Renal Sympathetic Denervation in Heart Failure

• Project/Area Number: 25461080
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Fukuoka University
• Principal Investigator: Ogawa Masahiro 福岡大学, 医学部, 准教授 (70341485)
• Co-Investigator(Kenkyū-buntansha): SAKU Keijiro 福岡大学, 医学部, 教授 (40183371)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 心不全 / 不整脈 / 交感神経除神経 / カテーテルアブレーション

Outline of Final Research Achievements

We examined the physiological responses by electrical stimulation from intra- renal arteries,the histopathological distribution of peri-renal arterial nerves and effects of renal denervation in canines with heart failure. Significant physiological responses by electrical stimulation were observed in many points of intra-renal arteries. Most peri-renal arterial nerve bundles were positive stein of tyrosine hydroxylase and coexisted with positive stein of CRGP as sensory nerves. Irrigated catheter ablation in intra-renal artery effectively ablated peri-renal nerves and can be expected beneficial effects in heart failure.