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Exercise program for the patients with cardiovascular disease using ambulatory blood pressure monitoring equipped with actigraphy

Research Project

Project/Area Number 25461065
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionJichi Medical University

Principal Investigator

HOSHIDE SATOSHI  自治医科大学, 医学部, 准教授 (90326851)

Co-Investigator(Kenkyū-buntansha) Kario Kazuomi  自治医科大学, 医学部, 教授 (60285773)
Nakayama Mio  自治医科大学, 医学部, 臨床助教 (20468333)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
KeywordsABPM / 身体活動度 / 携帯型自由行動下血圧計 / 高感度加速度センサー / サーカディアンリズム / 睡眠の質
Outline of Final Research Achievements

The aim of study is to clarify cardiovascular reactivity to daily physical activity using new device we have developed. This device was available to measure blood pressure (BP) and equipped with a high sensitive actigraph, which recorded the frequency of physical movement in three axes. Physical activity was continuously assessed and recorded in 5-sec epochs throughout 24-hour. We defined “cardiovascular reactivity” as the slope of the association between each systolic BP and sum or averaged of physical activity during 5 minutes before each systolic BP every 30 minutes. When we observe the association between systolic BP and physical activity in each case, that was difference depends on cases.
These findings showed that cardiovascular reactivity was difference depends on individuals. Cardiovascular reactivity might be affected by not only physical activity but also other environmental factors, such as temperature and atmosphere.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (37 results)

All 2015 2014 2013

All Journal Article (17 results) (of which Peer Reviewed: 16 results,  Open Access: 3 results) Presentation (16 results) (of which Invited: 6 results) Book (4 results)

  • [Journal Article] Sleep Blood Pressure Self-Measured at Home as a Novel Determinant of Organ Damage: Japan Morning Surge Home Blood Pressure (J-HOP) Study.2015

    • Author(s)
      Kario K, Hoshide S, Haimoto H, Yamagiwa K, Uchiba K, Nagasaka S, Yano Y, Eguchi K, Matsui Y, Shimizu M, Ishikawa J, Ishikawa S
    • Journal Title

      J Clin Hypertens (Greenwich)

      Volume: 17 Issue: 5 Pages: 340-348

    • DOI

      10.1111/jch.12500

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Correlation of Central Blood Pressure to Hypertensive Target Organ Damages During Antihypertensive Treatment: The J-TOP Study2014

    • Author(s)
      Shimizu M, Hoshide S, Ishikawa J, Yano Y, Eguchi K, Kario K.
    • Journal Title

      Am J Hypertens

      Volume: 28 Issue: 8 Pages: 980-986

    • DOI

      10.1093/ajh/hpu250

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] A New Proposal for the Target Value for Home BP in Type 2 Diabetes Patients: The J-HOP Study2014

    • Author(s)
      Eguchi K, Hoshide S, Komori T, Nagasaka S, Kario K
    • Journal Title

      Am J Hypertens

      Volume: 28 Issue: 8 Pages: 971-979

    • DOI

      10.1093/ajh/hpu249

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prognostic impact from clinic, daytime, and night-time systolic blood pressure in nine cohorts of 13,844 patients with hypertension.2014

    • Author(s)
      Roush GC, Fagard RH, Salles GF, Pierdomenico SD, Reboldi G, Verdecchia P, Eguchi K, Kario K, Hoshide S, Polonia J, de la Sierra A, Hermida RC, Dolan E, Zamalloa H.
    • Journal Title

      J Hypertens

      Volume: 32 Issue: 12 Pages: 2332-40

    • DOI

      10.1097/hjh.0000000000000355

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Day-to-day blood pressure variability as a phenotype in a high-risk patient.2014

    • Author(s)
      Toriumi S, Hoshide S, Nagai M, Kario K
    • Journal Title

      Geriatr Gerontol Int

      Volume: 14 Issue: 4 Pages: 1005-6

    • DOI

      10.1111/ggi.12216

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] BP variability and cognitive impairment: vascular risk factors for Alzheimer disease?2014

    • Author(s)
      Nagai M, Hoshide S, Kario K
    • Journal Title

      Alzheimer Dis Assoc Disord.

      Volume: 28 Issue: 4 Pages: 368-368

    • DOI

      10.1097/wad.0000000000000051

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association of high-sensitivity cardiac troponin T and N-terminal pro-brain-type natriuretic peptide with left ventricular structure: J-HOP study2014

    • Author(s)
      Hoshide S, Nagai M, Yano Y, Ishikawa J, Eguchi K, Kario K
    • Journal Title

      J Clin Hypertens (Greenwich)

      Volume: 16 Issue: 5 Pages: 354-61

    • DOI

      10.1111/jch.12321

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of nighttime single-dose administration of vasodilating vs sympatholytic antihypertensive agents on sleep blood pressure in hypertensive patients with sleep apnea syndrome.2014

    • Author(s)
      Kario K, Kuwabara M, Hoshide S, Nagai M, Shimpo M.
    • Journal Title

      J Clin Hypertens (Greenwich).

      Volume: 16 Issue: 6 Pages: 459-66

    • DOI

      10.1111/jch.12327

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] How many clinic BP readings are needed to predict cardiovascular events as accurately as ambulatory BP monitoring?2014

    • Author(s)
      Eguchi K, Hoshide S, Shimada K, Kario K.
    • Journal Title

      J Hum Hypertens.

      Volume: 印刷中 Issue: 12 Pages: 731-5

    • DOI

      10.1038/jhh.2014.8

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association of morning and evening blood pressure at home with asymptomatic organ damage in the J-HOP Study.2014

    • Author(s)
      Hoshide S, Kario K, Yano Y, Haimoto H, Yamagiwa K, Uchiba K, Nagasaka S, Matsui Y, Nakamura A, Fukutomi M, Eguchi K, Ishikawa J
    • Journal Title

      Am J Hypertens.

      Volume: 27 Issue: 7 Pages: 939-47

    • DOI

      10.1093/ajh/hpt290

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association of Morning and Evening Blood Pressure at Home With Asymptomatic Organ Damage in the J-HOP Study.2014

    • Author(s)
      Hoshide S, Kario K, Yano Y, Haimoto H, Yamagiwa K, Uchiba K, Nagasaka S, Matsui Y, Nakamura A, Fukutomi M, Eguchi K, Ishikawa J
    • Journal Title

      Am J Hypertens

      Volume: In press

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Assessment of the reductions in night-time blood pressure and dipping induced by antihypertensive medication using a home blood pressure monitor.2014

    • Author(s)
      Ishikawa J, Shimizu M, Sugiyama Edison E, Yano Y, Hoshide S, Eguchi K, Kario K; J-TOP (Japan Morning Surge-Target Organ Protection) Study Investigators Group.
    • Journal Title

      J Hypertens.

      Volume: 32 Issue: 1 Pages: 82-89

    • DOI

      10.1097/hjh.0b013e328365c8a8

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Differential effects of aliskiren/amlodipine combination and high-dose amlodipine monotherapy on endothelial function in elderly hypertensive patients.2014

    • Author(s)
      Fukutomi M, Hoshide S, Mizuno H, Kario K
    • Journal Title

      Am J Hypertens.

      Volume: 27 Issue: 1 Pages: 14-20

    • DOI

      10.1093/ajh/hpt158

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sleep duration and insomnia in the elderly : Associations with blood pressure variability and carotid artery remodeling2013

    • Author(s)
      Nagai M, Hoshide S, Nishikawa M, Shimada K, Kario K
    • Journal Title

      Am J Hypertens

      Volume: 26 Issue: 8 Pages: 981-989

    • DOI

      10.1093/ajh/hpt070

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Early morning hypertension: a narrative review.2013

    • Author(s)
      Hoshide S, Kario K.
    • Journal Title

      Blood Press Monit.

      Volume: 18 Issue: 6 Pages: 291-296

    • DOI

      10.1097/mbp.0000000000000004

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Low-grade inflammation and ambulatory blood pressure response to antihypertensive treatment: the ALPHABET study.2013

    • Author(s)
      Fukutomi M, Hoshide S, Eguchi K, Watanabe T, Kario K.
    • Journal Title

      Am J Hypertens.

      Volume: 26 Issue: 6 Pages: 784-792

    • DOI

      10.1093/ajh/hpt024

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hypertension and Circadian rhythm2013

    • Author(s)
      Hoshide S, Kario K.
    • Journal Title

      Nihon Rinsho

      Volume: 71 Pages: 2109-2013

    • NAID

      40019874402

    • Related Report
      2013 Research-status Report
  • [Presentation] Poster: Hypertension: Circadian Rhythm. Characteristics of Diurnal Change of Pulse Rate in Resistant Hypertension.2014

    • Author(s)
      Watanabe H, Kabutoya T, Hoshide S, Eguchi K, Kario K.
    • Organizer
      American Heart Association Scientific Sessions 2014
    • Place of Presentation
      Chicago
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] Poster: Hypertension; Circadian Rhythm. Association of Diurnal Blood Pressure Variation and Nocturnal Hypoxia in Patients With Cardiovascular Risk Factors: Japan Morning Surge-Home Blood Pressure (J-HOP) SAS Study2014

    • Author(s)
      Shimpo M, Hoshide S, Nagai M, Eguchi K, Kario K
    • Organizer
      American Heart Association Scientific Sessions 2014
    • Place of Presentation
      Chicago
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] Poster: Hypertension; Circadian Rhythm. Riser Pattern is Associated With Mild Cognitive Impairment in Heart Failure Patients.2014

    • Author(s)
      Komori T, Eguchi K, Saito T, Nishimura Y, Hoshide S, Kario K.
    • Organizer
      American Heart Association Scientific Sessions 2014
    • Place of Presentation
      Chicago
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] Poster: Hypertension; Circadian Rhythm. Home Blood Pressure Range and 24-hr Ambulatory Blood Pressure Control: The Japan Morning Surge Home Blood Pressure (J-HOP) Study-ABPM Substudy.2014

    • Author(s)
      Taki M, Hoshide S, Eguchi K, Yano Y, Kario K.
    • Organizer
      American Heart Association Scientific Sessions 2014
    • Place of Presentation
      Chicago
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] Poster: Hypertension; Circadian Rhythm. Long Sleep Duration and B-Type Natriuretic Peptide: Determinants of Left Ventricular Mass Index in the Japanese at High-Risk of Cardiovascular Disease.2014

    • Author(s)
      Nagai M, Niijima S, Hoshide S, Takahashi M, Shimpo M, Kario K.
    • Organizer
      American Heart Association Scientific Sessions 2014
    • Place of Presentation
      Chicago
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] Poster: Hypertension; Circadian Rhythm. Long Sleep Duration and Low-Grade Inflammation: New Indicators of Arterial Stiffness in the Japanese at High-risk of Cardiovascular Disease.2014

    • Author(s)
      Niijima S, Nagai M, Hoshide S, Takahashi M, Shimpo M, Kario K.
    • Organizer
      American Heart Association Scientific Sessions 2014
    • Place of Presentation
      Chicago
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] Oral: Hypertension: Clinical Nondipping Pulse Rate was Associated with a High Level of Brain Natriuretic Peptide in Treated Hypertensive Patients.2014

    • Author(s)
      Oba Y, Kabutoya T, Hoshide S, Eguchi K, Kario K
    • Organizer
      American Heart Association Scientific Sessions 2014
    • Place of Presentation
      Chicago
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] 在宅・遠隔モニタリングの最先端2013

    • Author(s)
      星出 聡
    • Organizer
      第24回臨床モニター学会総会
    • Place of Presentation
      奈良県新公会堂
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 睡眠と高血圧2013

    • Author(s)
      星出 聡
    • Organizer
      日本睡眠学会 第38回定期学術集会
    • Place of Presentation
      秋田キャッスルホテル
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 血管と血圧変動2013

    • Author(s)
      星出 聡
    • Organizer
      日本高血圧学会 第36回定期学術集会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 夜間血圧変動の意義2013

    • Author(s)
      星出 聡
    • Organizer
      日本高血圧学会 第36回定期学術集会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 家庭血圧の早朝血圧と就寝前血圧の高血圧臓器障害との関係: JHOP study2013

    • Author(s)
      星出 聡, 矢野裕一朗、福冨基城、永井道明、石川譲治、江口和男、苅尾七臣
    • Organizer
      日本高血圧学会 第36回定期学術集会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2013 Research-status Report
  • [Presentation] 血管不全と中心血圧2013

    • Author(s)
      星出 聡
    • Organizer
      日本臨床生理学会第50回日本臨床生理学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Association of Morning and Evening Blood Pressure at Home With Target Organ Damage in the J-HOP Study2013

    • Author(s)
      Hoshide S, Kario K, Eguchi K, Ishikawa J, Yano Y, Fukutom Mi, Nagai M
    • Organizer
      American Heart Association
    • Place of Presentation
      ダラスコンベンションセンター
    • Related Report
      2013 Research-status Report
  • [Presentation] Addition of Home Blood Pressure Measurement and Biomarkers for the Detection of Concentric Hypertrophy2013

    • Author(s)
      Hoshide S, Yano Y, Fukutomi M, Nagai M, Ishikawa, Eguchi K, Shimpo M, Kario K.
    • Organizer
      American Heart Association
    • Place of Presentation
      ダラスコンベンションセンター
    • Related Report
      2013 Research-status Report
  • [Presentation] 未病社会の診断技術開発について:臨床高血圧2013

    • Author(s)
      星出 聡
    • Organizer
      日本分子生物学会 第36回 日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2013 Research-status Report
    • Invited
  • [Book] 夜間の思いがけない高血圧2013

    • Author(s)
      星出 聡、苅尾七臣
    • Total Pages
      4
    • Publisher
      血圧 Vol20 No3
    • Related Report
      2013 Research-status Report
  • [Book] サーカディアン降圧療法2013

    • Author(s)
      星出 聡、苅尾七臣
    • Total Pages
      6
    • Publisher
      月刊 循環器 Circulation Vol3 No4
    • Related Report
      2013 Research-status Report
  • [Book] 血圧変動性と循環器疾患2013

    • Author(s)
      星出 聡、苅尾七臣
    • Total Pages
      6
    • Publisher
      Cardiovascular Frontier Vol4 No2
    • Related Report
      2013 Research-status Report
  • [Book] 血圧変動性とモーニングサージ2013

    • Author(s)
      星出 聡
    • Total Pages
      5
    • Publisher
      Heart View Vol 17. No 8
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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