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A comprehensive analysis of high density lipoprotein function

Research Project

Project/Area Number 25461085
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionKobe University

Principal Investigator

HIRATA KEN-ICHI  神戸大学, 医学(系)研究科(研究院), 教授 (20283880)

Co-Investigator(Kenkyū-buntansha) TOH Ryuji  神戸大学, 大学院医学研究科, 特命准教授 (50379418)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords高比重リポ蛋白 / 動脈硬化 / ミエロペルオキシダーゼ / パラオキソナーゼ1 / コレステロール取り込み能 / コレステロール
Outline of Final Research Achievements

Aim: Recent studies suggest that the function of high-density lipoprotein (HDL) modulate and predict the progression of cardiovascular disease in addition to the quantity of HDL. In the present studies, we sought to establish conventional methods to assess functional changes in HDL for clinical use. Results: 1) Myeloperoxidase (MPO) promotes oxidation of lipoproteins, while paraoxonase 1 (PON1) has antioxidant properties for HDL. Serum MPO/PON1 ratio is inversely related with the anti-inflammatory properties and cholesterol efflux capacity of HDL. We demonstrated the clinical utility of serum MPO/PON1 ratio in predicting recurrent coronary lesions after percutaneous coronary intervention (PCI). 2) We established the methods to assess cholesterol uptake capacity of HDL in a sensitive and high-throughput manner without using radioisotope-label and cells. We demonstrated a significant inverse association between requirement of revascularization after PCI and cholesterol uptake capacity.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (26 results)

All 2016 2015 2014 2013 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 4 results,  Acknowledgement Compliant: 2 results) Presentation (17 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results) Book (3 results)

  • [Journal Article] Serum Trans-Fatty Acid Concentration Is Elevated in Young Patients With Coronary Artery Disease in Japan2015

    • Author(s)
      Mori K, Ishida T, Yasuda T, Hasokawa M, Monguchi T, Sasaki M, Kondo K, Nakajima H, Shinohara M, Shinke T, Irino Y, Toh R, Nishimura K, Hirata K.
    • Journal Title

      Circulation Journal

      Volume: 79 Issue: 9 Pages: 2017-2025

    • DOI

      10.1253/circj.CJ-14-0750

    • NAID

      130005095322

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Administration of high dose eicosapentaenoic acid enhances anti-inflammatory properties of high-density lipoprotein in Japanese patients with dyslipidemia2014

    • Author(s)
      Tanaka N, Ishida T, Nagao M, Mori T, Monguchi T, Sasaki M, Mori K, Kondo K, Nakajima H, Honjo T, Irino Y, Toh R, Shinohara M, Hirata K
    • Journal Title

      Atherosclerosis

      Volume: 237 Issue: 2 Pages: 577-583

    • DOI

      10.1016/j.atherosclerosis.2014.10.011

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Trans-fatty acid promotes thrombus formation in mice by aggravating antithrombogenic endothelial functions via Toll-like receptors.2014

    • Author(s)
      Kondo K, Ishida T, Yasuda T, Nakajima H, Mori K, Tanaka N, Mori T, Monguchi T, Shinohara M, Irino Y, Toh R, Rikitake Y, Kiyomizu K, Tomiyama Y, Yamamoto J, Hirata K.
    • Journal Title

      Molecular Nutrition & Food Research

      Volume: 59 Issue: 4 Pages: 729-740

    • DOI

      10.1002/mnfr.201400537

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Serum myeloperoxidase/paraoxonase 1 ratio as potential indicator of dysfunctional high-density lipoprotein and risk stratification in coronary artery disease.2014

    • Author(s)
      Haraguchi Y1, Toh R2, Hasokawa M1, Nakajima H1, Honjo T1, Otsui K1, Mori K1, Miyamoto-Sasaki M1, Shinohara M1, Nishimura K3, Ishida T1, Hirata KI1
    • Journal Title

      Atherosclerosis

      Volume: 234 Issue: 2 Pages: 288-294

    • DOI

      10.1016/j.atherosclerosis.2014.03.009

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pitavastatin Increases HDL Particles Functionally Preserved with Cholesterol Efflux Capacity and Antioxidative Actions in Dyslipidemic Patients2013

    • Author(s)
      Maki Sasaki-Miyamoto
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 20 Issue: 9 Pages: 708-716

    • DOI

      10.5551/jat.17210

    • NAID

      130004845448

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Vasospasm of Atherosclerotic Coronary Arteries Precipitates Acute Ischemic Myocardial Damage in Myocardial Infarction-Prone Strain of the Watanabe Heritable Hyperlipidemic Rabbits.2013

    • Author(s)
      Shiomi M, Ishida T, Kobayashi T, Nitta N, Sonoda A, Yamada S, Koike T, Kuniyoshi N, Murata K, Hirata KI, Ito T, Libby P.
    • Journal Title

      Arteriosclerosis, Thrombosis, and Vascular Biology

      Volume: 33 Issue: 11 Pages: 2518-2523

    • DOI

      10.1161/atvbaha.113.301303

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Cholesterol Uptake Capacity, a New Measure for High-Density Lipoprotein Functionality And Its Association with Incident Cardiovascular Events2016

    • Author(s)
      Toshihiko Oshita, Tetsuya Hara, Amane Harada, Katsuhiro Murakami, Maria Kiriyama, Keiko Yoshikawa, Keiko Miwa, Yasuhiro Irino, Kenta Mori, Ryuji Toh, Tatsuro Ishida, Ken-ichi Hirata
    • Organizer
      第80回 日本循環器学会 学術集会
    • Place of Presentation
      仙台 日本
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Endothelial Lipase Regulates Plasma HDL-C Concentration without Affecting Cholesterol Uptake Capacity of HDL Particle in Patients with Coronary Artery Disease.2016

    • Author(s)
      Amane Harada, Ryuji Toh, Katsuhiro Murakami, Maria Kiriyama, Keiko Yoshikawa, Takuya Kubo, Keiko Miwa, Yasuhiro Irino, Kenta Mori, Nobuaki Tanaka, Tatsuro Ishida, Ken-ichi Hirata
    • Organizer
      第80回 日本循環器学会 学術集会
    • Place of Presentation
      仙台 日本
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Serum Myeloperoxidase/Paraoxonase 1 Ratio Predicts Recurrent Coronary Artery Disease2015

    • Author(s)
      Tsuda S, Toh R, Mori K, Nagao M, Tanaka N, Mori T, Monguchi T, Nakajima H, Honjo T, Shinohara M, Nishimura K, Ishida T, Hirata K
    • Organizer
      第47回 日本動脈硬化学会総会学術集会
    • Place of Presentation
      仙台 日本
    • Year and Date
      2015-07-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 冠動脈疾患二次予防における予測因子としての血清ミエロペルオキシダーゼ/パラオキソナーゼ1比の有用性についての検討2015

    • Author(s)
      Tsuda S, Toh R, Mori K, Nagao M, Tanaka N, Mori T, Monguchi T, Nakajima H, Honjo T, Shinohara M, Nishimura K, Ishida T, Hirata K
    • Organizer
      第15回日本NO学会
    • Place of Presentation
      大阪 日本
    • Year and Date
      2015-06-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] Serum myeloperoxidase/paraoxonase 1 ration predicts recurrent coronary artery disease2015

    • Author(s)
      Tsuda S, Toh R, Mori K, Nagao M, Tanaka N, Mori T, Monguchi T, Nakajima H, Honjo T, Shinohara M, Nishimura K, Ishida T, Hirata K
    • Organizer
      ATVB PVD 2015 Scientific Sessions
    • Place of Presentation
      サンフランシスコ 米国
    • Year and Date
      2015-05-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Impact of Serum Myeloperoxidase/Paraoxonase 1 Ratio as a Predictive Marker of for Secondary Prevention of Coronary Artery Disease2015

    • Author(s)
      Tsuda S, Toh R, Mori K, Nagao M, Tanaka N, Mori T, Monguchi T, Nakajima H, Honjo T, Shinohara M, Nishimura K, Ishida T, Hirata K
    • Organizer
      第79回 日本循環器学会 学術集会
    • Place of Presentation
      大阪 日本
    • Year and Date
      2015-04-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] Oral administration of eicosapentaenoic acid ameliorates anti-inflammatory functions of high-density lipoprotein in dyslipidemic patients2014

    • Author(s)
      Nobuaki Tanaka, Tatsuro Ishida, Manabu Nagao, Takeshige Mori, Tomoko Monguchi, Maki Sasaki, Kenta Mori, Kensuke Kondo, Hideto Nakajima, Tomoyuki Honjo, Ryuji Toh, Ken-ichi Hirata
    • Organizer
      American Heart Association Scientific Sessions 2014
    • Place of Presentation
      シカゴ アメリカ
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] Eicosapentaenoic acid improves anti-inflammatory functions of high-density lipoprotein in dyslipidemic patients2014

    • Author(s)
      Nobuaki Tanaka, Tatsuro Ishida, Manabu Nagao, Takeshige Mori, Tomoko Monguchi, Maki Sasaki, Kenta Mori, Kensuke Kondo, Hideto Nakajima, Tomoyuki Honjo, Ryuji Toh, Ken-ichi Hirata
    • Organizer
      第46回日本動脈硬化学会総会
    • Place of Presentation
      東京 日本
    • Year and Date
      2014-07-10 – 2014-07-11
    • Related Report
      2014 Research-status Report
  • [Presentation] 高比重リポ蛋白による心筋細胞保護作用の検討2014

    • Author(s)
      中島英人、石田達郎、平田健一
    • Organizer
      第46回日本動脈硬化学会総会
    • Place of Presentation
      東京 日本
    • Year and Date
      2014-07-10 – 2014-07-11
    • Related Report
      2014 Research-status Report
  • [Presentation] Impact of endothelial lipase on the low HDL-cholesterol level under inflammatory conditions2014

    • Author(s)
      Tatsuro Ishida, Ken-ichi Hirata
    • Organizer
      第46回日本動脈硬化学会総会
    • Place of Presentation
      東京 日本
    • Year and Date
      2014-07-10 – 2014-07-11
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Inflammation-Activated Angptl3-Endothelial Lipase System Regulates Serum HDL-C Levels in Acute Coronary Syndrome2014

    • Author(s)
      Kenta Mori, Tatsuro Ishida, Kazuya miyashita, Noriaki Kinoshita, Hideto Nakajima, Tomoyuki Yasuda, Ryuji Toh, Masahito Kawata, Susumu Sakamoto, Katsuyuki Nakajima, Ken-ichi Hirata.
    • Organizer
      第46回日本動脈硬化学会総会
    • Place of Presentation
      東京 日本
    • Year and Date
      2014-07-10 – 2014-07-11
    • Related Report
      2014 Research-status Report
  • [Presentation] 機能不全HDLの簡便な臨床評価法としての血清MPO/PON1比測定の有用性2014

    • Author(s)
      杜 隆嗣、石田 達郎、西村 邦宏、平田 健一
    • Organizer
      第111回 日本内科学会総会
    • Place of Presentation
      東京 日本
    • Year and Date
      2014-04-11 – 2014-04-13
    • Related Report
      2014 Research-status Report
  • [Presentation] Role of endothelial lipase in high-density lipoprotein (HDL) metabolism in humans.2013

    • Author(s)
      Tatsuro Ishida
    • Organizer
      The 81st Congress of the European Atherosclerosis Society
    • Place of Presentation
      Lyon, France
    • Related Report
      2013 Research-status Report
  • [Presentation] Increases of Serum Mass of Endothelial Lipase Impact Plasma High-Density Lipoprotein-Cholesterol Concentrations in Acute Myocardial Infarction.2013

    • Author(s)
      Kenta Mori
    • Organizer
      The 81st Congress of the European Atherosclerosis Society
    • Place of Presentation
      Lyon, France
    • Related Report
      2013 Research-status Report
  • [Presentation] Impact of oral eicosapentaenoic acid therapy on High-Density Lipoprotein function in patients with high risk of atherosclerosis.

    • Author(s)
      Nobuaki Tanaka
    • Organizer
      The 78th Annual Scientific Meeting of the Japanese Circulation Society.
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] Effect of cholesteryl ester transfer protein inhibitor on anti-inflammatory properties of high-density lipoproteins.

    • Author(s)
      Kenta Mori
    • Organizer
      The 78th Annual Scientific Meeting of the Japanese Circulation Society.
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] 機能不全HDLマーカーとしての血清MPO/PON1比の有用性

    • Author(s)
      杜 隆嗣
    • Organizer
      第43回日本心脈管作動物質学会総会
    • Place of Presentation
      神戸 日本
    • Related Report
      2013 Research-status Report
  • [Book] HDLコレステロール2014

    • Author(s)
      杜 隆嗣、平田 健一
    • Total Pages
      9
    • Publisher
      血管医学
    • Related Report
      2014 Research-status Report
  • [Book] 脂質代謝、動脈硬化における機能と臨床的意義 血管内皮リパーゼの炎症と血清HDL代謝における役割2013

    • Author(s)
      石田 達郎、平田 健一
    • Total Pages
      10
    • Publisher
      The Lipid
    • Related Report
      2013 Research-status Report
  • [Book] 【脂質異常症-基礎・臨床研究の最新知見-】 脂質異常症による粥状硬化発症進展機序2013

    • Author(s)
      石田 達郎、平田 健一
    • Total Pages
      8
    • Publisher
      日本臨床
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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