Disturbance of Circadian Rhythm in Heart Failure and Chronotherapeutic Approach to Heart Failure

• Project/Area Number: 25461113
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Nagasaki University
• Principal Investigator: MAEMURA Koji 長崎大学, 医歯薬学総合研究科(医学系), 教授 (90282649)
• Co-Investigator(Kenkyū-buntansha): TAKEDA Norihiko 東京大学, 医学部附属病院, 特任講師 (40422307)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 循環器疾患 / 心不全 / 時間生物学 / 高血圧 / 循環器・高血圧 / 概日リズム / 発現制御

Outline of Final Research Achievements

Circadian variation in the onset of acute myocardial infarction (AMI) has been reported to mostly occur in the early morning. The rise in blood pressure, heart rate, coagulation activity, and vascular tone in the early morning underlies the frequent onset of AMI in this time of day. It is known that obstructive sleep apnoea (OSA) is closely related with these physiological parameters and the OSA is frequently associated with heart failure. In this study, we showed that the incidence of AMI onset in the morning was significantly higher in OSA patients compared to the patients without OSA. The moderate-to-severe OSA significantly enhanced this circadian variation. The OSA may be associated with the onset time of AMI by affecting sleep rhythm and hypoxia. The OSA may be a therapeutic target from the viewpoint of chronobiology.

Research Products

• [Journal Article] Circadian clock and the onset of cardiovascular events. (2016)
  • Author(s): Takeda N, Maemura K.
  • Journal Title: Hypertens Res. Volume: in press Issue: 6 Pages: 383-90
  • DOI: 10.1038/hr.2016.9
  • Peer Reviewed
• [Journal Article] Clinical profile, management, and mortality in very-elderly patients hospitalized with acute decompensated heart failure: An analysis from the ATTEND registry. (2016)
  • Author(s): Mizuno M, Kajimoto K, Sato N, Yumino D, Minami Y, Murai K, Munakata R, Asai K, Keida T, Sakata Y, Hagiwara N, Takano T; ATTEND Investigators.
  • Journal Title: Eur J Intern Med. Volume: 27 Pages: 80-5
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  • Peer Reviewed
• [Journal Article] 睡眠・サーカディアンリズムと高血圧・循環器疾患 (2016)
  • Author(s): 前村浩二
  • Journal Title: 心臓 Volume: 48 Pages: 358-61
  • NAID: 130005439813
• [Journal Article] HIF-1α-PDK1 axis induced active glycolysis plays an essential role in macrophage migratory capacity. (2016)
  • Author(s): 2)Semba H, Takeda N, Isagawa T, Sugiura Y, Honda K, Wake M, Miyazawa H, Yamaguchi Y, Miura M, Jenkins D, Choi H, Kim JW, Asagiri M, Cowburn AS, Abe H, Soma K, Koyama K, Katoh M, Sayama K, Goda N, Johnson RS, Manabe I, Nagai R, Komuro I.
  • Journal Title: Nat commun Volume: 印刷中
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• [Journal Article] Redox-sensitive transient receptor potential channels in oxygen sensing and adaptation. (2016)
  • Author(s): Mori Y, Takahashi N, Polat OK, Kuroakwa T, Takeda N, Inoue M
  • Journal Title: Pflugers Arch. Eur. J. Physiol. Volume: 468 Issue: 1 Pages: 85-97
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  • NAID: 120005980858
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] The role of clock genes and circadian rhythm in the development of cardiovascular diseases. (2015)
  • Author(s): Takeda N, Maemura K.
  • Journal Title: Cell Mol Life Sci Volume: 72 Issue: 17 Pages: 3225-3234
  • DOI: 10.1007/s00018-015-1923-1
  • Peer Reviewed
• [Journal Article] Relationships Between Clinical Characteristics and Decreased Plakoglobin and Connexin 43 Expressions in Myocardial Biopsies From Patients With Arrhythmogenic Right Ventricular Cardiomyopathy (2015)
  • Author(s): Yoshida T, Kawano H, Kusumoto S, Fukae S, Koga S, Ikeda S, Koide Y, Abe K, Hayashi T, Maemura K.
  • Journal Title: International Heart Journal Volume: 56 Issue: 6 Pages: 626-631
  • DOI: 10.1536/ihj.15-144
  • NAID: 130005113062
  • ISSN: 1349-2365, 1349-3299
  • Peer Reviewed / Open Access
• [Journal Article] Effective Management of Atrioventricular Interval for Paroxysmal Atrial Fibrillation That Developed After DDDR Pacemaker Implantation in a Sick Sinus Syndrome Patient (2015)
  • Author(s): Tasaki H, Ashizawa N, Nagao S, Fukushima K, Furukawa R, Fukae S, Maemura K.
  • Journal Title: International Heart Journal Volume: 56 Issue: 5 Pages: 558-563
  • DOI: 10.1536/ihj.15-008
  • NAID: 130005102113
  • ISSN: 1349-2365, 1349-3299
  • Peer Reviewed / Open Access
• [Journal Article] Impact of Catheter Sheath Insertion into the Radial Artery on Vascular Endothelial Function Assessed by Reactive Hyperemia Peripheral Arterial Tonometry (2015)
  • Author(s): Nakata T, Ikeda S, Koga S, Yoshida T, Koide Y, Kawano H, Maemura K, Kohno S.
  • Journal Title: International Heart Journal Volume: 56 Issue: 5 Pages: 489-494
  • DOI: 10.1536/ihj.15-094
  • NAID: 130005102133
  • ISSN: 1349-2365, 1349-3299
  • Peer Reviewed
• [Journal Article] Reliability of measurement of endothelial function across multiple institutions and establishment of reference values in Japanese. (2015)
  • Author(s): Tomiyama, H
  • Journal Title: Atherosclerosis Volume: 242 Issue: 2 Pages: 433-442
  • DOI: 10.1016/j.atherosclerosis.2015.08.001
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] iMap-Intravascular Ultrasound Radiofrequency Signal Analysis Reflects Plaque Components of Optical Coherence Tomography-Derived Thin-Cap Fibroatheroma (2015)
  • Author(s): Koga S, Ikeda S, Miura M, Yoshida T, Nakata T, Koide Y, Kawano H, Maemura K.
  • Journal Title: Circulation Journal Volume: 79 Issue: 10 Pages: 2231-2237
  • DOI: 10.1253/circj.CJ-15-0393
  • NAID: 130005099856
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Genotype-dependent differences in age of manifestation and arrhythmia complications in short QT syndrome. (2015)
  • Author(s): Harrell DT, Ashihara T, Ishikawa T, et al.
  • Journal Title: International Journal of Cardiology. Volume: 190 Pages: 393-402
  • DOI: 10.1016/j.ijcard.2015.04.090
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 生活習慣病における体内時計の役割 (2015)
  • Author(s): 前村浩二
  • Journal Title: 臨床医のための循環器診療 Volume: 23 Pages: 41-9
• [Journal Article] Hypoxia Signaling Cascade for Erythropoietin Production in Hepatocytes. (2015)
  • Author(s): Tojo Y, Sekine H, Hirano I, Pan X, Souma T, Tsujita T, Kawaguchi S, Takeda N, Takeda K, Fong GH, Dan T, Ichinose M, Miyata T, Yamamoto M, Suzuki N.
  • Journal Title: Mol Cell Biol. Volume: 35 Issue: 15 Pages: 2658-2672
  • DOI: 10.1128/mcb.00161-15
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effects of moderate-to-severe obstructive sleep apnea on the clinical manifestations of plaque vulnerability and the progression of coronary atherosclerosis in patients with acute coronary syndrome. (2015)
  • Author(s): Nakashima H, Kurobe M, Minami K, Furudono S, Uchida Y, Amenomori K, Nunohiro T, Takeshita S, Maemura K.
  • Journal Title: Eur Heart J Volume: 4 Issue: 1 Pages: 75-84
  • DOI: 10.1177/2048872614530865
  • Peer Reviewed
• [Journal Article] Sinus arrest as a result of rivastigmine in an elderly dementia with Lewy bodies patient. (2015)
  • Author(s): Muto S, Kawano H, Nakatomi D, Yamasa T, Maemura K.
  • Journal Title: Geriatr Gerontol Int Volume: 15 Issue: 2 Pages: 229-230
  • DOI: 10.1111/ggi.12311
  • Peer Reviewed
• [Journal Article] Adipose-derived regenerative cell therapy inhibits the progression of monocrotaline-induced pulmonary hypertension in rats. (2014)
  • Author(s): Eguchi M, Ikeda S, Kusumoto S, Sato D, Koide Y, Kawano H, Maemura K.
  • Journal Title: Life sci Volume: 118 Issue: 2 Pages: 306-312
  • DOI: 10.1016/j.lfs.2014.05.008
  • Peer Reviewed / Open Access
• [Journal Article] Longitudinal strain of right ventricular free wall by 2-dimensional speckle-tracking echocardiography is useful for detecting pulmonary hypertension (2014)
  • Author(s): Ikeda S, Tsuneto A, Kojima S, Koga S, Nakata T, Yoshida T, Eto M, Minami T, Yanagihara K, Maemura K.
  • Journal Title: Life sci Volume: 111 Issue: 1-2 Pages: 12-17
  • DOI: 10.1016/j.lfs.2014.06.024
  • NAID: 120006986439
  • Peer Reviewed
• [Journal Article] Cardiac diastolic dysfunction predicts in-hospital mortality in acute ischemic stroke with atrial fibrillation. (2014)
  • Author(s): Tateishi Y, Tsujino A, Hamabe J, Tsuneto A, Maemura K, Tasaki O, Horie N, Izumo T, Hayashi K, Nagata I.
  • Journal Title: J Neurol Sci Volume: 345 Issue: 1-2 Pages: 83-86
  • DOI: 10.1016/j.jns.2014.07.011
  • NAID: 120006986375
  • Peer Reviewed
• [Journal Article] Impairment of flow-mediated dilation correlates with aortic dilation in patients with Marfan syndrome. (2014)
  • Author(s): Takata M, Amiya E, Watanabe M, Omori K, Imai Y, Fujita D, Nishimura H, Kato M, Morota T, Nawata K, Ozeki A, Watanabe A, Kawarasaki S, Hosoya Y, Nakao T, Maemura K, Nagai R, Hirata Y, Komuro I.
  • Journal Title: Heart Vessels Volume: 29 Issue: 4 Pages: 478-485
  • DOI: 10.1007/s00380-013-0393-3
  • Peer Reviewed
• [Journal Article] Sodium channelopathy underlying familial sick sinus syndrome with early onset and predominantly male characteristics. (2014)
  • Author(s): Abe K, Machida T, Sumitomo N, Yamamoto H, Ohkubo K, Watanabe I, Makiyama T, Fukae S, Kohno M, Harrell DT, Ishikawa T, Tsuji Y, Nogami A, Watabe T, Oginosawa Y, Abe H, Maemura K, Motomura H, Makita N.
  • Journal Title: Circ Arrhythm Electrophysiol Volume: in press Issue: 3 Pages: 511-517
  • DOI: 10.1161/circep.113.001340
  • NAID: 120006986434
  • Peer Reviewed
• [Journal Article] Right bundle branch block without overt heart disease predicts higher risk of pacemaker implantation: the study of atomic-bomb survivors. (2014)
  • Author(s): Kusumoto S, Kawano H, Makita N, Ichimaru S, Kaku T, Haruta D, Hida A, Sera N, Imaizumi M, Nakashima E, Maemura K, Akahoshi M.
  • Journal Title: Int J Cardiol. Volume: 174 Issue: 1 Pages: 77-82
  • DOI: 10.1016/j.ijcard.2014.03.152
  • Peer Reviewed
• [Journal Article] Honeycomb-like neointima of sirolimus-eluting stent in saphenous vein graft: insights from OCT and IVUS. (2014)
  • Author(s): Koga S, Ikeda S, Maemura K.
  • Journal Title: Int J Cardiol Volume: 172 Issue: 2 Pages: 522-523
  • DOI: 10.1016/j.ijcard.2014.01.028
  • NAID: 120006986493
  • Peer Reviewed
• [Journal Article] Non-invasive diagnosis of coronary artery disease by 123I-BMIPP/201TlCl dual myocardial SPECT in patients with heart failure (2014)
  • Author(s): Abe H, Iguchi N, Utanohara Y, Inoue K, Takamisawa I, Seki A, Tanizaki K, Takeda N, Tohbaru T, Asano R, Nagayama M, Takayama M, Umemura J, Sumiyoshi T, Tomoike H.
  • Journal Title: Int J Cardiol Volume: 176 Issue: 3 Pages: 969-974
  • DOI: 10.1016/j.ijcard.2014.08.129
  • Peer Reviewed
• [Journal Article] 特集 血圧変動へのRAS への関与を探る 血圧日内変動とRAS：時計遺伝子を含めて (2014)
  • Author(s): 前村浩二
  • Journal Title: Angiotensin Research Volume: 11 Pages: 22-27
• [Journal Article] 特集：血液サーカディアンリズム－24時間血圧管理の重要性― 時時計遺伝子と血圧サーカディアンリズム (2014)
  • Author(s): 前村浩二
  • Journal Title: 日本臨牀 Volume: 72 Pages: 1354-1360
• [Journal Article] 最新臨床高血圧学 高血圧発症の最前線:V高血圧発症・進展因子の関わり:血圧リズムと時計遺伝子 (2014)
  • Author(s): 前村浩二
  • Journal Title: 日本臨牀 Volume: 72 Pages: 258-262
• [Journal Article] Plasma pentraxin 3 is a more potent predictor of endothelial dysfunction than high-sensitive c-reactive protein. (2014)
  • Author(s): Yasunaga T, Ikeda S, Koga S, Nakata T, Yoshida T, Masuda N, Kohno S, Maemura K.
  • Journal Title: Int Heart J Volume: 55 Pages: 160-164
  • NAID: 130003392077
  • Peer Reviewed
• [Journal Article] Efficacy of bepridil to prevent ventricular fibrillation in severe form of early repolarization syndrome (2014)
  • Author(s): Katsuumi G, Shimizu W, Watanabe H, Noda T, Nogami A, Ohkubo K, Makiyama T, Takehara N, Kawamura Y, Hosaka Y, Sato M, Fukae S, Chinushi M, Oda H, Okabe M, Kimura A, Maemura K, Watanabe I, Kamakura S, Horie M, Aizawa Y, Makita N, Minamino T
  • Journal Title: Int J Cardiol Volume: 172 Issue: 2 Pages: 519-522
  • DOI: 10.1016/j.ijcard.2014.01.036
  • Peer Reviewed / Open Access
• [Journal Article] Effect of pimobendan in addition to standard therapy for heart failure on prevention of readmission in elderly patients with severe chronic heart failure. (2014)
  • Author(s): Kawano H, Arakawa S, Satoh O, Matsumoto Y, Hayano M, Nakatomi D, Yamasa T, Maemura K.
  • Journal Title: Geriatr Gerontol Int Volume: 14 Issue: 1 Pages: 109-114
  • DOI: 10.1111/ggi.12067
  • Peer Reviewed
• [Journal Article] Obstructive sleep apnoea increases the incidence of morning peak of onset in acute myocardial infarction. (2013)
  • Author(s): Nakashima H, Henmi T, Minami K, Uchida Y, Shiraishi Y, Nunohiro T, Maemura K.
  • Journal Title: Eur Heart J Acute Cardiovasc Care Volume: 2 Issue: 2 Pages: 153-158
  • DOI: 10.1177/2048872613478557
  • Peer Reviewed
• [Journal Article] Vegf-a induces its negative regulator, soluble form of vegfr-1, by modulating its alternative splicing. (2013)
  • Author(s): Saito T, Takeda N, Amiya E, Nakao T, Abe H, Semba H, Soma K, Koyama K, Hosoya Y, Imai Y, Isagawa T, Watanabe M, Manabe I, Komuro I, Nagai R, Maemura K.
  • Journal Title: FEBS letters Volume: 587 Issue: 14 Pages: 2179-2185
  • DOI: 10.1016/j.febslet.2013.05.038
  • Peer Reviewed
• [Journal Article] Melatonin ameliorates angiotensin ii-induced vascular endothelial damage via its antioxidative properties. (2013)
  • Author(s): Nakao T, Morita H, Maemura K, Amiya E, Inajima T, Saito Y, Watanabe M, Manabe I, Kurabayashi M, Nagai R, Komuro I.
  • Journal Title: J Pineal Res Volume: 55 Issue: 3 Pages: 287-293
  • DOI: 10.1111/jpi.12071
  • Peer Reviewed
• [Journal Article] Elevated levels of systemic pentraxin 3 are associated with thin-cap fibroatheroma in coronary culprit lesions: assessment by optical coherence tomography and intravascular ultrasound. (2013)
  • Author(s): Koga S, Ikeda S, Yoshida T, Nakata T, Takeno M, Masuda N, Koide Y, Kawano H, Maemura K.
  • Journal Title: JACC Cardiovasc Interv Volume: 6 Issue: 9 Pages: 945-954
  • DOI: 10.1016/j.jcin.2013.04.024
  • NAID: 120006986086
  • Peer Reviewed
• [Journal Article] Angiotensin II impairs endothelial nitric-oxide synthase bioavailability under free cholesterol-enriched conditions via intracellular free cholesterol-rich membrane microdomains (2013)
  • Author(s): Amiya E, Watanabe M, Takeda N, Saito T, Shiga T, Hosoya Y, Nakao T, Imai Y, Manabe I, Nagai R, Komuro I, Maemura K.
  • Journal Title: J Biol Chem Volume: 288 Issue: 20 Pages: 14497-509
  • DOI: 10.1074/jbc.m112.448522
  • Peer Reviewed
• [Journal Article] Differences in Body Temperature Variability Between Subjects With and Without Diabetes and Predictive Value for Cardiovascular Events. (2013)
  • Author(s): Amiya E, Watanabe M, Takata M, Watanabe S, Ozeki A, Watanabe A, Kawarasaki S, Nakao T, Hosoya Y, Omori K, Maemura K, Hirata Y, Nagai R, Komuro I.
  • Journal Title: Circ J Volume: 77 Pages: 1844-1853
  • NAID: 10031173767
  • Peer Reviewed
• [Journal Article] Circadian expressions of cardiac ion channel genes in mouse might be associated with the central clock in the SCN but not the peripheral clock in the heart. (2013)
  • Author(s): Tong M, Watanabe E, Yamamoto N, Nagahata-Ishiguro M, Maemura K, Takeda N, Nagai R, Ozaki Y.
  • Journal Title: Biol Rhythm Res Volume: 44 Issue: 4 Pages: 519-530
  • DOI: 10.1080/09291016.2012.704801
  • Peer Reviewed
• [Journal Article] 血圧日内変動・体内時計を考慮した高血圧診療 (2013)
  • Author(s): 前村浩二
  • Journal Title: 日本透析医会雑誌 Volume: 28 Pages: 1610-1613
  • Peer Reviewed
• [Journal Article] 最新臨床睡眠学―睡眠障害の基礎と臨床― XII各科領域・疾患における睡眠障害 虚血性心疾患・心不全 (2013)
  • Author(s): 前村浩二
  • Journal Title: 日本臨牀 Volume: 71 Pages: 569-574
• [Journal Article] 概日リズムと疾患 II.概日リズムと疾患 ―病態・診断・治療の最新知見― 虚血性心疾患 (2013)
  • Author(s): 前村浩二
  • Journal Title: 日本臨牀 Volume: 71 Pages: 2124-2129
• [Journal Article] 血管内皮細胞における脂質ラフトの役割 (2013)
  • Author(s): 網谷英介、前村浩二
  • Journal Title: 血管 Volume: 34 Pages: 139-148
  • Peer Reviewed
• [Journal Article] 生体のサーカディアンリズム 体内時計と循環器疾患 (2013)
  • Author(s): 前村浩二
  • Journal Title: 月刊循環器 CIRCULATION Volume: 3 Pages: 14-21
• [Journal Article] 時間医学と循環器疾患 PART①時計遺伝子と循環器疾患 (2013)
  • Author(s): 前村浩二
  • Journal Title: Cardiovascular Frontier Volume: 4 Pages: 90-95
• [Presentation] 睡眠・サーカディアンリズムと循環器疾患～体内時計の視点から～ (2015)
  • Author(s): 前村浩二
  • Organizer: 第25回日本循環薬理学会
  • Place of Presentation: 東大寺総合文化センター(奈良市）
  • Year and Date: 2015-12-04
  • Invited
• [Presentation] HIF-1α-PDK1を介する解糖系代謝シフトがマクロファージ遊走能を促進する (2015)
  • Author(s): 武田憲彦
  • Organizer: 第38回日本分子生物学会年会・第88回日本生化学会大会合同大会
  • Place of Presentation: 神戸国際会議場（神戸市）
  • Year and Date: 2015-12-01
  • Invited
• [Presentation] 睡眠・サーカディアンリズムと生活習慣病 ～体内時計の視点から～ (2015)
  • Author(s): 前村浩二
  • Organizer: 第22回日本時間生物学会学術大会
  • Place of Presentation: 東京大学本郷キャンパス（東京都）
  • Year and Date: 2015-11-21
  • Invited
• [Presentation] 低酸素シグナルを介する心血管病態治療の可能性 (2015)
  • Author(s): 武田憲彦
  • Organizer: 第47回日本動脈硬化学会総会学術集会
  • Place of Presentation: 仙台国際センター(仙台市）
  • Year and Date: 2015-07-09
  • Invited
• [Presentation] 生活習慣病における体内時計の役割 (2015)
  • Author(s): 前村浩二
  • Organizer: 日本循環器学会プレスセミナー
  • Place of Presentation: 帝国ホテルタワー（東京都）
  • Year and Date: 2015-01-16
• [Presentation] 高血圧と時間医学：睡眠、サーカディアンリズム、時計遺伝子 : 時計遺伝子と心血管病 (2014)
  • Author(s): 前村浩二
  • Organizer: 第３７回日本高血圧学会総会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2014-10-17 – 2014-10-19
  • Invited
• [Presentation] 血管障害に対する多面的アプローチの必要性 (2014)
  • Author(s): 前村浩二
  • Organizer: 第６２回日本心臓病学会学術集会
  • Place of Presentation: 仙台国際会議場（仙台市）
  • Year and Date: 2014-09-26 – 2014-09-28
• [Presentation] 明らかな器質的心疾患のない右脚ブロック症例では、ペースメーカー植え込みのリスクが高くなる；原爆被爆者における調査 (2014)
  • Author(s): 楠本三郎、河野浩章、小出優史、池田聡司、前村浩二
  • Organizer: 第56回日本老年医学会学術集会
  • Place of Presentation: 福岡国際会議場（福岡市）
  • Year and Date: 2014-06-12 – 2014-06-14
• [Presentation] 生活習慣病における体内時計の役割 (2014)
  • Author(s): 前村浩二
  • Organizer: 第１回日本健康促進医学会学術総会
  • Place of Presentation: 長崎大学医学部記念講堂（長崎市）
  • Year and Date: 2014-05-17 – 2014-05-18
  • Invited
• [Presentation] Transcriptional Regulation：Role of Clock Genes and Circadian Rhythm in the Development of Cardiovascular Diseases (2014)
  • Author(s): Koji Maemura, Norihiko Takeda, Tomoko Nakao, Hiroyuki Morita, Hiroaki Kawano
  • Organizer: The 18th International Vascular Biology Meeting
  • Place of Presentation: 京都みやこメッセ（京都市）
  • Year and Date: 2014-04-14 – 2014-04-17
  • Invited
• [Presentation] 時計から見たアンチエイジング (2014)
  • Author(s): 前村浩二
  • Organizer: 日本抗加齢医学会専門医・指導士認定委員会講習会
  • Place of Presentation: サンケイホール（東京都）
  • Invited
• [Presentation] サーカディアンリズムと高血圧～体内時計の視点から～ (2014)
  • Author(s): 前村浩二
  • Organizer: 日医生涯教育協力講座セミナー
  • Place of Presentation: 新潟県医師会館（新潟県）
  • Invited
• [Remarks] 長崎大学大学院医歯薬学総合研科循環器内科学
  • URL: http://www.med.nagasaki-u.ac.jp/junkanki/
• [Remarks] 長崎大学大学院医歯薬学総合研究科循環器内科学
  • URL: http://www.med.nagasaki-u.ac.jp/renew/information/intmed_3/index.html
• [Remarks] 長崎大学大学院医歯薬学総合研究科循環器内科学
  • URL: http://www.med.nagasaki-u.ac.jp/junkanki/