| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Ghrelin is a food intake promotion peptide that was discovered in the stomach by the group of Kenji kangawa (Director General, National Cerebral and Cardiovascular Center Research Institute). We previously reported that ghrelin administration improves pathogenesis of myocardial infarction model. In the present study, we found that endogenous ghrelin improves pathogenesis of myocardial infarction and cardiac hypertrophy model, ghrelin protect the heart from remodeling after myocardial infarction and cardiac hypertrophy by inhibiting sympathetic nervous activity and activating parasympathetic nervous activity, and also ghrelin receptor agonist; hexarelin improves pathogenesis of myocardial infarction model. These findings suggest that not only ghrelin but also hexarelin can be a therapeutic agent of cardiac diseases.
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