Vascular endothelial function, its associated factors and hypertensive organ damage in general cohort study

• Project/Area Number: 25461083
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Tohoku University
• Principal Investigator: KIKUYA Masahiro 東北大学, 東北メディカル・メガバンク機構, 准教授 (80361111)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2014: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2013: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
• Keywords: 血管内皮機能 / 動脈硬化 / AI / PWV / 血圧

Outline of Final Research Achievements

We measured brachial-ankle pulse wave velocity (baPWV) and augmentation index (AI) in 232 subjects aged 61.9 years (90 men and 142 women) from a general population in FY2013 and FY2014. After adjustment applied for age, sex, systolic blood pressure, carotid intima-media thickness, carotid plaque, and anti-hypertensive drug, baPWV was significantly associated with AI (beta＝－0.23922, P=0.001). Then we participated in Babies and their parents’ longitudinal Observation in Suzuki memorial Hospital on Intrauterine period (BOSHI) study, and measured flow mediated dilation (FMD) to estimate vascular endothelial function in 31 women after childbirth aged 38.1±4.7 years in FY2015. Mean and standard deviation of FMD was 8.8±3.5%. FMD was associated with pulse pressure (r= 0.39) and body mass index (r= 0.35), but did not associated with blood pressure, low-density lipoprotein and high-density lipoprotein（r < 0.12）。

Research Products

• [Journal Article] Impaired Higher-Level Functional Capacity as a Predictor of Stroke in Community-Dwelling Older Adults: The Ohasama Study. (2016)
  • Author(s): Murakami K, Tsubota-Utsugi M, Satoh M, Asayama K, Inoue R, Ishiguro A, Matsuda A, Kanno A, Yasui D, Murakami T, Metoki H, Kikuya M, Imai Y, Ohkubo T.
  • Journal Title: Stroke Volume: 47 Issue: 2 Pages: 323-328
  • DOI: 10.1161/strokeaha.115.011131
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Long-Term Stroke Risk Due to Partial White-Coat or Masked Hypertension Based on Home and Ambulatory Blood Pressure Measurements: The Ohasama Study. (2016)
  • Author(s): Satoh M, Asayama K, Kikuya M, Inoue R, Metoki H, Hosaka M, Tsubota-Utsugi M, Obara T, Ishiguro A, Murakami K, Matsuda A, Yasui D, Murakami T, Mano N, Imai Y, Ohkubo T.
  • Journal Title: Hypertension Volume: 67(1) Issue: 1 Pages: 48-55
  • DOI: 10.1161/hypertensionaha.115.06461
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Maternal clinic and home blood pressure measurements during pregnancy and infant birth weight: the BOSHI study. (2016)
  • Author(s): 5.Iwama N, Metoki H, Ohkubo T, Ishikuro M, Obara T, Kikuya M, Yagihashi K, Nishigori H, Sugiyama T, Sugawara J, Yaegashi N, Hoshi K, Suzuki M, Kuriyama S, Imai Y; BOSHI Study Group
  • Journal Title: Hypertens Res. Volume: 39 Issue: 3 Pages: 151-157
  • DOI: 10.1038/hr.2015.108
  • Peer Reviewed
• [Journal Article] Association between N-terminal pro BNP and day-to-day blood pressure and heart rate variability in a general population: The Ohasama Study. (2015)
  • Author(s): Satoh M, Hosaka M, Asayama K, Kikuya M, Inoue R, Metoki H, Tsubota-Utsugi M, Hara A, Hirose T, Obara T, Totsune K, Hoshi H, Mano N, Node K, Imai Y, Ohkubo T.
  • Journal Title: Journal of Hypertension Volume: - Issue: 8 Pages: 1536-1541
  • DOI: 10.1097/hjh.0000000000000570
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Parity as a factor affecting the white-coat effect in pregnant women: the BOSHI study. (2015)
  • Author(s): Ishikuro M, Obara T, Metoki H, Ohkubo T, Iwama N, Katagiri M, Nishigori H, Narikawa Y, Yagihashi K, Kikuya M, Yaegashi N, Hoshi K, Suzuki M, Kuriyama S, Imai Y.
  • Journal Title: Hypertens Res. Volume: 38 Issue: 11 Pages: 770-775
  • DOI: 10.1038/hr.2015.97
  • Peer Reviewed
• [Journal Article] Differences between clinic and home blood pressure measurements during pregnancy. (2015)
  • Author(s): Ishikuro M, Obara T, Metoki H, Ohkubo T, Kikuya M, Yaegashi N, Kuriyama S, Imai Y.
  • Journal Title: J Hypertens. Volume: 33 Issue: 7 Pages: 1492-1493
  • DOI: 10.1097/hjh.0000000000000608
  • Peer Reviewed
• [Journal Article] Association of aldosterone-to-renin ratio with hypertension differs by sodium intake: the Ohasama study. (2015)
  • Author(s): Satoh M, Kikuya M, Hosaka M, et al.
  • Journal Title: Am J Hypertens. Volume: 28 Issue: 2 Pages: 208-215
  • DOI: 10.1093/ajh/hpu115
  • Peer Reviewed / Open Access
• [Journal Article] Day-to-Day Variability in Home Blood Pressure Is Associated With Cognitive Decline : The Ohasama Study. (2014)
  • Author(s): Matsumoto A, Satoh M, Kikuya M, Ohkubo T, Hirano M, Inoue R, Hashimoto T, Hara A, Hirose T, Obara T, Metoki H, Asayama K, Hosokawa A, Totsune K, Hoshi H, Hosokawa T, Sato H, Imai Y.
  • Journal Title: Hypertension. Volume: (印刷中) Issue: 6 Pages: 1333-1338
  • DOI: 10.1161/hypertensionaha.113.01819
  • Peer Reviewed
• [Journal Article] Aldosterone-to-renin ratio and nocturnal blood pressure decline assessed by self-measurement of blood pressure at home : the Ohasama Study (2014)
  • Author(s): Satoh M, Hosaka M, et al.
  • Journal Title: Clin Exp Hypertens. Volume: 36 Issue: 2 Pages: 108-114
  • DOI: 10.3109/10641963.2014.892121
  • Peer Reviewed
• [Journal Article] Personality traits as predictors of decline in higher-level functional capacity over a 7-year follow-up in older adults: the Ohasama study. (2014)
  • Author(s): Tsubota-Utsugi M, Satoh M, Hosaka M, Inoue R, Asayama K, Hirose T, Metoki H, Kikuya M, Imai Y, Ohkubo T.
  • Journal Title: Tohoku J Exp Med Volume: 234 (3) Pages: 197-207
  • NAID: 130004700366
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Night-time blood pressure is associated with the development of chronic kidney disease in a general population : the Ohasama Study. (2013)
  • Author(s): Kanno A, Kikuya M, Asayama K, Satoh M, Inoue R, Hosaka M, et al.
  • Journal Title: J Hypertens. Volume: 31 Issue: 12 Pages: 2410-2417
  • DOI: 10.1097/hjh.0b013e328364dd0f
  • Peer Reviewed
• [Journal Article] Associations between visit-to-visit variability in blood pressure measured in the office and antihypertensive drugs : the J-HOME-Morning Study (2013)
  • Author(s): Taku Obara, Masahiro Kikuya, Yuka Kobayashi, Kazuki Ishikura, Urara Ikeda, Mami Ishikuro, Hirohito Metoki, Nariyasu Mano, Shinichi Kuriyama, Takayoshi Ohkubo, Yutaka Imai, and the J-HOME-Morning Study Group
  • Journal Title: Clin. Exp. Hypertens Volume: 35 Issue: 4 Pages: 285-290
  • DOI: 10.3109/10641963.2013.780070
  • Peer Reviewed
• [Journal Article] Home blood pressure variability as cardiovascular risk factor in the population of Ohasama. (2013)
  • Author(s): Asayama K, Kikuya M, Schutte R, Thijs L, Hosaka M, Satoh M, Hara A, Obara T, Inoue R, Metoki H, Hirose T, Ohkubo T, Staessen JA, Imai Y.
  • Journal Title: Hypertension Volume: 61 Issue: 1 Pages: 61-69
  • DOI: 10.1161/hypertensionaha.111.00138
  • Peer Reviewed