Pathophysiology of brain ischemia focused on ROS-producing enzyme Nox4 expressed in brain microvascular pericytes
Project/Area Number |
25461134
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cardiovascular medicine
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Research Institution | Kyushu University |
Principal Investigator |
KURODA JUNYA 九州大学, 大学病院, 助教 (70614858)
|
Research Collaborator |
AGO Tetsuro
NISHIMURA Ataru
TACHIBANA Masaki
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Project Period (FY) |
2013-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | Nox4 / 脳血管周皮細胞 / 脳虚血 / 活性酸素 / Neurovascular Unit / 血液脳関門 / PDGFRβ / 脳梗塞治療 / 脳梗塞 / 脳浮腫 / 血管新生 |
Outline of Final Research Achievements |
Brain microvascular pericyte, one of the cells constituting neurovascular unit, plays a pivotal role in pathophysiology of brain ischemia. We have found that Nox4, an enzyme producing reactive oxygen species (ROS), was expressed in brain microvascular pericyte and that Nox4 was upregulated by some stimuli such as hypoxic condition and angiotensin II and was involved in proliferation of the cells. In brain ischemia, Nox4 was associated with breakdown of blood-brain barrier and enlargement of the infarct, and activation of NFκB and MMP9 was important as its mechanism. We also raised the possibility that in ischemic conditions, basic FGF could be involved in upregulation of PDGFRβ, a protein playing a role in pericyte function. Nox4 in brain pericytes could be a potential target for new therapies of cerebrovascular diseases.
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Report
(5 results)
Research Products
(15 results)
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[Journal Article] Possible involvement of basic FGF in the upregulation of PDGFRβ in pericytes after ischemic stroke2016
Author(s)
Nakamura K, Arimura K, Nishimura A, Tachibana M, Yoshikawa Y, Makihara N, Wakisaka Y, Kuroda J, Kamouchi M, Ooboshi H, Kitazono T, Ago T
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Journal Title
Brain Research
Volume: 1630
Pages: 98-108
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Involvement of platelet-derived growth factor receptor β in fibrosis through extracellular matrix protein production after ischemic stroke2015
Author(s)
Makihara N, Arimura K, Ago T, Tachibana M, Nishimura A, Nakamura K, Matsuo R, Wakisaka Y, Kuroda J, Sugimori H, Kamouchi M, Kitazono T
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Journal Title
Experimental Neurology
Volume: 264
Pages: 127-134
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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