Roles of soluble Flt-1 in renal dysfunction-related heart failure.
| Project/Area Number |
25461115
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Nara Medical University |
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Principal Investigator |
TAKEDA YUKIJI 奈良県立医科大学, 医学部, 研究員 (60398443)
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Yoshihiko 奈良県立医科大学, 医学部第1内科, 教授 (30250260)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 心腎連関 / 可溶性Flt-1 / PLGF / 心不全 / 肺水腫 / Flt-1 / 慢性腎臓病 / 心室リモデリング / sFlt-1 |
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| Outline of Final Research Achievements |
Cardiac hypertrophy and heart failure are highly associated with chronic kidney diseases (CKD), by which mechanism is not fully understood.
The present study showed that production of PLGF is up-regulated and and a soluble form of its receptor, fms-like tyrosine kinase, is down-regulated in CKD.
Given that sFlt-1 acts as an endogenous antagonist against PLGF, the present study also provides the evidence that the imbalance of PLGF and sFlt-1production enhances the biological signaling pathway via Flt-1, and is involved in the cardiac hypertrophy and heart failure associated with CKD, via relative activation of the PLGF/Flt-1 pathway, using mice specifically lacking sFlt-1 but not Flt-1. These findings raise the possibility that the treatment strategy, inhibiting PLGF action or enhancing sFLt-1 production, is useful for the treatment of hypertrophy and heart failure in CKD.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Angiogenic Factors and Risks of Technique Failure and Cardiovascular Events in Patients Receiving Peritoneal Dialysis.2016
Author(s)
Matsui M, Samejima K, Takeda Y, Morimoto K, Tagawa M, Onoue K, Okayama S, Kawata H, Kawakami R, Akai Y, Okura H, Saito Y.
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Journal Title
Cardiorenal Med.
Volume: 6
Pages: 251-259
Related Report
Peer Reviewed
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[Journal Article] Prognostic Impact of Placental Growth Factor on Mortality and Cardiovascular Events in Dialysis Patients.2015
Author(s)
Matsui M, Samejima K, Takeda Y, Tanabe K, Morimoto K, Okamoto K, Tagawa M, Onoue K, Okayama S, Kawata H, Kawakami R, Akai Y, Saito Y.
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Journal Title
American Journal of Nephrology
Volume: 42
Issue: 2
Pages: 117-125
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Placental Growth Factor As A Predictor Of Cardiovascular Events In Patients With Chronic Kidney Disease from the Novel Assessment of Risk management for Atherosclerotic diseases in Chronic Kidney Disease (NARA-CKD) Study.2015
Author(s)
Matsui M, Uemura S, Takeda Y, Samejima K, Matsumoto T, Hasegawa A Tsushima H, Hoshino E, Ueda T, Morimoto K, Okamoto K, Okada S, Onoue K, Okayama S, Kawata H, Kawakami R, Maruyama N, Akai Y, Iwano M, Shiiki H, Saito Y, for the NARA-CKD investigators.
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Journal Title
J Am Soc Nephrol.
Volume: 26
Pages: 2871-81
Related Report
Peer Reviewed
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[Journal Article] Suppressed Soluble Fms-Like Tyrosine Kinase-1 Production Aggravates Atherosclerosis in CKD : Evaluation by Circulating sFlt-1 Levels after Low-Dose Heparin Injection.2014
Author(s)
Matsui M, Takeda Y, Uemura S, Matsumoto T, Seno A, Onoue K, Tsushima H, Morimoto K, Soeda T, Okayama S, Somekawa S, Samejima K, Kawata H, Kawakami R, Nakatani K, Iwano M, Saito Y.
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Journal Title
Kid Int.
Volume: 85
Pages: 393-403
Related Report
Peer Reviewed
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