| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
A total of 1,118 hypertensive patients without previous paroxysmal atrial fibrillation (AF) or structural heart disease were enrolled and followed up. By multivariate Cox regression analysis, age, smoking, and the presence of chronic kidney disease (CKD) were significantly related to the occurrence of AF. When the effects of antihypertensive agents and statin on the occurrence of AF were evaluated after adjustment for various confounding factors by multivariate Cox regression analysis, the use of renin-angiotensin system (RAS) inhibitors was independently associated with a decreased risk of AF. Our findings demonstrate that the complication of CKD is a powerful predictor of new-onset AF and that treatment with RAS inhibitors may have a beneficial effect on the primary prevention of AF in hypertensive patients.
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