| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Outline of Final Research Achievements |
Circadian variation in the onset of acute myocardial infarction (AMI) has been reported to mostly occur in the early morning. The rise in blood pressure, heart rate, coagulation activity, and vascular tone in the early morning underlies the frequent onset of AMI in this time of day. It is known that obstructive sleep apnoea (OSA) is closely related with these physiological parameters and the OSA is frequently associated with heart failure. In this study, we showed that the incidence of AMI onset in the morning was significantly higher in OSA patients compared to the patients without OSA. The moderate-to-severe OSA significantly enhanced this circadian variation. The OSA may be associated with the onset time of AMI by affecting sleep rhythm and hypoxia. The OSA may be a therapeutic target from the viewpoint of chronobiology.
|
