| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Progression of atherosclerotic plaques in the aorta and carotid artery is the cause of symptomatic brain infarction or thromboembolism. Therefore, it is important to clarify the predictors and mechanism of the plaque progression or destabilization in these arteries. We have reported the association of several risk factors and inflammatory or oxidative stress biomarkers with the destabilization of aortic or carotid plaques using cardiovascular imaging. In the present study, we showed that new risk factors such as chronic kidney disease or blood pressure variabilities are also closely associated with aortic plaque progression, and that advanced aortic plaques relates the presence of silent brain infarction on brain MRI.
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