| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Outline of Final Research Achievements |
To develop a novel therapy for hypertension, we evaluate the effectivity of vaccines against renin-angiotensin system. Angiotensin II DNA vaccine reduced perivascular fibrosis of heart tissue in spontaneously hypertensive rat (SHR). Then we construct renin epitope DNA vaccine. Anti-renin antibody was produced by administration of renin vaccine in SHR. Systolic blood pressure was significantly reduced in the renin vaccine group. Histological analysis revealed that there are no any pathological findings in the kidney, liver, and heart. These results indicate that small epitope vaccine targeting renin is safe and effective.
|
