| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Brain microvascular pericyte, one of the cells constituting neurovascular unit, plays a pivotal role in pathophysiology of brain ischemia. We have found that Nox4, an enzyme producing reactive oxygen species (ROS), was expressed in brain microvascular pericyte and that Nox4 was upregulated by some stimuli such as hypoxic condition and angiotensin II and was involved in proliferation of the cells. In brain ischemia, Nox4 was associated with breakdown of blood-brain barrier and enlargement of the infarct, and activation of NFκB and MMP9 was important as its mechanism. We also raised the possibility that in ischemic conditions, basic FGF could be involved in upregulation of PDGFRβ, a protein playing a role in pericyte function. Nox4 in brain pericytes could be a potential target for new therapies of cerebrovascular diseases.
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