Clinical differential diagnosis between syncope and epilepsy
Project/Area Number |
25461081
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cardiovascular medicine
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Research Institution | University of Occupational and Environmental Health, Japan |
Principal Investigator |
ABE Haruhiko 産業医科大学, 医学部, 教授 (70231967)
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Co-Investigator(Kenkyū-buntansha) |
河野 律子 産業医科大学, 医学部, 講師 (20449945)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 失神 / てんかん / 心電図 / 感別診断 / QT dispersion / J波 / 早期再分極 / けいれん発作 / けいれん / 一過性意識消失発作 / 意識消失発作 |
Outline of Final Research Achievements |
Objectives: To determine the clinical differential diagnosis between cardiogenic syncope and epilepsy, electrocardiographic (ECG) findings and clinical findings were analyzed. Methods: Magnitude of QT dispersion, J-point elevation and ST segment morphology after ER was assessed in 320 patients (30 ± 13 years; 54% men) with intractable epilepsy, 100 syncope patients, and 150 age- and sex-matched controls. Results: The magnitude of QTc dispersion was greater in epilepsy patients). In addition, ER prevalence (>0.1 mV and >0.2 mV J-point elevation) was greater in inferior ECG leads in epilepsy patients. Finally, among epilepsy patients with ER who achieved remission with antiepileptic therapy, both magnitude of QTc dispersions and J-point elevations were reduced (p=0.01, p=0.02, respectively vs. pre-treatment). Conclusions: Presence of automatism, ECG findings are useful marker for the differential diagnosis between cardiogenic syncope and epilepsy.
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Report
(4 results)
Research Products
(109 results)
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[Journal Article] Japan implantable devices in coronary artery disease (JID-CAD): study design2015
Author(s)
Shimizu A, Mitsuhashi T, Nitta T, Mitamura H, Kurita T, Abe H, Nakazato Y, Sumitomo N, Kadota K, Kimura K, Okumura K:
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Journal Title
Journal of Arrhythmia
Volume: 31
Pages: 631-635
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Genotype-dependent differences in age of manifestation and arrhythmia complications observed in short QT syndrome.2015
Author(s)
Harrell DT, Ashihara T, Ishikawa T, Tominaga I, Mazzanti A, Komiya N, Takahashi K, Oginosawa Y, Abe H, Maemura K, Sumitomo N, Uno K, Takano M, Priori AG, Makita N:
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Journal Title
Int J Cardiol
Volume: 190
Pages: 393-402
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[Journal Article] Syncope Unit: rationale and requirement-the European Heart Rhythm Association position statement endorsed by Heart Rhythm Society.2015
Author(s)
Kenny RA, Brignole M, Dan GA, Deharo JC, van Dijk JG, Doherty C, Hamdam M, Moya A, Parry SW, Sutton R, Ungar A, Wieling W, Asgari M, Baron-Esquivias G, Blanc JJ,Casagranda I, Cunnigham C, Fedorowski A, Furlan R, Gall N, De Lange FJ, Mcmahon G, Mitro P, Pietrucha A, Podoleanu C, Rabiele A, Abe H, Savelieva I:
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Journal Title
Europace
Volume: 17(9)
Pages: 1325-40
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[Journal Article] Coronary plaque progression of non-culprit lesions after culprit percutaneous coronary intervention in patients with moderate to advanced chronic kidney disease: intravascular ultrasound and integrated backscatter intravascular ultrasound study.2015
Author(s)
Kashiyama K, Sonoda S, Muraoka Y, Suzuki Y, Kamezaki F, Tsuda Y, Araki M, TamuraM, Takeuchi M, Abe H, Okazaki M, Fujino Y, Otsuji Y:
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Journal Title
Int J Cardiovasc Imaging
Volume: 印刷中
Related Report
Peer Reviewed / Open Access
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[Journal Article] A Novel <i>UMOD</i> Gene Mutation Associated with Uromodulin-associated Kidney Disease in a Young Woman with Moderate Kidney Dysfunction2015
Author(s)
Kuma A, Tamura M, Ishimatsu N, Miyamoto T, Serino R, Ishimori S, Morisada N, IijimaK, Takeuchi M, Abe H, Otsuji Y:
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Journal Title
Internal Medicine
Volume: 54
Issue: 6
Pages: 631-635
DOI
NAID
ISSN
0918-2918, 1349-7235
Related Report
Peer Reviewed / Open Access
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[Journal Article] Laminopathy and sodium channelopathy underlying early onset and male predominant subset of familial sick sinus syndrome.2014
Author(s)
Abe K, Okamura T, Sumitomo N, Yamamoto H, Ohkubo K, Watanabe I, Makiyama T, Fukae S, Kohno M, Harrell DT, Ishikawa T, Tsuji Y, Nogami A, Watabe T, Oginosawa Y, Abe H, Maemura K, Motomura H, Makita N:
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Journal Title
Circulation Arrhythm Electrophysiol
Volume: 7 (3)
Pages: 511-517
Related Report
Peer Reviewed / Open Access
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[Journal Article] Can the combination of E/A<0.75 and deceleration time>140 ms with E/ε’>10 define a distinct entity regarding diastolic dysfunction grade?2014
Author(s)
Kuwaki H, Takeuchi M, Wu VC, Otani K, Nagata Y, Hayashi A, Iwataki M, Fukuda S, Yoshitani H, Abe H, Otsuji Y:
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Journal Title
JACC Imaging
Volume: 7 (8)
Pages: 749-758
Related Report
Peer Reviewed / Open Access
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[Journal Article] Plasma levels of nitric oxide metabolites are markedly reduced in normotensive men with electrocardiographically determined left ventricular hypertrophy2014
Author(s)
Kamezaki F, Tsutsui M, Takahashi M, Sonoda S, Kubo T, Fujino Y, Adachi T, Abe H, Takeuchi M, Mayumi T, Otsuji Y
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Journal Title
Hypertension
Volume: 64
Issue: 3
Pages: 516-522
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Appropriate Duration of Driving Restrictions after Inappropriate Therapy from Implantable Cardiac Shock Devices: Data from the Interim Analysis of the Nippon Storm Study2014
Author(s)
Noda T, Kurita T, Nitta T, Abe H, Watanabe S, Furushima H, Matsumoto N, Toyoshima T,Shimizu A, Mitamura H, Ohe T, Aizawa Y
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Journal Title
Circ J
Volume: 78 (8)
Pages: 1989-1991
Related Report
Peer Reviewed / Open Access
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[Journal Article] Prognostic value of LA volumes assessed by transthoracic 3D echocardiography: comparison with 2D echocardiography.2013
Author(s)
Wu VC, Takeuchi M, Kuwaki H, Iwataki M, Nagata Y, Otani K, Haruki N, Yoshitani H, Tamura M, Abe H, Negishi K, Lin FC, Otsuji Y
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Journal Title
JACC Cardiovasc Imaging
Volume: 10
Pages: 1025-35
Related Report
Peer Reviewed
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[Journal Article] Immediate amelioration of mechanical pulsus alterations by adaptive servo-ventilation therapy.2013
Author(s)
88. Haruki N, Takeuchi M, Yoshitani H, Otani K, Kuwaki H, Iwataki M, Abe H, Tamura M, Okazaki M, Otsuji Y
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Journal Title
Heart, Lung and Circulation
Volume: 22
Pages: 300-2
Related Report
Peer Reviewed
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[Journal Article] Ethnic differences in atrial fibrillation identified using implantable cardiac devices.2013
Author(s)
Lau CP, Gbadebo TD, Connolly SJ, Van Gelder IC, Capucci A, Gold MR, Israel CW, Morillo CA, Siu CW, Abe H, Carlson MD, Tse HF, Hohnloser SH, Healey JS, for the ASSERT investigators
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Journal Title
J Cardiovasc Electrophysiol
Volume: 24
Pages: 381-387
Related Report
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[Journal Article] Prospective randomized study to assess the efficacy of site and rate of atrial pacing on long-term progression of atrial fibrillation in sick sinus syndrome –septal pacing for atrial fibrillation suppression evaluation (SAFE) study.2013
Author(s)
Lau CP, Tachapong N, Wang CC, Wang JF, Abe H, Kong CW, Liew R, Shin DG, Padeletti L, Kim YH, Omar R, Jirarojanakorn K, Kim YN, Chen MC, Sritanasathavorn C, Munawar M, Kam R, Chen JY, Cho YK, Li YG, Wu SL, Bailleul C, Tse HF, for the SAFE study group
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Journal Title
Circulation
Volume: 128
Pages: 687-93
Related Report
Peer Reviewed
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[Presentation] Meta-analysis of short QT syndrome discloses genotype-dependent clinical characteristics in age of manifestation and arrhythmia complication.2015
Author(s)
Harrell DT, Ashihara T, Ishikawa T, Mazzanti A, Takahashi K, Oginosawa Y, Abe H, Maemura K, Sumitomo N, Uno K, Takano M, Priori SG, Makita N:
Organizer
The 30th Annual Meeting of the JHRS/ the 32th Annual Scientific Meeting of the JSE.
Place of Presentation
国立京都国際会館他(京都府京都市)
Year and Date
2015-07-28
Related Report
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[Presentation] 不整脈のデバイス療法2014
Author(s)
安部治彦
Organizer
第24回日本病態生理学会、シンポジウム1
Place of Presentation
北九州国際会議場(福岡県北九州市)
Year and Date
2014-08-09 – 2014-08-10
Related Report
Invited
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[Presentation] Outcomes of single- or dual-lead ICD system in Japanese patients: experience of 2 university hospitals in Japan.2014
Author(s)
Ueda A, Oginosawa Y, Soejima K, Abe H, Momose Y, Kohno R, Ohe H, Nagaoka M, Matsushita N, Hoshida K, Higuchi S, Miwa Y, Miyakoshi M, Sato T, Yoshino H:
Organizer
第29回日本不整脈学会/第31回日本心電学会合同学術大会
Place of Presentation
ザ・プリンズパークタワー東京、東京プリンスホテル(東京都港区)
Year and Date
2014-07-22 – 2014-07-25
Related Report
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[Presentation] The spectrum of most frequent mutation on short QT syndrome.2014
Author(s)
Hu D, Zhang J, Li Y, Gollob M, Healey J, Harrell DT, Makita N, Abe H, Sun Y, Ahang L, Yan G, Mah D, Walsh E, Leopold H, Giustetto C, Gaita F, Barajas-Martinez H, Antzelevitch C:
Organizer
Heart Rhythm 2014
Place of Presentation
San Francisco, USA
Year and Date
2014-05-07 – 2014-05-10
Related Report
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[Presentation] Kohno R, Abe H, Akamatsu N, Oginosawa Y, Hayashi K, Ohe H, Watabe T, Otsuji Y2014
Author(s)
Kohno R, Abe H, Akamatsu N, Oginosawa Y, Hayashi K, Ohe H, Watabe T, Otsuji Y
Organizer
78th Annual Scientific Meeting of the Japanese Circulation Society
Place of Presentation
Tokyo
Related Report
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[Presentation] 電磁干渉2013
Author(s)
安部治彦
Organizer
日本臨床工学技師会、不整脈治療・応用編講習会
Place of Presentation
東京
Related Report
Invited
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