Prediction of drug-induced cardiomyopathy with transthoracic echocardiography and cardiac biomarkers

• Project/Area Number: 25461044
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: The University of Tokyo
• Principal Investigator: Watanabe Atai 東京大学, 医科学研究所, 助教 (00597271)
• Co-Investigator(Kenkyū-buntansha): YAMASHITA Naohide 東京大学, 医科学研究所, 教授 (90174680)
• Co-Investigator(Renkei-kenkyūsha): TOJO Arinobu 東京大学, 医科学研究所, 教授 (00211681) ; ISOO Naoyuki 東京大学, 医科学研究所, 助教 (80420214) ; OHNO Hideki 東京女子医科大学, 東医療センター, 講師 (30396866)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2013: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: 薬剤性心筋症 / 心エコー図検査 / 左室拡張機能 / バイオマーカー / 心臓超音波検査

Outline of Final Research Achievements

The purpose of this study is to predict drug-induced cardiomyopathy using transthoracic echocardiography and cardiac biomarkers (BNP, high-sensitive troponin T, high-sensitive CRP, pentraxin 3 and ST2) in patients with hematologic malignancies. Of the 76 patients, 5 (6.6 %) developed drug-induced cardiomyopathy after treatments. In these patients, diastolic wall strain, a parameter of left ventricular diastolic function, was significantly decreased before treatments as compared with patients without cardiomyopathy (P = 0.04). Values of biomarkers were not associated with development of cardiomyopathy. This result suggests that a patient who has left ventricular diastolic dysfunction before treatments with anticancer agents may often develop drug-induced cardiomyopathy. Diastolic wall strain may be a useful predictor of drug-induced cardiomyopathy.

Research Products

• [Journal Article] Left Atrial Remodeling Assessed by Transthoracic Echocardiography Predicts Left Atrial Appendage Flow Velocity in Patients With Paroxysmal Atrial Fibrillation (2016)
  • Author(s): Watanabe A, Suzuki S, Kano H, Matsuno S, Takai H, Kato Y, Otsuka T, Uejima T, Oikawa Y, Nagashima K, Kirigaya H, Kunihara T, Sagara K, Yamashita N, Sawada H, Aizawa T, Yajima J, Yamashita T.
  • Journal Title: International Heart Journal Volume: 57 Issue: 2 Pages: 177-182
  • DOI: 10.1536/ihj.15-345
  • NAID: 130005139775
  • ISSN: 1349-2365, 1349-3299
  • Peer Reviewed / Open Access
• [Journal Article] Blood Stasis Secondary to Heart Failure Forms Warfarin-Resistant Left Atrial Thrombus. (2014)
  • Author(s): Watanabe A, Yamashita N, Yamashita T
  • Journal Title: International Heart Journal Volume: 55 Pages: 506-511
  • NAID: 130004694363
  • Peer Reviewed / Open Access
• [Journal Article] Safety test of a supplement, 5^aminolevuline acid phosphate with sodium ferrous citrate, in diabetic patients treated with oral hypoglycemic agents (2014)
  • Author(s): Naohide Yamashita, Atai Watanabe, Hikaru Kondo, Satofumi Kawata, Tohru Tanaka, Motowo Nakajima
  • Journal Title: Functional Foods in Health and Disease Volume: 4 Pages: 415-428
  • Peer Reviewed / Open Access
• [Presentation] A Case of Dasatinib-induced Pulmonary Arterial Hypertension in Chronic Myelogenous Leukemia (2015)
  • Author(s): Atai WATANABE, Kazuaki YOKOYAMA, Nobuhiro OHNO, Kaoru UCHIMARU, Naohide YAMASHITA, Arinobu TOJO
  • Organizer: 第88回日本超音波医学会学術集会
  • Place of Presentation: グランドプリンスホテル新高輪(東京都港区）
  • Year and Date: 2015-05-22
• [Presentation] A Case of Cardiac Myxoma with Significant Eosinophilia (2013)
  • Author(s): Atai WATANABE, Kota SATO, Koichiro YUJI, Kaoru UCHIMARU, Shinnosuke HIGASHINO, Hitoshi SAWADA, Hiroaki TANABE, Naohide YAMASHITA, Arinobu TOJO
  • Organizer: 日本超音波医学会第86回学術集会
  • Place of Presentation: グランキューブ大阪（大阪府大阪市）