Clinical importance of vascular elasticity of the brachial artery

• Project/Area Number: 25461090
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Jichi Medical University
• Principal Investigator: KABUTOYA TOMOYUKI 自治医科大学, 医学部, 講師 (00458291)
• Co-Investigator(Kenkyū-buntansha): 苅尾 七臣 自治医科大学, 医学部, 教授 (60285773) ; 星出 聡 自治医科大学, 医学部, 准教授 (90326851) ; 江口 和男 自治医科大学, 医学部, 教授 (80364503)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 血管内皮機能 / 動脈硬化 / 血圧変動

Outline of Final Research Achievements

The SPB values were significantly associated with total choresterol and inversely associated with age and high-sensitivity C-reactive protein , but not associated with diurnal blood pressure change. The SPB values were significantly positively associated with the baseline diameter of the brachial artery. The diameter of nrachial artery is affected by age and gender, and young male often have larze size of brachial artery. The limitation of this study is that SPB is strongly affected by the size of brachial artery.

Research Products

• [Journal Article] Relationship between endothelial dysfunction and kidney disease. (2014)
  • Author(s): Kabutoya T, et al.
  • Journal Title: Journal of Clinical Hypertension Volume: 16 Issue: 2 Pages: 156-156
  • DOI: 10.1111/jch.12236
  • Peer Reviewed
• [Journal Article] Masked hypertension defined by home blood pressure monitoring is associated with impaired flow-mediated vasodilatation in patients with cardiovascular risk factors (2013)
  • Author(s): Kabutoya T, Hoshide S, Ogata Y, Eguchi K, Kario K
  • Journal Title: J Clin Hypertens (Greenwich) Volume: 15 Issue: 9 Pages: 630-636
  • DOI: 10.1111/jch.12155
  • Peer Reviewed
• [Presentation] ハイリスク患者でのFMDの積分値(FMD-AUC)測定の臨床的意義 (2016)
  • Author(s): 甲谷友幸
  • Organizer: 血管不全学会
  • Place of Presentation: 東京医科大学大教室（東京都新宿区）
  • Year and Date: 2016-04-17
  • Invited
• [Presentation] Decrease of the shear rate in the brachial artery at rest is associated with cardiovascular events (2016)
  • Author(s): Niijima S, Kabutoya T, Hoshide S, Kario K.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際会議場（宮城県仙台市）
  • Year and Date: 2016-03-18
• [Presentation] Stiffness Parameter β of the Brachial Artery is Associated with Total Cholesterol and High Sensitivity C-reactive Protein (2015)
  • Author(s): Tomoyuki Kabutoya, Satoshi Hoshide, Kazuomi Kario
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: グランフロント大阪 北館 B2階 ナレッジキャピタル コングレコンベンションセンター ホールB＋C）
  • Year and Date: 2015-04-25