Theoretical studies on ablation targets and optimal approach of chronic atrial fibrillation treatment.
| Project/Area Number |
25461106
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
Ashihara Takashi 滋賀医科大学, 医学部, 助教(学内講師) (80396259)
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| Co-Investigator(Kenkyū-buntansha) |
OZAWA Tomoya 滋賀医科大学, 医学部, 助教 (20584395)
HARAGUCHI Ryo 国立研究開発法人国立循環器病研究センター, 情報統括部, 室長 (00393215)
INADA Shin 国立研究開発法人国立循環器病研究センター, 研究情報基盤管理室, 研究員 (50349792)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 分子心臓学 / 不整脈学 |
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| Outline of Final Research Achievements |
The mechanisms underlying complex fractionated atrial electrogram (CFAE)-targeted chronic atrial fibrillation (CAF) ablation are poorly understood. To provide theoretical bases for the CAF ablation strategies, we developed a computer model of human CAF, conducted simulation of CFAE, and tried to propose optimal strategy for the CAF ablation. Then we found that fibroblast proliferation in atria causes the sustainment of the rotors (spiral wave reentries) during CAF, and success or failure of CAF ablation is determined by the balance of rotor increase or decrease. In addition, the knowledge obtained in this study was applied to the development of real-time phase mapping system of human CAF.
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Report
(4 results)
Research Products
(182 results)
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[Journal Article] Splicing misregulation of SCN5A contributes to cardiac-conduction delay and heart arrhythmia in myotonic dystrophy.2016
Author(s)
Freyermuth F, Rau F, Kokunai Y, Linke T, Sellier C, Nakamori M, Kino Y,.......Zimmer T, Furling D, Takahashi MP, Charlet-Berguerand N.
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Journal Title
Nat Commun.
Volume: 7
Issue: 1
Pages: 11067-11067
DOI
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Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] An autopsic examination case of diagnosed Brugada syndrome.2014
Author(s)
Furukawa S, Morita S, Okunaga H, Wingenfeld L, Takaya A, Nakagawa T, Sakaguchi I, Yamamoto Y, Ashihara T, Horie M, Nishi K, Hitosugi M.
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Journal Title
Am J Int Med.
Volume: 2
Pages: 79-82
Related Report
Peer Reviewed
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[Journal Article] A novel KCNQ1 missense mutation identified in a patient with juvenile-onset atrial fibrillation causes constitutively open IKs channels.2014
Author(s)
Hasegawa K, Ohno S, Ashihara T, Itoh H, Ding WG, Toyoda F, Makiyama T, Aoki H, Nakamura Y, Delisle BP, Matsuura H, Horie M.
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Journal Title
Heart Rhythm
Volume: 11
Issue: 1
Pages: 67-75
DOI
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Peer Reviewed
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[Presentation] Multi-scale simulation studies of excitation conduction including cardiac conduction systems and whole ventricles.2016
Author(s)
Inada S, Harrell DT, Haraguchi R, Ashihara T, Aiba T, Yamashita F, Shibata N, Ikeda T, Mitsui K, Makita N, Honjo H, Boyett MR, Nakazawa K.
Organizer
第93回日本生理学会大会．
Place of Presentation
札幌
Year and Date
2016-03-22
Related Report
Invited
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[Presentation] Development of a novel real-time phase mapping system, called ExTRa Mapping, using in silico technique for identifying unstable rotors in patients with non-paroxysmal atrial fibrillation.2015
Author(s)
Ashihara T, Sakata K, Ozawa T, Kato K, Tsuchiya T, Haraguchi R, Inada S, Nakazawa K, Horie M.
Organizer
The 8th Asia-Pacific Heart Rhythm Society Scientific Session (APHRS).
Place of Presentation
メルボルン（豪州）
Year and Date
2015-11-19
Related Report
Int'l Joint Research
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[Presentation] Possible mechanisms of effective rotor ablation for chronic atrial fibrillation: A simulation study.2015
Author(s)
Ashihara T, Haraguchi R, Inada S, Nakazawa K, Tsuchiya T, Yamaguchi T, Fukui A, Ozawa T, Hattori T, Kato K, Horie M.
Organizer
第30回日本不整脈学会学術大会/第32回日本心電学会学術集会．
Place of Presentation
京都
Year and Date
2015-07-28 – 2015-07-31
Related Report
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[Presentation] シンポジウム16：再生医療と不整脈：Can computer simulation technique contribute regenerative medicine?2015
Author(s)
Inada S, Harrell DT, Haraguchi R, Ashihara T, Aiba T, Ikeda T, Mitsui K, Honjo H, Shibata N, Makita N, Kamiya K, Kodama I, Nakazawa K.
Organizer
第30回日本不整脈学会学術大会(JHRS)/第32回日本心電学会学術集会(JSE)．
Place of Presentation
京都
Year and Date
2015-07-28
Related Report
Invited
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[Presentation] Possible mechanisms of effective rotor ablation for chronic atrial fibrillation: A simulation study.2015
Author(s)
Ashihara T, Haraguchi R, Inada S, Nakazawa K, Tsuchiya T, Yamaguchi T, Fukui A, Ozawa T, Hattori T, Kato K, Horie M.
Organizer
第30回日本不整脈学会学術大会(JHRS)/第32回日本心電学会学術集会(JSE)．
Place of Presentation
京都
Year and Date
2015-07-28
Related Report
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[Presentation] Investigating excitation conduction in the atrioventricular node and Purkinje network using computer simulation.2014
Author(s)
Inada S, Harrell DT, Ono T, Shibata N, Haraguchi R, Ashihara T, keda T, Mitsui K, Dobrzynski H, Boyett MR, Makita N, Nakazawa K.
Organizer
第9回田原アショフシンポジウム．
Place of Presentation
東京
Year and Date
2014-07-26 – 2014-07-27
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[Presentation] Topic “Cardiac Simulator”: Technological development of heart simulators for various computer platforms in the medical and health-care fields.2014
Author(s)
Nakazawa K, Inada S, Haraguchi R, Ashihara T, Shiraishi I, Kurosaki K, Kanzaki S, Igarashi T, Ijiri T, Koyama Y, Ikeda T.
Organizer
The 78th Annual Scientific Meeting of Japanese Circulation Society.
Place of Presentation
東京
Related Report
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[Presentation] Simulation study of ventricular rate control therapy during atrial fibrillation using one-dimensional cable model with two conduction pathways.2013
Author(s)
Inada S, Ono T, Shibata N, Iwata M, Haraguchi R, Ashihara T, Abe A, Ikeda T, Mitsui K, Boyett MR, Dobrzynski H, Nakazawa K.
Organizer
The 40th International Congress on Electrocardiology.
Place of Presentation
グラスゴー（スコットランド）
Related Report
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[Presentation] Multi-scale simulation studies of excitation conduction from the sinoatrial node to the ventricles in the heart.2013
Author(s)
Inada S, Harrell DT, Ono T, Haraguchi R, Ashihara T, Dobrzynski H, Honjo H, Shibata N, Ikeda T, Mitsui K, Kodama I, Boyett MR, Nakazawa K.
Organizer
The 2nd HD Physiology International Symposium: Integrative Multi-level Systems Biology for In Silico Cardiology and Pharmacokinetics.
Place of Presentation
東京
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[Book] Electrocardiology 2013.2014
Author(s)
Inada S, Ono T, Shibata N, Iwata M, Haraguchi R, Ashihara T, Abe A, Ikeda T, Mitsui K, Boyett MR, Dobrzynski H, Nakazawa K.
Publisher
VEDA, Publishing House of the Slovak Academy of Sciences, Slovakia
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