| Project/Area Number |
25461078
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ISHIZAKA Nobukazu 大阪医科大学, 医学部, 教授 (20270879)
TERASAKI Fumio 大阪医科大学, 医学部, 教授 (20236988)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 心臓MRI / T2* / 鉄代謝 / 心機能 / 心筋症 / 心臓ＭＲＩ / Ｔ２ star / 鉄 |
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| Outline of Final Research Achievements |
We investigated the possible association between cardiac function and iron content in the heart and liver, estimated non-invasively by T2 star (T2*)-weighted magnetic resonance imaging. In total 218 patients were enrolled. Among those patients, 48 patients with dilated cardiomyopathy (DCM), 16 patients with hypertrophic cardiomyopathy (HCM), 7 patients with cardiac sarcoidosis and 18 patients without apparent cardiovascular abnormalities. Cardiac T2* values were lower in the DCM group and cardiac sarcoidosis group than in the HCM and control groups, although hepatic T2* values did not differ significantly across the groups. Among the whole population, the highest cardiac T2* tertile was significantly negatively associated with a low left ventricular ejection fraction of <50 %. The possibility that cardiac iron overload may have a role in reducing the systolic cardiac function in DCM patients who do not have systemic iron overload requires further investigation in the future.
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