Analysis of blood flow in the heart using MRI

• Project/Area Number: 25461050
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: SAITOH TAKEJI 浜松医科大学, 医学部附属病院, 講師 (50402277)
• Co-Investigator(Kenkyū-buntansha): SATOH HIROSHI 浜松医科大学, 医学部附属病院, 講師 (30293632) ; TAKEHARA YASUO 浜松医科大学, 医学部附属病院, 教授 (70188217) ; SAOTOME MASAO 浜松医科大学, 医学部附属病院, 助教 (70509512) ; URUSHIDA TSUYOSHI 浜松医科大学, 医学部, 助教 (20334980) ; KATOH HIDEKI 浜松医科大学, 医学部, 助教 (80314029) ; 阪原 晴海 浜松医科大学, 医学部, 教授 (10187031) ; 林 秀晴 浜松医科大学, 医学部, 教授 (50135258)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000); Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 心腔内血流 / 左室 / 左房 / 心不全 / 血流 / 心臓

Outline of Final Research Achievements

Intra-cardiac blood flow changes under various conditions and might affect global cardiac function. In this study, by using phase-resolved 3-dimensional cine phase contrast magnetic resonance imaging (4D-Flow), vortex formation in the left atrium (LA) and the left ventricle (LV) was visualized and factors affecting the intra-cardiac flow dynamics were examined. The vortex formation in LA might depend on LV and LA volume. The intra-LV vortex during the diastolic phase was larger and located at the more apical LV in patients with impaired LV function. 4D-Flow can show the 3-dimensional alterations of intra-cardiac flow dynamics in a noninvasive and comprehensive manner.

Research Products

• [Journal Article] Intra-left ventricular flow dynamics in patients with preserved and impaired left ventricular function: analysis with three-dimensional cine phase contrast magnetic resonance imaging (4D-Flow) (2016)
  • Author(s): Suwa K, Saitoh T, Takehara Y, Sano M, Saotome M, Urushida T, Katoh H, Satoh H, Sugiyama M, Wakayama T, Sakahara H, Hayashi H
  • Journal Title: Journal of Magnetic Resonance Imaging Volume: 印刷中
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Characteristics of Intra-Left Atrial Flow Dynamics and Factors Affecting Formation of the Vortex Flow (2014)
  • Author(s): Suwa K, Saitoh T, Takehara Y, Sano M, Nobuhara M, Saotome M, Urushida T, Katoh H, Satoh H, Sugiyama M, Wakayama T, Sakahara H, Hayashi H.
  • Journal Title: Circulation Journal Volume: 79 Issue: 1 Pages: 144-152
  • DOI: 10.1253/circj.CJ-14-0562
  • NAID: 130004704021
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Quantitative Evaluation of Retrograde Blood Flow in Ascending Aorta in Aortic Regurgitation by Phase-Resolved 3D-Cine Phase-Contrast MRI (4D-Flow MRI) (2016)
  • Author(s): Tomoaki Sakakibara, Hiroshi Satoh, Takeji Saitoh, Yasuo Takehara, Makoto Sano, Masao Saotome, Tsuyoshi Urushida, Hideki Katoh, Marcus Alley, Harumi Sakahara, Hideharu Hayashi
  • Organizer: 日本循環器病学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18
• [Presentation] Changes in Wall Shear Stress in Pulmonary Artery Visualized with Phase-resolved 3D Cine Phase Contrast MRI (4D-Flow) in Patients with Systemic Sclerosis (2016)
  • Author(s): Tomoaki Sakakibara, Hiroshi Satoh, Takeji Saitoh, Yasuo Takehara, Makoto Sano, Masao Saotome, Tsuyoshi Urushida, Hideki Katoh, Marcus Alley, Harumi Sakahara, Hideharu Hayashi
  • Organizer: 日本循環器病学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18
• [Presentation] Alterations in Flow Patterns and Wall Shear Stress in Pulmonary Artery Visualized With Phase-resolved 3D Cine Phase Contrast MRI (4D-Flow) in Patients With Systemic Sclerosis (2015)
  • Author(s): Kenichiro Suwa, Tomoaki Sakakibara, Takeji Saitoh, Yutaro Kaneko, Makoto Sano, Masao Saotome, Tsuyoshi Urushida, Hideki Katoh, Hiroshi Satoh, Yasuo Takehara, Harumi Sakahara, and Hideharu Hayashi
  • Organizer: American Heart Association Scientific Sessions 2015
  • Place of Presentation: 米国 オーランド
  • Year and Date: 2015-11-07
  • Int'l Joint Research
• [Presentation] Subclinical Changes of Flow Dynamics in Pulmonary Artery (PA) Visualized with Phase-Resolved 3D-Cine Phase-Contrast MRI (4D-Flow) in Systemic Scleroderma (SSc) (2015)
  • Author(s): Suwa K, Saitoh T, Takehara Y, Sano M, Nobuhara M, Saotome M, Urushida T, Katoh H, Satoh H, Sugiyama M, Wakayama T, Sakahara H, Hayashi H.
  • Organizer: The 79th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 東京
  • Year and Date: 2015-04-25
• [Presentation] 左室駆出率正常例と低下例におけるPhase-Resolved 3D Cine Phase-Contrast MRI (4D-Flow)を用いた左室内血流の比較 (2014)
  • Author(s): 諏訪賢一郎 齊藤岳児 佐藤洋 佐野誠 渡辺知幸 早乙女雅夫 漆田毅 加藤秀樹 竹原康雄 林秀晴
  • Organizer: 第2回血流会
  • Place of Presentation: 東京
  • Year and Date: 2014-06-14
• [Presentation] Analyses of intra-left ventricular (LV) flow dynamics in patinets with normal and impaired LV function using phase-resolved 3D cine phase-contrast MRI (4D-Flow MRI) (2014)
  • Author(s): Kenichiro Suwa, Takeji Saitoh, Makoto Sano, Mamoru Nobuhara, Masao Saotome, Tsuyoshi Urushida, Hideki Katoh, Hiroshi Satoh, Marcus Alley, Yasuo Takehara, Harumi Sakahara, Hideharu Hayashi
  • Organizer: American College of Cardiology Annual Meeting 2014
  • Place of Presentation: 米国 ワシントンDC
• [Presentation] Visualization of intra-left ventricular (LV) vortex flow using phase-resolved 3D-cine phase-contrast MRI (4D-Flow MRI) (2014)
  • Author(s): Kenichiro Suwa, Takeji Saitoh, Makoto Sano, Mamoru Nobuhara, Masao Saotome, Tsuyoshi Urushida, Hideki Katoh, Hiroshi Satoh, Marcus Alley, Yasuo Takehara, Harumi Sakahara, Hideharu Hayashi
  • Organizer: 日本循環器病学会総会2014
  • Place of Presentation: 東京
• [Presentation] Analyses of intra-left ventricular (LV) flow dynamics in patients with normal and impaired LV function using phase-resolved 3D cine phase-contrast MRI (4D-Flow MRI) (2014)
  • Author(s): Kenichiro Suwa, Takeji Saitoh, Makoto Sano, Mamoru Nobuhara, Masao Saotome, Tsuyoshi Urushida, Hideki Katoh, Hiroshi Satoh, Marcus Alley, Yasuo Takehara, Harumi Sakahara, Hideharu Hayashi
  • Organizer: 日本循環器病学会総会2014
  • Place of Presentation: 東京
• [Presentation] Left Atrial Volume is Associated with the Intra-left Atrial Vortex Formation: Analysis with Phase-resolved Three-dimensional Cine Phase Contrast MRI (4D-Flow MRI) (2013)
  • Author(s): Takeji Saitoh, Kenichiro Suwa, Yasuo Takehara, Makoto Sano, Mamoru Nobuhara, Masao Saotome, Tsuyoshi Urushida, Hideki Katoh, Hiroshi Satoh, Marcus Alley, Harumi Sakahara, Hideharu Hayashi
  • Organizer: American Heart Association's Scientific Sessions 2013
  • Place of Presentation: 米国 ダラス
• [Book] 検査と技術 (2014)
  • Author(s): 齊藤岳児 佐藤洋 林秀晴 竹原康雄
  • Total Pages: 6
  • Publisher: 医学書院