Role of Capillary Stem Cells in Tissue Regeneration

• Project/Area Number: 25461121
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Asahikawa Medical College
• Principal Investigator: KAWABE JUNICHI 旭川医科大学, 医学部, 特任教授 (10400087)
• Co-Investigator(Kenkyū-buntansha): HIRA Yoshiki 旭川医科大学, 看護学, 准教授 (70199024)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 血管新生 / 毛細血管 / 再生医療 / 神経再生 / ぺりサイト / 間葉系幹細胞 / 神経幹細胞 / 周細胞 / 神経系幹細胞

Outline of Final Research Achievements

We found novel somatic stem cells, which is successfully isolated from capillary pericytes using cellular specific marker. These cells can form capillary by their own, and have multipotency to differentiate to mesenchymaland neuronal cells. These cells, termed capillary stem cells, CapSCs have regenerative potency in several diseases such as peripheral ischemia. Now, we are developing new strategy using CapSCs for regenerative medicine.

Research Products

• [Journal Article] Ninjurin1 is a novel factor to regulate angiogenesis through the function of pericytes. (2015)
  • Author(s): Matsuki M, Kabara M, Saito Y, Shimamura K, Minoshima A, Nishimura M, Aonuma T, Takehara N, Hasebe N, Kawabe J .
  • Journal Title: Circ J. Volume: 79 Pages: 1364-1371
  • NAID: 130005073159
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Ninjurin1 Is a Novel Factor to Regulate Angiogenesis Through the Function of Pericytes (2015)
  • Author(s): Matsuki M, Hasebe N, et.al
  • Journal Title: Circulation Journal Volume: 79 Issue: 6 Pages: 1363-1371
  • DOI: 10.1253/circj.CJ-14-1376
  • NAID: 130005073159
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Immortalized multipotent pericytes derived from the vasa vasorum in the injured vasculature. A cellular tool for studies of vascular remodeling and regeneration. (2014)
  • Author(s): Kabara M, Hasebe N, et al
  • Journal Title: Lab Invest. Volume: 94 Issue: 12 Pages: 1340-1354
  • DOI: 10.1038/labinvest.2014.121
  • Peer Reviewed
• [Journal Article] Kawabe J, Hasebe N. Role of the vasa vasorum and vascular resident stem cells in atherosclerosis. (2014)
  • Author(s): Kawabe J, Hasebe N.
  • Journal Title: BioMed research international. Volume: 2014 Pages: 1-8
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Role of the vasa vasorum and vascular resident stem cells in atherosclerosis (2014)
  • Author(s): Kawabe J, Hasebe N
  • Journal Title: Biomed Res Int Volume: Epub 2014 Mar 5 Pages: 1-8
  • DOI: 10.1155/2014/701571
  • NAID: 120005418199
  • Peer Reviewed / Open Access
• [Presentation] Adventitial Angiogenesis and Vascular Remodeling -Novel Role of Capillary Pericytes in Neovessel- (2016)
  • Author(s): 川辺淳一
  • Organizer: 第80回 日本循環器学会学術総会
  • Place of Presentation: 仙台、日本
  • Year and Date: 2016-03-10
  • Invited
• [Presentation] 組織再生における幹細胞様ペリサイトCapillary Stem Cellsの役割 (2015)
  • Author(s): 川辺淳一
  • Organizer: 第23回 日本血管生物医学会学術総会
  • Place of Presentation: 神戸、日本
  • Year and Date: 2015-12-10
  • Invited
• [Presentation] 新規マーカーによる毛細血管由来の多分化能をもつ周細胞の同定とその機能解析 (2015)
  • Author(s): 鹿原 真樹, 川辺 淳一, 松木 孝樹, 蓑島 暁帆, 島村 公平, 青沼 達也, 西村 正人, 齊藤 幸裕, 竹原 有史, 長谷部 直幸
  • Organizer: 第23回日本血管生物医学会学術集会
  • Place of Presentation: 神戸、日本
  • Year and Date: 2015-12-10
  • Int'l Joint Research
• [Presentation] Identification of Novel Multipotent Pericytes to Form Capillary-like Structure On Their Own and Differentiate into Mesenchymal and Neural Lineage Cells (2015)
  • Author(s): M Kabara, J Kawabe, K Shimamura, A Minoshima, M Matsuki, M Nishimura, T Aonuma, K Maruyama, T Kitagawa, N Nakagawa, Y Saito, N Takehara, N Hasebe
  • Organizer: AHA （アメリカ心臓病学会)
  • Place of Presentation: Orlando, USA
  • Year and Date: 2015-11-07
  • Int'l Joint Research
• [Presentation] 毛細血管の秘めた能力―Capillary Stem Cellsによる臓器再生療法― (2015)
  • Author(s): 川辺淳一
  • Organizer: 第63回 日本輸血・細胞治療学会総会
  • Place of Presentation: 東京、日本
  • Year and Date: 2015-05-29
  • Invited
• [Presentation] Identification and characterization of capillary-derived pluripotent pericytes using immortalized pericytes cell library (2014)
  • Author(s): Motoki Matsuki, Jun-ichi Kawabe et al.
  • Organizer: International Vascular Biology Meeting
  • Place of Presentation: Kyoto
• [Presentation] Characteristics of novel capillary delived stem cells from vasa vasorum of injured vascular walls (2014)
  • Author(s): Maki Kabara, Jun-ichi Kawabe et al.
  • Organizer: 日本循環器学会 総会
  • Place of Presentation: 東京
• [Patent(Industrial Property Rights)] 毛細血管由来幹細胞 その用途および製造方法 (2015)
  • Inventor(s): 川辺淳一
  • Industrial Property Rights Holder: 川辺淳一
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2015-151601
  • Filing Date: 2015-07-01