| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Aim: Recent studies suggest that the function of high-density lipoprotein （HDL） modulate and predict the progression of cardiovascular disease in addition to the quantity of HDL. In the present studies, we sought to establish conventional methods to assess functional changes in HDL for clinical use. Results: 1) Myeloperoxidase (MPO) promotes oxidation of lipoproteins, while paraoxonase 1 (PON1) has antioxidant properties for HDL. Serum MPO/PON1 ratio is inversely related with the anti-inflammatory properties and cholesterol efflux capacity of HDL. We demonstrated the clinical utility of serum MPO/PON1 ratio in predicting recurrent coronary lesions after percutaneous coronary intervention (PCI). 2) We established the methods to assess cholesterol uptake capacity of HDL in a sensitive and high-throughput manner without using radioisotope-label and cells. We demonstrated a significant inverse association between requirement of revascularization after PCI and cholesterol uptake capacity.
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