| Project/Area Number |
25461064
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
Orii Makoto 和歌山県立医科大学, 医学部, 助教 (70508986)
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| Co-Investigator(Kenkyū-buntansha) |
Akasaka Takashi 和歌山県立医科大学, 医学部, 教授 (70322584)
Imanishi Toshio 和歌山県立医科大学, 医学部, 研究員 (00285389)
Hirata Kumiko 和歌山県立医科大学, 医学部, 講師 (10382152)
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| Co-Investigator(Renkei-kenkyūsha) |
Eishi Yoshinobu 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (70151959)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 心サルコイドーシス / 炎症性単球 / ミノサイクリン / 肉芽腫 / FDG-PET / 心臓MRI / 18F FDG PET / 単球サブセット / 18F FDG PET/CT / 副腎皮質ステロイド / アクネ菌 / 単球 / FDG PET |
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| Outline of Final Research Achievements |
We aimed to evaluate whether specific monocyte subsets could serve as surrogate markers of disease activity in cardiac sarcoidosis (CS) evaluated by 18F-FDG PET.
We divided the CS patients into 2 groups: known CS receiving corticosteroid therapy (Rx(+)) and new-onset CS (Rx(－)), and analyzed 3 distinct monocyte subsets (CD14+CD16－, CD14++CD16+, and CD14+－CD16+). Monocyte subsets were also analyzed in Rx(－) patients before and 12 weeks after starting corticosteroid therapy. Inflammatory activity was quantified by FDG uptake. The proportion of CD14++CD16+ monocytes in Rx(+) patients was significantly lower than in Rx(－) patients. After corticosteroid therapy, FDG uptake was significantly improved. The proportion of CD14++16+ monocytes showed a significant decrease. The decrease in the proportion of CD14++16+ monocytes significantly correlated with the decrease in FDG uptake.
CD14++16+ monocytes are a possible surrogate marker of the therapeutic effect of corticosteroid therapy in CS.
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