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The role of long non-cording RNA in pathological mechanism of heart failure.

Research Project

Project/Area Number 25461114
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionKumamoto University

Principal Investigator

MIYATA KEISHI  熊本大学, 生命科学研究部, 特任准教授 (50398228)

Co-Investigator(Kenkyū-buntansha) 荒木 喜美  熊本大学, 学内共同利用施設等, 教授 (90211705)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsnon-coding RNA / non-cording RNA / 心不全
Outline of Final Research Achievements

We found that embryonic cardiac specific expressed-clones among unknown long non-coding RNA (lnc RNA) clones using gene trap methods. In one clone of them, the trap vector was inserted into the intron site of lnc RNA AK141659 gene. We elucidated that its clone’s homozygous mice were AK141659 KO mice. AK141659 KO mice did not exhibit significant differences in cardiac morphology and function compared with wild-type mice. To assess the role of AK141659 in pathological mechanism of heart failure, we operated transverse aorta constriction model (TAC) using AK141659 KO mice and analyzed the cardiac function of them.

Academic Significance and Societal Importance of the Research Achievements

マウスの個体を用いたlncRNAと心疾患の病態形成分子機構に関する解析は現在数少なく、この研究方法および結果は非常に貴重な成果になると期待される。本研究により細胞質に存在するlncRNAの新たな作用機構の解明だけでなく、種々の遺伝子改変マウスを用いることで生体の心臓における分子機構が明らかになると期待される。さらに、この心不全病態形成における細胞質lncRNAの基盤研究が、トランスレーショナルリサーチとして、心不全の予防医学に向けた新規治療法開発へと期待される。

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report

Research Products

(25 results)

All 2016 2015 2014 2013

All Journal Article (23 results) (of which Peer Reviewed: 23 results,  Acknowledgement Compliant: 13 results,  Open Access: 12 results) Presentation (2 results)

  • [Journal Article] Angiopoietin-like protein 2 increases renal fibrosis by accelerating transforming growth factor-β signaling in chronic kidney disease.2016

    • Author(s)
      Jun Morinaga, Tsuyoshi Kadomatsu, Keishi Miyata, Motoyoshi Endo, Kazutoyo Terada, Zhe Tian, Taichi Sugizaki, Hiroki Tanigawa, Jiabin Zhao, Shunshun Zhu, Michio Sato, Kimi Araki, Ken-ichi Iyama, Kengo Tomita, Masashi Mukoyama, Kimio Tomita, Kenichiro Kitamura, Yuichi Oike
    • Journal Title

      Kidney Int

      Volume: 89 Pages: 327-341

    • DOI

      10.1016/j.kint.2015.12.021

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Glutathione S-transferase K1 genotype and overweight status in schizophrenia patients: A pilot study.2016

    • Author(s)
      Oniki K, Kamihashi R, Tomita T, Ishioka M, Yoshimori Y, Osaki N, Tsuchimine S, Sugawara N, Kajiwara A, Morita K, Miyata K, Otake K, Nakagawa K, Ogata Y, Saruwatari J, Yasui-Furukori N.
    • Journal Title

      Psychiatry Res

      Volume: 239 Pages: 190-195

    • DOI

      10.1016/j.psychres.2016.03.025

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The exacerbating roles of CCAAT/enhancer-binding protein homologous protein (CHOP) in the development of bleomycin-induced pulmonary fibrosis and the preventive effects of tauroursodeoxycholic acid (TUDCA) against pulmonary fibrosis in mice.2015

    • Author(s)
      Tanaka Y, Ishitsuka Y, Hayasaka M, Yamada Y, Miyata K, Endo M, Kondo Y, Moriuchi H, Irikura M, Tanaka K, Mizushima T, Oike Y, Irie T.
    • Journal Title

      Pharmacological Research

      Volume: 99 Pages: 52-62

    • DOI

      10.1016/j.phrs.2015.05.004

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A Muscle-liver-fat signaling axis is essential for central control of adaptive adipose remodeling2015

    • Author(s)
      Shimizu N, Maruyama T, Yoshikawa N, Matsumiya R, Ma Y, Ito N, Tasaka Y, Kuribara-Souta A, Miyata K, Oike Y, Berger S, Schutz G, Takeda S & Tanaka H
    • Journal Title

      Nat Commun.

      Volume: - Pages: 6693-6693

    • DOI

      10.1038/ncomms7693

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Tinea nigra showing a parallel ridge pattern on dermoscopy.2015

    • Author(s)
      Noguchi H, Hiruma M, Inoue Y, Miyata K, Tanaka M, Ihn H.
    • Journal Title

      J Dermatol.

      Volume: 42(5) Pages: 518-520

    • DOI

      10.1111/1346-8138.12830

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ANGPTL2 increases bone metastasis of breast cancer cells through enhancing CXCR4 signaling.2015

    • Author(s)
      Masuda T, Endo M, Yamamoto Y, Odagiri H, Kadomatsu T, Nakamura T, Tanoue H, Ito H, Yugami M, Miyata K, Morinaga J, Horiguchi H, Motokawa I, Terada K, Morioka MS, Manabe I, Iwase H, Mizuta H, Oike Y.
    • Journal Title

      Sci. Rep.

      Volume: 5 Pages: 9170-9170

    • DOI

      10.1038/srep09170

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Cdk5rap1-mediated 2-methylthio modification of mitochondrial tRNAs governs protein translation and contributes to myopathy in mice and humans.2015

    • Author(s)
      Wei FY, Zhou B, Suzuki T, Miyata K, Ujihara Y, Horiguchi H, Takahashi N, Xie P, Michiue H, Fujimura A, Kaitsuka T, Matsui H, Koga Y, Mohri S, Suzuki T, Oike Y, Tomizawa K.
    • Journal Title

      Cell Metabolism

      Volume: 21 Pages: 428-42

    • DOI

      10.1016/j.cmet.2015.01.019

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] IRAP deficiency attenuates diet-induced obesity in mice through increased energy expenditure.2015

    • Author(s)
      Niwa M, Numaguchi Y, Ishii M, Kuwahata T, Kondo M, Shibata R, Miyata K, Oike Y, Murohara T.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 457(1) Pages: 12-18

    • DOI

      10.1016/j.bbrc.2014.12.071

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] The secreted protein ANGPTL2 promotes metastasis of osteosarcoma cells through integrin alpha5beta1, p38 MAPK, and matrix metalloproteinases.2015

    • Author(s)
      Odagiri et al.
    • Journal Title

      Sci Signal.

      Volume: 7

    • DOI

      10.1126/scisignal.2004612

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Clinical features of 80 cases of tinea faciei treated at a rural clinic in Japan2014

    • Author(s)
      Noguchi H, Jinnin M, Miyata K, Hiruma M, Ihn H.
    • Journal Title

      DD&T

      Volume: 8(6) Issue: 6 Pages: 245-248

    • DOI

      10.5582/ddt.2014.01049

    • NAID

      130005054795

    • ISSN
      1881-7831, 1881-784X
    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Protection afforded by pre- or post-treatment with 4-phenylbutyrateagainst liver injury induced by acetaminophen overdose in mice2014

    • Author(s)
      Daisuke Shimizua, Yoichi Ishitsuka, Keishi Miyata, Yoshiro Tomishima, Yuki Kondo, Mitsuru Irikura, Takao Iwawaki, Yuichi Oike, Tetsumi Irie
    • Journal Title

      Pharmacol Res.

      Volume: 87 Pages: 26-41

    • DOI

      10.1016/j.phrs.2014.06.003

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] The adipocyte-inducible secreted phospholipases PLA2G5 and PLA2G2E play distinct roles in obesity.2014

    • Author(s)
      Sato H, Taketomi Y, Ushida A, Isogai Y, Kojima T, Hirabayashi T, Miki Y, Yamamoto K, Nishito Y, Kobayashi T, Ikeda K, Taguchi R, Hara S, Ida S, Miyamoto Y, Watanabe M, Baba H, Miyata K, Oike Y, Gelb MH, Murakami M.
    • Journal Title

      Cell Matabolism

      Volume: 20 Pages: 119-132

    • DOI

      10.1016/j.cmet.2014.05.002

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Diverse roles of ANGPTL2 in physiology and pathophysiology.2014

    • Author(s)
      Kadomatsu T, Endo M, Miyata K, Oike Y.
    • Journal Title

      Trends Endocrinol. Metab.

      Volume: 25(5) Pages: 245-254

    • DOI

      10.1016/j.tem.2014.03.012

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tissue Inhibitor of Metalloproteinase-3 Knockout Mice Exhibit Enhanced Energy Expenditure through Thermogenesis2014

    • Author(s)
      Hanaoka Y, Yasuda O, Soejima H, Miyata K, Yamamoto E, Izumiya Y, Maeda N, Ohishi M, Rakugi H, Oike Y, Kim-Mitsuyama S, Ogawa H
    • Journal Title

      PLoS One.

      Volume: 9

    • DOI

      10.1371/journal.pone.0094930

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway.2014

    • Author(s)
      Yoshizawa T, Karim Md. F, Sato Y, Senokuchi T, Miyata K, Fukuda T, Go C, Tasaki M, Uchimura K, Kadomatsu T, Tian Z, Smolka C, Sawa T, Kakeya M, Tomizawa K, Ando Y, Araki E, Akaike T, Braun T, Oike Y, Bober E, Yamagata K.
    • Journal Title

      Cell metab

      Volume: 9 Pages: 712-21

    • DOI

      10.1016/j.cmet.2014.03.006

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The effects of seijo-bofu-to, a traditional Japanese herbal medicine containing furanocoumarin derivatives, on the drug-metabolizing enzyme activities in healthy male volunteers.2014

    • Author(s)
      Saruwatari J, Takashima A, Yoshida K, Soraoka H, Ding TB, Uchiyashiki Y, Tsuda Y, Imamura M, Oniki K, Miyata K, Nakagawa K.
    • Journal Title

      Basic & Clinical Pharmacology & Toxicology

      Volume: - Pages: 360-365

    • DOI

      10.1111/bcpt.12224

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Serum ANGPTL2 levels reflect clinical features of breast cancer patients: implications for the pathogenesis of breast cancer metastasis.2014

    • Author(s)
      Endo M, Yamamoto Y, Nakano M, Masuda T, Odagiri H, Horiguchi H, Miyata K, Kadomatsu T, Motokawa I, Okada S, Iwase H, Oike Y.
    • Journal Title

      Int. J. Biol. Markers

      Volume: 印刷中 Pages: 0-0

    • DOI

      10.5301/jbm.5000080

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Role of endothelial cell-derived angptl2 in vascular inflammation leading to endothelial dysfunction and atherosclerosis progression.2014

    • Author(s)
      Horio E, Kadomatsu T, Miyata K, Arai Y, Hosokawa K, Doi Y, et al.
    • Journal Title

      Arterioscler. Thromb. Vasc. Biol.

      Volume: 34 Pages: 790-800

    • DOI

      10.1161/atvbaha.113.303116

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Treatment of onychomycosis using a 1064nm Nd:YAG laser.2013

    • Author(s)
      Noguchi H, Miyata K, Sugita T, Hiruma M, Hiruma M.
    • Journal Title

      Med Mycol J.

      Volume: 54 Pages: 333-9

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] The angiotensin II AT1 receptor-associated protein Arap1 is involved in sepsis-induced hypotension.2013

    • Author(s)
      Mederle K, Schweda F, Kattler V, Doblinger E, Miyata K, Höcherl K, Oike Y, Castrop H.
    • Journal Title

      Crit Care.

      Volume: 17

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Angiopoietin-like protein 2 is a potent hemangiogenic and lymphangiogenic factor in corneal inflammation.2013

    • Author(s)
      Toyono T, Usui T, Yokoo S, Kimakura M, Nakagawa S, Yamagami S, Miyata K, Oike Y, Amano S.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 54 Pages: 4278-85

    • DOI

      10.1167/iovs.12-11497

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A molecular clock regulates angiopoietin-like protein 2 expression.2013

    • Author(s)
      Kadomatsu T et al
    • Journal Title

      PLoS One.

      Volume: 8

    • DOI

      10.1371/journal.pone.0057921

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Perivascular adipose tissue-secreted angiopoietin-like protein2 (Angptl2) accelerates neointimal hyperplasia after endovascular injury.2013

    • Author(s)
      Tian Z, Miyata K, Tazume H, Sakauguchi H, Kadomatsu T, Horio E, Takahashi O, Komohara Y, Araki K, Hirata Y, Tabata M, Takanashi S, Takeya M, Hao H, Shimabukuro M, Sata M, Kawasuji M, Oike Y.
    • Journal Title

      Journal of Molecular and Cellular Cardiology

      Volume: 57 Pages: 1-12

    • DOI

      10.1016/j.yjmcc.2013.01.004

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 病的血管リモデリングにおける血管周囲脂肪組織由来Angptl2の役割2015

    • Author(s)
      宮田敬士
    • Organizer
      第23回日本血管生物医学会学術集会
    • Place of Presentation
      兵庫県神戸市
    • Related Report
      2015 Annual Research Report
  • [Presentation] Lack of Angiopoietin-like Protein 2 (Angptl2) Prevents Heart Failure in Murine Left Ventricular Pressure-overload Model2014

    • Author(s)
      Keishi Miyata、Zhe Tian、Eiji Horio、Hirokazu Tadume、Yuichi Oike
    • Organizer
      第78回日本循環器学会学術集会
    • Place of Presentation
      東京・東京国際フォーラム
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2022-01-27  

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