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Vascular endothelial function, its associated factors and hypertensive organ damage in general cohort study

Research Project

Project/Area Number 25461083
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionTohoku University

Principal Investigator

KIKUYA Masahiro  東北大学, 東北メディカル・メガバンク機構, 准教授 (80361111)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2013: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Keywords血管内皮機能 / 動脈硬化 / AI / PWV / 血圧
Outline of Final Research Achievements

We measured brachial-ankle pulse wave velocity (baPWV) and augmentation index (AI) in 232 subjects aged 61.9 years (90 men and 142 women) from a general population in FY2013 and FY2014. After adjustment applied for age, sex, systolic blood pressure, carotid intima-media thickness, carotid plaque, and anti-hypertensive drug, baPWV was significantly associated with AI (beta=-0.23922, P=0.001). Then we participated in Babies and their parents’ longitudinal Observation in Suzuki memorial Hospital on Intrauterine period (BOSHI) study, and measured flow mediated dilation (FMD) to estimate vascular endothelial function in 31 women after childbirth aged 38.1±4.7 years in FY2015. Mean and standard deviation of FMD was 8.8±3.5%. FMD was associated with pulse pressure (r= 0.39) and body mass index (r= 0.35), but did not associated with blood pressure, low-density lipoprotein and high-density lipoprotein(r < 0.12)。

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (13 results)

All 2016 2015 2014 2013

All Journal Article (13 results) (of which Peer Reviewed: 13 results,  Acknowledgement Compliant: 4 results,  Open Access: 1 results)

  • [Journal Article] Impaired Higher-Level Functional Capacity as a Predictor of Stroke in Community-Dwelling Older Adults: the Ohasama Study2016

    • Author(s)
      Murakami K, Tsubota-Utsugi M, Satoh M, Asayama K, Inoue R, Ishiguro A, Matsuda A, Kanno A, Yasui D, Murakami T, Metoki H, Kikuya M, Imai Y, Ohkubo T.
    • Journal Title

      Stroke

      Volume: 47 Issue: 2 Pages: 323

    • DOI

      10.1161/strokeaha.115.011131

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Long-Term Stroke Risk Due to Partial White-Coat or Masked Hypertension Based on Home and Ambulatory Blood Pressure Measurements: The Ohasama Study2016

    • Author(s)
      Satoh M, Asayama K, Kikuya M, Inoue R, Metoki H, Hosaka M, Tsubota-Utsugi M, Obara T, Ishiguro A, Murakami K, Matsuda A, Yasui D, Murakami T, Mano N, Imai Y, Ohkubo T.
    • Journal Title

      Hypertension

      Volume: 67 Issue: 1 Pages: 48

    • DOI

      10.1161/hypertensionaha.115.06461

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Maternal clinic and home blood pressure measurements during pregnancy and infant birth weight: The BOSHI study2016

    • Author(s)
      5.Iwama N, Metoki H, Ohkubo T, Ishikuro M, Obara T, Kikuya M, Yagihashi K, Nishigori H, Sugiyama T, Sugawara J, Yaegashi N, Hoshi K, Suzuki M, Kuriyama S, Imai Y; BOSHI Study Group
    • Journal Title

      Hypertens Res.

      Volume: 39 Issue: 3 Pages: 151

    • DOI

      10.1038/hr.2015.108

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between N-terminal pro B-type natriuretic peptide and day-to-day blood pressure and heart rate variability in a general population: The Ohasama study2015

    • Author(s)
      Satoh M, Hosaka M, Asayama K, Kikuya M, Inoue R, Metoki H, Tsubota-Utsugi M, Hara A, Hirose T, Obara T, Totsune K, Hoshi H, Mano N, Node K, Imai Y, Ohkubo T.
    • Journal Title

      Journal of Hypertension

      Volume: 33 Issue: 8 Pages: 1536

    • DOI

      10.1097/hjh.0000000000000570

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Parity as a factor affecting the white-coat effect in pregnant women: The BOSHI study2015

    • Author(s)
      Ishikuro M, Obara T, Metoki H, Ohkubo T, Iwama N, Katagiri M, Nishigori H, Narikawa Y, Yagihashi K, Kikuya M, Yaegashi N, Hoshi K, Suzuki M, Kuriyama S, Imai Y.
    • Journal Title

      Hypertens Res.

      Volume: 38 Issue: 11 Pages: 770

    • DOI

      10.1038/hr.2015.97

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Corrpondence: Differences between clinic and home blood pressuremeasurements during pregnancy2015

    • Author(s)
      Ishikuro M, Obara T, Metoki H, Ohkubo T, Kikuya M, Yaegashi N, Kuriyama S, Imai Y.
    • Journal Title

      J Hypertens.

      Volume: 33 Issue: 7 Pages: 1492

    • DOI

      10.1097/hjh.0000000000000608

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of aldosterone-to-renin ratio with hypertension differs by sodium intake: The ohasama study2015

    • Author(s)
      Satoh M, Kikuya M, Hosaka M, et al.
    • Journal Title

      Am J Hypertens.

      Volume: 28 Issue: 2 Pages: 208

    • DOI

      10.1093/ajh/hpu115

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Day-to-day variability in home blood pressure is associated with cognitive decline: The ohasama study2014

    • Author(s)
      Matsumoto A, Satoh M, Kikuya M, Ohkubo T, Hirano M, Inoue R, Hashimoto T, Hara A, Hirose T, Obara T, Metoki H, Asayama K, Hosokawa A, Totsune K, Hoshi H, Hosokawa T, Sato H, Imai Y.
    • Journal Title

      Hypertension.

      Volume: 63 Issue: 6 Pages: 1333

    • DOI

      10.1161/hypertensionaha.113.01819

    • URL

      https://pure.teikyo.jp/en/publications/0b3128a0-31c2-4226-877c-b6c51f8e7232

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Aldosterone-to-renin ratio and nocturnal blood pressure decline assessed by self-measurement of blood pressure at home: The Ohasama Study2014

    • Author(s)
      Satoh M, Hosaka M, et al.
    • Journal Title

      Clin Exp Hypertens.

      Volume: 36 Issue: 2 Pages: 108

    • DOI

      10.3109/10641963.2014.892121

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Personality traits as predictors of decline in higher-level functional capacity over a 7-year follow-up in older adults: the Ohasama study.2014

    • Author(s)
      Tsubota-Utsugi M, Satoh M, Hosaka M, Inoue R, Asayama K, Hirose T, Metoki H, Kikuya M, Imai Y, Ohkubo T.
    • Journal Title

      Tohoku J Exp Med

      Volume: 234 (3) Pages: 197-207

    • NAID

      130004700366

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Night-time blood pressure is associated with the development of chronic kidney disease in a general population: The Ohasama Study2013

    • Author(s)
      Kanno A, Kikuya M, Asayama K, Satoh M, Inoue R, Hosaka M, et al.
    • Journal Title

      J Hypertens.

      Volume: 31 Issue: 12 Pages: 2410

    • DOI

      10.1097/hjh.0b013e328364dd0f

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Associations between visit-to-visit variability in blood pressure measured in the office and antihypertensive drugs: The J-HOME-Morning Study2013

    • Author(s)
      Taku Obara, Masahiro Kikuya, Yuka Kobayashi, Kazuki Ishikura, Urara Ikeda, Mami Ishikuro, Hirohito Metoki, Nariyasu Mano, Shinichi Kuriyama, Takayoshi Ohkubo, Yutaka Imai, and the J-HOME-Morning Study Group
    • Journal Title

      Clin. Exp. Hypertens

      Volume: 35 Issue: 4 Pages: 285

    • DOI

      10.3109/10641963.2013.780070

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Home blood pressure variability as cardiovascular risk factor in the population of ohasama2013

    • Author(s)
      Asayama K, Kikuya M, Schutte R, Thijs L, Hosaka M, Satoh M, Hara A, Obara T, Inoue R, Metoki H, Hirose T, Ohkubo T, Staessen JA, Imai Y.
    • Journal Title

      Hypertension

      Volume: 61 Issue: 1 Pages: 61

    • DOI

      10.1161/hypertensionaha.111.00138

    • Related Report
      2013 Research-status Report
    • Peer Reviewed

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Published: 2014-07-25   Modified: 2019-07-29  

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