Role of impaired mitochondrial function on endothelial dysfunction in cardiovascular diseases

• Project/Area Number: 25461086
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Kumamoto University
• Principal Investigator: Sugiyama Seigo 熊本大学, 生命科学研究部, 非常勤講師 (90274711)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: endothelial function / mitochondria / AMPK / cardiovascular events / heart failure / vascular biology / atherosclerosis / endothelial cell / 血管内皮機能 / ミトコンドリア / 動脈硬化 / 冠動脈疾患 / Polyvascular disease / 心不全 / 老化 / ATP産生 / 酸化ストレス / 心血管イベント

Outline of Final Research Achievements

Mitochondrial dysfunction plays an important role in cellular senescence and impaired function of vascular endothelium, resulted in cardiovascular diseases. AMP-activated protein kinase (AMPK) plays a critical role in mitochondrial biogenesis and endothelial function. In cultured human coronary artery endothelial cells (HCAECs), telmisartan (Telmi) significantly enhanced mitochondrial activity assessed by mitochondrial reductase activity and intracellular ATP production and increased the expression of mitochondria related genes. Telmi prevented cellular senescence and exhibited the anti-apoptotic and pro-angiogenic properties. All of these effects were abolished by inhibition of AMPK. Telmi enhanced mitochondrial activity and exhibited anti-senescence effects and improving endothelial function through AMPK in HCAECs. Telmi could provide beneficial effects on vascular diseases via enhancement of mitochondrial activity and modulating endothelial function through AMPK activation.

Research Products

• [Journal Article] Advanced peripheral microvascular endothelial dysfunction and polyvascular disease in patients with high cardiovascular risk. (2016)
  • Author(s): Maeda H, Sugiyama S, Jinnouchi H, Matsuzawa Y, Fujisue K, Hirata Y, Kurokawa H, Ohba K, Matsubara J, Nozaki T, Konishi M, Akiyama E, Sugamura K, Yamamoto E, Sumida H, Ogawa H.
  • Journal Title: J Cardiol. Volume: 67 Issue: 5 Pages: 455-462
  • DOI: 10.1016/j.jjcc.2015.07.003
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Low-Normal Serum Sodium and Heart Failure-Related Events in Patients With Heart Failure With Preserved Left Ventricular Ejection Fraction (2016)
  • Author(s): Kusaka H, Sugiyama S, Yamamoto E, Akiyama E, Matsuzawa Y, Hirata Y, Fujisue K, Kurokawa H, Matsubara J, Sugamura K, Maeda H, Jinnouchi H, Matsui K, Ogawa H.
  • Journal Title: Circulation Journal Volume: 80 Issue: 2 Pages: 411-417
  • DOI: 10.1253/circj.CJ-15-0878
  • NAID: 130005120919
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Telmisartan enhances mitochondrial activity and alters cellular functions in human coronary artery endothelial cells via AMP-activated protein kinase pathway (2015)
  • Author(s): Kurokawa H, Sugiyama S, Nozaki T, Sugamura K, Toyama K, Matsubara J, Fujisue K, Ohba K, Maeda H, Konishi M, Akiyama E, Sumida H, Izumiya Y, Yasuda O, Kim-Mitsuyama S, Ogawa H
  • Journal Title: Atherosclerosis Volume: 239(2) Issue: 2 Pages: 375-385
  • DOI: 10.1016/j.atherosclerosis.2015.01.037
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Significance of low plasma levels of brain-derived neurotrophic factor in patients with heart failure. (2015)
  • Author(s): Takashio S, Sugiyama S, Yamamuro M, Takahama H, Hayashi T, Sugano Y, Izumiya Y, Hokimoto S, Minamino N, Yasuda S, Anzai T, Ogawa H.
  • Journal Title: Am J Cardiol. Volume: 116 Issue: 2 Pages: 243-249
  • DOI: 10.1016/j.amjcard.2015.04.018
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Prognostic Significance of Peripheral Microvascular Endothelial Dysfunction in Heart Failure With Reduced Left Ventricular Ejection Fraction (2015)
  • Author(s): Fujisue K, Sugiyama S, Matsuzawa Y, Akiyama E, Sugamura K, Matsubara J, Kurokawa H, Maeda H, Hirata Y, Kusaka H, Yamamoto E, Iwashita S, Sumida H, Sakamoto K, Tsujita K, Kaikita K, Hokimoto S, Matsui K, Ogawa H.
  • Journal Title: Circulation Journal Volume: 79 Issue: 12 Pages: 2623-2631
  • DOI: 10.1253/circj.CJ-15-0671
  • NAID: 130005110928
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Reactive hyperemia peripheral arterial tonometry（RH-PAT））検査を臨床診療に活かす (2015)
  • Author(s): 杉山 正悟
  • Journal Title: 循環器内科 Volume: 78 Pages: 246-255
• [Journal Article] Decreased plasma levels of active glucagon-like peptide-1 in coronary artery disease. (2015)
  • Author(s): Akiyama E, Sugiyama S, Matsubara J, Kurokawa H, Konishi M, Nozaki T, Ohba K, Fujisue K, Maeda H, Sakamoto K, Sugamura K, Sumida H, Jinnouchi H, Sakamaki K, Morita S, Kimura K, Umemura S, Ogawa H.
  • Journal Title: J Am Coll Cardiol. Volume: 65 Issue: 7 Pages: 754-755
  • DOI: 10.1016/j.jacc.2014.11.043
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Reactive oxygen metabolites are closely associated with the diagnosis and prognosis of coronary artery disease. (2015)
  • Author(s): Hirata Y, Yamamoto E, Tokitsu T, Kusaka H, Fujisue K, Kurokawa H, Sugamura K, Maeda H, Tsujita K, Kaikita K, Hokimoto S, Sugiyama S, Ogawa H.
  • Journal Title: J Am Heart Assoc. Volume: 4 Issue: 2
  • DOI: 10.1161/jaha.114.001451
  • Peer Reviewed / Open Access
• [Journal Article] Plaque REgression with Cholesterol absorption Inhibitor or Synthesis inhibitor Evaluated by IntraVascular UltraSound (PRECISE-IVUS Trial): Study protocol for a randomized controlled trial. (2015)
  • Author(s): Tsujita K, Sugiyama S, Sumida H, Shimomura H, Yamashita T, Yamanaga K, Komura N, Sakamoto K, Ono T, Oka H, Nakao K, Nakamura S, Ishihara M, Matsui K, Sakaino N, Nakamura N, Yamamoto N, Koide S, Matsumura T, Fujimoto K, Tsunoda R, Morikami Y, Matsuyama K, Oshima S, Kaikita K, Hokimoto S, Ogawa H
  • Journal Title: J Cardiol. Volume: 65 Issue: 4 Pages: 353-358
  • DOI: 10.1016/j.jjcc.2014.12.011
  • Peer Reviewed
• [Journal Article] Reactive oxidative metabolites are associated with the severity of heart failure and predict future cardiovascular events in heart failure with preserved left ventricular ejection fraction. (2015)
  • Author(s): Hirata Y, Yamamoto E, Tokitsu T, Kusaka H, Fujisue K, Kurokawa H, Sugamura K, Maeda H, Tsujita K, Yamamuro M, Kaikita K, Hokimoto S, Sugiyama S, Ogawa H.
  • Journal Title: Int J Cardiol. Volume: 179 Pages: 305-308
  • DOI: 10.1016/j.ijcard.2014.11.018
  • Peer Reviewed
• [Journal Article] Effect of a hydrophilic and a hydrophobic statin on cardiac salvage after ST-elevated acute myocardial infarction - a pilot study. (2014)
  • Author(s): Chitose T, Sugiyama S, Sakamoto K, Shimomura H, Yamashita T, Hokamaki J, Tsunoda R, Shiraishi S, Yamashita Y, Ogawa H.
  • Journal Title: Atherosclerosis Volume: 237 Issue: 1 Pages: 251-258
  • DOI: 10.1016/j.atherosclerosis.2014.08.053
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Differences between rosuvastatin and atorvastatin in lipid-lowering action and effect on glucose metabolism in Japanese hypercholesterolemic patients with concurrent diabetes. Lipid-lowering with highly potent statins in hyperlipidemia with type 2 diabetes patients (LISTEN) study. (2014)
  • Author(s): Ogawa H, Matsui K, Saito Y, Sugiyama S, Jinnouchi H, Sugawara M, Masuda I, Mori H, Waki M, Yoshiyama M, Watada H.
  • Journal Title: Circ J Volume: 78 Pages: 2512-2515
  • NAID: 130004687291
  • Peer Reviewed / Open Access
• [Journal Article] Incremental prognostic significance of the elevated levels of pentraxin 3 in patients with heart failure with normal left ventricular ejection fraction. (2014)
  • Author(s): Matsubara J, Sugiyama S, Nozaki T, Akiyama E, Matsuzawa Y, Kurokawa H, Maeda H, Fujisue K, Sugamura K, Yamamoto E, Matsui K, Jinnouchi H, Ogawa H.
  • Journal Title: J Am Heart Assoc. Volume: 3 Issue: 4
  • DOI: 10.1161/jaha.114.000928
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Clinical Features and Prognosis of Patients With Coronary Spasm Induced Non ST Segment Elevation Acute Coronary Syndrome. (2014)
  • Author(s): Nakayama N, Kaikita K, Fukunaga T, Matsuzawa Y, Sato K, Horio E, Yoshimura H, Mizobe M, Takashio S, Tsujita K, Kojima S, Tayama S, Hokimoto S, Sakamoto T, Nakao K, Sugiyama S, Kimura K, Ogawa H.
  • Journal Title: Journal of the American Heart Association Volume: 3 Issue: 3
  • DOI: 10.1161/jaha.114.000795
  • Peer Reviewed / Open Access
• [Journal Article] Utility of noninvasive endothelial function test for prediction of deep vein thrombosis after total hip or knee arthroplasty. (2014)
  • Author(s): Suzuki H, Matsuzawa Y, Konishi M, Akiyama E, Takano K, Nakayama N, Kataoka S, Ebina T, Kosuge M, Hibi K, Tsukahara K, Iwahashi N, Endo M, Maejima N, Shinohara K, Taki N, Mitsugi N, Taguri M, Sugiyama S, Ogawa H, Umemura S, Kimura K.
  • Journal Title: Circ J Volume: 78 Pages: 1723-1732
  • NAID: 130003391143
  • Peer Reviewed / Open Access
• [Journal Article] Endothelial function and cardiovascular events in chronic kidney disease. (2014)
  • Author(s): Hirata Y, Sugiyama S, Yamamoto E, Matsuzawa Y, Akiyama E, Kusaka H, Fujisue K, Kurokawa H, Matsubara J, Sugamura K, Maeda H, Iwashita S, Jinnouchi H, Matsui K, Ogawa H.
  • Journal Title: Int J Cardiol. Volume: 173(3) Issue: 3 Pages: 481-486
  • DOI: 10.1016/j.ijcard.2014.03.085
  • Peer Reviewed
• [Journal Article] Correlation between extent of myocardial fibrosis assessed by cardiac magnetic resonance and cardiac troponin T release in patients with nonischemic heart failure. (2014)
  • Author(s): Takashio S, Yamamuro M, Uemura T, Utsunomiya D, Morita K, Izumiya Y, Sugiyama S, Kojima S, Yamamoto E, Tsujita K, Tanaka T, Tayama S, Kaikita K, Hokimoto S, Yasuda O, Yamashita Y, Ogawa H.
  • Journal Title: American Journal of Cardiology Volume: 113 Issue: 10 Pages: 1697-1704
  • DOI: 10.1016/j.amjcard.2014.02.029
  • Peer Reviewed / Open Access
• [Journal Article] Statins combined with exercise are associated with the increased renal function mediated by high-molecular-weight adiponectin in coronary artery disease patients. (2014)
  • Author(s): Toyama K, Sugiyama S, Oka H, Iwasaki Y, Sumida H, Tanaka T, Tayama S, Jinnouchi H, Ogawa H.
  • Journal Title: J Cardiol. Volume: S0914-5087 Issue: 2 Pages: 91-97
  • DOI: 10.1016/j.jjcc.2013.11.018
  • Peer Reviewed
• [Journal Article] Reactive hyperemia peripheral arterial tonometry (RH-PAT)による血管内皮機能 (2014)
  • Author(s): 杉山正悟
  • Journal Title: 心臓 Volume: 46 Pages: 1330-1335
• [Journal Article] Insulin supersensitivity and normoinsulinaemic hypoglycaemia in uncontrolled type 2 diabetes mellitus: clinical usefulness of 3 h assessment in the 75 g oral glucose tolerance test. (2014)
  • Author(s): Sugiyama S, Jinnouchi H, Hieshima K, Jinnouchi T.
  • Journal Title: BMJ Case Rep. Volume: 8 Pages: bcr2013201908-bcr2013201908
  • DOI: 10.1136/bcr-2013-201908
  • Peer Reviewed
• [Journal Article] Peripheral endothelial function and cardiovascular events in high-risk patients. (2013)
  • Author(s): Matsuzawa Y, Sugiyama S, Sumida H, Sugamura K, Nozaki T, Ohba K, Matsubara J, Kurokawa H, Fujisue K, Konishi M, Akiyama E, Suzuki H, Nagayoshi Y, Yamamuro M, Sakamoto K, Iwashita S, Jinnouchi H, Taguri M, Morita S, Matsui K, Kimura K, Umemura S, Ogawa H.
  • Journal Title: J Am Heart Assoc Volume: 2 Issue: 6
  • DOI: 10.1161/jaha.113.000426
  • Peer Reviewed
• [Journal Article] Successful Diet and Exercise Therapy as Evaluated on Self-Assessment Score Significantly Improves Endothelial Function in Metabolic Syndrome Patients (2013)
  • Author(s): Matsuzawa Y, Sugiyama S, Sugamura K, Sumida H, Kurokawa H, Fujisue K, Konishi M, Akiyama E, Suzuki H, Nakayama N, Yamamuro M, Iwashita S, Jinnouchi H, Kimura K, Umemura S, Ogawa H.
  • Journal Title: Circulation Journal Volume: 77 Issue: 11 Pages: 2807-2815
  • DOI: 10.1253/circj.CJ-13-0549
  • NAID: 10031196835
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] Effects of Endothelial Dysfunction on Residual Platelet Aggregability After Dual Antiplatelet Therapy With Aspirin and Clopidogrel in Patients With Stable Coronary Artery Disease (2013)
  • Author(s): K. Fujisue, S. Sugiyama, (他14名)
  • Journal Title: Circ. Cardiovasc. Interv. Volume: 6 Issue: 4 Pages: 452-459
  • DOI: 10.1161/circinterventions.112.000278
  • Peer Reviewed
• [Journal Article] 血管内皮機能検査 -FMDとRH-PAT検査は共存できるか- (2013)
  • Author(s): 杉山正悟、菅村公一、松原純一、松澤泰志、秋山英一
  • Journal Title: Heart View； 特集：循環器医に必要な血管機能検査 Volume: 6 Pages: 39-46
• [Presentation] Dual Lipid-Lowering with Ezetimibe/Statin as a Promising Anti-Atherosclerotic Strategy (2016)
  • Author(s): Tsujita K, Sugiyama S, Shimomura H, Yamanaga K, Tsunoda R, Morikami Y, Matsuyama K, Ohshima S, Oka H, Nakao K, Nakamura S, Ishihara M, Matsui K, Sakaino N, Yamamoto N, Nakamura N, Koide S, Fujimoto K, Kaikita K, Hokimoto S, Ogawa H.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 宮城県仙台市
  • Year and Date: 2016-03-18
• [Presentation] Colchicine Improved Survival, Left Ventricular Remodeling, and Chronic Cardiac Function after Acute Myocardial Infarction (2016)
  • Author(s): Fujisue K, Sugiyama S, Sugamura K, Kurokawa H, Matsubara J, Kaikita K, Ogawa H.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 宮城県仙台市
  • Year and Date: 2016-03-18
• [Presentation] The Clinical Significance and Novel Mechanism of Reactive Oxygen Species (ROS) in Heart Failure with Preserved Ejection Fraction (HFpEF) (2016)
  • Author(s): Hirata Y, Yamamoto E, Tokitsu T, Fujisue K, Sugamura K, Sakamoto K, Tsujita K, Kaikita K, Hokimoto S, Sugiyama S, Ogawa H.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 宮城県仙台市
  • Year and Date: 2016-03-18
• [Presentation] Risk Stratification of Heart Failure (HF) with Preserved Ejection Fraction (HFpEF) Patients by Using Ankle-Brachial Index (ABI) Devices (2016)
  • Author(s): Tokitsu T, Yamamoto E, Hirata Y, Kusaka H, Fujisue K, Sugamura K, Yamamuro M, Kaikita K, Hokimoto S, Sugiyama S, Ogawa H.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 宮城県仙台市
  • Year and Date: 2016-03-18
• [Presentation] Clinical Significance of Pulse Pressure (PP) in Patients with Heart Failure (HF) with Preserved Left Ventricular (LV) Ejection Fraction (HFpEF) (2016)
  • Author(s): Tokitsu T, Yamamoto E, Hirata Y, Fujisue K, Kusaka H, Sugamura K, Yamamuro M, Kaikita K, Hokimoto S, Sugiyama S, Ogawa H.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 宮城県仙台市
  • Year and Date: 2016-03-18
• [Presentation] Impact of Statin-Ezetimibe Combination on Coronary Atheroma Progression/Regression in Patients with and without Statin Pretreatment― Subanalysis of PRECISE-IVUS Trial ― (2016)
  • Author(s): Tsujita K, Yamanaga K, Sugiyama S, Shimomura H, Yamashita T, Sakamoto K, Nakao K, Nakamura S, Ishihara M, Matsui K, Yamamoto N, Koide S, Matsumura T, Fujimoto K, Tsunoda R, Morikami Y, Matsuyama K, Ohshima S, Kaikita K, Hokimoto S, Ogawa H.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 宮城県仙台市
  • Year and Date: 2016-03-18
• [Presentation] The Usefulness of Digital Assessment of Peripheral Vascular Endothelial Function for the Risk Stratification in Patients with Essential Hypertension (HT) (2016)
  • Author(s): Yamamoto E, Sugiyama S, Matsuzawa Y, Hirata Y, Tokistu T, Fujisue K, Akiyama E, Sugamura K, Maeda H, Ogawa H.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 宮城県仙台市
  • Year and Date: 2016-03-18
• [Presentation] The Comparison of Statin Monotherapy and Statin-Ezetimibe Combined Therapy to Reduce LDL-C under 70mg/dl in Patients with Coronary Artery Disease (2016)
  • Author(s): Yamanaga K, Tsujita K, Sugiyama S, Sumida H, Shimomura H, Komura N, Sakamoto K, Nakao K, Nakamura S, Ishihara M, Matsui K, Nakamura N, Yamamoto N, Koide S, Tsunoda R, Morikami Y, Matsuyama K, Ohshima S, Kaikita K, Hokimoto S, Ogawa H.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 宮城県仙台市
  • Year and Date: 2016-03-18
• [Presentation] Predictive Value of Endothelial Function for the Recurrence of Atrial Fibrillation after Catheter Ablation (2016)
  • Author(s): Kanazawa H, Yamabe H, Sugiyama S, Iwashita S, Ito M, Kaneko S, Ogawa H.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 宮城県仙台市
  • Year and Date: 2016-03-18
• [Presentation] Primary Prevention for Silent Myocardial Infarction and Acute Myocardial Infarction in Diabetic Patients (2016)
  • Author(s): Soejima H, Morimoto T, Okada S, Nakayama M, Sakuma M, Uemura S, Kanauchi M, Doi N, Jinnouchi H, Sugiyama S, Waki M, Saito Y, Ogawa H.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 宮城県仙台市
  • Year and Date: 2016-03-18
• [Presentation] Association between Circulating Leukocyte Subtype Counts and Peripheral Endothelial Dysfunction (ED) in Patients with Coronary Artery Disease (CAD) (2016)
  • Author(s): Yamamoto E, Hirata Y, Tokitsu T, Fujisue K, Sugamura K, Tsujita K, Hokimoto S, Sugiyama S, Ogawa H.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 宮城県仙台市
  • Year and Date: 2016-03-18
• [Presentation] Peripheral Microvascular Endothelial Dysfunction Improves Risk Determination of Seattle Heart Failure Model in Heart Failure with Reduced Left Ventricular Ejection Fraction (2015)
  • Author(s): Fujisue K, Sugiyama S, Akiyama E, Matsuzawa Y, Sugamura K, Matsubara J, Kurokawa H, Maeda H, Hirata Y, Kusaka H, Yamamoto E, Iwashita S, Sumida H, Tsujita K, Sakamoto K, Kaikita K, Hokimoto S, Matsui K, Ogawa H.
  • Organizer: American Heart Association Scientific Session
  • Place of Presentation: Orlando, Florida, USA
  • Year and Date: 2015-11-07
• [Presentation] The Impact of Statin-Ezetimibe Combination Therapy in Patients With Decreased Cholesterol Absorption Ability (2015)
  • Author(s): Yamanaga K, Tsujita K, Sugiyama S, Sumida H, Shimomura H, Yamashita T, Komura N, Sakamoto K, Oka H, Nakao K, Nakamura S, Ishihara M, Matsui K, Skaino N, Nakamura N, Yamamoto N, Koide S, Matsumura T, Fujimoto K, Tsunoda R, Morikami Y, Matsuyama K, Oshima S, KKaikita K, Hokimoto S, Ogawa H.
  • Organizer: American Heart Association Scientific Session
  • Place of Presentation: Orlando, Florida, USA
  • Year and Date: 2015-11-07
• [Presentation] Impact of Statin-Ezetimibe Combination on Coronary Atheroma Progression/Regression in Patients With and Without Prior Statin Therapy - Subanalysis of PRECISE-IVUS Trial (2015)
  • Author(s): Tsujita K, Yamanaga K, Sugiyama S, Shimomura H, Yamashita T, Sakamoto K, Nakao K, Nakamura S, Ishihara M, Matsui K, Yamamoto N, Koide S, Matsumura T, Fujimoto K, Tsunoda R, Morikami Y, Matsuyama K, Oshima S, Kaikita K, Hokimoto S, Ogawa H.
  • Organizer: American Heart Association Scientific Session
  • Place of Presentation: Orlando, Florida, USA
  • Year and Date: 2015-11-07
• [Presentation] Digital Assessment of Peripheral Vascular Endothelial Function is Useful for the Risk Stratification in Patients With Hypertension (2015)
  • Author(s): Yamamoto E, Sugiyama S, Matsuzawa Y, Hirata Y, Akiyama E, Fujisue K, Tokitsu T, Sugamura K, Kaikita K, Hokimoto S, Ogawa H.
  • Organizer: American Heart Association Scientific Session
  • Place of Presentation: Orlando, Florida, USA
  • Year and Date: 2015-11-07
• [Presentation] Olmesartan Improves Not Only Vascular Endothelial Dysfunction but Cardiac Diastolic Dysfunction in Hypertensive Heart Failure With Preserved Ejection Fraction - ORION Study (2015)
  • Author(s): Yamamoto E, Ohba K, Hirata Y, Tokitsu T, Sugamura K, Hokimoto S, Sugiyama S, Ogawa H.
  • Organizer: American Heart Association Scientific Session
  • Place of Presentation: Orlando, Florida, USA
  • Year and Date: 2015-11-07
• [Presentation] Blood Pressure Control in Diabetic Patients is Most Effective Between Ages 65 to 75 for Prevention of Atherosclerotic Events (2015)
  • Author(s): Soejima H, Morimoto T, Okada S, Sakuma M, Nakayama M, Uemura S, Masao K, Doi N, Jinnouchi H, Sugiyama S, Waki M, Saito Y, Ogawa H.
  • Organizer: American Heart Association Scientific Session
  • Place of Presentation: Orlando, Florida, USA
  • Year and Date: 2015-11-07
• [Presentation] Predictive Value of Endothelial Function for the Recurrence of Atrial Fibrillation After Catheter Ablation (2015)
  • Author(s): Kanazawa H, Yamabe H, Sugiyama S, Iwashita S, Hoshiyama T, Ito M, Kaneko S Ogawa H.
  • Organizer: American Heart Association Scientific Session
  • Place of Presentation: Orlando, Florida, USA
  • Year and Date: 2015-11-07
• [Presentation] The Clinical Significance of Pulse Pressure in Patients With Heart Failure With Preserved Ejection Fraction (2015)
  • Author(s): Tokitsu T, Yamamoto E, Hirata Y, Fujisue K, Sugamura K, Yamamuro M, Kaikita K, Hokimoto S, Sugiyama S, Ogawa H.
  • Organizer: American Heart Association Scientific Session
  • Place of Presentation: Orlando, Florida, USA
  • Year and Date: 2015-11-07
• [Presentation] Elevated Plasma levels of Neutral Endpeptidase in Hypertension Patients Treated with Angiotensin Converting Enzyme Inhibitors (2014)
  • Author(s): Sugamura K, Sugiyama S, Fujisue K, Hirata Y, Kurokawa H, Yamamoto E, Tsujita K, Kaikita K, Hokimoto S, Ogawa H.
  • Organizer: American Heart Association Scientific Sessions 2014
  • Place of Presentation: McCormick Place, Chicago, Illinois, USA
  • Year and Date: 2014-11-19
• [Presentation] Incremental Prognostic Significance of Peripheral Endothelial Dysfunction in Heart Failure With Reduced Left Ventricular Ejection Fraction (2014)
  • Author(s): Fujisue K, Sugiyama S, Matsuzawa Y, Akiyama E, Sugamura K, Matsubara J, Kurokawa H, Maeda H, Hirata Y, Kusaka H, Yamamoto E, Iwashita S, Sumida H, Tsujita K, Kaikita K, Hokimoto S, Matsui K, Ogawa H
  • Organizer: American Heart Association Scientific Sessions 2014
  • Place of Presentation: McCormick Place, Chicago, Illinois, USA
  • Year and Date: 2014-11-17
• [Presentation] Telmisartan, a Clinically Available Anti-hypertensive Medicine, Enhances Mitochondrial Function and Improves Endothelial Dysfunction through the AMPK Pathway (2014)
  • Author(s): Kurokawa H, Sugiyama S, Nozaki T, Sugamura K, Toyama K, Matsubara J, Fujisue K, Ohba K, Maeda H, Yamamoto E, Tsujita K, Kaikita K, Hokimoto S, Ogawa H.
  • Organizer: American Heart Association Scientific Sessions 2014
  • Place of Presentation: McCormick Place, Chicago, Illinois, USA
  • Year and Date: 2014-11-17
• [Presentation] Dipeptidyl-Peptidase-4 Inhibitor, Des-Fluoro-Sitagliptin, Prevented the Progression of Established Atheromatous Plaques in ApoE Deficient Mice - Possible Involvement of AMP-Activated Protein Kinase Pathway – (2014)
  • Author(s): Kurokawa H, Sugiyama S, Sugamura K, Matsubara J, Fujisue K, Maeda H, Yamamoto E, Tsujita K, Kaikita K, Hokimoto S, Ogawa H.
  • Organizer: American Heart Association Scientific Sessions 2014
  • Place of Presentation: McCormick Place, Chicago, Illinois, USA
  • Year and Date: 2014-11-17
• [Presentation] 正常冠動脈における内皮依存性冠血流量増加反応と血小板機能との関連性 (2014)
  • Author(s): 藤末 昂一郎,杉山 正悟、菅村 公一、大庭 圭介、海北 幸一、黒川 博文、前田 洋典、松原 純一、角田 等、山本 英一郎、山室 恵、田中 朋子、辻田 賢一、坂本 憲治、掃本 誠治、小川 久雄
  • Organizer: 第62回日本心臓病学会学術集会
  • Place of Presentation: 仙台市民会館、仙台市、宮城県
  • Year and Date: 2014-09-26
• [Presentation] 血管内皮機能検査で心血管リスクを評価する (2014)
  • Author(s): 杉山正悟
  • Organizer: 第46回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 京王プラザホテル、西新宿、東京
  • Year and Date: 2014-07-11
  • Invited
• [Presentation] Meet the Expert; 血管内皮機能測定の意義: 「Current Clinical Application and Future Perspective of Endothelial Function Assessment by Reactive Hyperemia Peripheral Arterial Tonometry (RH-PAT) in Cardiovascular Medicine」 (2014)
  • Author(s): 杉山正悟
  • Organizer: 日本循環器学会学術集会
  • Place of Presentation: 東京フォーラム、東京
  • Invited
• [Presentation] 明日へのシンポジウム2；画像診断や生理機能検査を実臨床にどう使うか：血管内皮機能検査：Endo-PAT ─ Reactive Hyperemia-Peripheral Arterial Tonometry（RH-PAT）検査- (2013)
  • Author(s): 杉山正悟
  • Organizer: 日本動脈硬化学会総会・学術集会
  • Place of Presentation: 京王プラザホテル、東京新宿
  • Invited
• [Presentation] エゼチミブは2型糖尿病患者における血管内皮機能障害を改善する (2013)
  • Author(s): 杉山正悟、陣内秀昭、陣内冨男、小川久雄
  • Organizer: 日本心臓病学会学術集会
  • Place of Presentation: ホテル日航熊本、熊本市
• [Presentation] Advanced Peripheral Endothelial Dysfunction Rather Than Increased Aortic Stiffness Correlates With Left Ventricular Diastolic Dysfunction and Heart Failure With Preserved Left Ventricular Ejection Fraction in Patients With Diabetes Mellitus (2013)
  • Author(s): Eiichi Akiyama, Seigo Sugiyama, Yasushi Matsuzawa, Hiroyuki Suzuki, Masaaki Konishi, Naoki Nakayama, Hirofumi Kurokawa, Kouichirou Fujisue, Toshimitsu Nozaki, Keisuke Ohba, Junichi Matsubara, Koichi Sugamura, Hitoshi Sumida,Kazuo Kimura, Satoshi Umemura, Hisao Ogawa
  • Organizer: Scientific Sessions of American Heart Association
  • Place of Presentation: Dallas, USA
• [Presentation] Peripheral Endothelial Function and Cardiovascular Events in Chronic Kidney Disease Patients (2013)
  • Author(s): Yoshihiro Hirata, Seigo Sugiyama, Eiichiro Yamamoto, Yasushi Matsuzawa, Eiichi Akiyama, Hiroaki Kusaka, Koichiro Fujisue, Hirofumi Kurokawa, Junichi Matsubara, Koichi Sugamura, Hirofumi Maeda, Satomi Iwashita, Hideaki Jinnouchi, Kunihiko Matsui, Hisao Ogawa
  • Organizer: Scientific Sessions of American Heart Association
  • Place of Presentation: Dallas, USA
• [Presentation] Prognostic Significance of Peripheral Endothelial Dysfunction in Heart Failure With Reduced Left Ventricular Ejection Fraction (2013)
  • Author(s): Koichiro Fujisue, Seigo Sugiyama, Eiichi Akiyama, Yasushi Matsuzawa, Hiofumi Kurokawa, Hiofumi Maeda, Junichi Matsubara, Koichi Sugamura, Yoshihiro Hirata, Hiroaki Kusaka, Satomi Iwashita, Eiichiro Yamamoto, Hisao Ogawa
  • Organizer: Scientific Sessions of American Heart Association
  • Place of Presentation: Dallas, USA
• [Presentation] Impairment of Peripheral Endothelial Function in Patients With Aortic Valve Stenosis in the Aging Population (2013)
  • Author(s): Koichiro Fujisue, Seigo Sugiyama, Hisayo Yasuda, Hirofumi Kurokawa, HIrofumi Maeda, Junichi Matsubara, Satomi Iwashita, Eiichiro Yamamoto, Eiichi Akiyama, Yasushi Matsuzawa, Hisao Ogawa
  • Organizer: Scientific Sessions of American Heart Association
  • Place of Presentation: Dallas, USA
• [Presentation] The Clinical Usefulness of Digital Peripheral Arterial Tonometry for Identifying Coronary Artery Disease (CAD) in Hypertensive Patients (2013)
  • Author(s): Eiichiro Yamamoto, Yasushi Matsuzawa, Yoshihiro Hirata, Takanori Tokitsu, Koichi Sugamura, Eiichi Akiyama, Seigo Sugiyama, Hisao Ogawa
  • Organizer: Scientific Sessions of American Heart Association
  • Place of Presentation: Dallas, USA
• [Presentation] Association between Abnormal Glucose Metabolism and Coronary Hyperperfusion in Normal Coronary Patients Without Ischemic Heart Disease (2013)
  • Author(s): Koichiro Fujisue, Keisuke Ohba, Seigo Sugiyama, Junichi Matsubara, Toshimitsu Nozaki, Hirofumi Kurokawa, Hirofumi Maeda, Hitoshi Sumida, Yasuhiro Nagayoshi, Kenji Sakamoto, Eiichiro Yamamoto, Kenichi Tsujita, Seiji Hokimoto, Hisao Ogawa
  • Organizer: Scientific Sessions of American Heart Association
  • Place of Presentation: Dallas, USA
• [Book] 血管機能の非侵襲的評価法に関するガイドライン (2013)
  • Author(s): 山科 章
  • Total Pages: 142
  • Publisher: 日本循環器学会