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Elucidation of epigenetic regulation of BMPR2 gene in pulmonary arterial hypertension

Research Project

Project/Area Number 25461139
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionKyorin University

Principal Investigator

Satoh Toru  杏林大学, 医学部, 教授 (20170764)

Co-Investigator(Kenkyū-buntansha) 蒲生 忍  杏林大学, その他部局等, 特任教授 (90122308)
吉野 秀朗  杏林大学, 医学部, 教授 (90129734)
Co-Investigator(Renkei-kenkyūsha) KATAOKA Masaharu  慶應義塾大学, 医学部, 講師 (20445208)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords肺動脈性肺高血圧症 / 病態医学 / 循環器病学 / 遺伝子学 / 遺伝子解析 / BMPR2 / PAH / IPAH / ncRNA / PAH / IPAH
Outline of Final Research Achievements

In this study, we investigated the mutation of BMPR2 gene using large number of samples of Japanese patient with pulmonary arterial hypertension (PAH). BMPR2 gene mutations was checked by both of PCR direct sequencing and MLPA method. As a result, 41 BMPR2 gene mutations including 3 de-novo mutations were identified. Based on the results in this study, database analysis was performed. In addition, the mechanism of exon deletion was investigated, resulting the possibility of Alu-mediated deletion. Furthermore, we analyzed the relationship between BMPR2 gene mutation and clinical prognosis, demonstrating that the prognosis of patients with BMPR2 mutation was better than those without mutation.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (6 results)

All 2016 2015 2013

All Journal Article (6 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 6 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results)

  • [Journal Article] Familial Chronic Thromboembolic Pulmonary Hypertension in a Pair of Japanese Brothers.2016

    • Author(s)
      Kataoka M, Momose Y, Aimi Y, Fukuda K, Gamou S, Satoh T.
    • Journal Title

      Chest

      Volume: 150 Issue: 3 Pages: 748-749

    • DOI

      10.1016/j.chest.2016.06.021

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Improved Survival of Patients with Pulmonary Arterial Hypertension with BMPR2 Mutations in the Last Decade.2016

    • Author(s)
      Isobe S, Kataoka M, Aimi Y, Gamou S, Satoh T, Fukuda K.
    • Journal Title

      Am J Respir Crit Care Med

      Volume: 193 Issue: 11 Pages: 1310-1314

    • DOI

      10.1164/rccm.201601-0158le

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] De Novo Mutations in the BMPR2 Gene in Patients with Heritable Pulmonary Arterial Hypertension2015

    • Author(s)
      Momose Y, Aimi Y, Hirayama T, Kataoka M, Ono M, Yoshino H, Satoh T, Gamou S.
    • Journal Title

      Annals of human genetics

      Volume: 79 Issue: 2 Pages: 85-91

    • DOI

      10.1111/ahg.12096

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 肺動脈性肺高血圧症の遺伝解析の現状と問題点2013

    • Author(s)
      相見祐樹、片岡雅晴、水見彩子、佐藤徹、吉野秀朗、岡明、小野正恵、蒲生忍
    • Journal Title

      杏林医学界雑誌

      Volume: 44-2 Pages: 43-51

    • NAID

      130003364548

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A novel break point of the BMPR2 gene exonic deletion in patient with pulmonary arterial hypertension2013

    • Author(s)
      Aimi Y, Hirayama T, Kataoka M, Momose Y, Nishimaki S, Matsushita K, Yoshino H, Satoh T, Gamou S
    • Journal Title

      J Hum Genet.

      Volume: 58(12) Pages: 815-8

    • NAID

      40019919326

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Alu-mediated nonallelic homologous and nonhomologous recombination in the BNPR2 gene inheritable pulmonary arterial hypertension2013

    • Author(s)
      Kataoka M, Aimi Y, Yanagisawa R, Ono M, Oka A, Fukuda K, Yoshino H, Satoh T, Gamou S
    • Journal Title

      Genet Med

      Volume: 15(12) Pages: 941-7

    • Related Report
      2013 Research-status Report
    • Peer Reviewed

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Published: 2014-07-25   Modified: 2019-07-29  

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