Impact of Alogliptin on coronary plaque stability in patients with diabetes mellitus

• Project/Area Number: 25461095
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Kawasaki Medical School
• Principal Investigator: Kume Teruyoshi 川崎医科大学, 医学部, 講師 (60341088)
• Co-Investigator(Kenkyū-buntansha): NEISHI YOJI 川崎医科大学, 医学部, 准教授 (80319946) ; 川元 隆弘 川崎医科大学, 医学部, 講師 (30368667)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 光干渉断層撮影法 / 糖尿病 / 冠動脈 / プラーク / 不安定性 / 血管内イメージング / 不安定プラーク / 血管内超音波

Outline of Final Research Achievements

We analyzed 37 patients (51 lesions) with coronary artery disease by using optical coherence tomography (OCT). Previous histopathological studies showed that thinner fibrous cap thickness covering lipid core might be related to vulnerable plaque. We compared the change of fibrous cap thickness between patients with and without diabetes mellitus during 9 months follow-up. There was no significant difference in the change of fibrous cap thickness between the 2 groups (-9.6±33.7 vs. 8.1±43.4 μm). Clarifying the effect of DPP-4(dipeptidyl Peptidase-4) inhibitor on plaque stability might need longer follow-up period with a large number of patients.

Research Products

• [Journal Article] Detection of plaque neovascularization by optical coherence tomography: ex-vivo feasibility study and in vivo observation in patients with angina pectoris. (2016)
  • Author(s): 117．Kume T, Okura H, Yamada R, Koyama T, Fukuhara K, Kawamura A, Imai K, Neishi Y, Uemura S
  • Journal Title: J Invasive Cardiol Volume: ２８ Pages: 17-22
  • Open Access
• [Journal Article] In-stent neointimal characteristics and late neointimal response after drug-eluting stent implantation: A preliminary observation. (2016)
  • Author(s): 113．Fukuhara K, Okura H, Kume T, Yamada R, Neishi Y, Uemura S.
  • Journal Title: J Cardiol Volume: ６７ Pages: 437-41
  • Open Access
• [Presentation] In Vivo Assessment of Vasa Vasorum Neovascularization Using Optical Coherence Tomography: A Comparison between Unstable and Stable Angina Pectoris. (2016)
  • Author(s): Teruyoshi Kume, Ryotaro Yamada, Terumasa Koyama, Kenzo Fukuhara, Yutaka Goryo, Hiroshi Okamoto, Yusuke Kobayashi, Yoji Neishi, Shiro Uemura.
  • Organizer: American College of Cardiology 65rd Annual Scientific Session
  • Place of Presentation: 米国シカゴ
  • Year and Date: 2016-04-02
  • Int'l Joint Research
• [Presentation] In Vivo Assessment of Vasa Vasorum Neovascularization Using Optical Coherence Tomography: A Comparison between Unstable and Stable Angina Pectoris. (2016)
  • Author(s): Teruyoshi Kume, Ryotaro Yamada, Terumasa Koyama, Kenzo Fukuhara, Yutaka Goryo, Ai Kawamura, Hiroshi Okamoto, Yusuke Kobayashi, Tomoko Tamada, Kikuko Obase, Koichiro Imai, Yoji Neishi, Shiro Uemura.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-03-18