Endothelial cellular gap junctions regulate the vascular angiogenesis
| Project/Area Number |
25461125
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Mie University |
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Principal Investigator |
Okamoto Takayuki 三重大学, 医学(系)研究科(研究院), 助教 (30378286)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 血管生物学 / 血管内皮細胞 / 血管新生 / ギャップ結合 / 細胞間接着分子 / コネキシン / 血管リモデリング |
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| Outline of Final Research Achievements |
Gap junctions (GJs) are comprised of members of the connexin (Cx) family and endothelial GJs play an important role in vascular function, stability, and homeostasis. Endothelial dysfunction is related to cardiovascular diseases such as atherosclerosis. The alteration of Cxs expression in vascular endothelial cells contributes to the development of endothelial dysfunction and cardiovascular diseases. We have reported that endothelial GJs regulate vascular inflammation and blood coagulation. In this study, we have identified the role of endothelial GJ in vascular angiogenesis.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Host protein C inhibitor inhibits tumor growth, but promotes tumor metastasis, which is closely correlated with hypercoagulability.2015
Author(s)
Akita N, Ma N, Okamoto T, Asanuma K, Yoshida K, Nishioka J, Shimaoka M, Suzuki K, Hayashi T.
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Journal Title
Thromb Res.
Volume: 135
Issue: 6
Pages: 1203-1208
DOI
Related Report
Peer Reviewed
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