| Project/Area Number |
25461050
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
SAITOH TAKEJI 浜松医科大学, 医学部附属病院, 講師 (50402277)
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| Co-Investigator(Kenkyū-buntansha) |
SATOH HIROSHI 浜松医科大学, 医学部附属病院, 講師 (30293632)
TAKEHARA YASUO 浜松医科大学, 医学部附属病院, 教授 (70188217)
SAOTOME MASAO 浜松医科大学, 医学部附属病院, 助教 (70509512)
URUSHIDA TSUYOSHI 浜松医科大学, 医学部, 助教 (20334980)
KATOH HIDEKI 浜松医科大学, 医学部, 助教 (80314029)
阪原 晴海 浜松医科大学, 医学部, 教授 (10187031)
林 秀晴 浜松医科大学, 医学部, 教授 (50135258)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 心腔内血流 / 左室 / 左房 / 心不全 / 血流 / 心臓 |
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| Outline of Final Research Achievements |
Intra-cardiac blood flow changes under various conditions and might affect global cardiac function. In this study, by using phase-resolved 3-dimensional cine phase contrast magnetic resonance imaging (4D-Flow), vortex formation in the left atrium (LA) and the left ventricle (LV) was visualized and factors affecting the intra-cardiac flow dynamics were examined. The vortex formation in LA might depend on LV and LA volume. The intra-LV vortex during the diastolic phase was larger and located at the more apical LV in patients with impaired LV function. 4D-Flow can show the 3-dimensional alterations of intra-cardiac flow dynamics in a noninvasive and comprehensive manner.
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