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Role of impaired mitochondrial function on endothelial dysfunction in cardiovascular diseases

Research Project

Project/Area Number 25461086
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionKumamoto University

Principal Investigator

Sugiyama Seigo  熊本大学, 生命科学研究部, 非常勤講師 (90274711)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsendothelial function / mitochondria / AMPK / cardiovascular events / heart failure / vascular biology / atherosclerosis / endothelial cell / 血管内皮機能 / ミトコンドリア / 動脈硬化 / 冠動脈疾患 / Polyvascular disease / 心不全 / 老化 / ATP産生 / 酸化ストレス / 心血管イベント
Outline of Final Research Achievements

Mitochondrial dysfunction plays an important role in cellular senescence and impaired function of vascular endothelium, resulted in cardiovascular diseases. AMP-activated protein kinase (AMPK) plays a critical role in mitochondrial biogenesis and endothelial function. In cultured human coronary artery endothelial cells (HCAECs), telmisartan (Telmi) significantly enhanced mitochondrial activity assessed by mitochondrial reductase activity and intracellular ATP production and increased the expression of mitochondria related genes. Telmi prevented cellular senescence and exhibited the anti-apoptotic and pro-angiogenic properties. All of these effects were abolished by inhibition of AMPK. Telmi enhanced mitochondrial activity and exhibited anti-senescence effects and improving endothelial function through AMPK in HCAECs. Telmi could provide beneficial effects on vascular diseases via enhancement of mitochondrial activity and modulating endothelial function through AMPK activation.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (59 results)

All 2016 2015 2014 2013

All Journal Article (24 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 21 results,  Open Access: 7 results,  Acknowledgement Compliant: 8 results) Presentation (34 results) (of which Invited: 3 results) Book (1 results)

  • [Journal Article] Advanced peripheral microvascular endothelial dysfunction and polyvascular disease in patients with high cardiovascular risk.2016

    • Author(s)
      Maeda H, Sugiyama S, Jinnouchi H, Matsuzawa Y, Fujisue K, Hirata Y, Kurokawa H, Ohba K, Matsubara J, Nozaki T, Konishi M, Akiyama E, Sugamura K, Yamamoto E, Sumida H, Ogawa H.
    • Journal Title

      J Cardiol.

      Volume: 67 Issue: 5 Pages: 455-462

    • DOI

      10.1016/j.jjcc.2015.07.003

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Low-Normal Serum Sodium and Heart Failure-Related Events in Patients With Heart Failure With Preserved Left Ventricular Ejection Fraction2016

    • Author(s)
      Kusaka H, Sugiyama S, Yamamoto E, Akiyama E, Matsuzawa Y, Hirata Y, Fujisue K, Kurokawa H, Matsubara J, Sugamura K, Maeda H, Jinnouchi H, Matsui K, Ogawa H.
    • Journal Title

      Circulation Journal

      Volume: 80 Issue: 2 Pages: 411-417

    • DOI

      10.1253/circj.CJ-15-0878

    • NAID

      130005120919

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Telmisartan enhances mitochondrial activity and alters cellular functions in human coronary artery endothelial cells via AMP-activated protein kinase pathway2015

    • Author(s)
      Kurokawa H, Sugiyama S, Nozaki T, Sugamura K, Toyama K, Matsubara J, Fujisue K, Ohba K, Maeda H, Konishi M, Akiyama E, Sumida H, Izumiya Y, Yasuda O, Kim-Mitsuyama S, Ogawa H
    • Journal Title

      Atherosclerosis

      Volume: 239(2) Issue: 2 Pages: 375-385

    • DOI

      10.1016/j.atherosclerosis.2015.01.037

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Significance of low plasma levels of brain-derived neurotrophic factor in patients with heart failure.2015

    • Author(s)
      Takashio S, Sugiyama S, Yamamuro M, Takahama H, Hayashi T, Sugano Y, Izumiya Y, Hokimoto S, Minamino N, Yasuda S, Anzai T, Ogawa H.
    • Journal Title

      Am J Cardiol.

      Volume: 116 Issue: 2 Pages: 243-249

    • DOI

      10.1016/j.amjcard.2015.04.018

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Prognostic Significance of Peripheral Microvascular Endothelial Dysfunction in Heart Failure With Reduced Left Ventricular Ejection Fraction2015

    • Author(s)
      Fujisue K, Sugiyama S, Matsuzawa Y, Akiyama E, Sugamura K, Matsubara J, Kurokawa H, Maeda H, Hirata Y, Kusaka H, Yamamoto E, Iwashita S, Sumida H, Sakamoto K, Tsujita K, Kaikita K, Hokimoto S, Matsui K, Ogawa H.
    • Journal Title

      Circulation Journal

      Volume: 79 Issue: 12 Pages: 2623-2631

    • DOI

      10.1253/circj.CJ-15-0671

    • NAID

      130005110928

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Reactive hyperemia peripheral arterial tonometry(RH-PAT))検査を臨床診療に活かす2015

    • Author(s)
      杉山 正悟
    • Journal Title

      循環器内科

      Volume: 78 Pages: 246-255

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Decreased plasma levels of active glucagon-like peptide-1 in coronary artery disease.2015

    • Author(s)
      Akiyama E, Sugiyama S, Matsubara J, Kurokawa H, Konishi M, Nozaki T, Ohba K, Fujisue K, Maeda H, Sakamoto K, Sugamura K, Sumida H, Jinnouchi H, Sakamaki K, Morita S, Kimura K, Umemura S, Ogawa H.
    • Journal Title

      J Am Coll Cardiol.

      Volume: 65 Issue: 7 Pages: 754-755

    • DOI

      10.1016/j.jacc.2014.11.043

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Reactive oxygen metabolites are closely associated with the diagnosis and prognosis of coronary artery disease.2015

    • Author(s)
      Hirata Y, Yamamoto E, Tokitsu T, Kusaka H, Fujisue K, Kurokawa H, Sugamura K, Maeda H, Tsujita K, Kaikita K, Hokimoto S, Sugiyama S, Ogawa H.
    • Journal Title

      J Am Heart Assoc.

      Volume: 4 Issue: 2

    • DOI

      10.1161/jaha.114.001451

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Plaque REgression with Cholesterol absorption Inhibitor or Synthesis inhibitor Evaluated by IntraVascular UltraSound (PRECISE-IVUS Trial): Study protocol for a randomized controlled trial.2015

    • Author(s)
      Tsujita K, Sugiyama S, Sumida H, Shimomura H, Yamashita T, Yamanaga K, Komura N, Sakamoto K, Ono T, Oka H, Nakao K, Nakamura S, Ishihara M, Matsui K, Sakaino N, Nakamura N, Yamamoto N, Koide S, Matsumura T, Fujimoto K, Tsunoda R, Morikami Y, Matsuyama K, Oshima S, Kaikita K, Hokimoto S, Ogawa H
    • Journal Title

      J Cardiol.

      Volume: 65 Issue: 4 Pages: 353-358

    • DOI

      10.1016/j.jjcc.2014.12.011

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Reactive oxidative metabolites are associated with the severity of heart failure and predict future cardiovascular events in heart failure with preserved left ventricular ejection fraction.2015

    • Author(s)
      Hirata Y, Yamamoto E, Tokitsu T, Kusaka H, Fujisue K, Kurokawa H, Sugamura K, Maeda H, Tsujita K, Yamamuro M, Kaikita K, Hokimoto S, Sugiyama S, Ogawa H.
    • Journal Title

      Int J Cardiol.

      Volume: 179 Pages: 305-308

    • DOI

      10.1016/j.ijcard.2014.11.018

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of a hydrophilic and a hydrophobic statin on cardiac salvage after ST-elevated acute myocardial infarction - a pilot study.2014

    • Author(s)
      Chitose T, Sugiyama S, Sakamoto K, Shimomura H, Yamashita T, Hokamaki J, Tsunoda R, Shiraishi S, Yamashita Y, Ogawa H.
    • Journal Title

      Atherosclerosis

      Volume: 237 Issue: 1 Pages: 251-258

    • DOI

      10.1016/j.atherosclerosis.2014.08.053

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Differences between rosuvastatin and atorvastatin in lipid-lowering action and effect on glucose metabolism in Japanese hypercholesterolemic patients with concurrent diabetes. Lipid-lowering with highly potent statins in hyperlipidemia with type 2 diabetes patients (LISTEN) study.2014

    • Author(s)
      Ogawa H, Matsui K, Saito Y, Sugiyama S, Jinnouchi H, Sugawara M, Masuda I, Mori H, Waki M, Yoshiyama M, Watada H.
    • Journal Title

      Circ J

      Volume: 78 Pages: 2512-2515

    • NAID

      130004687291

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Incremental prognostic significance of the elevated levels of pentraxin 3 in patients with heart failure with normal left ventricular ejection fraction.2014

    • Author(s)
      Matsubara J, Sugiyama S, Nozaki T, Akiyama E, Matsuzawa Y, Kurokawa H, Maeda H, Fujisue K, Sugamura K, Yamamoto E, Matsui K, Jinnouchi H, Ogawa H.
    • Journal Title

      J Am Heart Assoc.

      Volume: 3 Issue: 4

    • DOI

      10.1161/jaha.114.000928

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Clinical Features and Prognosis of Patients With Coronary Spasm Induced Non ST Segment Elevation Acute Coronary Syndrome.2014

    • Author(s)
      Nakayama N, Kaikita K, Fukunaga T, Matsuzawa Y, Sato K, Horio E, Yoshimura H, Mizobe M, Takashio S, Tsujita K, Kojima S, Tayama S, Hokimoto S, Sakamoto T, Nakao K, Sugiyama S, Kimura K, Ogawa H.
    • Journal Title

      Journal of the American Heart Association

      Volume: 3 Issue: 3

    • DOI

      10.1161/jaha.114.000795

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Utility of noninvasive endothelial function test for prediction of deep vein thrombosis after total hip or knee arthroplasty.2014

    • Author(s)
      Suzuki H, Matsuzawa Y, Konishi M, Akiyama E, Takano K, Nakayama N, Kataoka S, Ebina T, Kosuge M, Hibi K, Tsukahara K, Iwahashi N, Endo M, Maejima N, Shinohara K, Taki N, Mitsugi N, Taguri M, Sugiyama S, Ogawa H, Umemura S, Kimura K.
    • Journal Title

      Circ J

      Volume: 78 Pages: 1723-1732

    • NAID

      130003391143

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Endothelial function and cardiovascular events in chronic kidney disease.2014

    • Author(s)
      Hirata Y, Sugiyama S, Yamamoto E, Matsuzawa Y, Akiyama E, Kusaka H, Fujisue K, Kurokawa H, Matsubara J, Sugamura K, Maeda H, Iwashita S, Jinnouchi H, Matsui K, Ogawa H.
    • Journal Title

      Int J Cardiol.

      Volume: 173(3) Issue: 3 Pages: 481-486

    • DOI

      10.1016/j.ijcard.2014.03.085

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Correlation between extent of myocardial fibrosis assessed by cardiac magnetic resonance and cardiac troponin T release in patients with nonischemic heart failure.2014

    • Author(s)
      Takashio S, Yamamuro M, Uemura T, Utsunomiya D, Morita K, Izumiya Y, Sugiyama S, Kojima S, Yamamoto E, Tsujita K, Tanaka T, Tayama S, Kaikita K, Hokimoto S, Yasuda O, Yamashita Y, Ogawa H.
    • Journal Title

      American Journal of Cardiology

      Volume: 113 Issue: 10 Pages: 1697-1704

    • DOI

      10.1016/j.amjcard.2014.02.029

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Statins combined with exercise are associated with the increased renal function mediated by high-molecular-weight adiponectin in coronary artery disease patients.2014

    • Author(s)
      Toyama K, Sugiyama S, Oka H, Iwasaki Y, Sumida H, Tanaka T, Tayama S, Jinnouchi H, Ogawa H.
    • Journal Title

      J Cardiol.

      Volume: S0914-5087 Issue: 2 Pages: 91-97

    • DOI

      10.1016/j.jjcc.2013.11.018

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Reactive hyperemia peripheral arterial tonometry (RH-PAT)による血管内皮機能2014

    • Author(s)
      杉山正悟
    • Journal Title

      心臓

      Volume: 46 Pages: 1330-1335

    • Related Report
      2014 Research-status Report
  • [Journal Article] Insulin supersensitivity and normoinsulinaemic hypoglycaemia in uncontrolled type 2 diabetes mellitus: clinical usefulness of 3 h assessment in the 75 g oral glucose tolerance test.2014

    • Author(s)
      Sugiyama S, Jinnouchi H, Hieshima K, Jinnouchi T.
    • Journal Title

      BMJ Case Rep.

      Volume: 8 Pages: bcr2013201908-bcr2013201908

    • DOI

      10.1136/bcr-2013-201908

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Peripheral endothelial function and cardiovascular events in high-risk patients.2013

    • Author(s)
      Matsuzawa Y, Sugiyama S, Sumida H, Sugamura K, Nozaki T, Ohba K, Matsubara J, Kurokawa H, Fujisue K, Konishi M, Akiyama E, Suzuki H, Nagayoshi Y, Yamamuro M, Sakamoto K, Iwashita S, Jinnouchi H, Taguri M, Morita S, Matsui K, Kimura K, Umemura S, Ogawa H.
    • Journal Title

      J Am Heart Assoc

      Volume: 2 Issue: 6

    • DOI

      10.1161/jaha.113.000426

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Successful Diet and Exercise Therapy as Evaluated on Self-Assessment Score Significantly Improves Endothelial Function in Metabolic Syndrome Patients2013

    • Author(s)
      Matsuzawa Y, Sugiyama S, Sugamura K, Sumida H, Kurokawa H, Fujisue K, Konishi M, Akiyama E, Suzuki H, Nakayama N, Yamamuro M, Iwashita S, Jinnouchi H, Kimura K, Umemura S, Ogawa H.
    • Journal Title

      Circulation Journal

      Volume: 77 Issue: 11 Pages: 2807-2815

    • DOI

      10.1253/circj.CJ-13-0549

    • NAID

      10031196835

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of Endothelial Dysfunction on Residual Platelet Aggregability After Dual Antiplatelet Therapy With Aspirin and Clopidogrel in Patients With Stable Coronary Artery Disease2013

    • Author(s)
      K. Fujisue, S. Sugiyama, (他14名)
    • Journal Title

      Circ. Cardiovasc. Interv.

      Volume: 6 Issue: 4 Pages: 452-459

    • DOI

      10.1161/circinterventions.112.000278

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 血管内皮機能検査 -FMDとRH-PAT検査は共存できるか-2013

    • Author(s)
      杉山正悟、菅村公一、松原純一、松澤泰志、秋山英一
    • Journal Title

      Heart View; 特集:循環器医に必要な血管機能検査

      Volume: 6 Pages: 39-46

    • Related Report
      2013 Research-status Report
  • [Presentation] Dual Lipid-Lowering with Ezetimibe/Statin as a Promising Anti-Atherosclerotic Strategy2016

    • Author(s)
      Tsujita K, Sugiyama S, Shimomura H, Yamanaga K, Tsunoda R, Morikami Y, Matsuyama K, Ohshima S, Oka H, Nakao K, Nakamura S, Ishihara M, Matsui K, Sakaino N, Yamamoto N, Nakamura N, Koide S, Fujimoto K, Kaikita K, Hokimoto S, Ogawa H.
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      宮城県仙台市
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Colchicine Improved Survival, Left Ventricular Remodeling, and Chronic Cardiac Function after Acute Myocardial Infarction2016

    • Author(s)
      Fujisue K, Sugiyama S, Sugamura K, Kurokawa H, Matsubara J, Kaikita K, Ogawa H.
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      宮城県仙台市
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] The Clinical Significance and Novel Mechanism of Reactive Oxygen Species (ROS) in Heart Failure with Preserved Ejection Fraction (HFpEF)2016

    • Author(s)
      Hirata Y, Yamamoto E, Tokitsu T, Fujisue K, Sugamura K, Sakamoto K, Tsujita K, Kaikita K, Hokimoto S, Sugiyama S, Ogawa H.
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      宮城県仙台市
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Risk Stratification of Heart Failure (HF) with Preserved Ejection Fraction (HFpEF) Patients by Using Ankle-Brachial Index (ABI) Devices2016

    • Author(s)
      Tokitsu T, Yamamoto E, Hirata Y, Kusaka H, Fujisue K, Sugamura K, Yamamuro M, Kaikita K, Hokimoto S, Sugiyama S, Ogawa H.
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      宮城県仙台市
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Clinical Significance of Pulse Pressure (PP) in Patients with Heart Failure (HF) with Preserved Left Ventricular (LV) Ejection Fraction (HFpEF)2016

    • Author(s)
      Tokitsu T, Yamamoto E, Hirata Y, Fujisue K, Kusaka H, Sugamura K, Yamamuro M, Kaikita K, Hokimoto S, Sugiyama S, Ogawa H.
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      宮城県仙台市
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Impact of Statin-Ezetimibe Combination on Coronary Atheroma Progression/Regression in Patients with and without Statin Pretreatment― Subanalysis of PRECISE-IVUS Trial ―2016

    • Author(s)
      Tsujita K, Yamanaga K, Sugiyama S, Shimomura H, Yamashita T, Sakamoto K, Nakao K, Nakamura S, Ishihara M, Matsui K, Yamamoto N, Koide S, Matsumura T, Fujimoto K, Tsunoda R, Morikami Y, Matsuyama K, Ohshima S, Kaikita K, Hokimoto S, Ogawa H.
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      宮城県仙台市
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] The Usefulness of Digital Assessment of Peripheral Vascular Endothelial Function for the Risk Stratification in Patients with Essential Hypertension (HT)2016

    • Author(s)
      Yamamoto E, Sugiyama S, Matsuzawa Y, Hirata Y, Tokistu T, Fujisue K, Akiyama E, Sugamura K, Maeda H, Ogawa H.
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      宮城県仙台市
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] The Comparison of Statin Monotherapy and Statin-Ezetimibe Combined Therapy to Reduce LDL-C under 70mg/dl in Patients with Coronary Artery Disease2016

    • Author(s)
      Yamanaga K, Tsujita K, Sugiyama S, Sumida H, Shimomura H, Komura N, Sakamoto K, Nakao K, Nakamura S, Ishihara M, Matsui K, Nakamura N, Yamamoto N, Koide S, Tsunoda R, Morikami Y, Matsuyama K, Ohshima S, Kaikita K, Hokimoto S, Ogawa H.
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      宮城県仙台市
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Predictive Value of Endothelial Function for the Recurrence of Atrial Fibrillation after Catheter Ablation2016

    • Author(s)
      Kanazawa H, Yamabe H, Sugiyama S, Iwashita S, Ito M, Kaneko S, Ogawa H.
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      宮城県仙台市
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Primary Prevention for Silent Myocardial Infarction and Acute Myocardial Infarction in Diabetic Patients2016

    • Author(s)
      Soejima H, Morimoto T, Okada S, Nakayama M, Sakuma M, Uemura S, Kanauchi M, Doi N, Jinnouchi H, Sugiyama S, Waki M, Saito Y, Ogawa H.
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      宮城県仙台市
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Association between Circulating Leukocyte Subtype Counts and Peripheral Endothelial Dysfunction (ED) in Patients with Coronary Artery Disease (CAD)2016

    • Author(s)
      Yamamoto E, Hirata Y, Tokitsu T, Fujisue K, Sugamura K, Tsujita K, Hokimoto S, Sugiyama S, Ogawa H.
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      宮城県仙台市
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Peripheral Microvascular Endothelial Dysfunction Improves Risk Determination of Seattle Heart Failure Model in Heart Failure with Reduced Left Ventricular Ejection Fraction2015

    • Author(s)
      Fujisue K, Sugiyama S, Akiyama E, Matsuzawa Y, Sugamura K, Matsubara J, Kurokawa H, Maeda H, Hirata Y, Kusaka H, Yamamoto E, Iwashita S, Sumida H, Tsujita K, Sakamoto K, Kaikita K, Hokimoto S, Matsui K, Ogawa H.
    • Organizer
      American Heart Association Scientific Session
    • Place of Presentation
      Orlando, Florida, USA
    • Year and Date
      2015-11-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] The Impact of Statin-Ezetimibe Combination Therapy in Patients With Decreased Cholesterol Absorption Ability2015

    • Author(s)
      Yamanaga K, Tsujita K, Sugiyama S, Sumida H, Shimomura H, Yamashita T, Komura N, Sakamoto K, Oka H, Nakao K, Nakamura S, Ishihara M, Matsui K, Skaino N, Nakamura N, Yamamoto N, Koide S, Matsumura T, Fujimoto K, Tsunoda R, Morikami Y, Matsuyama K, Oshima S, KKaikita K, Hokimoto S, Ogawa H.
    • Organizer
      American Heart Association Scientific Session
    • Place of Presentation
      Orlando, Florida, USA
    • Year and Date
      2015-11-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] Impact of Statin-Ezetimibe Combination on Coronary Atheroma Progression/Regression in Patients With and Without Prior Statin Therapy - Subanalysis of PRECISE-IVUS Trial2015

    • Author(s)
      Tsujita K, Yamanaga K, Sugiyama S, Shimomura H, Yamashita T, Sakamoto K, Nakao K, Nakamura S, Ishihara M, Matsui K, Yamamoto N, Koide S, Matsumura T, Fujimoto K, Tsunoda R, Morikami Y, Matsuyama K, Oshima S, Kaikita K, Hokimoto S, Ogawa H.
    • Organizer
      American Heart Association Scientific Session
    • Place of Presentation
      Orlando, Florida, USA
    • Year and Date
      2015-11-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] Digital Assessment of Peripheral Vascular Endothelial Function is Useful for the Risk Stratification in Patients With Hypertension2015

    • Author(s)
      Yamamoto E, Sugiyama S, Matsuzawa Y, Hirata Y, Akiyama E, Fujisue K, Tokitsu T, Sugamura K, Kaikita K, Hokimoto S, Ogawa H.
    • Organizer
      American Heart Association Scientific Session
    • Place of Presentation
      Orlando, Florida, USA
    • Year and Date
      2015-11-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] Olmesartan Improves Not Only Vascular Endothelial Dysfunction but Cardiac Diastolic Dysfunction in Hypertensive Heart Failure With Preserved Ejection Fraction - ORION Study2015

    • Author(s)
      Yamamoto E, Ohba K, Hirata Y, Tokitsu T, Sugamura K, Hokimoto S, Sugiyama S, Ogawa H.
    • Organizer
      American Heart Association Scientific Session
    • Place of Presentation
      Orlando, Florida, USA
    • Year and Date
      2015-11-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] Blood Pressure Control in Diabetic Patients is Most Effective Between Ages 65 to 75 for Prevention of Atherosclerotic Events2015

    • Author(s)
      Soejima H, Morimoto T, Okada S, Sakuma M, Nakayama M, Uemura S, Masao K, Doi N, Jinnouchi H, Sugiyama S, Waki M, Saito Y, Ogawa H.
    • Organizer
      American Heart Association Scientific Session
    • Place of Presentation
      Orlando, Florida, USA
    • Year and Date
      2015-11-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] Predictive Value of Endothelial Function for the Recurrence of Atrial Fibrillation After Catheter Ablation2015

    • Author(s)
      Kanazawa H, Yamabe H, Sugiyama S, Iwashita S, Hoshiyama T, Ito M, Kaneko S Ogawa H.
    • Organizer
      American Heart Association Scientific Session
    • Place of Presentation
      Orlando, Florida, USA
    • Year and Date
      2015-11-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] The Clinical Significance of Pulse Pressure in Patients With Heart Failure With Preserved Ejection Fraction2015

    • Author(s)
      Tokitsu T, Yamamoto E, Hirata Y, Fujisue K, Sugamura K, Yamamuro M, Kaikita K, Hokimoto S, Sugiyama S, Ogawa H.
    • Organizer
      American Heart Association Scientific Session
    • Place of Presentation
      Orlando, Florida, USA
    • Year and Date
      2015-11-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] Elevated Plasma levels of Neutral Endpeptidase in Hypertension Patients Treated with Angiotensin Converting Enzyme Inhibitors2014

    • Author(s)
      Sugamura K, Sugiyama S, Fujisue K, Hirata Y, Kurokawa H, Yamamoto E, Tsujita K, Kaikita K, Hokimoto S, Ogawa H.
    • Organizer
      American Heart Association Scientific Sessions 2014
    • Place of Presentation
      McCormick Place, Chicago, Illinois, USA
    • Year and Date
      2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] Incremental Prognostic Significance of Peripheral Endothelial Dysfunction in Heart Failure With Reduced Left Ventricular Ejection Fraction2014

    • Author(s)
      Fujisue K, Sugiyama S, Matsuzawa Y, Akiyama E, Sugamura K, Matsubara J, Kurokawa H, Maeda H, Hirata Y, Kusaka H, Yamamoto E, Iwashita S, Sumida H, Tsujita K, Kaikita K, Hokimoto S, Matsui K, Ogawa H
    • Organizer
      American Heart Association Scientific Sessions 2014
    • Place of Presentation
      McCormick Place, Chicago, Illinois, USA
    • Year and Date
      2014-11-17
    • Related Report
      2014 Research-status Report
  • [Presentation] Telmisartan, a Clinically Available Anti-hypertensive Medicine, Enhances Mitochondrial Function and Improves Endothelial Dysfunction through the AMPK Pathway2014

    • Author(s)
      Kurokawa H, Sugiyama S, Nozaki T, Sugamura K, Toyama K, Matsubara J, Fujisue K, Ohba K, Maeda H, Yamamoto E, Tsujita K, Kaikita K, Hokimoto S, Ogawa H.
    • Organizer
      American Heart Association Scientific Sessions 2014
    • Place of Presentation
      McCormick Place, Chicago, Illinois, USA
    • Year and Date
      2014-11-17
    • Related Report
      2014 Research-status Report
  • [Presentation] Dipeptidyl-Peptidase-4 Inhibitor, Des-Fluoro-Sitagliptin, Prevented the Progression of Established Atheromatous Plaques in ApoE Deficient Mice - Possible Involvement of AMP-Activated Protein Kinase Pathway –2014

    • Author(s)
      Kurokawa H, Sugiyama S, Sugamura K, Matsubara J, Fujisue K, Maeda H, Yamamoto E, Tsujita K, Kaikita K, Hokimoto S, Ogawa H.
    • Organizer
      American Heart Association Scientific Sessions 2014
    • Place of Presentation
      McCormick Place, Chicago, Illinois, USA
    • Year and Date
      2014-11-17
    • Related Report
      2014 Research-status Report
  • [Presentation] 正常冠動脈における内皮依存性冠血流量増加反応と血小板機能との関連性2014

    • Author(s)
      藤末 昂一郎,杉山 正悟、菅村 公一、大庭 圭介、海北 幸一、黒川 博文、前田 洋典、松原 純一、角田 等、山本 英一郎、山室 恵、田中 朋子、辻田 賢一、坂本 憲治、掃本 誠治、小川 久雄
    • Organizer
      第62回日本心臓病学会学術集会
    • Place of Presentation
      仙台市民会館、仙台市、宮城県
    • Year and Date
      2014-09-26
    • Related Report
      2014 Research-status Report
  • [Presentation] 血管内皮機能検査で心血管リスクを評価する2014

    • Author(s)
      杉山正悟
    • Organizer
      第46回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      京王プラザホテル、西新宿、東京
    • Year and Date
      2014-07-11
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Meet the Expert; 血管内皮機能測定の意義: 「Current Clinical Application and Future Perspective of Endothelial Function Assessment by Reactive Hyperemia Peripheral Arterial Tonometry (RH-PAT) in Cardiovascular Medicine」2014

    • Author(s)
      杉山正悟
    • Organizer
      日本循環器学会学術集会
    • Place of Presentation
      東京フォーラム、東京
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 明日へのシンポジウム2;画像診断や生理機能検査を実臨床にどう使うか:血管内皮機能検査:Endo-PAT  ─ Reactive Hyperemia-Peripheral Arterial Tonometry(RH-PAT)検査-2013

    • Author(s)
      杉山正悟
    • Organizer
      日本動脈硬化学会総会・学術集会
    • Place of Presentation
      京王プラザホテル、東京新宿
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] エゼチミブは2型糖尿病患者における血管内皮機能障害を改善する2013

    • Author(s)
      杉山正悟、陣内秀昭、陣内冨男、小川久雄
    • Organizer
      日本心臓病学会学術集会
    • Place of Presentation
      ホテル日航熊本、熊本市
    • Related Report
      2013 Research-status Report
  • [Presentation] Advanced Peripheral Endothelial Dysfunction Rather Than Increased Aortic Stiffness Correlates With Left Ventricular Diastolic Dysfunction and Heart Failure With Preserved Left Ventricular Ejection Fraction in Patients With Diabetes Mellitus2013

    • Author(s)
      Eiichi Akiyama, Seigo Sugiyama, Yasushi Matsuzawa, Hiroyuki Suzuki, Masaaki Konishi, Naoki Nakayama, Hirofumi Kurokawa, Kouichirou Fujisue, Toshimitsu Nozaki, Keisuke Ohba, Junichi Matsubara, Koichi Sugamura, Hitoshi Sumida,Kazuo Kimura, Satoshi Umemura, Hisao Ogawa
    • Organizer
      Scientific Sessions of American Heart Association
    • Place of Presentation
      Dallas, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] Peripheral Endothelial Function and Cardiovascular Events in Chronic Kidney Disease Patients2013

    • Author(s)
      Yoshihiro Hirata, Seigo Sugiyama, Eiichiro Yamamoto, Yasushi Matsuzawa, Eiichi Akiyama, Hiroaki Kusaka, Koichiro Fujisue, Hirofumi Kurokawa, Junichi Matsubara, Koichi Sugamura, Hirofumi Maeda, Satomi Iwashita, Hideaki Jinnouchi, Kunihiko Matsui, Hisao Ogawa
    • Organizer
      Scientific Sessions of American Heart Association
    • Place of Presentation
      Dallas, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] Prognostic Significance of Peripheral Endothelial Dysfunction in Heart Failure With Reduced Left Ventricular Ejection Fraction2013

    • Author(s)
      Koichiro Fujisue, Seigo Sugiyama, Eiichi Akiyama, Yasushi Matsuzawa, Hiofumi Kurokawa, Hiofumi Maeda, Junichi Matsubara, Koichi Sugamura, Yoshihiro Hirata, Hiroaki Kusaka, Satomi Iwashita, Eiichiro Yamamoto, Hisao Ogawa
    • Organizer
      Scientific Sessions of American Heart Association
    • Place of Presentation
      Dallas, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] Impairment of Peripheral Endothelial Function in Patients With Aortic Valve Stenosis in the Aging Population2013

    • Author(s)
      Koichiro Fujisue, Seigo Sugiyama, Hisayo Yasuda, Hirofumi Kurokawa, HIrofumi Maeda, Junichi Matsubara, Satomi Iwashita, Eiichiro Yamamoto, Eiichi Akiyama, Yasushi Matsuzawa, Hisao Ogawa
    • Organizer
      Scientific Sessions of American Heart Association
    • Place of Presentation
      Dallas, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] The Clinical Usefulness of Digital Peripheral Arterial Tonometry for Identifying Coronary Artery Disease (CAD) in Hypertensive Patients2013

    • Author(s)
      Eiichiro Yamamoto, Yasushi Matsuzawa, Yoshihiro Hirata, Takanori Tokitsu, Koichi Sugamura, Eiichi Akiyama, Seigo Sugiyama, Hisao Ogawa
    • Organizer
      Scientific Sessions of American Heart Association
    • Place of Presentation
      Dallas, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] Association between Abnormal Glucose Metabolism and Coronary Hyperperfusion in Normal Coronary Patients Without Ischemic Heart Disease2013

    • Author(s)
      Koichiro Fujisue, Keisuke Ohba, Seigo Sugiyama, Junichi Matsubara, Toshimitsu Nozaki, Hirofumi Kurokawa, Hirofumi Maeda, Hitoshi Sumida, Yasuhiro Nagayoshi, Kenji Sakamoto, Eiichiro Yamamoto, Kenichi Tsujita, Seiji Hokimoto, Hisao Ogawa
    • Organizer
      Scientific Sessions of American Heart Association
    • Place of Presentation
      Dallas, USA
    • Related Report
      2013 Research-status Report
  • [Book] 血管機能の非侵襲的評価法に関するガイドライン2013

    • Author(s)
      山科 章
    • Total Pages
      142
    • Publisher
      日本循環器学会
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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