Noninvasive Assessment of Inflammatory Response after Coronary Stenting by 18F-

• Project/Area Number: 25461073
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Nippon Medical School
• Principal Investigator: Hitoshi Takano 日本医科大学, 医学部, 准教授 (90277533)
• Co-Investigator(Kenkyū-buntansha): KUMITA Shinichiro 日本医科大学, 大学院医学研究科, 教授 (70234523) ; 稲見 茂信 国際医療福祉大学, 大学病院, 准教授 (30350044) ; 加藤 浩司 日本医科大学, 医学部, 助教 (90366667)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 冠動脈ステント / ステント血栓症 / 炎症反応 / 血栓症 / 再狭窄 / 炎症 / 不安定プラーク

Outline of Final Research Achievements

[Background] Inflammatory response has been considered to play an important role in the development of adverse events in patients who receive coronary stenting. This study aimed to determine the usefulness of 18-F fludeoxyglucose (FDG)-positron emission tomography (PET) in evaluating the regional inflammatory process after coronary stent implantation. [Method] Patients who received drug-eluting stent (DES) at proximal LAD lesion were enrolled. They underwent FDG-PET 8 weeks later and follow-up coronary arteriography with optical coherence tomography (OCT) 10 months later. [Results] There was no significant difference in NIH thickness between the patients with FDG uptake and those without. However, the incidences of uncovered strut as well as malapposed strut were significantly higher in FDG positive than in FDG negative patients. [Conclusion] FDG-PET is useful for evaluating the regional inflammatory response after DES implantation.

Research Products

• [Journal Article] Patients with reduced heart rate response to adenosine infusion have low myocardial flow reserve in 13N-ammonia PET studies. (2015)
  • Author(s): Tomiyama T, Kumita SI, Ishihara K, Suda M, Sakurai M, Hakozaki K, Hashimoto H, Takahashi N, Takano H, Kobayashi Y, Kiriyama T, Fukushima Y, Shimizu W
  • Journal Title: Int J Cardiovasc Imaging Volume: e-pub
  • Peer Reviewed
• [Journal Article] Ultrastructural features of cardiomyocytes in dilated cardiomyopathy with initially decompensated heart failure as a predictor of prognosis. (2015)
  • Author(s): Saito T, Asai K, Sato S, Takano H, Mizuno K, Shimizu W.
  • Journal Title: Eur Heart J Volume: 36 Issue: 12 Pages: 724-732
  • DOI: 10.1093/eurheartj/ehu404
  • Peer Reviewed
• [Journal Article] Relationship between cholesterol crystals and culprit lesion characteristics in patients with stable coronary artery disease: an optical coherence tomography study. (2014)
  • Author(s): Nakamura S, Inami S, Murai K, Takano M, Takano H, Asai K, Yasutake M, Shimizu W, Mizuno K.
  • Journal Title: Clin Res Cardiol Volume: 103 Issue: 12 Pages: 1015-1021
  • DOI: 10.1007/s00392-014-0748-5
  • Peer Reviewed
• [Journal Article] Impact of time-of-flight on qualitative and quantitative analyses of myocardial perfusion PET studies using 13N-ammonia. (2014)
  • Author(s): Tomiyama T, Ishihara K, Suda M, Kanaya K, Sakurai M, Takahashi N, Takano H, Nitta K, Hakozaki K, Kumita SI.
  • Journal Title: J Nucl Cardiol. Volume: e-pub
  • Peer Reviewed
• [Journal Article] Prognostic values of highly sensitive cardiac troponin T and B-type natriuretic peptide for clinical features in hypertrophic obstructive cardiomyopathy: a cross-sectional study. (2014)
  • Author(s): Nakamura S, Takano H, Matsuda J, Chinen D, Kitamura M, Murai K, Asai K, Yasutake M, Takayama M, Shimizu W
  • Journal Title: BMJ Open Volume: 17 Issue: 9 Pages: e005968-e005968
  • DOI: 10.1136/bmjopen-2014-005968
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of perfusion-metabolism mismatch in 99mTc-MIBI and 123I-BMIPP scintigraphy with cardiac magnetic resonance in patients with dilated cardiomyopathy. (2013)
  • Author(s): Yoshida A, Takano H, Asai K, Yasutake M, Amano Y, Kumita S, Shimizu W, Mizuno K.
  • Journal Title: J Card Fail. Volume: 19 Pages: 445-453
  • Peer Reviewed
• [Presentation] Noninvasive Assessment of Inflammatory Response after Coronary Stenting by 18F-Fluorodeoxyglucose Positron Emission Tomography (2016)
  • Author(s): 高野仁司
  • Organizer: 日本循環器学会シンポジウム
  • Place of Presentation: 東北大学百周年記念会館
  • Year and Date: 2016-03-18
• [Presentation] Clinical implication of myocardial glucose metabolism in patients with hypertrophic cardiomyopathy assessed by 18F-FDG-PET (2015)
  • Author(s): Rie Aoyama, Hitoshi Takano,Yasuhiro Kobayashi, Mitsunobu Kitamura, Shinichirou Kumita, Wataru Shimizu
  • Organizer: 日本循環器学会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24 – 2015-04-26
• [Presentation] Coronary Plaque Characteristics in Patients Impaired Glucose Tolerance -A Multiple Vessel Optical Coherence Tomography study- (2015)
  • Author(s): Keishi Suzuki, Yoshiaki Kubota, Daigo Chinen, Yuuki Nakamura, Hideto Sangen, Keisuke Inui, Rie Aoyama, Shunichi Nakamura, Koji Murai, Koji Katoh, Gen Takagi, Hitoshi Takano, Kuniya Asai, Wataru Shimizu:1
  • Organizer: 日本循環器学会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24 – 2015-04-26
• [Presentation] Cost-effectiveness Analysis of Percutaneous Coronary Intervention in Patients Complicated with Atrial Fibrillation (2015)
  • Author(s): Hitoshi Takano, Shunichi Nakamura, Isamu Fukuizumi, Koji Kato, Takeshi Yamamoto, Wataru Shimizu.
  • Organizer: 日本循環器学会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24 – 2015-04-26
• [Presentation] 非冠動脈疾患のPET/CTによる病態生理の検討 (2014)
  • Author(s): 高野仁司
  • Organizer: 日本循環器学会
  • Place of Presentation: 東京
  • Invited