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Impact of Alogliptin on coronary plaque stability in patients with diabetes mellitus

Research Project

Project/Area Number 25461095
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionKawasaki Medical School

Principal Investigator

Kume Teruyoshi  川崎医科大学, 医学部, 講師 (60341088)

Co-Investigator(Kenkyū-buntansha) NEISHI YOJI  川崎医科大学, 医学部, 准教授 (80319946)
川元 隆弘  川崎医科大学, 医学部, 講師 (30368667)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords光干渉断層撮影法 / 糖尿病 / 冠動脈 / プラーク / 不安定性 / 血管内イメージング / 不安定プラーク / 血管内超音波
Outline of Final Research Achievements

We analyzed 37 patients (51 lesions) with coronary artery disease by using optical coherence tomography (OCT). Previous histopathological studies showed that thinner fibrous cap thickness covering lipid core might be related to vulnerable plaque. We compared the change of fibrous cap thickness between patients with and without diabetes mellitus during 9 months follow-up. There was no significant difference in the change of fibrous cap thickness between the 2 groups (-9.6±33.7 vs. 8.1±43.4 μm). Clarifying the effect of DPP-4(dipeptidyl Peptidase-4) inhibitor on plaque stability might need longer follow-up period with a large number of patients.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (4 results)

All 2016

All Journal Article (2 results) (of which Open Access: 2 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Detection of plaque neovascularization by optical coherence tomography: ex-vivo feasibility study and in vivo observation in patients with angina pectoris.2016

    • Author(s)
      117.Kume T, Okura H, Yamada R, Koyama T, Fukuhara K, Kawamura A, Imai K, Neishi Y, Uemura S
    • Journal Title

      J Invasive Cardiol

      Volume: 28 Pages: 17-22

    • Related Report
      2015 Annual Research Report
    • Open Access
  • [Journal Article] In-stent neointimal characteristics and late neointimal response after drug-eluting stent implantation: A preliminary observation.2016

    • Author(s)
      113.Fukuhara K, Okura H, Kume T, Yamada R, Neishi Y, Uemura S.
    • Journal Title

      J Cardiol

      Volume: 67 Pages: 437-41

    • Related Report
      2015 Annual Research Report
    • Open Access
  • [Presentation] In Vivo Assessment of Vasa Vasorum Neovascularization Using Optical Coherence Tomography: A Comparison between Unstable and Stable Angina Pectoris.2016

    • Author(s)
      Teruyoshi Kume, Ryotaro Yamada, Terumasa Koyama, Kenzo Fukuhara, Yutaka Goryo, Hiroshi Okamoto, Yusuke Kobayashi, Yoji Neishi, Shiro Uemura.
    • Organizer
      American College of Cardiology 65rd Annual Scientific Session
    • Place of Presentation
      米国シカゴ
    • Year and Date
      2016-04-02
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] In Vivo Assessment of Vasa Vasorum Neovascularization Using Optical Coherence Tomography: A Comparison between Unstable and Stable Angina Pectoris.2016

    • Author(s)
      Teruyoshi Kume, Ryotaro Yamada, Terumasa Koyama, Kenzo Fukuhara, Yutaka Goryo, Ai Kawamura, Hiroshi Okamoto, Yusuke Kobayashi, Tomoko Tamada, Kikuko Obase, Koichiro Imai, Yoji Neishi, Shiro Uemura.
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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