| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Outline of Final Research Achievements |
In patients with heart failure, one of the main cause of myocardial systolic dysfunction is considered to be myocardial calcium overload, however there is no method to show calcium overload directly in vivo in heart failure patients. Therefore, we hypothesized that calcium overload was a condition in which the amount of calcium loaded in myocardial sarcoplasmic reticulum was too much to release effectively in a coupling interval. Then we examined patterns of change in left ventricular systolic force by changing heart rate using atrial pacing during cardiac catheterization. We found that in patients with left ventricular systolic dysfunction showed enhancement of systolic force during tachycardia was smaller than that of control although cessation of pacing and following long coupling interval enhanced systolic force significantly more than that of control. These findings and our other findings suggest calcium overload in patients with heart failure.
|
