Predictors for the progression of aortic plaques using cardiovascular imaging and biomarkers

• Project/Area Number: 25461087
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Osaka City University
• Principal Investigator: SUGIOKA KENICHI 大阪市立大学, 大学院医学研究科, 講師 (60382149)
• Co-Investigator(Kenkyū-buntansha): UEDA MAKIKO 大阪市立大学, 大学院医学研究科, 教授 (10137193)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 大動脈プラーク / 脳梗塞 / 経食道心エコー / バイオマーカー / 動脈塞栓症 / 心血管画像診断法 / 心血管イベント / 不安定プラーク / プラーク不安定性

Outline of Final Research Achievements

Progression of atherosclerotic plaques in the aorta and carotid artery is the cause of symptomatic brain infarction or thromboembolism. Therefore, it is important to clarify the predictors and mechanism of the plaque progression or destabilization in these arteries. We have reported the association of several risk factors and inflammatory or oxidative stress biomarkers with the destabilization of aortic or carotid plaques using cardiovascular imaging. In the present study, we showed that new risk factors such as chronic kidney disease or blood pressure variabilities are also closely associated with aortic plaque progression, and that advanced aortic plaques relates the presence of silent brain infarction on brain MRI.

Research Products

• [Journal Article] Higher visit-to-visit intra-dialytic blood pressure is associated with the progression of aortic valve stenosis in chronic hemodialysis patients. (2016)
  • Author(s): Norioka N, Sugioka K et al.
  • Journal Title: Heart Vessel Volume: 印刷中
• [Journal Article] Utility of T-wave alternans during night time as a predictor for ventricular fibrillation in patients with Brugada syndrome. (2016)
  • Author(s): Sakamoto S, Sugioka K et al.
  • Journal Title: Heart Vessel Volume: 印刷中
• [Journal Article] Four cases of investigational therapy with interleukin-11 against acute myocardial infarction. (2016)
  • Author(s): Nakagawa M, Sugioka K et al.
  • Journal Title: Heart Vessel Volume: 印刷中
• [Journal Article] Predictors of silent brain infarction on magnetic resonance imaging in patients with nonvalvular atrial fibrillation: A transesophageal echocardiographic study (2015)
  • Author(s): Sugioka K, Takagi M, Sakamoto S, Fujita S, Ito A, Iwata S, Matsumura Y, Nakagawa M, Doi A, Miki Y, Yoshiyama M, Ueda M
  • Journal Title: Am Heart J. Volume: 印刷中 Issue: 6 Pages: 783-790
  • DOI: 10.1016/j.ahj.2015.03.016
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Aortic arch atherosclerosis in patients with severe aortic stenosis can be argued by greater day-by-day blood pressure variability (2015)
  • Author(s): Iwata, S
  • Journal Title: Atherosclerosis Volume: 241 Issue: 1 Pages: 42-47
  • DOI: 10.1016/j.atherosclerosis.2015.04.807
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Enhanced expression of hemoglobin scavenger receptor and heme oxygenase-1 is associated with aortic valve stenosis in patients undergoing hemodialysis. (2014)
  • Author(s): Inaba M, Sugioka K, Naruko T, Yunoki K, Kato Y, Shibata T, Inoue T, Ohsawa M, Yoshiyama M, Ueda M.
  • Journal Title: Hemodial Int Volume: 18 Issue: 3 Pages: 632-640
  • DOI: 10.1111/hdi.12147
  • Peer Reviewed
• [Journal Article] Relationship between CHADS2 score and complex aortic plaques by transesophageal echocardiography in patients with nonvalvular atrial fibrillation (2014)
  • Author(s): Sugioka K, Fujita S, Iwata S, Ito A, Matsumura Y, Hanatan A, Doi A, Takagi M, Naruko T, Ueda M, Yoshiyama M
  • Journal Title: Ultrasound Med Biol. Volume: 40 Issue: 10 Pages: 2358-2364
  • DOI: 10.1016/j.ultrasmedbio.2014.05.006
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Association between chronic kidney disease and thoracic aortic atherosclerosis detected using transesophageal echocardiography (2014)
  • Author(s): Matsumura Y, Sugioka K, Fujita S, Ito A, Iwata S, Yoshiyama M
  • Journal Title: Atherosclerosis Volume: 237 Issue: 1 Pages: 301-306
  • DOI: 10.1016/j.atherosclerosis.2014.09.013
  • Peer Reviewed
• [Journal Article] Relationship between CHADS2 score and complex aortic plaques by transesophageal echocardiography in patients with nonvalvular atrial fibrillation (2014)
  • Author(s): Sugioka K, et al.
  • Journal Title: Ultrasound Med Biol. Volume: 40
  • Peer Reviewed
• [Journal Article] Rapid and accurate assessment of aortic arch atherosclerosis using simultaneous multi-plane imaging by transesophageal echocardiography (2013)
  • Author(s): Ito A, Sugioka K, et al.
  • Journal Title: Ultrasound Med Biol. Volume: 39 Issue: 8 Pages: 1337-1342
  • DOI: 10.1016/j.ultrasmedbio.2013.03.011
  • Peer Reviewed
• [Presentation] Association of Silent Brain Infarction With CHADS2 Score and Left Atrial Abnormalities in Patients With Nonvalvular Atrial Fibrillation. (2015)
  • Author(s): Kawai Y, Sugioka K et al.
  • Organizer: American Heart Association 2015
  • Place of Presentation: オーランド（アメリカ合衆国）
  • Year and Date: 2015-11-10
  • Int'l Joint Research
• [Presentation] Mitral Annular Calcification is Associated with Aortic Atherosclerosis in Patients with Aortic Stenosis. (2015)
  • Author(s): Fujita S, Sugioka K et al.
  • Organizer: 第45回日本動脈硬化学会学術集会
  • Place of Presentation: 仙台国際センター 仙台市
  • Year and Date: 2015-07-09
• [Presentation] 大動脈病変と脳卒中 非弁膜症性心房細動における無症候性脳梗塞と大動脈プラーク弓部との関連 (2015)
  • Author(s): 杉岡憲一 その他
  • Organizer: 第2回日本心血管脳卒中学術集会
  • Place of Presentation: クレメンス徳島(徳島県徳島市）
  • Year and Date: 2015-06-12
• [Presentation] 非弁膜症性心房細動における無症候性脳梗塞発症の予測因子：経食道心エコーによる検討 (2015)
  • Author(s): 杉岡憲一 その他
  • Organizer: 日本超音波医学会第88回学術集会
  • Place of Presentation: グランドプリンスホテル高輪（東京都）
  • Year and Date: 2015-05-24
• [Presentation] Relationship between Mitral Annular Calcification and Echocardiographic Parameters in Patients with Aortic Stenosis (2015)
  • Author(s): Suwako Fujita, Kenichi Sugioka, Asahiro Ito, Shinichi Iwata, Yoshiki Matsumura, Akihisa Hanatani, Masahiko Takagi, Makiko Ueda, Minoru Yoshiyama
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: グランフロント大阪（大阪府大阪市）
  • Year and Date: 2015-04-26
• [Presentation] Silent Brain Infarcts and Aortic Arch Atherosclerosis in Patients with Nonvalvular Atrial Fibrillation: A Transesophageal Echocardiographic Study. (2015)
  • Author(s): Sugioka K et al.
  • Organizer: 第79回日本循環器病学会学術集会
  • Place of Presentation: ABCホール（大阪府大阪市）
  • Year and Date: 2015-04-25
• [Presentation] Silent Brain Infarcts and Aortic Arch Atherosclerosis in Patients with Nonvalvular Atrial Fibrillation: A Transesophageal Echocardiographic Study (2015)
  • Author(s): Kenichi Sugioka, Suwako Fujita, Asahiro Ito, Shinichi Iwata, Yoshiki Matsumura, Akihisa Hanatani, Atsushi Doi, Masahiko Takagi, Makiko Ueda, Minoru Yoshiyama
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: ABCホール（大阪府大阪市）
  • Year and Date: 2015-04-25
• [Presentation] 非弁膜症性心房細動における大動脈プラークと心不全との関連：経食道心エコーによる検討 (2014)
  • Author(s): 伊藤朝広、杉岡憲一、藤田澄吾子、岩田真一、松村嘉起、穂積健之、花谷彰久、土井淳史、高木雅彦、成子隆彦、上田真喜子、葭山稔
  • Organizer: 第68回日本心臓病学会学術集会
  • Place of Presentation: 仙台市民センター（宮城県仙台市）
  • Year and Date: 2014-09-28
• [Presentation] 非弁膜症性心房細動例におけるCHADS2スコアと大動脈complexプラークとの関連 (2014)
  • Author(s): 杉岡憲一、藤田澄吾子、伊藤朝広、岩田真一、松村嘉起、穂積健之、花谷彰久、土井淳史、高木雅彦、成子隆彦、上田真喜子、葭山稔
  • Organizer: 第68回日本心臓病学会学術集会
  • Place of Presentation: 仙台市民センター（宮城県仙台市）
  • Year and Date: 2014-09-28
• [Presentation] Relationship between CHADS2 score and complex aortic plaques by transesophageal echocardiography in patients with nonvalvular atrial fibrillation (2014)
  • Author(s): Suwako Fujita, Kenichi Sugioka, Shinichi Iwata, Asahiro Ito, Yoshiki Matsumura, Atsushi Doi, Masahiko Takagi, Makiko Ueda, Minoru Yoshiyama
  • Organizer: 第46回日本動脈硬化学会学術集会
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2014-07-11
• [Presentation] Aortic arch calcification on chest X-ray is a simple predictor of aortic arch complex plaques in patients with nonvalvular atrial fibrillation (2014)
  • Author(s): Asahiro Ito, Kenichi Sugioka, Suwako Fujita, Shinichi Iwata, Yoshiki Matsumura, Akihisa Hanatani, Masahiko Takagi, Makiko Ueda, Minoru Yoshiyama
  • Organizer: 第46回日本動脈硬化学会学術集会
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2014-07-11
• [Presentation] Relationship between CHADS2 score and complex plaques in the thoracic aorta in patients with nonvalvular atrial fibrillation (2014)
  • Author(s): Fujita S, Sugioka K, et al.
  • Organizer: 第78回日本循環器学会学術集会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] 非弁膜症性心房細動例における大動脈プラークの頻度と関連因子について：経食道心エコーによる検討 (2013)
  • Author(s): 藤田澄吾子、杉岡憲一、他
  • Organizer: 第61回日本心臓病学会
  • Place of Presentation: 熊本市現代美術館
• [Presentation] 重症大動脈弁狭窄症における日間血圧変動と大動脈弓部プラークとの関連 (2013)
  • Author(s): 岩田真一、杉岡憲一、他
  • Organizer: 第61回日本心臓病学会
  • Place of Presentation: 鶴屋ホール、パレア(熊本市）
• [Presentation] 非弁膜症性心房細動における経食道心エコーによる大動脈プラーク検索の意義：CHA2DS2-VASCスコアへの影響 (2013)
  • Author(s): 山下智子、杉岡憲一、他
  • Organizer: 第61回日本心臓病学会
  • Place of Presentation: 熊本市現代美術館