Development of a novel gene transferable HDL-generating peptide.
Project/Area Number |
25461141
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cardiovascular medicine
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Research Institution | Fukuoka University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
SAKU KEIJIRO 福岡大学, 医学部, 教授 (40183371)
MATSUNAGA YOUICHI 徳島文理大学, 薬学部, 教授 (80239053)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | ペプチド / アポリポ蛋白 / 高比重リポ蛋白 / 人工HDL / 動脈硬化 / 遺伝子導入 / 高比重リポタンパク |
Outline of Final Research Achievements |
HDL-targeted therapy is in the spotlight for anti-atherosclerosis treatment. An apoA-I mimetic peptides, FAMP5 has been established, and it confirmed that 16-weeks treatment of FAMP5 inhibits aortic atherosclerotic plaque progressions with an improvement of HDL biological functions in ApoE-/- atherosclerotic model. Furthermore, FAMP5-Duo, a novel symmetrical ApoA-I mimetic peptide which has a lysine with the side chain at the C-terminus end was developed. Consequently, it was identified a gene transferring and confirmed the transferred protein expressions by FAMP5-Duo in addition to an improvement of ABCA1-specificity. A novel gene transferable HDL-generating peptide was developed and it has significant atheroprotective potential and may prove to be a therapeutic tool for atherosclerotic diseases.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] A Novel Inducible Cholesterol Efflux Peptide, FAMP, Protects Against Myocardial Ischemia Reperfusion Injury Through a Nitric Oxide Pathway.2016
Author(s)
Suematsu Y, Miura S, Takata K, Shimizu T, Kuwano T, Imaizumi S, Yahiro E, Uehara Y, Saku K.
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Journal Title
Int J Cardiol
Volume: 202
Pages: 810-816
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Newly developed apolipoprotein A-I mimetic peptide promotes macrophage reverse cholesterol transport in vivo.2015
Author(s)
Shimizu T, Tanigawa H, Miura S, Kuwano T, Takata K, Suematsu Y, Imaizumi S, Yahiro E, Zhang B, Uehara Y, Saku K.
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Journal Title
Int J Cardiol.
Volume: 192
Pages: 82-88
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Newly developed apolipoprotein A-I mimetic peptide promotes macrophage reverse cholesterol transport in vivo.2015
Author(s)
Shimizu T, Tanigawa H, Miura S, Kuwano T, Takata K, Suematsu Y, Imaizumi S, Yahiro E, Zhang B, Uehara Y, Saku K.
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Journal Title
Int J Cardiol.
Volume: 192
Pages: 82-88
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Impact of Cigarette Smoking Cessation on High-Density Lipoprotein Functionality.2014
Author(s)
Takata K, Imaizumi S, Kawachi E, Suematsu Y, Shimizu T, Abe S, Matsuo Y, Tsukahara H, Noda K, Yahiro E, Zhang B, Uehara Y, Miura SI, Saku K.
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Journal Title
Circ J.
Volume: 78
Pages: 2955-62
Related Report
Peer Reviewed / Open Access
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[Journal Article] FAMP, a novel apoA-I mimetic peptide, suppresses aortic plaque formation through promotion of biological HDL function in ApoE-deficient mice.2013
Author(s)
Uehara, Y., S. Ando, E. Yahiro, K. Oniki, M. Ayaori, S. Abe, E. Kawachi, B. Zhang, S. Shioi, H. Tanigawa, S. Imaizumi, S. Miura, and K. Saku.
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Journal Title
J Am Heart Assoc
Volume: 2
Issue: 3
DOI
Related Report
Peer Reviewed
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[Journal Article] Novel Molecular Imaging of Atherosclerosis With Gallium-68-Labeled Apolipoprotein A-I Mimetic Peptide and Positron Emission Tomography2013
Author(s)
Kawachi E, Uehara Y, Hasegawa K, Yahiro E, Ando S, Wada Y, Yano T, Nishikawa H, Shiomi M, Miura S, Watanabe Y, Saku K.
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Journal Title
Circulation Journal
Volume: 77
Issue: 6
Pages: 1482-1489
DOI
NAID
ISSN
1346-9843, 1347-4820
Related Report
Peer Reviewed
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