| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
The following findings were obtained by analyzing the functions and mode of action of cell adhesion molecules in atherosclerosis. (1) Necl-5 facilitated dedifferentiation of smooth muscle cells from a contractile to a synthetic phenotype, cell movement and proliferation, and intimal thickening after the common carotid artery ligation. (2) Necl-4, whose expression increased as vascular endothelial cells become confluent, induced contact inhibition of movement and proliferation by suppressing autophosphorylation of the vascular endothelial growth factor receptor via PTPN13. (3) In vascular endothelial cells FAM5C increased in response to inflammatory stimuli and promoted expression of monocyte adhesion molecules via enhanced production of reactive oxygen species and activation of NF-kappa B.
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