 / ３次元心エコー図

Outline of Final Research Achievements

Based on the complex morphological nature of the right ventricle (RV), three-dimensional (3D) approaches would be more appropriate for assessing RV function than two-dimensional approaches. Then, we have developed a novel 3D speckle-tracking echocardiography (3D-STE) system specialized for the RV. In the experimental study using sheep model, the reliability of 3D-STE was validated using sonomicrometry crystals implantation. In the comparisons between 3D-STE data sets and sonomicrometry data, strong correlations were revealed (R2 = 0.82 to 0.88; p < 0.001). To assess clinical feasibility, 30 controls and 11 patients with pulmonary arterial hypertension (PAH) were studied. The PAH group had lower RV global deformation values than the control group (p < 0.001). Thus, the novel 3D-STE system specialized for the RV is reliable for RV deformation analyses and may provide additional information about RV global and segmental function. The clinical feasibility of this system is acceptable.

Research Products

• [Journal Article] Right Ventricular Deformation Analyses Using a Three-Dimensional Speckle-Tracking Echocardiographic System Specialized for the Right Ventricle. (2016)
  • Author(s): Atsumi A, Seo Y, Ishizu T, Nakamura A, Enomoto Y, Harimura Y, Okazaki T, Abe Y, Aonuma K.
  • Journal Title: Journal of the American Society of Echocardiography Volume: in press Issue: 5 Pages: 402-411.e2
  • DOI: 10.1016/j.echo.2015.12.014
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Clinical feasibility of a novel three-dimensional speckle tracking imaging system specialized for the right ventricle. (2015)
  • Author(s): Yoshihiro Seo, Akiko Atsumi, Tomoko Ishizu, Masayoshi Yamamoto, Kazutaka Aonuma.
  • Organizer: 26th Annual Scientific Sessions of the American Society of Echocardiography 2015
  • Place of Presentation: Boston (USA)
  • Year and Date: 2015-06-13
  • Int'l Joint Research
• [Presentation] Experimental Validation Study for the Purpose-built 3-Dimensional Speckle Tracking Echocardiography System for Right Ventricle (2015)
  • Author(s): Yoshihiro Seo
  • Organizer: 日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-25
• [Presentation] Validations for the Reliability of a Dedicated 3- Dimensional Speckle Tracking Imaging System for Right Ventricular Function Analysis (2014)
  • Author(s): Yoshihiro Seo
  • Organizer: American Heart Association Annual meeting 2014
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-11-17