| Project/Area Number |
25461093
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 急性冠症候群 / 動脈硬化 / プラーク破綻 / 血管内イメージング / 流体力学 / ３次元画像構築 / 3次元画像構築 |
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| Outline of Final Research Achievements |
This study compared the geometrical and hemodynamical features between coronary plaque ruptures that provoked acute coronary syndrome(Group A, n=75) and silent plaque ruptures (Group S, n=24) with using 3D intravascular ultrasound images. The shape of rupture orifice was more longitudinal in Group A (Group A vs. Group S: 59% vs. 29%, p=0.012), whereas it was more oval in Group S. The configuration of fibrous cap residuals had a wide variety: 1) shoulder fissure pattern, 2) flow-disturbing fibrous flaps (88% vs. 71%, p=0.047), and 3) fibrous cap bridge. The combination of longitudinal orifice and flow-disturbing flaps was significantly more frequent in Group A than Group S (57% vs. 21%, p=0.002). According to a computer simulation of blood flow, plaque ruptures in Group A had a significant flow disturbance compared to that in Group S. In conclusion, plaque rupture that provokes acute coronary syndrome has specific geometrical and hemodynamic features compared to silent plaque rupture.
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