Impact of Alogliptin on coronary plaque stability in patients with diabetes mellitus
Project/Area Number |
25461095
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cardiovascular medicine
|
Research Institution | Kawasaki Medical School |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
NEISHI YOJI 川崎医科大学, 医学部, 准教授 (80319946)
川元 隆弘 川崎医科大学, 医学部, 講師 (30368667)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 光干渉断層撮影法 / 糖尿病 / 冠動脈 / プラーク / 不安定性 / 血管内イメージング / 不安定プラーク / 血管内超音波 |
Outline of Final Research Achievements |
We analyzed 37 patients (51 lesions) with coronary artery disease by using optical coherence tomography (OCT). Previous histopathological studies showed that thinner fibrous cap thickness covering lipid core might be related to vulnerable plaque. We compared the change of fibrous cap thickness between patients with and without diabetes mellitus during 9 months follow-up. There was no significant difference in the change of fibrous cap thickness between the 2 groups (-9.6±33.7 vs. 8.1±43.4 μm). Clarifying the effect of DPP-4(dipeptidyl Peptidase-4) inhibitor on plaque stability might need longer follow-up period with a large number of patients.
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Report
(4 results)
Research Products
(4 results)
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[Presentation] In Vivo Assessment of Vasa Vasorum Neovascularization Using Optical Coherence Tomography: A Comparison between Unstable and Stable Angina Pectoris.2016
Author(s)
Teruyoshi Kume, Ryotaro Yamada, Terumasa Koyama, Kenzo Fukuhara, Yutaka Goryo, Ai Kawamura, Hiroshi Okamoto, Yusuke Kobayashi, Tomoko Tamada, Kikuko Obase, Koichiro Imai, Yoji Neishi, Shiro Uemura.
Organizer
第80回日本循環器学会学術集会
Place of Presentation
仙台国際センター(宮城県仙台市)
Year and Date
2016-03-18
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