The mechanism of vascular calcification and endothelial dysfunction in chronic kidney disease
Project/Area Number |
25461140
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cardiovascular medicine
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Research Institution | Kurume University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
岩元 美子 久留米大学, 医学部, 助教 (30597422)
打和 大幹 久留米大学, 医学部, 助教 (30624506)
甲斐 久史 久留米大学, その他部局等, 教授 (60281531)
|
Project Period (FY) |
2013-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 慢性腎不全 / 血管病 / 血管内皮機能 / 血管石灰化 |
Outline of Final Research Achievements |
BMP receptor signaling has a pivotal role in endothelial dysfunction, in addition to osteogenic differentiation of VSMCs, in the early stage of CKD without vascular remodeling. An increase in PTEN protein is involved in the mechanism by which BMP receptor activation inhibits Akt-eNOS signaling in CKD. Our observations suggest that BMP receptor signaling would be a promising target for the prevention and treatment of both endothelial dysfunction and vascular calcification in the early stage of CKD patients.
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Report
(5 results)
Research Products
(8 results)
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[Journal Article] Interleukin-1β is associated with coronary endothelial dysfunction in patients with mTOR inhibitor-eluting stent implantation.2017
Author(s)
Chibana H, Kajimoto H, Ueno T, Yokoyama S, Sasaki K, Ohtsuka M, Koiwaya H, Nakayoshi T, Mitsutake Y, Itaya N, Sasaki M, Fukumoto Y.
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Journal Title
Heart and Vessels
Volume: 1
Issue: 7
Pages: 823-832
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] BMP type I receptor inhibition attenuates endothelial dysfunction in mice with chronic kidney disease2014
Author(s)
Kajimoto, H. Kai, H. Aoki, H. Uchiwa, H. Aoki, Y. Yasuoka, S. Anegawa, T. Mishina, Y. Suzuki, A. Fukumoto, Y. Imaizumi, T.
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Journal Title
Kidney international
Volume: 87
Issue: 1
Pages: 128-36
DOI
Related Report
Peer Reviewed
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[Journal Article] Large Blood Pressure Variability Aggravates Arteriolosclerosis and Cortical Sclerotic Changes in the Kidney in Hypertensive Rats2014
Author(s)
Aoki Y, Kai H, Kajimoto H, Kudo H, Takayama N, Yasuoka S, Anegawa T, Iwamoto Y, Uchiwa H, Fukuda K, Kage M, Kato S, Fukumoto Y, Imaizumi T.
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Journal Title
Circulation Journal
Volume: 78
Issue: 9
Pages: 2284-2291
DOI
NAID
ISSN
1346-9843, 1347-4820
Related Report
Peer Reviewed / Open Access
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