| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Outline of Final Research Achievements |
Gap junctions (GJs) are comprised of members of the connexin (Cx) family and endothelial GJs play an important role in vascular function, stability, and homeostasis. Endothelial dysfunction is related to cardiovascular diseases such as atherosclerosis. The alteration of Cxs expression in vascular endothelial cells contributes to the development of endothelial dysfunction and cardiovascular diseases. We have reported that endothelial GJs regulate vascular inflammation and blood coagulation. In this study, we have identified the role of endothelial GJ in vascular angiogenesis.
|
