Comprehensive analysis of the mechanism linking between atrial remodeling and stretch or inflammation in atrium.

• Project/Area Number: 25461045
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Sasano Tetsuo 東京医科歯科大学, 保健衛生学研究科, 准教授 (00466898)
• Co-Investigator(Renkei-kenkyūsha): FURUKAWA TETSUSHI 東京医科歯科大学, 難治疾患研究所, 教授 (80251552)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 心房細動 / 細胞外ATP / マイクロRNA / 高脂肪食 / 糖尿病 / 圧負荷 / メタボリック症候群 / ギャップジャンクション / 心房リモデリング / ATP / 線維化 / 炎症 / 心房圧負荷 / pannexin / 炎症性サイトカイン

Outline of Final Research Achievements

It has been well known that lifestyle-related diseases like hypertension, metabolic syndrome, and diabetes are the risk of atrial fibrillation. We aimed to clarify the mechanism linking these pathological conditions and atrial arrhythmias using mice model, focusing on the involvement of microRNA (miR). We performed electrophysiological analysis and comprehensive expression analysis of miR, to identify the miRs playing a key role for atrial arrhythmias.
We then performed thorough examination in metabolic syndrome model, and found that the expression of miR-27b was increased in atrium. The expression of Cx40, a major gap-junction channel in atrium was regulated by miR-27b. The increased expression of miR-27b caused the conduction disturbance, resulting in the higher inducibility of atrial tachyarrhythmias.

Research Products

• [Journal Article] High-fat diet increases vulnerability to atrial arrhythmia by conduction disturbance via miR-27b (2016)
  • Author(s): Takahashi K, Sasano T, Sugiyama K, Kurokawa J, Tamura N, Soejima Y, Sawabe M, Isobe M, Furukawa T.
  • Journal Title: J Mol Cell Cardiol. Volume: 90 Pages: 38-46
  • DOI: 10.1016/j.yjmcc.2015.11.034
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Intravital imaging of Ca(2+) signals in lymphocytes of Ca(2+) biosensor transgenic mice: indication of autoimmune diseases before the pathological onset. (2016)
  • Author(s): Yoshikawa S, Usami T, Kikuta J, Ishii M, Sasano T, Sugiyama K, Furukawa T, Nakasho E, Takayanagi H, Tedder TF, Karasuyama H, Miyawaki A, Adachi T.
  • Journal Title: Sci Rep. 2016 Jan 6;6:18738. Volume: 6 Issue: 1 Pages: 18738-18738
  • DOI: 10.1038/srep18738
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Oxidative Stress Induced Ventricular Arrhythmia and Impairment of Cardiac Function in <i>Nos1ap</i> Deleted Mice (2016)
  • Author(s): Sugiyama K, Sasano T, Kurokawa J, Takahashi K, Okamura T, Kato N, Isobe M and Furukawa T
  • Journal Title: International Heart Journal Volume: 57 Issue: 3 Pages: 341-349
  • DOI: 10.1536/ihj.15-471
  • NAID: 130005153706
  • ISSN: 1349-2365, 1349-3299
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Genetic defects in a His-Purkinje system transcription factor, IRX3, cause lethal cardiac arrhythmias. (2016)
  • Author(s): Koizumi A, Sasano T, Kimura W, Miyamoto Y, Aiba T, Ishikawa T, Nogami A, Fukamizu S, Sakurada H, Takahashi Y, Nakamura H, Ishikura T, Koseki H, Arimura T, Kimura A, Hirao K, Isobe M, Shimizu W, Miura N, Furukawa T.
  • Journal Title: European Heart Journal. Volume: 37 (18) Issue: 18 Pages: 1469-1475
  • DOI: 10.1093/eurheartj/ehv449
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Heterozygous deletion of sarcolipin maintains normal cardiac function. (2015)
  • Author(s): Shimura D, Kusakari Y, Sasano T, Nakashima Y, Nakai G, Jiao Q, Jin M, Yokota T, Ishikawa Y, Nakano A, Goda N, Minamisawa S.
  • Journal Title: Am J Physiol Heart Circ Physiol. Volume: 310(1) Issue: 1 Pages: 92-103
  • DOI: 10.1152/ajpheart.00411.2015
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 心房頻拍モデルマウスおよび心房細動患者における、心房炎症とマイクロRNA発現の網羅的解析 (2015)
  • Author(s): 笹野 哲郎、古川 哲史
  • Journal Title: 循環器専門医 Volume: 23 Pages: 202-9
  • NAID: 130006575707
• [Journal Article] High Atrial Defibrillation Threshold With Internal Cardioversion Indicates Arrhythmogenicity of Superior Vena Cava in Non-Long-Standing Persistent Atrial Fibrillation (2015)
  • Author(s): Ihara K, Sasaki T, Shirai Y, Tao S, Maeda S, Kawabata M, Sasano T, Yokoyama Y, Isobe M and Hirao K.
  • Journal Title: Circulation Journal Volume: 79 Issue: 7 Pages: 1479-1485
  • DOI: 10.1253/circj.CJ-14-1300
  • NAID: 130005083939
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] Severe iatrogenic bradycardia related to the combined use of beta-blocking agents and sodium channel blockers. (2015)
  • Author(s): Kawabata M, Yokoyama Y, Sasaki T, Tao S, Ihara K, Shirai Y, Sasano T, Goya M, Furukawa T, Isobe M and Hirao K.
  • Journal Title: Clinical pharmacology Volume: 7 Pages: 29-36
  • DOI: 10.2147/cpaa.s77021
  • Peer Reviewed / Open Access
• [Journal Article] Aborted sudden cardiac death due to intractable ventricular fibrillation caused by coronary spasm refractory to implantable cardioverter defibrillator therapy. (2014)
  • Author(s): Goto K, Kurabayashi M, Nakamura T, Asano M, Suzuki H, Shimura T, Sasano T, Hirao K, Isobe M, Okishige K
  • Journal Title: Int J Cardiol Volume: 176 Issue: 3 Pages: e133-e134
  • DOI: 10.1016/j.ijcard.2014.07.209
  • Peer Reviewed
• [Journal Article] Multiparametric Molecular Imaging Provides Mechanistic Insights into Sympathetic Innervation Impairment in the Viable Infarct Border Zone. (2014)
  • Author(s): Lautamaki R, Sasano T, Higuchi T, Nekolla SG, Lardo AC, Holt DP, Dannals RF, Abraham MR and Bengel FM.
  • Journal Title: J Nucl Med. Volume: 56 Issue: 3 Pages: 457-463
  • DOI: 10.2967/jnumed.114.149971
  • Peer Reviewed
• [Journal Article] His-Purkinje特異的な転写因子の機能異常とJ波症候群の関連 －J波症候群の新たな原因・修飾遺伝子の可能性－ (2014)
  • Author(s): 笹野 哲郎、小泉 章子、古川 哲史
  • Journal Title: 循環器専門医 Volume: 22 Pages: 223-230
• [Journal Article] Bleeding events and activated partial thromboplastin time with dabigatran in clinical practice. (2013)
  • Author(s): Kawabata M, Yokoyama Y, Sasano T, Hachiya H, Tanaka Y, Yagishita A, Sugiyama K, Nakamura T, Suzuki M, Isobe M, Hirao K
  • Journal Title: J. Cardiol. Volume: 62 Issue: 2 Pages: 121-126
  • DOI: 10.1016/j.jjcc.2013.03.010
  • Peer Reviewed
• [Journal Article] Amiodarone-Induced Thyrotoxicosis Late After Amiodarone Withdrawal (2013)
  • Author(s): Yagishita A, Hachiya H, Kawabata M, Nakamura T, Sugiyama K, Tanaka Y, Sasano T, Isobe M, Hirao K
  • Journal Title: Circulation Journal Volume: 77 Issue: 12 Pages: 2898-2903
  • DOI: 10.1253/circj.CJ-13-0220
  • NAID: 10031203573
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] Gene therapy for cardiac arrhythmias. (2013)
  • Author(s): Sasano T, Takahashi K, Sugiyama K
  • Journal Title: Acta Cardiologica Sinica Volume: 29 Pages: 226-234
  • Peer Reviewed
• [Journal Article] NOS1AP, an emergent new genetic marker for QT prolongation and sudden cardiac death. (2013)
  • Author(s): Chang KC, Sasano T, Huang S
  • Journal Title: Acta Cardiologica Sinica Volume: 29 Pages: 217-225
  • Peer Reviewed
• [Journal Article] 心房細動の薬物療法 (2013)
  • Author(s): 笹野 哲郎
  • Journal Title: ファルマシア Volume: 8 Pages: 758-763
  • NAID: 110009995779
• [Presentation] Selective assessment of left atrial activation and conduction disturbance using a high-sensitive vector magnetocardiography. (2016)
  • Author(s): Natsume Y, Hasegawa Y, Nishimura T, Sasaki T, Shirai Y, Kawabata M, Kawabata S, Adachi Y, Sumi Y, Goya M, Hirao K, Sasano T
  • Organizer: Heart Rhythm Society meeting
  • Place of Presentation: Moscone Center, San Francisco, USA
  • Year and Date: 2016-05-05
  • Int'l Joint Research
• [Presentation] Multichannel measurement of P wave fragmentations by high-sensitive vector magnetocardiography can evaluate the conduction disturbance in left atrium. (2016)
  • Author(s): Hasegawa Y, Natsume Y, Shirai Y, Nishimura T, Sasaki T, Kawabata M, Kawabata S, Sumi Y, Goya M, Hirao K, Sasano T
  • Organizer: Heart Rhythm Society meeting
  • Place of Presentation: Moscone Center, San Francisco, USA
  • Year and Date: 2016-05-05
  • Int'l Joint Research
• [Presentation] Genetic deletion of Nos1ap induced ventricular arrhythmia and impairment of cardiac function under oxidative stress condition. (2016)
  • Author(s): Sasano T, Sugiyama K, Kurokawa J, Takahashi K, Okamura T, Kato N, Isobe M, Furukawa T
  • Organizer: 5th International Conference of Cardiovascular Medicine
  • Place of Presentation: China Medical University, Taichung, Taiwan
  • Year and Date: 2016-03-05
  • Int'l Joint Research / Invited
• [Presentation] IRX3, a His-Purkinje system specific transcription factor is related with ventricular tachyarrhythmia. (2015)
  • Author(s): Sasano T, Koizumi A, Kimura W, Nogami A, Fukamizu S, Sakurada H, Hirao K, Isobe M, Kimura A, Aiba T, Miyamoto Y, Shimizu W, Miura N, Furukawa T
  • Organizer: Asia-pacific Heart Rhythm Society meeting
  • Place of Presentation: Melbourne Convention and Exhibition Centre, Melbourne, Australia
  • Year and Date: 2015-11-22
  • Int'l Joint Research / Invited
• [Presentation] Comprehensive analysis identifies common microRNA expression involved in murine models of atrial remodeling and clinical specimen (2015)
  • Author(s): Sasano T, Takahashi K, Ihara K, Sugiyama K, Nishimura T, Shirai Y, Tao S, Sasaki T, Kawabata M, Goya M, Hirao K, Isobe M, Furukawa T
  • Organizer: Asia-pacific Heart Rhythm Society meeting
  • Place of Presentation: Melbourne Convention and Exhibition Centre, Melbourne, Australia
  • Year and Date: 2015-11-22
  • Int'l Joint Research
• [Presentation] Oxidative stress induced ventricular arrhythmias and impaired cardiac function in Nos1ap deleted mice. (2015)
  • Author(s): Sugiyama K, Sasano T, Tamura N, Okamura T, Kato N, Isobe M, Frukawa T
  • Organizer: Asia-pacific Heart Rhythm Society meeting
  • Place of Presentation: Melbourne Convention and Exhibition Centre, Melbourne, Australia
  • Year and Date: 2015-11-21
  • Int'l Joint Research
• [Presentation] Number of P wave fragmentations measured by vector magnetocardiography may evaluate conduction disturbance in left atrium. (2015)
  • Author(s): Hasegawa Y, Natsume Y, Nishimura T, Shirai Y, Tao S, Sasaki T, Kawabata M, Sumi Y, Goya M, Isobe M, Hirao K, Sasano T
  • Organizer: Asia-pacific Heart Rhythm Society meeting
  • Place of Presentation: Melbourne Convention and Exhibition Centre, Melbourne, Australia
  • Year and Date: 2015-11-20
  • Int'l Joint Research
• [Presentation] Novel Dielectric Blood Coagulometry Can Evaluate Factor Xa Activity and Reduced Coagulability by Dalteparin. (2015)
  • Author(s): Hamada S, Hasegawa Y, Nishimura T, Sumi Y, Koyama T, Furukawa T, Hirao K, Sasano T
  • Organizer: Asia-pacific Heart Rhythm Society meeting
  • Place of Presentation: Melbourne Convention and Exhibition Centre, Melbourne, Australia
  • Year and Date: 2015-11-20
  • Int'l Joint Research
• [Presentation] Detection of pulmonary venous activity utilizing high-sensitive vector magnetocardiography. (2015)
  • Author(s): Sasano T, Oya M, Hasegawa Y, Terui M, Adachi Y, Hirao K
  • Organizer: Asian Symposium of magnetocardiography
  • Place of Presentation: Korea Research Institute of Standards and Science, Daejeon, Korea
  • Year and Date: 2015-11-02
  • Int'l Joint Research / Invited
• [Presentation] J波と心臓MRIにおける遅延造影との関連性の検討および川崎病におけるJ波の頻度 (2015)
  • Author(s): 澤田 由梨子、宇佐 知里郁、小山 望、角 勇樹、寺島 正浩、平尾 見三、磯部 光章、笹野 哲郎
  • Organizer: 日本不整脈学会・心電学会合同学術集会
  • Place of Presentation: 国立京都国際会館、京都府京都市
  • Year and Date: 2015-07-31
• [Presentation] Nocturnal Variations in Atrial and Ventricular Electrophysiological Properties in Obstructive Sleep Apnea. (2015)
  • Author(s): Sasano T, Ishihara Y, Oya M, Fujie T, Tamaoka M, Sumi Y, Matsuura M, Miyazaki Y, Hirao K
  • Organizer: 日本不整脈学会・心電学会合同学術集会
  • Place of Presentation: 国立京都国際会館、京都府京都市
  • Year and Date: 2015-07-31
• [Presentation] 指尖容積脈波を用いた末梢血管自律神経機能評価 (2015)
  • Author(s): 濱田 里美、石原 有理、井上 芳徳、磯部 光章、平尾 見三、笹野 哲郎
  • Organizer: 日本不整脈学会・心電学会合同学術集会
  • Place of Presentation: 国立京都国際会館、京都府京都市
  • Year and Date: 2015-07-30
• [Presentation] Filtered P Wave Duration by Vector Magnetocardiography may Evaluate Conduction Disturbance in Left Atrium. (2015)
  • Author(s): Hasegawa Y, Hamada S, Nishimura T, Shirai Y, Tao S, Sasaki T, Kawabata M, Goya M, Sumi Y, Isobe M, Hirao K, Sasano T
  • Organizer: 日本不整脈学会・心電学会合同学術集会
  • Place of Presentation: 国立京都国際会館、京都府京都市
  • Year and Date: 2015-07-29
• [Presentation] 高感度ベクトル心磁図による肺静脈周囲心筋興奮の検出 (2015)
  • Author(s): 笹野 哲郎、大矢 麻美子、長谷川 由貴、照井 まりな、川端 茂徳、足立 善昭、平尾 見三
  • Organizer: 第31回日本生体磁気学会
  • Place of Presentation: 旭川市大雪クリスタルホール、北海道旭川市
  • Year and Date: 2015-06-06
  • Invited
• [Presentation] Novel dielectric coagulometer identifies the increased coagulability in patients with high CHADS2 score. (2015)
  • Author(s): Hasegawa Y, Hamada S, Nishimura T, Shirai Y, Tao S, Sasaki T, Kawabata M, Goya M, Isobe M, Koyama T, Sumi Y, Hirao K, Sasano T
  • Organizer: Heart Rhythm Society meeting
  • Place of Presentation: Boston Convention & Exhibition Center, Boston, USA
  • Year and Date: 2015-05-15
  • Int'l Joint Research
• [Presentation] Comprehensive Analysis Linking MicroRNA and Atrial Inflammation in Mouse and Human. (2015)
  • Author(s): Sasano T, Takahashi K, Zhang P, Ihara K, Sugiyama K, Tamura N, Nishimura T, Shirai Y, Tao S, Sasaki T, Kawabata M, Goya M, Hirao K, Isobe M, Furukawa T
  • Organizer: 第79回日本循環器学会
  • Place of Presentation: 大阪国際会議場、大阪府大阪市
  • Year and Date: 2015-04-24
• [Presentation] High-Fat Diet Increases Vulnerability to Atrial Arrhythmia by Conduction Disturbance via MicroRNA. (2015)
  • Author(s): Takahashi K, Sasano T, Sugiyama K, Isobe M, Furukawa T
  • Organizer: 第79回日本循環器学会
  • Place of Presentation: 大阪国際会議場、大阪府大阪市
  • Year and Date: 2015-04-24
• [Presentation] Nocturnal Variation of P-wave Signal Averaged Electrocardiogram Parameters in Obstructive Sleep Apnea Patients. (2015)
  • Author(s): Ishihara Y, Kono A, Oya M, Fujie T, Tamaoka M, Matsuura M, Sumi Y, Miyazaki Y, Isobe M, Hirao K, Sasano T.
  • Organizer: 第79回日本循環器学会
  • Place of Presentation: 大阪国際会議場、大阪府大阪市
  • Year and Date: 2015-04-24
• [Presentation] 閉塞性睡眠時無呼吸症候群患者における無呼吸・低呼吸イベントとT-wave alternansの関連 (2014)
  • Author(s): 石原有理、大矢麻美子、日比祥子、藤江俊秀、玉岡明洋、松浦雅人、宮崎泰成、平尾見三、笹野哲郎.
  • Organizer: 日本不整脈学会・心電学会合同学術集会
  • Place of Presentation: 東京プリンスホテル、東京
  • Year and Date: 2014-07-25
• [Presentation] 高感度ベクトル心磁計を用いた左心房興奮の中心周波数解析 (2014)
  • Author(s): 大矢麻美子、志賀圭祐、白井康大、井原健介、田尾進、佐々木毅、川端美穂子、横山泰廣、足立善昭、関原謙介、平尾見三、笹野哲郎
  • Organizer: 日本不整脈学会・心電学会合同学術集会
  • Place of Presentation: 東京プリンスホテル、東京
  • Year and Date: 2014-07-25
• [Presentation] Involvement of Pannexin-1 for Cardioprotection and Ventricular Arrhythmia in Ischemia/Reperfusion Injury and Ischemic Preconditioning and Postconditioning. (2014)
  • Author(s): Sasano T, Orui Y, Takahashi K, Zhang P, Sugiyama K, Furukawa T
  • Organizer: 日本不整脈学会・心電学会合同学術集会
  • Place of Presentation: 東京プリンスホテル、東京
  • Year and Date: 2014-07-25
• [Presentation] High-Fat Diet Increases Vulnerability of Atrial Arrhythmia by Conduction Disturbance via MicroRNA. (2014)
  • Author(s): Takahashi K, Sasano T, Sugiyama K, Furukawa T.
  • Organizer: 日本不整脈学会・心電学会合同学術集会
  • Place of Presentation: 東京プリンスホテル、東京
  • Year and Date: 2014-07-24
• [Presentation] Dominant frequency analysis of the left atrium utilizing high-sensitive vector magnetocardiography. (2014)
  • Author(s): Oya M, Ishihara Y, Shirai Y, Ihara K, Tao S, Sasaki T, Kawabata M, Yokoyama Y, Hirao K, Sasano T.
  • Organizer: Heart Rhythm Society meeting
  • Place of Presentation: Moscone Convention Center, San Fransisco, USA
  • Year and Date: 2014-05-08
• [Presentation] Nocturnal Variation of P-wave Signal Averaged Electrocardiogram Parameters in Obstructive Sleep Apnea Patients. (2014)
  • Author(s): Ishihara Y, Kono A, Oya M, Fujie T, Tamaoka M, Matsuura M, Sumi Y, Miyazaki Y, Isobe M, Hirao K, Sasano T.
  • Organizer: 第79回日本循環器学会
  • Place of Presentation: 大阪国際会議場、大阪
  • Year and Date: 2014-04-26
• [Presentation] Oxidative Stress Induced Ventricular Arrhythmias and Impaired Cardiac Function in Nos1ap Deleted Mice (2014)
  • Author(s): Sugiyama K, Sasano T, Tamura N, Okamura T, Kato N, Isobe M, Frukawa T
  • Organizer: 第79回日本循環器学会
  • Place of Presentation: 大阪国際会議場、大阪
  • Year and Date: 2014-04-25
• [Presentation] Comprehensive Analysis Linking MicroRNA and Atrial Inflammation in Mouse and Human. (2014)
  • Author(s): Sasano T, Takahashi K, Zhang P, Ihara K, Sugiyama K, Tamura N, Nishimura T, Shirai Y, Tao S, Sasaki T, Kawabata M, Goya M, Hirao K, Isobe M, Furukawa T
  • Organizer: 第79回日本循環器学会
  • Place of Presentation: 大阪国際会議場、大阪
  • Year and Date: 2014-04-24
• [Presentation] High-Fat Diet Increases Vulnerability to Atrial Arrhythmia by Conduction Disturbance via MicroRNA. (2014)
  • Author(s): Takahashi K, Sasano T, Sugiyama K, Isobe M, Furukawa T
  • Organizer: 第79回日本循環器学会
  • Place of Presentation: 大阪国際会議場、大阪
  • Year and Date: 2014-04-24
• [Presentation] Electrocardiographic Features Predicting Positive Late Gadolinium Enhancement in Cardiac Magnetic Resonance Imaging.
  • Author(s): Sasano T, Usa S, Ishihara Y, Oya M, Terashima M, Hirao K, Matsuura M.
  • Organizer: Heart Rhythm Society meeting
  • Place of Presentation: Denver, USA
• [Presentation] Increased Short-Term Variability in the Peak-to-end of the T wave in Heart Disease.
  • Author(s): Ishihara Y, Sasano T, Sekine H, Oya M, Hibi S, Hirao K, Matsuura M
  • Organizer: Venice arrhythmia
  • Place of Presentation: Venice, Italy
• [Presentation] Prevalence of Pulmonary Vein Activity in Patients with Atrial Fibrillation and Healthy Subjects Utilizing High-Sensitive Vector Magnetocardiography
  • Author(s): Oya M, Sasano T, Aoyama K, Terui M, Okamoto R, Ishihara Y, Hibi S, Hirao K, Matsuura M.
  • Organizer: Venice arrhythmia
  • Place of Presentation: Venice, Italy
• [Presentation] Dominant frequency analysis of the left atrium utilizing high-sensitive vector magnetocardiography.
  • Author(s): Oya M, Ishihara Y, Shirai Y, Ihara K, Tao S, Sasaki T, Kawabata M, Yokoyama Y, Hirao K, Sasano T.
  • Organizer: Heart Rhythm Society meeting
  • Place of Presentation: San Fransisco, USA
• [Presentation] High-fat diet increases vulnerability of atrial arrhythmia by conduction disturbance via microRNA.
  • Author(s): Takahashi K, Sasano T, Sugiyama K, Orui Y, Isobe M, Furukawa T
  • Organizer: 日本循環器学会学術集会
  • Place of Presentation: 東京国際フォーラム、東京
• [Presentation] Genetic Defects in a His-Purkinje System-Specific Transcription Factor as a Cause of J Wave Syndrome.
  • Author(s): Sasano T, Koizumi A, Kimura W, Nogani A, Fukamizu S, Sakurada H, Hirao K, Isobe M, Kimura A, Miyamoto Y, Shimizu W, Miura N, Furukawa T
  • Organizer: 日本循環器学会学術集会
  • Place of Presentation: 東京国際フォーラム、東京