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Theoretical studies on ablation targets and optimal approach of chronic atrial fibrillation treatment.

Research Project

Project/Area Number 25461106
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionShiga University of Medical Science

Principal Investigator

Ashihara Takashi  滋賀医科大学, 医学部, 助教(学内講師) (80396259)

Co-Investigator(Kenkyū-buntansha) OZAWA Tomoya  滋賀医科大学, 医学部, 助教 (20584395)
HARAGUCHI Ryo  国立研究開発法人国立循環器病研究センター, 情報統括部, 室長 (00393215)
INADA Shin  国立研究開発法人国立循環器病研究センター, 研究情報基盤管理室, 研究員 (50349792)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords分子心臓学 / 不整脈学
Outline of Final Research Achievements

The mechanisms underlying complex fractionated atrial electrogram (CFAE)-targeted chronic atrial fibrillation (CAF) ablation are poorly understood. To provide theoretical bases for the CAF ablation strategies, we developed a computer model of human CAF, conducted simulation of CFAE, and tried to propose optimal strategy for the CAF ablation. Then we found that fibroblast proliferation in atria causes the sustainment of the rotors (spiral wave reentries) during CAF, and success or failure of CAF ablation is determined by the balance of rotor increase or decrease. In addition, the knowledge obtained in this study was applied to the development of real-time phase mapping system of human CAF.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (182 results)

All 2016 2015 2014 2013 Other

All Journal Article (27 results) (of which Int'l Joint Research: 3 results,  Open Access: 8 results,  Peer Reviewed: 9 results,  Acknowledgement Compliant: 2 results) Presentation (142 results) (of which Int'l Joint Research: 23 results,  Invited: 55 results) Book (8 results) Remarks (2 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 1 results)

  • [Journal Article] ヒトiPS細胞から成熟した心筋細胞の開発と安全性評価への応用.2016

    • Author(s)
      諫田泰成,芦原貴司,黒川洵子.
    • Journal Title

      日本薬理学雑誌.

      Volume: 147

    • NAID

      130005156509

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 継往開来:先人たちの偉業を継続・発展,さらなる開拓へ.2016

    • Author(s)
      井上 博,古川哲史,芦原貴司,池田隆徳.
    • Journal Title

      心電図.

      Volume: 34 Pages: 303-319

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Splicing misregulation of SCN5A contributes to cardiac-conduction delay and heart arrhythmia in myotonic dystrophy.2016

    • Author(s)
      Freyermuth F, Rau F, Kokunai Y, Linke T, Sellier C, Nakamori M, Kino Y,.......Zimmer T, Furling D, Takahashi MP, Charlet-Berguerand N.
    • Journal Title

      Nat Commun.

      Volume: 7 Issue: 1 Pages: 11067-11067

    • DOI

      10.1038/ncomms11067

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] High Frequency of Early Repolarization and Brugada-Type Electrocardiograms in Hypercalcemia.2016

    • Author(s)
      Sonoda K, Watanabe H, Hisamatsu T, Ashihara T, et al.
    • Journal Title

      Ann Noninvasive Electrocardiol.

      Volume: 21 Issue: 1 Pages: 30-40

    • DOI

      10.1111/anec.12303

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Applicability of Human Induced Pluripotent Stem Cell-derived Myocardial Sheet to the Study of Arrhythmias:From the Viewpoint of <I>in silico</I> Arrhythmology2015

    • Author(s)
      芦原貴司, 黒川洵子, 諫田泰成, 原口亮, 稲田慎, 中沢一雄, 堀江稔
    • Journal Title

      Transactions of Japanese Society for Medical and Biological Engineering

      Volume: 53 Issue: 3 Pages: 100-105

    • DOI

      10.11239/jsmbe.53.100

    • NAID

      130005106893

    • ISSN
      1347-443X, 1881-4379
    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Open Access
  • [Journal Article] Investigating Mechanisms of Ventricular Arrhythmias Induced in the Purkinje Fiber Network Using Computer Simulation2015

    • Author(s)
      稲田慎, Daniel T. Harrell, 原口亮, 芦原貴司, 蒔田直昌, 中沢一雄
    • Journal Title

      Transactions of Japanese Society for Medical and Biological Engineering

      Volume: 53 Issue: 3 Pages: 106-114

    • DOI

      10.11239/jsmbe.53.106

    • NAID

      130005106894

    • ISSN
      1347-443X, 1881-4379
    • Related Report
      2015 Annual Research Report
    • Open Access
  • [Journal Article] Visual Simulation of Cardiac Beating Motion with Shape Matching Dynamics2015

    • Author(s)
      井尻 敬,芦原貴司,梅谷信行,小山裕己,五十嵐健夫,原口 亮,横田秀夫,中沢一雄
    • Journal Title

      Transactions of Japanese Society for Medical and Biological Engineering

      Volume: 53 Issue: 3 Pages: 130-137

    • DOI

      10.11239/jsmbe.53.130

    • NAID

      130005106897

    • ISSN
      1347-443X, 1881-4379
    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Open Access
  • [Journal Article] Genotype-dependent differences in age of manifestation and arrhythmia complications in short QT syndrome.2015

    • Author(s)
      Harrell DT, Ashihara T, Ishikawa T, et al.
    • Journal Title

      International Journal of Cardiology.

      Volume: 190 Pages: 393-402

    • DOI

      10.1016/j.ijcard.2015.04.090

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] コンピュータシミュレーションによるプルキンエ起源の心室性不整脈発生機序の検討.2015

    • Author(s)
      稲田 慎,Harrell DT,原口 亮,芦原貴司,蒔田直昌,中沢一雄.
    • Journal Title

      生体医工学.

      Volume: 53

    • Related Report
      2014 Research-status Report
  • [Journal Article] 電気ショックは二相性よりも多相性…その直感はあたっているのか?2015

    • Author(s)
      芦原貴司.
    • Journal Title

      心電図.

      Volume: 34 Pages: 403-408

    • NAID

      130005090856

    • Related Report
      2014 Research-status Report
  • [Journal Article] Ischemia-Related Subcellular Redistribution of Sodium Channels Enhances the Proarrhythmic Effect of Class I Antiarrhythmic Drugs: A Simulation Study2014

    • Author(s)
      Tsumoto K, Ashihara T, Haraguchi R, Nakazawa K, Kurachi Y
    • Journal Title

      PLoS ONE

      Volume: 9(10) Issue: 10 Pages: e109271-e109271

    • DOI

      10.1371/journal.pone.0109271

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] An autopsic examination case of diagnosed Brugada syndrome.2014

    • Author(s)
      Furukawa S, Morita S, Okunaga H, Wingenfeld L, Takaya A, Nakagawa T, Sakaguchi I, Yamamoto Y, Ashihara T, Horie M, Nishi K, Hitosugi M.
    • Journal Title

      Am J Int Med.

      Volume: 2 Pages: 79-82

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Self-terminated long-lasting ventricular fibrillation: What is the mechanism?2014

    • Author(s)
      Konishi S, Minaguchi H, Ashihara T, Okuyama Y.
    • Journal Title

      Journal of Cardiology Cases.

      Volume: 10 Issue: 4 Pages: 136-139

    • DOI

      10.1016/j.jccase.2014.06.005

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Long-term Pharmacological Therapy of Brugada Syndrome: Is J-wave Attenuation a Marker of Drug Efficacy?2014

    • Author(s)
      Hasegawa K, Ashihara T, Kimura H, Jo H, Itoh H, Yamamoto T, Aizawa Y, Horie M.
    • Journal Title

      Internal Medicine

      Volume: 53 Issue: 14 Pages: 1523-1526

    • DOI

      10.2169/internalmedicine.53.1829

    • NAID

      130004466395

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] コンピュータシミュレーションと遺伝性不整脈.2014

    • Author(s)
      芦原貴司.
    • Journal Title

      医学のあゆみ.

      Volume: Suppl. Pages: 16-24

    • Related Report
      2014 Research-status Report
  • [Journal Article] 慢性心房細動のインシリコ研究.2014

    • Author(s)
      芦原貴司.
    • Journal Title

      京滋奈良ハートリズム研究会:不整脈ニュース.

      Volume: 6 Pages: 1-4

    • Related Report
      2014 Research-status Report 2013 Research-status Report
  • [Journal Article] 二相性ショックの優位性という摩訶不思議なパズルの最後のピース.2014

    • Author(s)
      芦原貴司.
    • Journal Title

      心電図.

      Volume: 24 Pages: 29-34

    • NAID

      130005090808

    • Related Report
      2014 Research-status Report
  • [Journal Article] 医薬品安全性評価におけるin silicoアプローチの可能性について考える.2014

    • Author(s)
      黒川洵子,古谷和春,中谷晴昭,芦原貴司,久田俊明,杉浦清了,岡田純一,田保充康,吉永貴志.
    • Journal Title

      心電図.

      Volume: 34 Pages: 326-329

    • NAID

      130005090845

    • Related Report
      2014 Research-status Report
  • [Journal Article] 新しいパラダイムの主な方向:In silicoによる心臓安全性薬理評価.2014

    • Author(s)
      芦原貴司.
    • Journal Title

      心電図.

      Volume: 34 Pages: 291-296

    • Related Report
      2014 Research-status Report
  • [Journal Article] A novel KCNQ1 missense mutation identified in a patient with juvenile-onset atrial fibrillation causes constitutively open IKs channels.2014

    • Author(s)
      Hasegawa K, Ohno S, Ashihara T, Itoh H, Ding WG, Toyoda F, Makiyama T, Aoki H, Nakamura Y, Delisle BP, Matsuura H, Horie M.
    • Journal Title

      Heart Rhythm

      Volume: 11 Issue: 1 Pages: 67-75

    • DOI

      10.1016/j.hrthm.2013.09.073

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] TECH PLUS: In silico心室筋モデルにより検討したiPS細胞由来心筋細胞シートの応用可能性.2014

    • Author(s)
      芦原貴司.
    • Journal Title

      不整脈+PLUS.

      Volume: 8 Pages: 12-13

    • Related Report
      2013 Research-status Report
  • [Journal Article] Symposia:構造的リモデリング下の心房筋における興奮伝播のシミュレーション.2014

    • Author(s)
      芦原貴司.
    • Journal Title

      日本生理学雑誌.

      Volume: 76 Pages: 16-17

    • Related Report
      2013 Research-status Report
  • [Journal Article] Simulation study of complex action potential conduction in atrioventricular node.2013

    • Author(s)
      Inada S, Ono T, Shibata N, Iwata M, Haraguchi R, Ashihara T, Mitsui K, Boyett MR, Dobrzynski H, Nakazawa K.
    • Journal Title

      Conf Proc IEEE Eng Med Biol Soc.

      Volume: Suppl. Pages: 6850-6853

    • DOI

      10.1109/embc.2013.6611131

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 致死性不整脈疾患への新たなアプローチ法:コンピュータシミュレーション:不整脈治療へ向けた新たなアプローチ.2013

    • Author(s)
      芦原貴司.
    • Journal Title

      最新医学.

      Volume: 68 Pages: 1531-1540

    • Related Report
      2013 Research-status Report
  • [Journal Article] コンピュータシミュレーションと遺伝性不整脈.2013

    • Author(s)
      芦原貴司.
    • Journal Title

      医学のあゆみ.

      Volume: 245 Pages: 710-718

    • Related Report
      2013 Research-status Report
  • [Journal Article] 不整脈診断のためのコンピュータシミュレーション解析.2013

    • Author(s)
      芦原貴司.
    • Journal Title

      循環器内科.

      Volume: 73 Pages: 507-513

    • Related Report
      2013 Research-status Report
  • [Journal Article] 心房細動と心原性脳塞栓症の最近の話題.2013

    • Author(s)
      芦原貴司.
    • Journal Title

      大津市医師会誌.

      Volume: 36 Pages: 83-86

    • Related Report
      2013 Research-status Report
  • [Presentation] ExTRa Mappingライブデモンストレーション.2016

    • Author(s)
      芦原貴司,小澤友哉,坂田憲祐.
    • Organizer
      カテーテルアブレーション関連秋季大会2016.
    • Place of Presentation
      福岡
    • Year and Date
      2016-10-27
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 線維芽細胞と分裂電位:in silicoでの検討.2016

    • Author(s)
      芦原貴司.
    • Organizer
      第31回犬山不整脈カンファランス.
    • Place of Presentation
      名古屋
    • Year and Date
      2016-08-20
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Symposium 31: Atrial fibrillation and autonomic nerve function: Autonomic nerve activity is not involved in the mechanisms of non-paroxysmal atrial fibrillation: ExTRa Mapping Project.2016

    • Author(s)
      Ashihara T, Sakata K, Ozawa T, Tsuchiya T, Haraguchi R, Inada S, Nakazawa K, Horie M.
    • Organizer
      The 63rd Annual Meeting of the Japanese Heart Rhythm Society (JHRS 2016).
    • Place of Presentation
      札幌
    • Year and Date
      2016-07-14
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] JHRS-JSMBE Joint Symposium: Current status and future perspective of biomedical engineering in electrocardiology and arrhythmia studies: Challenge of in silico in developing the innovation of catheter ablation for non-paroxysmal atrial fibrillation: ExTRa Mapping Project.2016

    • Author(s)
      Ashihara T, Sakata K, Ozawa T, Tsuchiya T, Haraguchi R, Inada S, Nakazawa K, Horie M.
    • Organizer
      The 63rd Annual Meeting of the Japanese Heart Rhythm Society (JHRS 2016).
    • Place of Presentation
      札幌
    • Year and Date
      2016-07-14
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Symposium 8: State of Arts in Arrhythmia Research: Simulation and Development/Regeneration: Exploration of non-paroxysmal atrial fibrillation drivers by an in silico-integrated online and real-time phase mapping system: ExTRa Mapping Project.2016

    • Author(s)
      Ashihara T, Sakata K, Ozawa T, Tsuchiya T, Haraguchi R, Inada S, Nakazawa K, Horie M.
    • Organizer
      The 63rd Annual Meeting of the Japanese Heart Rhythm Society (JHRS 2016).
    • Place of Presentation
      札幌
    • Year and Date
      2016-07-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Symposium 19: Approaches to catheter ablation for atrial fibrillation: Triggers or substrate modification: Significance of direct recording of AF wave dynamics rather than detecting indirect indicator of driver/perpetuator for non-PAF ablation: ExTRa Mapping Project.2016

    • Author(s)
      Ashihara T, Sakata K, Ozawa T, Tsuchiya T, Haraguchi R, Inada S, Nakazawa K, Horie M.
    • Organizer
      The 63rd Annual Meeting of the Japanese Heart Rhythm Society (JHRS 2016).
    • Place of Presentation
      札幌
    • Year and Date
      2016-07-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 心房線維化とrotorの関係.2016

    • Author(s)
      芦原貴司.
    • Organizer
      第1回START研究会.
    • Place of Presentation
      札幌
    • Year and Date
      2016-07-14
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] ExTRa Mappingで持続性心房細動の謎に迫る:細動研究20年越しの挑戦.2016

    • Author(s)
      芦原貴司.
    • Organizer
      第2回関東・関西不整脈合同カンファランス.
    • Place of Presentation
      大阪
    • Year and Date
      2016-06-04
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Stationary rotors are not therapeutic targets in patients with non-paroxysmal atrial fibrillation?: A clinical study employing a novel "online" real-time phase mapping system (ExTRa Mapping).2016

    • Author(s)
      Sakata K, Ashihara T, Ozawa T, Tsuchiya T, Haraguchi R, Inada S, Nakazawa K, Horie M.
    • Organizer
      Heart Rhythm 2016 Scientific Sessions.
    • Place of Presentation
      サンフランシスコ(米国)
    • Year and Date
      2016-05-04
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] オーガナイズドセッションOS18「多階層な生体機能に基づく不整脈疾患における可視化および計算科学的研究」:慢性心房細動アブレーションに向けたオンラインリアルタイム位相マッピングの意義:ExTRa Mapping研究.2016

    • Author(s)
      芦原貴司,坂田憲祐,小澤友哉,土谷 健,原口 亮,稲田 慎,中沢一雄,堀江 稔.
    • Organizer
      第55回日本生体医工学会大会(JSMBE).
    • Place of Presentation
      富山
    • Year and Date
      2016-04-26
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Multi-scale simulation studies of excitation conduction including cardiac conduction systems and whole ventricles.2016

    • Author(s)
      Inada S, Harrell DT, Haraguchi R, Ashihara T, Aiba T, Yamashita F, Shibata N, Ikeda T, Mitsui K, Makita N, Honjo H, Boyett MR, Nakazawa K.
    • Organizer
      第93回日本生理学会大会.
    • Place of Presentation
      札幌
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Plenary Session: Catheter Ablation: The Current Status and the Future Direction: 3-dimensional scroll wave dynamics during atrial fibrillation in isolated sheep hearts: Implications for rotor mapping and ablation.2016

    • Author(s)
      Yamazaki M, Honjo H, Sakuma I, Ashihara T, Nakazawa K, Shibata N, Kamiya K, Kalifa J.
    • Organizer
      The 80th Annual Scientific Meeting of Japanese Circulation Society.
    • Place of Presentation
      仙台
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Plenary Session: Catheter Ablation: The Current Status and the Future Direction: Significance of online real-time phase mapping during catheter ablation for non-paroxysmal atrial fibrillation: A clinical study using ExTRa Mapping system.2016

    • Author(s)
      Ashihara T, Sakata K, Ozawa T, Tsuchiya T, Haraguchi R, Inada S, Nakazawa K, Horie M.
    • Organizer
      The 80th Annual Scientific Meeting of Japanese Circulation Society.
    • Place of Presentation
      仙台
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Non-invasive risk stratification of ventricular arrhythmias initiated from right ventricular outflow tract: A simulation study for the Brugada syndrome.2016

    • Author(s)
      Inada S, Aiba T, Haraguchi R, Ashihara T, Kusano K, Shimizu W, Ikeda T, Nakazawa K.
    • Organizer
      The 80th Annual Scientific Meeting of Japanese Circulation Society.
    • Place of Presentation
      仙台
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Acute results of rotor mapping-guided atrial fibrillation ablation in patients with non-paroxysmal AF.2016

    • Author(s)
      Yamaguchi T, Tsuchiya T, Fukui A, Inada S, Nakazawa K, Ashihara T.
    • Organizer
      The 80th Annual Scientific Meeting of Japanese Circulation Society.
    • Place of Presentation
      仙台
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A new approach to driver ablation for non-paroxysmal atrial fibrillation: A case report of ExTRa Mapping-guided ablation.2016

    • Author(s)
      Ashihara T, Sakata K, Ozawa T, Tsuchiya T, Haraguchi R, Inada S, Nakazawa K, Horie M.
    • Organizer
      The 80th Annual Scientific Meeting of Japanese Circulation Society.
    • Place of Presentation
      仙台
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Are stationary rotors therapeutic targets in non-PAF patients?: A clinical study employing an original real-time phase mapping system (ExTRa Mapping).2016

    • Author(s)
      Sakata K, Ashihara T, Ozawa T, Tsuchiya T, Haraguchi R, Inada S, Nakazawa K, Horie M.
    • Organizer
      The 80th Annual Scientific Meeting of Japanese Circulation Society.
    • Place of Presentation
      仙台
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] シンポジウム「インシリコアプローチによる心毒性予測の最前線」:安全性薬理評価のニーズ実現に向けたインシリコ:迅速薬理評価モデルからiPS細胞由来心筋まで.2016

    • Author(s)
      芦原貴司.
    • Organizer
      第89回日本薬理学会年会.
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-09
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 慢性心房細動治療への新たな挑戦:ExTRa Mappingとin silicoが問いかけるもの.2016

    • Author(s)
      芦原貴司.
    • Organizer
      第55回神奈川不整脈研究会.
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-05
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] シンポジウム2「In silico研究の現状:課題と展望を探る」:心臓安全性 in silico 評価の基礎から臨床:ヒトiPS細胞由来心筋細胞の安全性薬理への応用に向けて.2016

    • Author(s)
      芦原貴司.
    • Organizer
      第7回日本安全性薬理研究会.
    • Place of Presentation
      東京
    • Year and Date
      2016-02-19
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] ExTRa Mapping:持続性心房細動に対する新たな挑戦.2016

    • Author(s)
      芦原貴司.
    • Organizer
      第7回東京アブレーションフォーラム.
    • Place of Presentation
      東京
    • Year and Date
      2016-02-12
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] ヒトiPS分化技術を活用した医薬品の次世代毒性・安全性評価試験系の開発と国際標準化:ヒトiPS細胞分化技術がもたらす非臨床試験の変革:iPS心筋による安全性薬理評価をin silicoで科学する.2016

    • Author(s)
      芦原貴司.
    • Organizer
      日本医療研究開発機構(AMED)レギュラトリーサイエンス研究シンポジウム.
    • Place of Presentation
      東京(よみうり大手町ホール)
    • Year and Date
      2016-02-01
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] In silico導入によるイノベーティブな不整脈治療システムの創出とその効率化を目指して.2016

    • Author(s)
      芦原貴司.
    • Organizer
      つくば医工連携フォーラム2016:医工連携・橋渡しのつくばモデル.
    • Place of Presentation
      つくば
    • Year and Date
      2016-01-22
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 慢性心房細動のアブレーション治療におけるイノベーション創出に向けたin silicoの挑戦.2015

    • Author(s)
      芦原貴司,小澤友哉,坂田憲祐,土谷 健,原口 亮,稲田 慎,中沢一雄,堀江 稔.
    • Organizer
      第24回日本コンピュータ外科学会大会.
    • Place of Presentation
      東京
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] No stationary rotors are observed in patients with non-paroxysmal atrial fibrillation: A combined clinical and in silico study employing a novel real-time phase mapping system (ExTRa Mapping).2015

    • Author(s)
      Sakata K, Ashihara T, Ozawa T, Kato K, Tsuchiya T, Haraguchi R, Inada S, Nakazawa K, Horie M.
    • Organizer
      The 8th Asia-Pacific Heart Rhythm Society Scientific Session (APHRS).
    • Place of Presentation
      メルボルン(豪州)
    • Year and Date
      2015-11-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of a novel real-time phase mapping system, called ExTRa Mapping, using in silico technique for identifying unstable rotors in patients with non-paroxysmal atrial fibrillation.2015

    • Author(s)
      Ashihara T, Sakata K, Ozawa T, Kato K, Tsuchiya T, Haraguchi R, Inada S, Nakazawa K, Horie M.
    • Organizer
      The 8th Asia-Pacific Heart Rhythm Society Scientific Session (APHRS).
    • Place of Presentation
      メルボルン(豪州)
    • Year and Date
      2015-11-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Rotor distribution does not always match with the anatomic distribution of complex fractionated atrial electrogram sites in patients with non-paroxysmal atrial fibrillation: A clinical observational study employing a novel real-time phase mapping system (ExTRa Mapping).2015

    • Author(s)
      Ashihara T, Sakata K, Ozawa T, Kato K, Tsuchiya T, Haraguchi R, Inada S, Nakazawa K, Horie M.
    • Organizer
      The 8th Asia-Pacific Heart Rhythm Society Scientific Session (APHRS).
    • Place of Presentation
      メルボルン(豪州)
    • Year and Date
      2015-11-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 心房細動アブレーションにおける肺静脈隔離術の目的とは…隔離すること?2015

    • Author(s)
      小澤友哉,坂田憲祐,芦原貴司,藤居祐介,伊藤英樹,杉本喜久,伊藤 誠,堀江 稔.
    • Organizer
      第30回京滋奈良ハートリズム研究会.
    • Place of Presentation
      京都
    • Year and Date
      2015-11-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] 心房での不整脈起源の同定を目指した12誘導心電図解析システムの開発.2015

    • Author(s)
      稲田 慎,竹村匡正,鈴木信宏,芦原貴司,三井和幸,柴田仁太郎,中沢一雄.
    • Organizer
      第35回医療情報学連合大会(第16回日本医療情報学会学術集会).
    • Place of Presentation
      宜野湾(沖縄)
    • Year and Date
      2015-11-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 慢性心房細動アブレーションにおけるイノベーション実現に向けたin silicoの挑戦:ExTRa Mappingの開発.2015

    • Author(s)
      芦原貴司,坂田憲祐,小澤友哉,土谷 健,原口 亮,稲田 慎,中沢一雄,堀江 稔.
    • Organizer
      第31回心電情報処理ワークショップ(JSCE2015).
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] 心房の異常自動能発生部位の同定を目指した心電図心房波解析手法の検討.2015

    • Author(s)
      稲田 慎,柴田仁太郎,竹村匡正,鈴木信宏,芦原貴司,三井和幸,中沢一雄.
    • Organizer
      第31回心電情報処理ワークショップ(JSCE2015).
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] 慢性心房細動に治療標的となるような定在ローターは存在するか?:ExTRa Mappingによる臨床的観察研究.2015

    • Author(s)
      坂田憲祐,芦原貴司,小澤友哉,土谷 健,原口 亮,稲田 慎,中沢一雄,堀江 稔.
    • Organizer
      第31回心電情報処理ワークショップ(JSCE2015).
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] 心房細動治療のイノベーション実現に向けたin silicoの挑戦.2015

    • Author(s)
      芦原貴司.
    • Organizer
      第63回日本心臓病学会学術集会.
    • Place of Presentation
      横浜
    • Year and Date
      2015-09-18 – 2015-09-20
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] ビジュアルワークショップ4「生きた心臓を心臓シミュレーションで再現」:慢性心房細動アブレーション治療のイノベーション実現に向けたin silicoの挑戦.2015

    • Author(s)
      芦原貴司.
    • Organizer
      第63回日本心臓病学会学術集会.
    • Place of Presentation
      横浜
    • Year and Date
      2015-09-18
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Development of a novel real-time phase mapping system using in silico technique for identifying unstable rotors in human atrial fibrillation.2015

    • Author(s)
      Ashihara T, Ozawa T, Tsuchiya T, Yamaguchi T, Fukui A, Haraguchi R, Inada S, Nakazawa K, Horie M.
    • Organizer
      第30回日本不整脈学会学術大会/第32回日本心電学会学術集会.
    • Place of Presentation
      京都
    • Year and Date
      2015-07-28 – 2015-07-31
    • Related Report
      2014 Research-status Report
  • [Presentation] Possible mechanisms of effective rotor ablation for chronic atrial fibrillation: A simulation study.2015

    • Author(s)
      Ashihara T, Haraguchi R, Inada S, Nakazawa K, Tsuchiya T, Yamaguchi T, Fukui A, Ozawa T, Hattori T, Kato K, Horie M.
    • Organizer
      第30回日本不整脈学会学術大会/第32回日本心電学会学術集会.
    • Place of Presentation
      京都
    • Year and Date
      2015-07-28 – 2015-07-31
    • Related Report
      2014 Research-status Report
  • [Presentation] シンポジウム16:再生医療と不整脈:Can computer simulation technique contribute regenerative medicine?2015

    • Author(s)
      Inada S, Harrell DT, Haraguchi R, Ashihara T, Aiba T, Ikeda T, Mitsui K, Honjo H, Shibata N, Makita N, Kamiya K, Kodama I, Nakazawa K.
    • Organizer
      第30回日本不整脈学会学術大会(JHRS)/第32回日本心電学会学術集会(JSE).
    • Place of Presentation
      京都
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] パネルディスカッション5:Imaging Technologyの不整脈診療における役割:Development of a novel real-time phase mapping system using in silico technique for identifying unstable rotors in human atrial fibrillation.2015

    • Author(s)
      Ashihara T, Ozawa T, Tsuchiya T, Yamaguchi T, Fukui A, Haraguchi R, Inada S, Nakazawa K, Horie M.
    • Organizer
      第30回日本不整脈学会学術大会(JHRS)/第32回日本心電学会学術集会(JSE).
    • Place of Presentation
      京都
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] シンポジウム17:心房細動のメカニズム研究の新展開:How rotor is related to substrate in human atrial fibrillation (AF).2015

    • Author(s)
      Tsuchiya T, Ashihara T, Yamaguchi T, Nakahara S, Fukui A.
    • Organizer
      第30回日本不整脈学会学術大会(JHRS)/第32回日本心電学会学術集会(JSE).
    • Place of Presentation
      京都
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] シンポジウム13:Resolution of the mechanism of atrial fibrillation and its application 2: Rotor mapping its theory and reality: Rotor mapping and atrial fibrillation (AF) ablation.2015

    • Author(s)
      Tsuchiya T, Ashihara T, Yamaguchi T, Fukui A, Nagamoto Y.
    • Organizer
      第30回日本不整脈学会学術大会(JHRS)/第32回日本心電学会学術集会(JSE).
    • Place of Presentation
      京都
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Newly developed near-real-time phase mapping system called "ExTRa Mapping" nicely elucidates rotors and it was preferentially located at fibrotic tissue border.2015

    • Author(s)
      Fukui A, Tsuchiya T, Yamaguchi T, Nagatomo Y, Inada S, Nakazawa K, Ashihara T.
    • Organizer
      第30回日本不整脈学会学術大会(JHRS)/第32回日本心電学会学術集会(JSE).
    • Place of Presentation
      京都
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Low voltage zone (LVZ) is closely related to repetitively appearing rotors: An analysis with a novel phase mapping system called “ExTRa Mapping”.2015

    • Author(s)
      Fukui A, Tsuchiya T, Yamaguchi T, Nagatomo Y, Inada S, Nakazawa K, Ashihara T.
    • Organizer
      第30回日本不整脈学会学術大会(JHRS)/第32回日本心電学会学術集会(JSE).
    • Place of Presentation
      京都
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Site with repetitively appearing rotors exhibits high dominant frequency (DF) in atrial fibrillation (AF): An analysis with a novel phase mapping system called "ExTRa Mapping".2015

    • Author(s)
      Fukui A, Tsuchiya T, Yamaguchi T, Nagatomo Y, Inada S, Nakazawa K, Ashihara T.
    • Organizer
      第30回日本不整脈学会学術大会(JHRS)/第32回日本心電学会学術集会(JSE).
    • Place of Presentation
      京都
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] A case with a stable rotor observed during atrial fibrillation using a novel phase mapping system called "ExTRa Mapping".2015

    • Author(s)
      Fukui A, Tsuchiya T, Yamaguchi T, Nagatomo Y, Inada S, Nakazawa K, Ashihara T.
    • Organizer
      第30回日本不整脈学会学術大会(JHRS)/第32回日本心電学会学術集会(JSE).
    • Place of Presentation
      京都
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Analyzing 12 lead ECG to predict the origin of premature ventricular contraction.2015

    • Author(s)
      Inada S, Shibata N, Ashihara T, Mitsui K, Nakazawa K.
    • Organizer
      第30回日本不整脈学会学術大会(JHRS)/第32回日本心電学会学術集会(JSE).
    • Place of Presentation
      京都
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Possible mechanisms of effective rotor ablation for chronic atrial fibrillation: A simulation study.2015

    • Author(s)
      Ashihara T, Haraguchi R, Inada S, Nakazawa K, Tsuchiya T, Yamaguchi T, Fukui A, Ozawa T, Hattori T, Kato K, Horie M.
    • Organizer
      第30回日本不整脈学会学術大会(JHRS)/第32回日本心電学会学術集会(JSE).
    • Place of Presentation
      京都
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] In silicoヒトiPS細胞由来心筋細胞の構築と不整脈研究への応用可能性.2015

    • Author(s)
      芦原貴司,黒川洵子,諫田泰成,関野祐子,原口 亮,稲田 慎,中沢一雄,堀江 稔.
    • Organizer
      第51回日本小児循環器学会総会・学術集会.
    • Place of Presentation
      東京
    • Year and Date
      2015-07-16
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Conduction delay of right ventricular outflow tract and ventricular tachyarrhythmia: A simulation study for Brugada syndrome.2015

    • Author(s)
      Inada S, Aiba T, Harrell DT, Haraguchi R, Ashihara T, Makita N, Shimizu W, Ikeda T, Nakazawa K.
    • Organizer
      The 42nd International Congress on Electrocardiology (ICE).
    • Place of Presentation
      コマンダツゥーバ島(ブラジル)
    • Year and Date
      2015-06-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 心房細動治療におけるRotor Revisited:in silicoと臨床の見地から.2015

    • Author(s)
      芦原貴司.
    • Organizer
      第13回慶應・日医不整脈カンファレンス.
    • Place of Presentation
      東京
    • Year and Date
      2015-06-19
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 慢性心房細動治療の新たな展開.2015

    • Author(s)
      芦原貴司.
    • Organizer
      第120回滋賀県内科医会学術講演会.
    • Place of Presentation
      大津
    • Year and Date
      2015-06-13
    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Invited
  • [Presentation] 慢性心房細動の治療戦略:自験例と理論的見地から.2015

    • Author(s)
      坂田憲祐,小澤友哉,芦原貴司,藤居祐介,服部哲久,伊藤英樹,杉本喜久,伊藤 誠,堀江 稔.
    • Organizer
      第30回京滋奈良ハートリズム研究会.
    • Place of Presentation
      京都
    • Year and Date
      2015-05-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] Panel Discussion: Defining and Mapping Rotors: Development of novel real-time phase mapping system: For defining and mapping rotors of human atrial fibrillation.2015

    • Author(s)
      Ashihara T.
    • Organizer
      Asia Night in Boston 2015: St. Jude Medical Innovation Seminar.
    • Place of Presentation
      ボストン(米国)
    • Year and Date
      2015-05-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Defining and Mapping Rotors.2015

    • Author(s)
      Ashihara T.
    • Organizer
      Asia Night in Boston 2015: St. Jude Medical Innovation Seminar.
    • Place of Presentation
      Boston,アメリカ合衆国
    • Year and Date
      2015-05-15
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Possible mechanisms of rotor ablation for chronic atrial fibrillation: A simulation study.2015

    • Author(s)
      Ashihara T, Ozawa T, Hattori T, Kato K, Tsuchiya T, Yamaguchi T, Haraguchi R, Inada S, Nakazawa K, Horie M.
    • Organizer
      Heart Rhythm 2015 Scientific Sessions.
    • Place of Presentation
      Boston,アメリカ合衆国
    • Year and Date
      2015-05-13 – 2015-05-16
    • Related Report
      2014 Research-status Report
  • [Presentation] Spiral wave behaviors and antiarrhythmic drug efficacy in human induced pluripotent stem cell-derived myocardial sheet are different from those in original heart: A simulation study.2015

    • Author(s)
      Ashihara T, Kurokawa J, Kanda Y, Haraguchi R, Nakazawa K, Horie M.
    • Organizer
      Heart Rhythm 2015 Scientific Sessions.
    • Place of Presentation
      Boston,アメリカ合衆国
    • Year and Date
      2015-05-13 – 2015-05-16
    • Related Report
      2014 Research-status Report
  • [Presentation] Spiral wave behaviors and antiarrhythmic drug efficacy in human induced pluripotent stem cell-derived myocardial sheet are different from those in original heart: A simulation study.2015

    • Author(s)
      Ashihara T, Kurokawa J, Kanda Y, Haraguchi R, Nakazawa K, Horie M.
    • Organizer
      Heart Rhythm 2015 Scientific Sessions.
    • Place of Presentation
      ボストン(米国)
    • Year and Date
      2015-05-13
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Possible mechanisms of rotor ablation for chronic atrial fibrillation: A simulation study.2015

    • Author(s)
      Ashihara T, Ozawa T, Hattori T, Kato K, Tsuchiya T, Yamaguchi T, Haraguchi R, Inada S, Nakazawa K, Horie M.
    • Organizer
      Heart Rhythm 2015 Scientific Sessions.
    • Place of Presentation
      ボストン(米国)
    • Year and Date
      2015-05-13
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 慢性心房細動の新たな治療戦略に向けて:in silicoによるリアルタイムPhase Mappingシステムの開発.2015

    • Author(s)
      芦原貴司,小澤友哉,土谷 健,原口 亮,稲田 慎,中沢一雄,堀江 稔.
    • Organizer
      第54回日本生体医工学会大会.
    • Place of Presentation
      名古屋
    • Year and Date
      2015-05-07 – 2015-05-09
    • Related Report
      2014 Research-status Report
  • [Presentation] 不整脈起源の同定を目指した12誘導心電図解析システムの開発.2015

    • Author(s)
      稲田 慎,朝井隆裕,竹村匡正,鈴木信宏,芦原貴司,三井和幸,柴田仁太郎,中沢一雄.
    • Organizer
      第54回日本生体医工学会大会.
    • Place of Presentation
      名古屋
    • Year and Date
      2015-05-07 – 2015-05-09
    • Related Report
      2014 Research-status Report
  • [Presentation] オーガナイズドセッションOS2「心房細動維持機構の可視化と計算科学に基づく新たなアブレーション治療戦略の構築」:慢性心房細動の新たな治療戦略に向けて:in silicoによるリアルタイムPhase Mappingシステムの開発.2015

    • Author(s)
      芦原貴司,小澤友哉,土谷 健,原口 亮,稲田 慎,中沢一雄,堀江 稔.
    • Organizer
      第54回日本生体医工学会大会(JSMBE).
    • Place of Presentation
      名古屋
    • Year and Date
      2015-05-07
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 不整脈起源の同定を目指した12誘導心電図解析システムの開発.2015

    • Author(s)
      稲田 慎,朝井隆裕,竹村匡正,鈴木信宏,芦原貴司,三井和幸,柴田仁太郎,中沢一雄.
    • Organizer
      第54回日本生体医工学会大会(JSMBE).
    • Place of Presentation
      名古屋
    • Year and Date
      2015-05-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] Detection of rotors during atrial fibrillation (AF) using a newly developed (quasi-) real-time phase mapping system called ExTRa Mapping.2015

    • Author(s)
      Fukui A, Yamaguchi T, Nagamoto Y, Inada S, Nakazawa K, Ashihara T, Tsuchiya T.
    • Organizer
      第79回日本循環器学会学術集会.
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-24 – 2015-04-26
    • Related Report
      2014 Research-status Report
  • [Presentation] Low voltage zone (LVZ) harbors rotors: An analysis with a novel (quasi-) real-time phase mapping system called “ExTRa Mapping”.2015

    • Author(s)
      Fukui A, Yamaguchi T, Nagamoto Y, Inada S, Nakazawa K, Ashihara T, Tsuchiya T.
    • Organizer
      第79回日本循環器学会学術集会.
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-24 – 2015-04-26
    • Related Report
      2014 Research-status Report
  • [Presentation] A newly developed (quasi-) real-time phase mapping system called “ExTRa Mapping” is superior to NavX activation mapping to detect rotor.2015

    • Author(s)
      Fukui A, Yamaguchi T, Nagamoto Y, Inada S, Nakazawa K, Ashihara T, Tsuchiya T.
    • Organizer
      第79回日本循環器学会学術集会.
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-24 – 2015-04-26
    • Related Report
      2014 Research-status Report
  • [Presentation] Rotor during atrial fibrillation frequently meanders along sites with fractionated electrogram: A study with (quasi-) real-time phase mapping system.2015

    • Author(s)
      Fukui A, Yamaguchi T, Nagamoto Y, Inada S, Nakazawa K, Ashihara T, Tsuchiya T.
    • Organizer
      第79回日本循環器学会学術集会.
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-24 – 2015-04-26
    • Related Report
      2014 Research-status Report
  • [Presentation] Rotor site is related to high dominant frequency in human atrial fibrillation: A study with (quasi-) real-time phase mapping system.2015

    • Author(s)
      Fukui A, Yamaguchi T, Nagamoto Y, Inada S, Nakazawa K, Ashihara T, Tsuchiya T.
    • Organizer
      第79回日本循環器学会学術集会.
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-24 – 2015-04-26
    • Related Report
      2014 Research-status Report
  • [Presentation] Rotor is not associated with complex fractionated atrial electrograms: A study with (quasi-) real-time phase mapping system called ExTRa Mapping.2015

    • Author(s)
      Fukui A, Yamaguchi T, Nagamoto Y, Inada S, Nakazawa K, Ashihara T, Tsuchiya T.
    • Organizer
      第79回日本循環器学会学術集会.
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-24 – 2015-04-26
    • Related Report
      2014 Research-status Report
  • [Presentation] Antiarrhythmic drug efficacy in induced pluripotent stem cell-derived myocardium may be different from that in original heart: A simulation study.2015

    • Author(s)
      Ashihara T, Haraguchi R, Kurokawa J, Nakazawa K, Horie M.
    • Organizer
      第79回日本循環器学会学術集会.
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-24 – 2015-04-26
    • Related Report
      2014 Research-status Report
  • [Presentation] Possible mechanisms of rotor ablation for chronic atrial fibrillation: A simulation study.2015

    • Author(s)
      Ashihara T, Ozawa T, Hattori T, Kato K, Tsuchiya T, Yamaguchi T, Haraguchi R, Inada S, Nakazawa K, Horie M.
    • Organizer
      第79回日本循環器学会学術集会.
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-24 – 2015-04-26
    • Related Report
      2014 Research-status Report
  • [Presentation] Detection of rotors during atrial fibrillation (AF) using a newly developed (quasi-) real-time phase mapping system called ExTRa Mapping.2015

    • Author(s)
      Fukui A, Yamaguchi T, Nagamoto Y, Inada S, Nakazawa K, Ashihara T, Tsuchiya T.
    • Organizer
      The 79th Annual Scientific Meeting of Japanese Circulation Society.
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Low voltage zone (LVZ) harbors rotors: An analysis with a novel (quasi-) real-time phase mapping system called “ExTRa Mapping”.2015

    • Author(s)
      Fukui A, Yamaguchi T, Nagamoto Y, Inada S, Nakazawa K, Ashihara T, Tsuchiya T.
    • Organizer
      The 79th Annual Scientific Meeting of Japanese Circulation Society.
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A newly developed (quasi-) real-time phase mapping system called “ExTRa Mapping” is superior to NavX activation mapping to detect rotor.2015

    • Author(s)
      Fukui A, Yamaguchi T, Nagamoto Y, Inada S, Nakazawa K, Ashihara T, Tsuchiya T.
    • Organizer
      The 79th Annual Scientific Meeting of Japanese Circulation Society.
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Rotor during atrial fibrillation frequently meanders along sites with fractionated electrogram: A study with (quasi-) real-time phase mapping system.2015

    • Author(s)
      Fukui A, Yamaguchi T, Nagamoto Y, Inada S, Nakazawa K, Ashihara T, Tsuchiya T.
    • Organizer
      The 79th Annual Scientific Meeting of Japanese Circulation Society.
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Rotor site is related to high dominant frequency in human atrial fibrillation: A study with (quasi-) real-time phase mapping system.2015

    • Author(s)
      Fukui A, Yamaguchi T, Nagamoto Y, Inada S, Nakazawa K, Ashihara T, Tsuchiya T
    • Organizer
      The 79th Annual Scientific Meeting of Japanese Circulation Society.
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Rotor is not associated with complex fractionated atrial electrograms: A study with (quasi-) real-time phase mapping system called ExTRa Mapping.2015

    • Author(s)
      Fukui A, Yamaguchi T, Nagamoto Y, Inada S, Nakazawa K, Ashihara T, Tsuchiya T
    • Organizer
      The 79th Annual Scientific Meeting of Japanese Circulation Society.
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Antiarrhythmic drug efficacy in induced pluripotent stem cell-derived myocardium may be different from that in original heart: A simulation study.2015

    • Author(s)
      Ashihara T, Haraguchi R, Kurokawa J, Nakazawa K, Horie M.
    • Organizer
      The 79th Annual Scientific Meeting of Japanese Circulation Society.
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Possible mechanisms of rotor ablation for chronic atrial fibrillation: A simulation study.2015

    • Author(s)
      Ashihara T, Ozawa T, Hattori T, Kato K, Tsuchiya T, Yamaguchi T, Haraguchi R, Inada S, Nakazawa K, Horie M.
    • Organizer
      The 79th Annual Scientific Meeting of Japanese Circulation Society.
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 膜輸送体を標的としたiPS細胞由来心筋の創薬応用.2015

    • Author(s)
      黒川洵子,芦原貴司,諫田泰成,古川哲史.
    • Organizer
      第88回日本薬理学会年会.
    • Place of Presentation
      名古屋
    • Year and Date
      2015-03-18 – 2015-03-20
    • Related Report
      2014 Research-status Report
  • [Presentation] 医療機器開発に向けたin silico:循環器領域におけるイノベーションの現場から.2015

    • Author(s)
      芦原貴司.
    • Organizer
      経済産業省:医療機器等の開発・実用化促進のためのガイドライン策定事業:第1回ナビゲーション医療分野(PDT機器)開発ワーキンググループ委員会.
    • Place of Presentation
      東京
    • Year and Date
      2015-02-13
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 抗凝固薬を安全に使用するために気をつけたい薬物間相互作用.2015

    • Author(s)
      田淵陽平,寺田智祐,芦原貴司,堀江 稔.
    • Organizer
      滋賀県病院薬剤師会:ハイリスク医薬品マネジメント研修会.
    • Place of Presentation
      大津
    • Year and Date
      2015-01-19
    • Related Report
      2014 Research-status Report
  • [Presentation] 不整脈治療のイノベーション実現に向けたin silico medicineの挑戦.2014

    • Author(s)
      芦原貴司.
    • Organizer
      分野横断型医工学研究プラットフォーム(BASIC):第42回講演会:医療イノベーションにおけるin silico研究の現在.
    • Place of Presentation
      東京
    • Year and Date
      2014-11-29
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 不整脈治療のイノベーション実現に向けたin silicoの挑戦.2014

    • Author(s)
      芦原貴司.
    • Organizer
      The 7th Kyoto New Generation Conference of Cardiology (KNCC 2014).
    • Place of Presentation
      京都
    • Year and Date
      2014-11-08
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 不整脈発生起源の推定が可能な12誘導心電図解析システムの開発.2014

    • Author(s)
      稲田 慎,朝井隆裕,小野多佳子,芦原貴司,竹村匡正,三井和幸,西原辰夫,柴田仁太郎,中沢一雄.
    • Organizer
      第34回医療情報学連合大会(第15回日本医療情報学会学術集会).
    • Place of Presentation
      千葉
    • Year and Date
      2014-11-06 – 2014-11-08
    • Related Report
      2014 Research-status Report
  • [Presentation] バーチャルiPS細胞由来心筋細胞への飽くなき挑戦.2014

    • Author(s)
      芦原貴司.
    • Organizer
      CBI学会2014年大会(情報計算化学生物学会).
    • Place of Presentation
      東京
    • Year and Date
      2014-10-28 – 2014-10-30
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Comparison of in silico human ventricular model assay with in vivo canine PK/PD analysis for predicting the cardiac safety of antipsychotic drugs.2014

    • Author(s)
      Kubo T, Ashihara T, Kadotsuji K, Katsura Y, Kobayashi A, Nomura N, Funabashi H, Horie M.
    • Organizer
      CBI学会2014年大会(情報計算化学生物学会).
    • Place of Presentation
      東京
    • Year and Date
      2014-10-28 – 2014-10-30
    • Related Report
      2014 Research-status Report
  • [Presentation] 12誘導心電図をInverse Dower法により変換したベクトル心電図を用いた心室期外収縮発生部位の推定に関する基礎研究.2014

    • Author(s)
      稲田 慎,朝井裕隆,小野多佳子,芦原貴司,竹村匡正,三井和幸,西原辰夫,柴田仁太郎,中沢一雄.
    • Organizer
      第30回心電情報処理ワークショップ.
    • Place of Presentation
      熱海
    • Year and Date
      2014-10-25 – 2014-10-26
    • Related Report
      2014 Research-status Report
  • [Presentation] Potential applications of heart simulation to the safety pharmacology study in the future.2014

    • Author(s)
      Ashihara T.
    • Organizer
      5th DIA Cardiac Safety Workshop in Japan.
    • Place of Presentation
      東京
    • Year and Date
      2014-10-23 – 2014-10-24
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] in silico assessment of cardiac safety of drugs using integrated computer model of failing heart.2014

    • Author(s)
      Kubo T, Ashihara T, Nomura N, Funabashi H, Horie M.
    • Organizer
      The 14th Annual Meeting of Safety Pharmacology Society.
    • Place of Presentation
      Washington DC,アメリカ合衆国
    • Year and Date
      2014-10-19 – 2014-10-22
    • Related Report
      2014 Research-status Report
  • [Presentation] In silicoによる不整脈の病態解明と治療法の開発.2014

    • Author(s)
      芦原貴司.
    • Organizer
      統計数理研究所研究集会「ダイナミカルバイオインフォマテイックスの展開III」.
    • Place of Presentation
      立川(東京)
    • Year and Date
      2014-09-18 – 2014-09-19
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 心筋Naチャネルの細胞内分布変化による組織興奮性の低下とNaチャネル遮断薬の催不整脈性への寄与.2014

    • Author(s)
      津元国親,芦原貴司,原口 亮,中沢一雄,倉智嘉久.
    • Organizer
      生理学研究所研究会「心血管膜輸送分子の構造・機能・病態の統合的研究戦略」.
    • Place of Presentation
      岡崎
    • Year and Date
      2014-09-04 – 2014-09-05
    • Related Report
      2014 Research-status Report
  • [Presentation] Spiral wave behaviors and antiarrhythmic drug efficacy in human induced pluripotent stem cell-derived myocardial sheet are different from those in original heart: A simulation study.2014

    • Author(s)
      Ashihara T, Haraguchi R, Kurokawa J, Nakazawa K, Horie M.
    • Organizer
      The 36th Annual Congress of the European Society of Cardiology (ESC Congress 2014).
    • Place of Presentation
      Barcelona,スペイン
    • Year and Date
      2014-08-30 – 2014-09-03
    • Related Report
      2014 Research-status Report
  • [Presentation] Investigating excitation conduction in the atrioventricular node and Purkinje network using computer simulation.2014

    • Author(s)
      Inada S, Harrell DT, Ono T, Shibata N, Haraguchi R, Ashihara T, keda T, Mitsui K, Dobrzynski H, Boyett MR, Makita N, Nakazawa K.
    • Organizer
      第9回田原アショフシンポジウム.
    • Place of Presentation
      東京
    • Year and Date
      2014-07-26 – 2014-07-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Theoretical analysis of atrial fibrillation.2014

    • Author(s)
      Ashihara T.
    • Organizer
      第29回日本不整脈学会学術大会/第31回日本心電学会学術集会.
    • Place of Presentation
      東京
    • Year and Date
      2014-07-22 – 2014-07-25
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Ischemia-induced subcellular sodium channel redistribution as a mechanism of arrhythmogenic effect of class-I antiarrhythmic drugs on ventricle: A simulation study.2014

    • Author(s)
      Tsumoto K, Ashihara T, Haraguchi R, Nakazawa K, Kurachi Y.
    • Organizer
      第29回日本不整脈学会学術大会/第31回日本心電学会学術集会.
    • Place of Presentation
      東京
    • Year and Date
      2014-07-22 – 2014-07-25
    • Related Report
      2014 Research-status Report
  • [Presentation] 左室心外膜側に頻拍回路起源を同定しイリゲーションカテーテルにて心内膜側からの通電にて回路の完全離断に成功した陳旧性心筋梗塞の一例.2014

    • Author(s)
      小澤友哉,芦原貴司,藤居祐介,伊藤英樹,杉本喜久,伊藤 誠,堀江 稔.
    • Organizer
      第3回九州関西3会合同カンファレンス.
    • Place of Presentation
      東京
    • Year and Date
      2014-07-22
    • Related Report
      2014 Research-status Report
  • [Presentation] ヒトiPS細胞由来心筋細胞シートの不整脈研究への応用可能性:in silico不整脈学の観点から.2014

    • Author(s)
      芦原貴司,原口 亮,稲田 慎,中沢一雄,堀江 稔.
    • Organizer
      第53回日本生体医工学会大会.
    • Place of Presentation
      仙台
    • Year and Date
      2014-06-24 – 2014-06-26
    • Related Report
      2014 Research-status Report
  • [Presentation] ギャップ結合コンダクタンスの低下したプルキンエ線維網起源の心室性不整脈のシミュレーションによる検討.2014

    • Author(s)
      稲田 慎,Harrell D,原口 亮,芦原貴司,蒔田直昌,中沢一雄.
    • Organizer
      第53回日本生体医工学会大会.
    • Place of Presentation
      仙台
    • Year and Date
      2014-06-24 – 2014-06-26
    • Related Report
      2014 Research-status Report
  • [Presentation] 心房細動の治療に関する最近の話題:基礎と臨床の両面から.2014

    • Author(s)
      芦原貴司.
    • Organizer
      武生医師会講演会.
    • Place of Presentation
      越前(福井)
    • Year and Date
      2014-04-10
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] In silicoによる不整脈の病態解明と治療法の開発.2014

    • Author(s)
      芦原貴司.
    • Organizer
      第11回CEMフォーラム.
    • Place of Presentation
      京都
    • Year and Date
      2014-04-05
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Spiral wave behaviors and antiarrhythmic drug efficacy in human induced pluripotent stem cell-derived myocardial sheet are different from those in original heart: A simulation study.2014

    • Author(s)
      Ashihara T, Haraguchi R, Kurokawa J, Nakazawa K, Horie M.
    • Organizer
      The 36th Annual Congress of the European Society of Cardiology.
    • Place of Presentation
      バルセロナ(スペイン)
    • Related Report
      2013 Research-status Report
  • [Presentation] Symposium: Pathophysiology of atrial fibrillation/Translational Science and Future Direction: Theoretical analysis of atrial fibrillation.2014

    • Author(s)
      Ashihara T.
    • Organizer
      第29回日本不整脈学会学術大会/第31回日本心電学会学術集会.
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] オーガナイズドセッション:心臓の多階層生体機能学を目指したシミュレーション研究の成果と進展:2014

    • Author(s)
      芦原貴司,原口 亮,稲田 慎,中沢一雄,堀江 稔.
    • Organizer
      ヒトiPS細胞由来心筋細胞シートの不整脈研究への応用可能性:in silico不整脈学の観点から.
    • Place of Presentation
      仙台
    • Related Report
      2013 Research-status Report
  • [Presentation] Topic “Cardiac Simulator”: In silico arrhythmology: To unlock the future of arrhythmia treatment.2014

    • Author(s)
      Ashihara T, Haraguchi R, Inada S, Nakazawa K, Ikeda T, Ozawa T, Ito M, Horie M.
    • Organizer
      The 78th Annual Scientific Meeting of Japanese Circulation Society.
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Topic “Cardiac Simulator”: Technological development of heart simulators for various computer platforms in the medical and health-care fields.2014

    • Author(s)
      Nakazawa K, Inada S, Haraguchi R, Ashihara T, Shiraishi I, Kurosaki K, Kanzaki S, Igarashi T, Ijiri T, Koyama Y, Ikeda T.
    • Organizer
      The 78th Annual Scientific Meeting of Japanese Circulation Society.
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] A simulation study of ventricular arrhythmias generated from the Purkinje network with gap junction mutation.2014

    • Author(s)
      Inada S, Harrell DT, Haraguchi R, Ashihara T, Makita N, Nakazawa K.
    • Organizer
      The 91st Annual Meeting of the Physiological Society of Japan.
    • Place of Presentation
      鹿児島
    • Related Report
      2013 Research-status Report
  • [Presentation] 心臓シミュレーションの安全性薬理試験への応用可能性と展望.2014

    • Author(s)
      芦原貴司.
    • Organizer
      第5回日本安全性薬理研究会.
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Future Perspectives on ICH S7B: Key Directions for the New Paradigm: In silico predictive modeling in cardiology.2014

    • Author(s)
      芦原貴司.
    • Organizer
      第1回心臓安全性に関するシンクタンクミーティング2014 in 霧島(霧島会議).
    • Place of Presentation
      霧島
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] A gap junction mutation expressed in the Purkinje network and lethal ventricular arrhythmias: A simulation study.2014

    • Author(s)
      Inada S, Harrell DT, Haraguchi R, Ashihara T, Makita N, Nakazawa K.
    • Organizer
      The 78th Annual Scientific Meeting of Japanese Circulation Society.
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] New oral anticoagulants need more heparin but reduce periprocedural bleeding than warfarin during atrial fibrillation (AF) ablation.2014

    • Author(s)
      Ito M, Ozawa T, Ashihara T, Sugimoto Y, Fujii Y, Nakazawa Y, Horie M.
    • Organizer
      The 78th Annual Scientific Meeting of Japanese Circulation Society.
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 虚血境界域における細胞内Naチャネル分布リモデリングがNaチャネル遮断薬による催不整脈作用に関与する可能性について.2014

    • Author(s)
      津元国親,芦原貴司,原口 亮,中沢一雄,倉智嘉久.
    • Organizer
      第87回日本薬理学会年会.
    • Place of Presentation
      仙台
    • Related Report
      2013 Research-status Report
  • [Presentation] 虚血境界域におけるNaチャネルの細胞内リモデリングがリエントリー性心室頻拍の機序に関与する可能性について.2014

    • Author(s)
      津元国親,芦原貴司,原口 亮,中沢一雄,倉智嘉久.
    • Organizer
      第91回日本生理学会大会.
    • Place of Presentation
      鹿児島
    • Related Report
      2013 Research-status Report
  • [Presentation] 薬剤の心臓安全性評価におけるin silico心臓シミュレーション評価の有用性.2014

    • Author(s)
      久保多恵子,芦原貴司,野村成章,船橋 斉,堀江 稔.
    • Organizer
      第5回日本安全性薬理研究会.
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 受賞講演:The role of fibroblasts in complex fractionated electrograms during persistent/permanent atrial fibrillation: Implications for electrogram-based catheter ablation.2013

    • Author(s)
      芦原貴司.
    • Organizer
      第30回日本心電学会学術集会.
    • Place of Presentation
      青森
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 学術委員会指定トピックス「iPS細胞の臨床応用:現状と展望」:ヒトiPS細胞分化心筋シートの薬効評価への応用可能性:in silico不整脈学の観点から.2013

    • Author(s)
      芦原貴司,原口 亮,中沢一雄,伊藤 誠,堀江 稔.
    • Organizer
      第30回日本心電学会学術集会.
    • Place of Presentation
      青森
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Application of biological simulations to the studies of ventricular defibrillation.2013

    • Author(s)
      Ashihara T.
    • Organizer
      The 6th Asia-Pacific Heart Rhythm Society Scientific Session (APHRS) and CARDIORHYTHM in conjunction with the 9th Asia-Pacific Atrial Fibrillation Symposium (APAFS).
    • Place of Presentation
      香港(中国)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] In silico不整脈学:新たな不整脈治療のために.2013

    • Author(s)
      芦原貴司.
    • Organizer
      第28回日本不整脈学会学術大会.
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Panel Discussion 3: Tunnel propagation as a unified hypothesis for electrical defibrillation by ICD shock: A theoretical study.2013

    • Author(s)
      芦原貴司.
    • Organizer
      第28回日本不整脈学会学術大会.
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Rotational anisotropy prevents transition of tachycardia to fibrillation in the ventricular wall model: a simulation study.2013

    • Author(s)
      Haraguchi R, Ashihara T, Inada S, Ikeda T, Nakazawa K.
    • Organizer
      The 6th Asia-Pacific Heart Rhythm Society Scientific Session (APHRS) and CARDIORHYTHM in conjunction with the 9th Asia-Pacific Atrial Fibrillation Symposium (APAFS).
    • Place of Presentation
      香港(中国)
    • Related Report
      2013 Research-status Report
  • [Presentation] Functional properties of complex fractionated atrial electrograms during atrial fibrillation can be explained by structural remodeling: A simulation study.2013

    • Author(s)
      Ashihara T, Haraguchi R, Inada S, Nakazawa K, Ikeda T, Ozawa T, Ito M, Trayanova N, Horie M.
    • Organizer
      The 40th International Congress on Electrocardiology.
    • Place of Presentation
      グラスゴー(スコットランド)
    • Related Report
      2013 Research-status Report
  • [Presentation] Simulation study of ventricular rate control therapy during atrial fibrillation using one-dimensional cable model with two conduction pathways.2013

    • Author(s)
      Inada S, Ono T, Shibata N, Iwata M, Haraguchi R, Ashihara T, Abe A, Ikeda T, Mitsui K, Boyett MR, Dobrzynski H, Nakazawa K.
    • Organizer
      The 40th International Congress on Electrocardiology.
    • Place of Presentation
      グラスゴー(スコットランド)
    • Related Report
      2013 Research-status Report
  • [Presentation] Ischemia-induced subcellular remodeling of sodium channels as a mechanism of ventricular proarrhythmia by class-I antiarrhythmic drug.2013

    • Author(s)
      Tsumoto K, Ashihara T, Haraguchi R, Nakazawa K, Kurachi Y.
    • Organizer
      The 37th International Congress of Physiological Sciences (IUPS 2013).
    • Place of Presentation
      バーミンガム(イギリス)
    • Related Report
      2013 Research-status Report
  • [Presentation] Simulation of excitation propagation in the novel brick-wall model of ventricular myocardium.2013

    • Author(s)
      Tsumoto K, Ashihara T, Haraguchi R, Nakazawa K, Kurachi Y.
    • Organizer
      35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society in conjunction with 52nd Annual Conference of Japanese Society for Medical and Biological Engineering.
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
  • [Presentation] Simulation studies of tachyarrhythmias in a 3-D ventricular wall model: Implications for electrophysiological heterogeneity and rotational anisotropy.2013

    • Author(s)
      Haraguchi R, Ashihara T, Inada S, Ikeda T, Nakazawa K.
    • Organizer
      35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society in conjunction with 52nd Annual Conference of Japanese Society for Medical and Biological Engineering.
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
  • [Presentation] Simulation study of complex action potential conduction in atrioventricular node.2013

    • Author(s)
      Inada S, Ono T, Shibata N, Iwata M, Haraguchi R, Ashihara T, Mitsui K, Boyett MR.
    • Organizer
      35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society in conjunction with 52nd Annual Conference of Japanese Society for Medical and Biological Engineering.
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
  • [Presentation] Electrophysiological characteristics and in-silico simulations of K channel mutations responsible for short QT syndrome.2013

    • Author(s)
      Harrell DT, Ashihara T, Tominaga I, Abe K, Sumitomo N, Uno K, Takano M, Makita N.
    • Organizer
      The 2nd HD Physiology International Symposium: Integrative Multi-level Systems Biology for In Silico Cardiology and Pharmacokinetics.
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] Proarrhythmic effects of class-I antiarrhythmic agents enhanced by ischemia-induced subcellular remodeling of sodium channels.2013

    • Author(s)
      Tsumoto K, Ashihara T, Haraguchi R, Nakazawa K, Kurachi Y,
    • Organizer
      The 2nd HD Physiology International Symposium: Integrative Multi-level Systems Biology for In Silico Cardiology and Pharmacokinetics.
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] Functional optimization of commercially available human induced pluripotent stem cell-derived cardiomyocytes for evaluation of drug-induced QT prolongation.2013

    • Author(s)
      Min L, Kanda Y, Ashihara T, Sekino Y, Furukawa T, Kurokawa J.
    • Organizer
      The 2nd HD Physiology International Symposium: Integrative Multi-level Systems Biology for In Silico Cardiology and Pharmacokinetics.
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] Rotational anisotropy prevents transition of tachycardia to fibrillation in ventricles under the large transmural dispersion of repolarization: A simulation study.2013

    • Author(s)
      Haraguchi R, Ashihara T, Inada S, Ikeda T, Nakazawa K.
    • Organizer
      The 2nd HD Physiology International Symposium: Integrative Multi-level Systems Biology for In Silico Cardiology and Pharmacokinetics.
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] Reentrant beat in the Purkinje network associated with gap junction mutation: A simulation study.2013

    • Author(s)
      Inada S, Harrell DT, Haraguchi R, Ashihara T, Makita N, Nakazawa K.
    • Organizer
      The 2nd HD Physiology International Symposium: Integrative Multi-level Systems Biology for In Silico Cardiology and Pharmacokinetics.
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] Multi-scale simulation studies of excitation conduction from the sinoatrial node to the ventricles in the heart.2013

    • Author(s)
      Inada S, Harrell DT, Ono T, Haraguchi R, Ashihara T, Dobrzynski H, Honjo H, Shibata N, Ikeda T, Mitsui K, Kodama I, Boyett MR, Nakazawa K.
    • Organizer
      The 2nd HD Physiology International Symposium: Integrative Multi-level Systems Biology for In Silico Cardiology and Pharmacokinetics.
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] ヒトiPS由来心筋を用いた薬剤誘発性不整脈の研究.2013

    • Author(s)
      黒川洵子,李敏,諫田泰成,芦原貴司,関野祐子,古川哲史.
    • Organizer
      生理学研究所研究会「心血管膜輸送分子の構造・機能・病態の統合的研究戦略」.
    • Place of Presentation
      岡崎
    • Related Report
      2013 Research-status Report
  • [Presentation] 心房細動に対するFIRMアブレーションは本当に可能か?:In silicoによる検証.2013

    • Author(s)
      芦原貴司,原口 亮,稲田 慎,中沢一雄,難波経豊,池田隆徳,小澤友哉,伊藤 誠,堀江 稔.
    • Organizer
      第29回心電情報処理ワークショップ.
    • Place of Presentation
      南魚沼
    • Related Report
      2013 Research-status Report
  • [Presentation] 高頻度心房興奮に対する房室結節の応答:シミュレーションによる検討.2013

    • Author(s)
      稲田 慎,小野多佳子,柴田仁太郎,原口 亮,芦原貴司, Dobrzynski R, Boyett MR, 三井和幸,池田隆徳,中沢一雄.
    • Organizer
      第29回心電情報処理ワークショップ.
    • Place of Presentation
      南魚沼
    • Related Report
      2013 Research-status Report
  • [Presentation] 心房細動に対するジギタリスおよびβ遮断によるレートコントロール機序のコンビュータシミュレーションによる検討.2013

    • Author(s)
      稲田 慎,小野多佳子,柴田仁太郎,原口 亮,芦原貴司,Dobrzynski H,Boyett M,三井和幸,池田隆徳,中沢一雄.
    • Organizer
      第30回日本心電学会学術集会.
    • Place of Presentation
      青森
    • Related Report
      2013 Research-status Report
  • [Presentation] 虚血心筋における細胞内Naチャネル分布リモデリングのI群抗不整脈薬による催不整脈増強作用.2013

    • Author(s)
      津元国親,芦原貴司,原口 亮,中沢一雄,倉智嘉久.
    • Organizer
      第30回日本心電学会学術集会.
    • Place of Presentation
      青森
    • Related Report
      2013 Research-status Report
  • [Presentation] 不整脈治療のイノベーション実現に向けたin silicoの挑戦.

    • Author(s)
      芦原貴司.
    • Organizer
      The 7th Kyoto New Generation Conference of Cardiology.
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 心房細動治療におけるエビデンスと最近の話題.

    • Author(s)
      芦原貴司.
    • Organizer
      講演会:心房細動・心不全治療を考える.
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 心室細動と電気的除細動の機序に関するコペルニクス的転回.

    • Author(s)
      芦原貴司.
    • Organizer
      第19回臨床難治性不整脈研究会.
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 臨床医の臨床医による臨床医のためのin silico不整脈学.

    • Author(s)
      芦原貴司.
    • Organizer
      第16回わいやいClub: Young Investigator’s Club.
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] アブレーションでSpiral Wave Reentryを停止できるか?

    • Author(s)
      芦原貴司.
    • Organizer
      第4回EP Expertsカンファレンス.
    • Place of Presentation
      福岡
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 心房細動の機序と治療に関する最近の話題.

    • Author(s)
      芦原貴司.
    • Organizer
      第21回Hertz Bessern.
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] コンピュータシミュレーションによる致死性不整脈発現の評価:心室較差と線維走向ねじれによる催不整脈性作用に着目して.

    • Author(s)
      原口 亮,芦原貴司,稲田 慎,池田隆徳,中沢一雄.
    • Organizer
      第33回日本ホルター・ノンインベイシブ心電学研究会.
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Book] 難治性不整脈治療のイノベーション実現に向けたin silico arrhythmology.奥山裕司編著:難治性不整脈診療:エキスパートのアプローチ.2016

    • Author(s)
      芦原貴司.
    • Publisher
      中外医学社,東京.
    • Related Report
      2015 Annual Research Report
  • [Book] コンピュータシミュレーションと不整脈.井上 博編:Medical Topics Series:不整脈2015.2015

    • Author(s)
      芦原貴司.
    • Publisher
      メディカルレビュー社,大阪.
    • Related Report
      2015 Annual Research Report
  • [Book] 滋賀医科大学医学部附属病院の先端医療:最先端技術による不整脈治療:カテーテルアブレーション.滋賀医科大学医学部附属病院編著:滋賀医科大学医学部附属病院の最新治療がわかる本:患者さんにやさしい医療を実践.2015

    • Author(s)
      芦原貴司.
    • Publisher
      バリューメディカル,東京.
    • Related Report
      2015 Annual Research Report
  • [Book] Medical Topics Series:不整脈2015:コンピュータシミュレーションと不整脈.2015

    • Author(s)
      芦原貴司.
    • Publisher
      メディカルレビュー社
    • Related Report
      2014 Research-status Report
  • [Book] 難治性不整脈診療:エキスパートのアプローチ.2015

    • Author(s)
      芦原貴司.
    • Publisher
      難治性不整脈治療のイノベーション実現に向けたin silico arrhythmology.
    • Related Report
      2014 Research-status Report
  • [Book] Electrocardiology 2013.2014

    • Author(s)
      Inada S, Ono T, Shibata N, Iwata M, Haraguchi R, Ashihara T, Abe A, Ikeda T, Mitsui K, Boyett MR, Dobrzynski H, Nakazawa K.
    • Publisher
      VEDA, Publishing House of the Slovak Academy of Sciences, Slovakia
    • Related Report
      2014 Research-status Report
  • [Book] 心房細動のトータルマネージメント:治療の常識が変わる!(分担執筆)2014

    • Author(s)
      芦原貴司,堀江 稔.
    • Publisher
      文光堂
    • Related Report
      2013 Research-status Report
  • [Book] 日本心電学会:30年の軌跡(日本心電学会30周年記念誌)2013

    • Author(s)
      芦原貴司.
    • Publisher
      日本心電学会
    • Related Report
      2013 Research-status Report
  • [Remarks] Spiral in Cardiology

    • URL

      http://square.umin.ac.jp/ash/vitae.html

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
  • [Remarks] Spiral in Cardiology

    • URL

      http://square.umin.ac.jp/ash/vitae.html

    • Related Report
      2013 Research-status Report
  • [Patent(Industrial Property Rights)] 心筋興奮判別装置2016

    • Inventor(s)
      芦原貴司,土谷 健,中沢一雄,稲田 慎ほか
    • Industrial Property Rights Holder
      国立大学法人滋賀医科大学,土谷 健ほか
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-03-15
    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] 心筋興奮補完・可視化装置及び心筋興奮検出装置2016

    • Inventor(s)
      芦原貴司,土谷 健,中沢一雄,稲田 慎ほか
    • Industrial Property Rights Holder
      国立大学法人滋賀医科大学,土谷 健ほか
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-03-15
    • Related Report
      2015 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 心筋興奮補完・可視化装置2015

    • Inventor(s)
      芦原貴司,土谷健,中沢一雄,稲田慎ほか
    • Industrial Property Rights Holder
      国立大学法人滋賀医科大学ほか
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-03-30
    • Related Report
      2014 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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