Diagnostic accuracy of novel semiconductor camera system for coronary artery disease with low-dose radioisotope
Project/Area Number |
25461072
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cardiovascular medicine
|
Research Institution | Tokyo Medical University |
Principal Investigator |
|
Co-Investigator(Renkei-kenkyūsha) |
TANAKA Nobuhiro 東京医科大学, 医学部, 准教授 (50297305)
HIDA Satoshi 東京医科大学, 医学部, 講師 (90297317)
TANAKA Hirokazu 東京医科大学, 医学部, 准教授 (20408107)
YAMASHITA Jun 東京医科大学, 医学部, 助教 (40424379)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 放射線被曝 / 心臓核医学検査 / radioisotope / SPECT / 半導体γカメラ / 冠動脈疾患 / fractional flow reserve |
Outline of Final Research Achievements |
Although stress single-photon emission computed tomography (SPECT) using a cadmium-zinc-telluride (CZT) camera enables radiation dose reduction, only few studies have evaluated its diagnostic accuracy by applying fractional flow reserve (FFR) measurements. We prospectively evaluated 104 consecutive patients with suspected or known coronary artery disease with a low-dose stress/rest protocol (99mTc radiotracer 185/370 MBq) using CZT SPECT. Within 3 months, coronary angiography was performed with FFR measurements. To detect individual coronary stenosis, respective sensitivity, specificity, and accuracy were 87%, 73%, and 82% for left anterior descending artery stenosis, 76%, 81%, and 79% for left circumflex artery stenosis, and 87%, 92%, and 90% for right coronary artery stenosis. In conclusion, CZT SPECT demonstrated a good diagnostic yield in detecting a significant coronary stenosis as assessed by FFR even when using a low-dose 99mTc protocol with an effective dose less than 5 mSv.
|
Report
(4 results)
Research Products
(24 results)
-
[Journal Article] Diagnostic Performance of a Cadmium-Zinc-Telluride Single-Photon Emission Computed Tomography System With Low-Dose Technetium-99m as Assessed by Fractional Flow Reserve2016
Author(s)
Taishiro Chikamori, Satoshi Hida, Nobuhiro Tanaka, Yuko Igarashi, Jun Yamashita, Chie Shiba, Naotaka Murata, Kou Hoshino, Yohei Hokama, Akira Yamashina
-
Journal Title
Circulation Journal
Volume: 80
Issue: 5
Pages: 1217-1224
DOI
NAID
ISSN
1346-9843, 1347-4820
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-
-
-
-
[Journal Article] Comparison of myocardial perfusion imaging between the new high-speed gamma camera and the standard Anger camera2013
Author(s)
Hirokazu Tanaka, Taishiro Chikamori, Satoshi Hida, Kenji Uchida, Yuko Igarashi, Tsuyoshi Yokoyama, Masaki Takahashi, Chie Shiba, Mana Yoshimura, Koichi Tokuuye, Akira Yamashina
-
Journal Title
Circulation Journal
Volume: 77
Pages: 1009-1017
NAID
Related Report
Peer Reviewed
-
[Presentation] Diagnostic performance of the cadmium-zinc-telluride SPECT system using low-dose technetium-99m with a short-scan time as assessed by fractional flow reserve2016
Author(s)
Satoshi Hida, Taishiro Chikamori, Jun Yamashita, Kou Hoshino, Naotaka Murata, Yuko Igarashi, Chie Shiba, Tetsushi Saitoh, Kimihiko Hirose, Akira Yamashina
Organizer
Eurepean Society of Cardiology Congress 2016
Place of Presentation
Rome, Italy
Year and Date
2016-08-27
Related Report
Int'l Joint Research
-
-
[Presentation] Diagnostic performance of the cadmium-zinc-telluride SPECT system using low-dose technetium-99m radiotopes with short-scan time as assessed by fractional flow reserve2016
Author(s)
Satoshi Hida, Taishiro Chikamori, Jun Yamashita, Naotaka Murata, Kunihiro Sakoda, Kou Hoshino, Yuko Igarashi, Chie Shiba, Tetsushi Saitoh, Kimihiko Hirose, Tsuguhisa Hatano, Akira Yamashina
Organizer
第80回日本循環器学会学術集会
Place of Presentation
仙台
Year and Date
2016-03-20
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-