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Analysis of mechanism of anemia and iron deficiency in heart failure via hepcidin

Research Project

Project/Area Number 25461047
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionNiigata University

Principal Investigator

Hanawa Haruo  新潟大学, 医歯学系, 准教授 (40282983)

Co-Investigator(Kenkyū-buntansha) 柏村 健  新潟大学, 医歯学総合病院, 助教 (70419290)
小澤 拓也  新潟大学, 医歯学系, 助教 (70467075)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords心不全 / 貧血 / 鉄欠乏 / ヘプシジン / 肝うっ血 / BMP-6 / IL-6 / Toll様受容体
Outline of Final Research Achievements

Anemia and iron deficiency are prevalent in patients with heart failure. The etiology of anemia and iron deficiency in heart failure patients is unclear. Hepcidin is known to be a main regulator of iron metabolism. The most frequent histopathologic finding in the liver of heart failure patients is congestion. Therefore, we speculated that liver congestion may induce the expression of hepcidin and result in exacerbated anemia. We prepared animal models with liver congestion and analyze mechanism of anemia and iron deficiency in heart failure via hepcidin. Our data indicated that liver congestion contributes to relative iron deficiency and anemia, and it does so via inappropriate expression of hepcidin. Moreover, our data in some patients with heart failure showed that the mechanism appeared.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (8 results)

All 2016 2015 2014 2013 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (4 results) Remarks (1 results)

  • [Journal Article] Liver Congestion in Heart Failure Contributes to Inappropriately Increased Serum Hepcidin despite Anemia2015

    • Author(s)
      Ohno Y, Hanawa H, Jiao S, Hayashi Y, Yoshida K, Suzuki T, Kashimura T, Obata H, Tanaka K, Watanabe T, Minamino T.
    • Journal Title

      The Tohoku Journal of Experimental Medicine

      Volume: 235 Issue: 1 Pages: 69-79

    • DOI

      10.1620/tjem.235.69

    • NAID

      130004822430

    • ISSN
      0040-8727, 1349-3329
    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Elevated Endomyocardial Biopsy Macrophage-Related Markers in Intractable Myocardial Diseases.2015

    • Author(s)
      Hayashi Y, Hanawa H, Jiao S, Hasegawa G, Ohno Y, Yoshida K, Suzuki T, Kashimura T, Obata H, Tanaka K, Watanabe T, Minamino T.
    • Journal Title

      Inflammation

      Volume: 38 Issue: 6 Pages: 2288-99

    • DOI

      10.1007/s10753-015-0214-1

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inappropriate expression of hepcidin by liver congestion contributes to anemia and relative iron deficiency.2014

    • Author(s)
      Suzuki T, Hanawa H, Jiao S, Ohno Y, Hayashi Y, Yoshida K, Kashimura T, Obata H, Minamino T.
    • Journal Title

      J Card Fail

      Volume: 20 Issue: 4 Pages: 268-277

    • DOI

      10.1016/j.cardfail.2014.01.008

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Potential role of cardiac iron metabolism in the failing heart2016

    • Author(s)
      Shuang Jiao, Ippei Shimizu, Yohko Yoshida, Masayoshi Suda, Yuka Hayashi, Goro Katsuumi, Hiromi Kayamori, Yukako Ohno, Haruo Hanawa, Tohru Minamino
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      仙台国際センター (宮城県仙台市)
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Influence of liver congestion and hypoxemia in heart failure on hematological and iron status via hepcidin2014

    • Author(s)
      Yukako Ohno, Haruo Hanawa , Shuang Jiao, Yuka Hayashi, Tomoyasu Suzuki, Tohru Watanabe, Hiroaki Obata, Takeshi Kashimura, Tohru Minamino
    • Organizer
      第18回日本心不全学会学術集会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2014-10-10 – 2014-10-12
    • Related Report
      2014 Research-status Report
  • [Presentation] Inappropriate Hepcidin Expression and Anemia in Heart Failure with Liver Congestion2014

    • Author(s)
      Yukako Ohno, Haruo Hanawa, Shuang Jiao, Yuka Hayashi, Tomoyasu Suzuki, Tohru Watanabe , Hiroaki Obata , Takeshi Kashimura , Tohru Minamino
    • Organizer
      第78会日本循環器学会学術集会
    • Place of Presentation
      東京国際フォーラム( 東京)
    • Related Report
      2013 Research-status Report
  • [Presentation] Mechanism of iron deficiency via inappropriate hepcidin expression in pulmonary artery hypertension with liver congestion2013

    • Author(s)
      Yukako Ohno, Haruo Hanawa, Shuang Jiao, Yuka Hayashi, Tomoyasu Suzuki, Hiroaki Obata, Takeshi Kashimura, Tohru Minamino
    • Organizer
      第17回日本心不全学会学術集会
    • Place of Presentation
      大宮ソニックシティ( 大宮)
    • Related Report
      2013 Research-status Report
  • [Remarks] World Biomedical Frontiers

    • URL

      http://biomedfrontiers.org/anemia-2014-12-1/

    • Related Report
      2014 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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