| Project/Area Number |
25461044
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Watanabe Atai 東京大学, 医科学研究所, 助教 (00597271)
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| Co-Investigator(Kenkyū-buntansha) |
YAMASHITA Naohide 東京大学, 医科学研究所, 教授 (90174680)
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| Co-Investigator(Renkei-kenkyūsha) |
TOJO Arinobu 東京大学, 医科学研究所, 教授 (00211681)
ISOO Naoyuki 東京大学, 医科学研究所, 助教 (80420214)
OHNO Hideki 東京女子医科大学, 東医療センター, 講師 (30396866)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 薬剤性心筋症 / 心エコー図検査 / 左室拡張機能 / バイオマーカー / 心臓超音波検査 |
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| Outline of Final Research Achievements |
The purpose of this study is to predict drug-induced cardiomyopathy using transthoracic echocardiography and cardiac biomarkers (BNP, high-sensitive troponin T, high-sensitive CRP, pentraxin 3 and ST2) in patients with hematologic malignancies. Of the 76 patients, 5 (6.6 %) developed drug-induced cardiomyopathy after treatments. In these patients, diastolic wall strain, a parameter of left ventricular diastolic function, was significantly decreased before treatments as compared with patients without cardiomyopathy (P = 0.04). Values of biomarkers were not associated with development of cardiomyopathy. This result suggests that a patient who has left ventricular diastolic dysfunction before treatments with anticancer agents may often develop drug-induced cardiomyopathy. Diastolic wall strain may be a useful predictor of drug-induced cardiomyopathy.
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