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Role of Capillary Stem Cells in Tissue Regeneration

Research Project

Project/Area Number 25461121
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionAsahikawa Medical College

Principal Investigator

KAWABE JUNICHI  旭川医科大学, 医学部, 特任教授 (10400087)

Co-Investigator(Kenkyū-buntansha) HIRA Yoshiki  旭川医科大学, 看護学, 准教授 (70199024)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords血管新生 / 毛細血管 / 再生医療 / 神経再生 / ぺりサイト / 間葉系幹細胞 / 神経幹細胞 / 周細胞 / 神経系幹細胞
Outline of Final Research Achievements

We found novel somatic stem cells, which is successfully isolated from capillary pericytes using cellular specific marker. These cells can form capillary by their own, and have multipotency to differentiate to mesenchymaland neuronal cells. These cells, termed capillary stem cells, CapSCs have regenerative potency in several diseases such as peripheral ischemia. Now, we are developing new strategy using CapSCs for regenerative medicine.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (13 results)

All 2016 2015 2014

All Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Acknowledgement Compliant: 3 results,  Open Access: 3 results) Presentation (7 results) (of which Int'l Joint Research: 2 results,  Invited: 3 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Ninjurin1 is a novel factor to regulate angiogenesis through the function of pericytes.2015

    • Author(s)
      Matsuki M, Kabara M, Saito Y, Shimamura K, Minoshima A, Nishimura M, Aonuma T, Takehara N, Hasebe N, Kawabe J .
    • Journal Title

      Circ J.

      Volume: 79 Pages: 1364-1371

    • NAID

      130005073159

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Ninjurin1 Is a Novel Factor to Regulate Angiogenesis Through the Function of Pericytes2015

    • Author(s)
      Matsuki M, Hasebe N, et.al
    • Journal Title

      Circulation Journal

      Volume: 79 Issue: 6 Pages: 1363-1371

    • DOI

      10.1253/circj.CJ-14-1376

    • NAID

      130005073159

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Immortalized multipotent pericytes derived from the vasa vasorum in the injured vasculature. A cellular tool for studies of vascular remodeling and regeneration.2014

    • Author(s)
      Kabara M, Hasebe N, et al
    • Journal Title

      Lab Invest.

      Volume: 94 Issue: 12 Pages: 1340-1354

    • DOI

      10.1038/labinvest.2014.121

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Kawabe J, Hasebe N. Role of the vasa vasorum and vascular resident stem cells in atherosclerosis.2014

    • Author(s)
      Kawabe J, Hasebe N.
    • Journal Title

      BioMed research international.

      Volume: 2014 Pages: 1-8

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Role of the vasa vasorum and vascular resident stem cells in atherosclerosis2014

    • Author(s)
      Kawabe J, Hasebe N
    • Journal Title

      Biomed Res Int

      Volume: Epub 2014 Mar 5 Pages: 1-8

    • DOI

      10.1155/2014/701571

    • NAID

      120005418199

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Adventitial Angiogenesis and Vascular Remodeling -Novel Role of Capillary Pericytes in Neovessel-2016

    • Author(s)
      川辺淳一
    • Organizer
      第80回 日本循環器学会学術総会
    • Place of Presentation
      仙台、日本
    • Year and Date
      2016-03-10
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 組織再生における幹細胞様ペリサイトCapillary Stem Cellsの役割2015

    • Author(s)
      川辺淳一
    • Organizer
      第23回 日本血管生物医学会学術総会
    • Place of Presentation
      神戸、日本
    • Year and Date
      2015-12-10
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 新規マーカーによる毛細血管由来の多分化能をもつ周細胞の同定とその機能解析2015

    • Author(s)
      鹿原 真樹, 川辺 淳一, 松木 孝樹, 蓑島 暁帆, 島村 公平, 青沼 達也, 西村 正人, 齊藤 幸裕, 竹原 有史, 長谷部 直幸
    • Organizer
      第23回日本血管生物医学会学術集会
    • Place of Presentation
      神戸、日本
    • Year and Date
      2015-12-10
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification of Novel Multipotent Pericytes to Form Capillary-like Structure On Their Own and Differentiate into Mesenchymal and Neural Lineage Cells2015

    • Author(s)
      M Kabara, J Kawabe, K Shimamura, A Minoshima, M Matsuki, M Nishimura, T Aonuma, K Maruyama, T Kitagawa, N Nakagawa, Y Saito, N Takehara, N Hasebe
    • Organizer
      AHA (アメリカ心臓病学会)
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2015-11-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 毛細血管の秘めた能力―Capillary Stem Cellsによる臓器再生療法―2015

    • Author(s)
      川辺淳一
    • Organizer
      第63回 日本輸血・細胞治療学会総会
    • Place of Presentation
      東京、日本
    • Year and Date
      2015-05-29
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Identification and characterization of capillary-derived pluripotent pericytes using immortalized pericytes cell library2014

    • Author(s)
      Motoki Matsuki, Jun-ichi Kawabe et al.
    • Organizer
      International Vascular Biology Meeting
    • Place of Presentation
      Kyoto
    • Related Report
      2013 Research-status Report
  • [Presentation] Characteristics of novel capillary delived stem cells from vasa vasorum of injured vascular walls2014

    • Author(s)
      Maki Kabara, Jun-ichi Kawabe et al.
    • Organizer
      日本循環器学会 総会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Patent(Industrial Property Rights)] 毛細血管由来幹細胞 その用途および製造方法2015

    • Inventor(s)
      川辺淳一
    • Industrial Property Rights Holder
      川辺淳一
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-151601
    • Filing Date
      2015-07-01
    • Related Report
      2015 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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