Analysis of mechanism of anemia and iron deficiency in heart failure via hepcidin

• Project/Area Number: 25461047
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Niigata University
• Principal Investigator: Hanawa Haruo 新潟大学, 医歯学系, 准教授 (40282983)
• Co-Investigator(Kenkyū-buntansha): 柏村 健 新潟大学, 医歯学総合病院, 助教 (70419290) ; 小澤 拓也 新潟大学, 医歯学系, 助教 (70467075)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 心不全 / 貧血 / 鉄欠乏 / ヘプシジン / 肝うっ血 / BMP-6 / IL-6 / Toll様受容体

Outline of Final Research Achievements

Anemia and iron deficiency are prevalent in patients with heart failure. The etiology of anemia and iron deficiency in heart failure patients is unclear. Hepcidin is known to be a main regulator of iron metabolism. The most frequent histopathologic finding in the liver of heart failure patients is congestion. Therefore, we speculated that liver congestion may induce the expression of hepcidin and result in exacerbated anemia. We prepared animal models with liver congestion and analyze mechanism of anemia and iron deficiency in heart failure via hepcidin. Our data indicated that liver congestion contributes to relative iron deficiency and anemia, and it does so via inappropriate expression of hepcidin. Moreover, our data in some patients with heart failure showed that the mechanism appeared.

Research Products

• [Journal Article] Liver Congestion in Heart Failure Contributes to Inappropriately Increased Serum Hepcidin despite Anemia (2015)
  • Author(s): Ohno Y, Hanawa H, Jiao S, Hayashi Y, Yoshida K, Suzuki T, Kashimura T, Obata H, Tanaka K, Watanabe T, Minamino T.
  • Journal Title: The Tohoku Journal of Experimental Medicine Volume: 235 Issue: 1 Pages: 69-79
  • DOI: 10.1620/tjem.235.69
  • NAID: 130004822430
  • ISSN: 0040-8727, 1349-3329
  • Peer Reviewed / Open Access
• [Journal Article] Elevated Endomyocardial Biopsy Macrophage-Related Markers in Intractable Myocardial Diseases. (2015)
  • Author(s): Hayashi Y, Hanawa H, Jiao S, Hasegawa G, Ohno Y, Yoshida K, Suzuki T, Kashimura T, Obata H, Tanaka K, Watanabe T, Minamino T.
  • Journal Title: Inflammation Volume: 38 Issue: 6 Pages: 2288-99
  • DOI: 10.1007/s10753-015-0214-1
  • Peer Reviewed / Open Access
• [Journal Article] Inappropriate expression of hepcidin by liver congestion contributes to anemia and relative iron deficiency. (2014)
  • Author(s): Suzuki T, Hanawa H, Jiao S, Ohno Y, Hayashi Y, Yoshida K, Kashimura T, Obata H, Minamino T.
  • Journal Title: J Card Fail Volume: 20 Issue: 4 Pages: 268-277
  • DOI: 10.1016/j.cardfail.2014.01.008
  • Peer Reviewed / Open Access
• [Presentation] Potential role of cardiac iron metabolism in the failing heart (2016)
  • Author(s): Shuang Jiao, Ippei Shimizu, Yohko Yoshida, Masayoshi Suda, Yuka Hayashi, Goro Katsuumi, Hiromi Kayamori, Yukako Ohno, Haruo Hanawa, Tohru Minamino
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター (宮城県仙台市)
  • Year and Date: 2016-03-18
• [Presentation] Influence of liver congestion and hypoxemia in heart failure on hematological and iron status via hepcidin (2014)
  • Author(s): Yukako Ohno, Haruo Hanawa , Shuang Jiao, Yuka Hayashi, Tomoyasu Suzuki, Tohru Watanabe, Hiroaki Obata, Takeshi Kashimura, Tohru Minamino
  • Organizer: 第18回日本心不全学会学術集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2014-10-10 – 2014-10-12
• [Presentation] Inappropriate Hepcidin Expression and Anemia in Heart Failure with Liver Congestion (2014)
  • Author(s): Yukako Ohno, Haruo Hanawa, Shuang Jiao, Yuka Hayashi, Tomoyasu Suzuki, Tohru Watanabe , Hiroaki Obata , Takeshi Kashimura , Tohru Minamino
  • Organizer: 第78会日本循環器学会学術集会
  • Place of Presentation: 東京国際フォーラム（ 東京）
• [Presentation] Mechanism of iron deficiency via inappropriate hepcidin expression in pulmonary artery hypertension with liver congestion (2013)
  • Author(s): Yukako Ohno, Haruo Hanawa, Shuang Jiao, Yuka Hayashi, Tomoyasu Suzuki, Hiroaki Obata, Takeshi Kashimura, Tohru Minamino
  • Organizer: 第17回日本心不全学会学術集会
  • Place of Presentation: 大宮ソニックシティ（ 大宮）
• [Remarks] World Biomedical Frontiers
  • URL: http://biomedfrontiers.org/anemia-2014-12-1/